Clinical trials: Infections, Coronavirus
Safety, SARS-CoV2 Infection
Efficacy of Ivermectin in COVID-19
The newly emerged corona virus disease 2019 (COVID-19) has spread to all over the world, with recent estimates of more than 236 million cases diagnosed and led to 4.8 million deaths as November 20211 .Therapeutic approaches are…
- Conditions
- Safety, SARS-CoV2 Infection, Ivermectin Poisoning, Effect of Drug
- Trial name
- NCT05076253
- Testing
- Ivermectin
- Where
- Thailand
- Volunteers
- 72 people
- Sponsor
- Bangkok Metropolitan Administration Medical College and Vajira Hospital
Transcranial Direct Current Stimulation, Mental Health Issue
Promote Brain Resilience for the Coronavirus (COVID-19) Pandemic
Background: By the end of 2020, the coronavirus disease (COVID-19) pandemic resulted in over 84 million cases and nearly 2 million deaths.
- Conditions
- Transcranial Direct Current Stimulation, Mental Health Issue, Public Health, Resilience, Psychological
- Trial name
- MBNPR (NCT05293431)
- Testing
- Transcranial Alternate Current Stimulation
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Institut Guttmann
Hypoxic Pulmonary Vasoconstriction, Hypoxemia
Effects in Oxygenation and Hypoxic Pulmonary Vasoconstriction in ARDS Secondary to SARS-CoV2
Summary Currently, the COVID-19 pandemic has overtaken health systems worldwide, exceeding the capacity of intensive care units.
- Conditions
- Hypoxic Pulmonary Vasoconstriction, Hypoxemia, Acute Respiratory Distress Syndrome, SARS-CoV-2 Acute Respiratory Disease
- Trial name
- COVID-19 (NCT04998253)
- Testing
- Effects in oxygenation and hypoxic pulmonary vasoconstriction
- Where
- Mexico
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Unidad Temporal COVID-19 en Centro Citibanamex
Covid19
Retrospective Study of ImmunoFormulation for COVID-19
Multicentre, retrospective, observational study to describe the course of SARS-CoV-2 disease in patients treated or not with IMUNO TF ® and a combination of nutraceuticals and who have tested positive in a COVID-19 diagnostic…
- Trial name
- NCT04666753
- Testing
- ImmunoFormulation
- Where
- 2 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Fagron Iberica S.A.U.
COVID-19
Exhaustion and Needs in Frontline COVID-19 Healthcare Workers: Cross-sectional Study in a Belgian Population
Background: In the Covid-19 pandemic context, all healthcare teams face clinical, organizational and technical challenges given the contagion, severity and mortality characteristics of the disease.
- Trial name
- NCT04344145
- Where
- 5 sites in Belgium
- Volunteers
- 693 people, healthy volunteers welcome
- Sponsor
- Université Libre de Bruxelles
COVID-19, SARS-CoV 2
Canakinumab in Covid-19 Cardiac Injury (The Three C Study)
TThe purpose of this prospective, Phase 2, single center, blinded, randomized controlled study is to demonstrate as a proof of concept that early treatment with canakinumab prevents progressive heart and respiratory failure in…
- Trial name
- NCT04365153
- Testing
- Canakinumab Injection 600mg, Canakinumab Injection 300mg
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- The Cleveland Clinic
Secondary Sclerosing Cholangitis, COVID-19
SSC-COVID in Patients After COVID-19
Analysis of occurrence of SSC-COVID in SARS-CoV-2-patients after the first wave of COVID-pandemic
- Trial name
- NCT05233553
- Testing
- control of liver enzymes
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- University Hospital Tuebingen
COVID-19
A Study to Evaluate Efficacy and Safety of the Combination of SCTA01 & SCTA01C in Outpatients With COVID-19
The study is comprised of two parts: safety evaluation part (Phase I/II) and the pivotal study (Phase III) to evaluate the efficacy and safety of the combination of SCTA01 \& SCTA01C compared to placebo in addition to Standard of…
- Trial name
- NCT05156645
- Testing
- SCTA01 and SCTA01C
- Sponsor
- Sinocelltech Ltd.
Covid-19
Rapid Diagnostic Test for COVID-19 Based on Antibody Detection (YCOVID)
Ycovid-19 aims to be a rapid diagnostic test for SARS-CoV-2 infection, which will allow a reliable diagnosis to be made in 10 minutes, and on easy-to-use devices.
- Trial name
- YCOVID (NCT04490837)
- Testing
- ELISA and Rapid test to detect antibodies against COVID-19
- Where
- Spain
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Corporacion Parc Tauli
COVID-19, SARS-CoV Infection
Chloroquine Diphosphate in the Prevention of SARS in Covid-19 Infection
This is a double-blind, randomized, placebo-controlled clinical trial. A total of 210 individuals aged over 18 years old, without a diagnosis of severe respiratory disease, who came to the study site with clinical and…
- Conditions
- COVID-19, SARS-CoV Infection, Severe Acute Respiratory Syndrome (SARS) Pneumonia, Clinical Trial
- Trial name
- CloroCOVID19II (NCT04342650)
- Testing
- Chloroquine Diphosphate
- Where
- Brazil
- Volunteers
- 152 people
- Sponsor
- Fundação de Medicina Tropical Dr. Heitor Vieira Dourado
COVID-19
Efficacy, Immunogenicity and Safety of Inactivated ERUCOV-VAC Compared With Placebo in COVID-19
The objective is to determine the efficacy, immunogenicity and safety of two different strengths (3 µg and 6 µg) of an inactivated COVID 19 Vaccine compared to placebo so that to demonstrate the efficacy and safety in prophylaxis…
- Trial name
- NCT04824391
- Testing
- ERUCOV-VAC 3 µg/0.5 ml Vaccine, ERUCOV-VAC 6 µg/0.5 ml Vaccine
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Health Institutes of Turkey
Coronavirus
COVID-19 Vaccine (ChAdOx1 nCoV-19) Trial in South African Adults With and Without HIV-infection
A Phase I/II, double-blinded, placebo-controlled, individually randomized trial to assess safety, immunogenicity and efficacy of the candidate Coronavirus disease (COVID-19) vaccine ChAdOx1 nCoV-19 in adults aged 18-65 years…
- Trial name
- NCT04444674
- Testing
- ChAdOx1 nCoV-19, Normal saline 0.9%
- Where
- 7 sites in South Africa
- Volunteers
- 2,130 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Myalgic Encephalomyelitis, Long-COVID
Low Dose Rapamycin in ME/CFS, Long-COVID, and Other Infection Associated Chronic Conditions
The goal of this observational study is to assess the clinical response and the effect of autophagy function in patients before, during and throughout oral low dose sirolimus (rapamycin) therapy.
- Trial name
- NCT06257420
- Testing
- Rapamycin
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Simmaron Research Inc.
COVID 19
Anti COVID-19 Convalescent Plasma Therapy
Why is the research needed? The pandemic known as COVID-19 is now spreading across the world with currently (April 10, 2020) more than 1 115 530 active cases and 96 791 deaths.
- Trial name
- NCT04345679
- Testing
- anti-SARS-CoV-2 convalescent plasma
- Where
- Hungary
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Orthosera Kft.
SARS-CoV-2
A Study to Evaluate Safety and Effectiveness of mRNA-1273 COVID-19 Vaccine in Healthy Children Between 6 Months of Age and Less Than 12 Years of Age
The primary goal for this study is to evaluate up to 3 dose levels of mRNA-1273 vaccine given to healthy children as intramuscular (IM) injection in 2 doses (in Parts 1 and 2) and 3 doses (in Part 3), and a third dose or an…
- Trial name
- NCT04796896
- Testing
- mRNA-1273, mRNA-1273.214
- Where
- 91 sites in United States, Canada
- Volunteers
- 11,942 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
Covid19
Use of Lung Ultrasound in Evaluating Physiological Response to Awake Self Proning
The primary objective of this study is to explore the physiological mechanism of awake, self proning among patients with acute hypoxemic respiratory failure induced by COVID-19, using LUS in the first three days and explore the…
- Trial name
- NCT04855162
- Where
- 2 sites in United States, Mexico
- Volunteers
- 74 people
- Sponsor
- Rush University Medical Center
Ebola Virus Disease, COVID-19
Safety and Immunogenicity of rVSVΔG-ZEBOV-GP Vaccination When Dosed Concurrently With mRNA COVID-19 Vaccine Booster Doses
Concurrent vaccination scheduling for key target populations in Rwanda, such as healthcare workers, may confer significant advantages in the provision of vaccine coverage to several infectious diseases.
- Trial name
- NCT06587503
- Testing
- BioNTech - Pfizer COVID-19 vaccine, 1mL saline solution, rVSV∆G-ZEBOV-GP
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Covid-19 Pneumonia, Cyotokine Storm
Adipose Mesenchymal Cells for Abatement of SARS-CoV-2 Respiratory Compromise in COVID-19 Disease
The aim of this study is to evaluate the safety and efficacy of autologous adipose-derived mesenchymal cells for treating confirmed or suspected patients with SARS-CoV-2 and compromised respiratory function requiring…
- Trial name
- NCT04352803
- Testing
- Autologous Adipose MSC's
- Volunteers
- 20 people
- Sponsor
- Regeneris Medical
Sarcopenia
Sarcopenia and Mechanical Ventilation in Older Patients Admitted Due to COVID-19
The SarcoV study aims at assessing the association between sarcopenia and the indication of mechanical ventilation in older hospitalized patients due to COVID-19 infection
- Trial name
- SARCO-V (NCT04772586)
- Where
- Belgium
- Volunteers
- 46 people
- Sponsor
- Brugmann University Hospital
Covid19
Antisense Therapy to Block the Kallikrein-kinin Pathway in COVID-19
Up to 1/3 of all patients infected with COVID-19 can develop complications that require hospitalization. Severe pneumonia associated with acute respiratory distress syndrome (ARDS) is the most threatening and feared complication…
- Trial name
- ASKCOV (NCT04549922)
- Testing
- ISIS 721744, Normal Saline
- Where
- 3 sites in Brazil
- Volunteers
- 111 people
- Sponsor
- Hospital do Coracao
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