Clinical trials: Infections, Coronavirus
COVID-19
Understanding the Determinants of Mucosal Immunity and Optimizing the Diagnosis of Infection With SARS-CoV-2 Variants
One of the current health challenges in the face of the COVID-19 pandemic that started in Wuhan in 2019, and still responsible for successive waves, is to better understand and diagnose the infection.
- Trial name
- COVARIANT (NCT05858502)
- Testing
- Blood sample collection, Saliva sample collection, Nasopharyngeal and nasal sample collection
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Post-Covid Syndrome
Residual Symptoms After Coronavirus Disease (COVID-19) in Lithuanian Population
The aim of the study is to describe the post-covid-19 syndrome in Lithuanian population regarding the remaining symptoms and their impact on physical functioning, work ability and needs of rehabilitation.
- Trial name
- Post-Covid (NCT05000229)
- Where
- Lithuania
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
COVID-19
COntinuous Signs Monitoring In Covid-19 Patients
This is a pilot study to assess whether artificial intelligence (AI) combined with continuous vital signs monitoring from wearable sensors can predict clinically relevant outcomes in patients with suspected or confirmed Covid-19…
- Trial name
- COSMIC-19 (NCT04581031)
- Testing
- Continuous vital sign monitoring - Isansys Patient Status Engine, Machine Learning/AI Algorithm
- Where
- 2 sites in United Kingdom
- Volunteers
- 48 people
- Sponsor
- The Christie NHS Foundation Trust
Speech Perception, Communication Barriers
The Effects of Operating Room COVID-19 Personal Protective Equipment on Speech Perception and Listening Effort
BACKGROUND: The aim of this study is to evaluate the effects of the combination surgical mask+N95 mask+face shield in operating room on speech perception and listening effort during the COVID-19 process.
- Conditions
- Speech Perception, Communication Barriers, Operating Rooms, Protective Devices
- Trial name
- NCT07505953
- Where
- Turkey (Türkiye)
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Covid19
Estradiol and Progesterone in Hospitalized COVID-19 Patients
The purpose of this study is to determine to what extent a short systemic steroid therapy with estradiol and progesterone, administered early to hospitalized and confirmed COVID-19 positive patients of both sexes in addition to…
- Trial name
- NCT04865029
- Testing
- Estradiol Cypionate 5 mg/ml, Progesterone 200 mg Oral Capsule
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Tulane University
Post-acute Sequelae of COVID-19, Long COVID
SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction
The purpose of this research study is to test if the combination of three drugs, valacyclovir, celecoxib, and Paxlovid will decrease the symptoms of Long COVID in adults compared to a placebo (this does not contain the…
- Trial name
- SHIELD (NCT07597902)
- Testing
- Valacyclovir, Celecoxib, Paxlovid
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Coronavirus Infection
Inhaled Corticosteroid Treatment of COVID19 Patients With Pneumonia
Randomized, prospective, controlled open label clinical trial aimed at investigating if the addition of inhaled corticosteroids (budesonide) reduces treatment failure (defined as a composite variable by the initiation of…
- Trial name
- NCT04355637
- Testing
- Inhaled budesonide
- Where
- 14 sites in Argentina, Spain
- Volunteers
- 120 people
- Sponsor
- Sara Varea
COVID-19, Vaccinations
COVID-19 Testing and Vaccination Among Spanish Speakers
Latinx communities are disproportionately affected by the COVID-19 pandemic, with Spanish-speaking Latinx communities carrying even heavier burdens of infection, hospitalization, and mortality.
- Trial name
- NCT05302908
- Testing
- NuestraSaludSegura
- Where
- United States
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Covid19, Brain
COVID-19 and the Brain
The main objective of this project is: 1. To assess the impact of COVID-19 on the brain and executive functioning. Twenty adult subjects of UZ Brussels (volunteers), who needed intensive care due to COVID-19 (n=10) or exhibited…
- Conditions
- Covid19, Brain, Neurocognition, fMRI
- Trial name
- NCT04726176
- Testing
- Exposure to COVID-19
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Vrije Universiteit Brussel
Covid19, SARS-CoV-2 PNEUMONIA
Evaluation of Safety and Efficiency of Method of Exosome Inhalation in SARS-CoV-2 Associated Pneumonia.
Coronavirus is an acute viral disease with prevailing upper respiratory tract infections caused by the RNA-containing virus of the genus Betacoronavirus of the Coronaviridae family.
- Conditions
- Covid19, SARS-CoV-2 PNEUMONIA, COVID-19
- Trial name
- COVID-19EXO (NCT04491240)
- Testing
- EXO 1 inhalation, EXO 2 inhalation
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- State-Financed Health Facility "Samara Regional Medical Center Dinasty"
Covid-19
CLBS119 for Repair of COVID-19 Induced Pulmonary Damage
This clinical trial will explore the safety and potential efficacy of CLBS119 for the repair of COVID-19 induced pulmonary damage in adults.
- Trial name
- NCT04522817
- Testing
- CLBS119
- Where
- United States
- Sponsor
- Lisata Therapeutics, Inc.
Vascular Stiffness, Cardiorespiratory Fitness
Comparison of Home- vs. Gym-based Exercise Delivery Modes
Home-based exercise interventions were the only alternatives to attenuate physical deconditioning and ameliorate traditional and emergent cardiovascular risk factors progression during the COVID-19 outbreak.
- Trial name
- UPSIDE DOWNS (NCT05701943)
- Testing
- Home-Based, Gym-Based
- Where
- Portugal
- Volunteers
- 17 people
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Covid19, Influenza
Wide Scale Monitoring for Acute Respiratory Infection Using a Mobile-Based Study Platform
This is a prospective observational study using a mobile study platform (app) that is designed for use on Android phones. Study participants will provide baseline demographic and medical information and report symptoms of…
- Conditions
- Covid19, Influenza, Respiratory Tract Infections, Acute Respiratory Tract Infection
- Trial name
- NCT04663776
- Where
- United States
- Volunteers
- 16,000 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
COVID-19, ARDS
Targeted Steroids for ARDS Due to COVID-19 Pneumonia: A Pilot Randomized Clinical Trial
This trial will determine the safety and estimate efficacy of targeted corticosteroids in mechanically ventilated patients with the hyper-inflammatory sub phenotype of ARDS due to coronavirus disease 2019 (COVID-19) by…
- Trial name
- NCT04360876
- Testing
- Dexamethasone injection
- Sponsor
- University of Colorado, Denver
Convalescence, Corona Virus Infection
Convalescent Plasma Therapy in Patients With COVID-19
Scientists and medical workers all around the world were running out of time to manage COVID-19. Several studies have been done to understand the disease and ultimately to find possible treatment.
- Conditions
- Convalescence, Corona Virus Infection, Plaque
- Trial name
- NCT04407208
- Testing
- Convalescent plasma
- Where
- Indonesia
- Volunteers
- 10 people
- Sponsor
- Biofarma
Virus; Pneumonia
A Survey of Psychological Status of Medical Workers and Residents in the Context of 2019 Novel Coronavirus Pneumonia
Due to the outbreak of 2019 Novel Coronavirus Pneumonia in Wuhan, Hubei province, medical staff and residents are facing great psychological pressure, the investigator plan to use electronic questionnaire to carry out…
- Trial name
- NCT04260308
- Where
- China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Adjustment Disorder, Anxiety
Online MBCT for Adjustment Disorder During COVID-19: Efficacy, Mechanisms, and RCT
This study tested a 4-week, internet-based Mindfulness-Based Cognitive Therapy (MBCT) program designed to help people experiencing adjustment disorder during the COVID-19 pandemic.
- Conditions
- Adjustment Disorder, Anxiety, Depressive
- Trial name
- NCT07128017
- Testing
- Mindfulness-Based Cognitive Therapy (Internet-delivered), Progressive Muscle Relaxation (Internet-delivered), No Intervention - Waitlist Control
- Where
- Poland
- Volunteers
- 301 people
- Sponsor
- University of Warsaw
Corona Virus Infection, Psychiatric Disorder
Psychological Impact of the Corona Virus (SARS-CoV-2) and COVID-19 Pandemic in Individuals With Psychiatric Disorders
The aim of this study is to measure current affective symptoms and psychological distress in individuals with severe mental illness during the COVID-19 pandemic using an online questionnaire survey.
- Conditions
- Corona Virus Infection, Psychiatric Disorder, Psychological Distress
- Trial name
- NCT04410835
- Testing
- Online Survey
- Where
- Austria
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Severe Acute Respiratory Syndrome, Coronavirus
A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of Vaccine CVnCoV in Healthy Adults for COVID-19
This study aims to evaluate the safety and reactogenicity profile after 1 and 2 dose administrations of CVnCoV at different dose levels.
- Conditions
- Severe Acute Respiratory Syndrome, Coronavirus, SARS-CoV-2, COVID-19
- Trial name
- NCT04449276
- Testing
- CVnCoV Vaccine
- Where
- 4 sites in Belgium, Germany
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- CureVac
COVID-19 Pandemic, Transplantation, Kidney
Seroprevalence of the Anti-SARS-CoV-2 Antibodies (Causing COVID-19) in Kidney Transplant Recipients in Severely Affected Region
Goal of this study is to evaluate the seroprevalence of anti-SARS-CoV-2 antibodies in patients after kidney transplantation who are one of the risk groups for the severe course of the infection and map the progression of the…
- Trial name
- SECOVtx (NCT04874740)
- Testing
- No intervention
- Where
- Czechia
- Volunteers
- 300 people
- Sponsor
- University Hospital Ostrava
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