Clinical trials: Infections, Coronavirus
COVID-19
A Phase II Clinical Trial to Evaluate the Recombinant Vaccine for COVID-19 (Adenovirus Vector)
This is a phase II, randomised, double-blinded and placebo-controlled clinical trial in healthy adults above 18 years of age. This clinical trial is designed to evaluate the immunogenicity and safety of Ad5-nCoV which encodes for…
- Trial name
- CTII-nCoV (NCT04341389)
- Testing
- Recombinant novel coronavirus vaccine (Adenovirus type 5 vector)
- Where
- China
- Volunteers
- 508 people, healthy volunteers welcome
- Sponsor
- Institute of Biotechnology, Academy of Military Medical Sciences, PLA of China
SARS-CoV Infection, Covid19
Cross Sectional CFAR HIV/COVID-19 Study
The main purpose of this research study is to learn the rate of SARS COV-2 on HIV infected children, adolescents, and youth receiving their primary HIV care at the University of Miami Miller School of Medicine.
- Trial name
- NCT04514016
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Miami
Covid19, Neurological Complication
COVID-19 Infection: Exploration of Respiratory Control Center Abnormalities
The purpose of the present study is to determine whether there is a decrease in the emotional response to experimental induction of dyspnea by hypoxic stimulation in subjects with a "neurological" form of COVID-19, compared to…
- Trial name
- CRC-COVID (NCT04363749)
- Testing
- hypoxia : 14.3 and 12.7% FIO2, hypercapnia 7% CO2, inspiratory mechanical constraint
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Covid19
Western Kenya Integrated COVID-19 Response
To respond to the COVID-19 pandemic, investigators will be deploying community health workers, equipped with mobile technology, and accompanied by youth to visit households door to door to screen for symptoms of COVID-19…
- Trial name
- NCT04501458
- Testing
- Training of youth, community health assistants and community health workers., Training clinicians in basic critical care and the management of severe COVID-19 cases
- Where
- Kenya
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Surgical Systems Research Group
Covid19, Kidney Diseases
Michigan Medicine COVID-19 Cohort: Clinical Characteristics, Inflammatory Markers and Outcomes of Patients Hospitalized for COVID-19
To better understand the role of inflammation in COVID-19, we established the Michigan Medicine COVID-19 Cohort (M2C2). M2C2 is a funded and ongoing cohort which has currently enrolled over 1500 adult patients (≥18 years) with…
- Conditions
- Covid19, Kidney Diseases, Inflammation, SARS-CoV Infection
- Trial name
- M2C2 (NCT04706533)
- Testing
- Biomarkers of inflammation
- Where
- United States
- Volunteers
- 3,402 people
- Sponsor
- University of Michigan
COVID-19 VACCINE, Covid19
Collaborative Study to Evaluate Heterologous Vaccination Against Covid-19 in Argentina
Randomized, open, multicenter, collaborative and adaptive non-inferiority trial to evaluate the immunogenicity and reactogenicity of the heterologous vaccination schedules made up of the combination of vaccines available in…
- Trial name
- ECEHeVac (NCT04988048)
- Testing
- COVID-19 vaccines
- Where
- 4 sites in Argentina
- Volunteers
- 1,760 people, healthy volunteers welcome
- Sponsor
- Ministry of Public Health, Argentina
Covid19, Mechanical Ventilation Complication
Efficacy of CONvalescent Plasma in Patients With COVID-19 Treated With Mechanical Ventilation
The principal objective of the CONFIDENT trial is to assess the efficacy of two units (400-500 mL in total) of convalescent plasma, as compared to Standard of Care (SoC), to reduce day-28 mortality in patients with SARS-CoV-2…
- Conditions
- Covid19, Mechanical Ventilation Complication, Corona Virus Infection, Respiratory Failure
- Trial name
- CONFIDENT (NCT04558476)
- Testing
- Convalescent Plasma, Standard of Care
- Where
- 17 sites in Belgium
- Volunteers
- 475 people
- Sponsor
- University of Liege
COVID-19
Clinical Study of F61 Injection in Healthy Chinese Subjects
Main purpose： To evaluate the safety and tolerability of single-dose ascending intravenous infusion of F61 in healthy subjects. Secondary purpose： To evaluate the pharmacokinetic profile and immunogenicity of F61 administered by…
- Trial name
- NCT05483504
- Testing
- F61 injection
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wuhan Institute of Biological Products Co., Ltd
COVID-19
Opportunistic Screening for Asymptomatic Left Ventricular Dysfunction in Coronavirus Disease 2019 (COVID19) Survivors
Coronavirus Disease 2019 (COVID-19) emerged in December 2019, and in mere few months has resulted in a pandemic of viral pneumonia.
- Trial name
- NCT04355884
- Testing
- Standard 12-lead ECG, NT-proBNP, echocardiography
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
COVID
Fear Among Dentists During COVID-19 Pandemic
This study aimed to evaluate the anxiety and fear of infection between dentists working during the present corona virus disease 2019 (COVID-19) pandemic and to explore dentist's knowledge about various practice modifications and…
- Trial name
- NCT04383626
- Where
- Egypt
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Cairo University
COVID-19
The Phase 2 Study to Evaluate the Safety and Efficacy of Clevudine in Patients With Moderate COVID-19
The purpose of this clinical trial is to assess the safety and efficacy of Clevudine 120 mg versus placebo once daily administration with standard of care therapy for 14 days (maximum up to 21 days) in patients with moderate…
- Trial name
- NCT04347915
- Testing
- Clevudine
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Bukwang Pharmaceutical
SARS-CoV2
Clinical Features of Severe Patients With COVID-19
As coronavirus disease 2019 (COVID-19) spreads across the world, the intensive care unit (ICU) community must prepare for the challenges associated with this pandemic.
- Trial name
- NCT04450017
- Testing
- The demographic, clinical, laboratory, and instrumental data
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Federal Research Clinical Center of Federal Medical & Biological Agency, Russia
Olfactory Dysfunction, COVID-19
Acupuncture Therapy for COVID-Related Olfactory Loss
This study is looking at the role of acupuncture as a treatment for olfactory dysfunction in patients who tested positive for COVID-19.
- Trial name
- NCT04952389
- Testing
- Acupuncture Therapy, Budesonide, Olfactory Training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
COVID, Coronavirus
Coronavirus Induced Acute Kidney Injury: Prevention Using Urine Alkalinization
Our overarching goal is to improve the outcomes of critically ill COVID-19 patients with or at risk for development of acute kidney injury (AKI).
- Conditions
- COVID, Coronavirus, Coronavirus Infection, AKI
- Trial name
- NCT04530448
- Testing
- Sodium bicarbonate, Standard of Care
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- West Virginia University
URTI, Bronchiolitis
Assessement of Effectiveness of Seawater Nasal Sprays on Sinonasal Symptoms
The purpose of this post-market clinical investigation is to assess in a real-life setting, the effectiveness, usage, tolerance, safety and satisfaction of 4 isotonic and hypertonic seawater-based CE-marked nasal sprays.
- Conditions
- URTI, Bronchiolitis, COVID - 19, Allergic Rhinitis
- Trial name
- SeaBridge (NCT07262450)
- Testing
- Respimer® Hygiene-Prevention -Baby, kids, adults, Respimer® Hygiene-Prevention Kids, adults, Respimer® Decongestion Baby, kids, adults
- Where
- 32 sites in France
- Volunteers
- 1,065 people
- Sponsor
- Laboratoire de la Mer
Covid-19
Use of PCR-Sars-CoV-2 in Children
The VIGIL study was set up at the beginning of the pandemic, in the spring of 2020, at a time when diagnostic testing for SARS-CoV-2 had to be performed according to specific clinical criteria (even if no clinical picture…
- Trial name
- VIGIL (NCT04412317)
- Where
- 2 sites in France
- Volunteers
- 12,000 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Influenza, COVID-19
Analysis of the Determinants of Adherence to Coadministration of Flu Vaccination With the Booster of COVID-19 Vaccine
This study investigates healthcare workers' attitudes towards co-administering COVID-19 and seasonal influenza vaccines, a method supported globally for its efficiency and potential to lessen healthcare burdens.
- Trial name
- CoVFlu (NCT05781191)
- Testing
- COMIRNATY
- Where
- Italy
- Volunteers
- 8,231 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
COVID-19
Viruxal Oral and Nasal Spray for Treating the Symptoms of COVID-19
Viruxal Oral and Nasal Spray is a Class I CE marked medical device manufactured by Kerecis hf (the "Device"). A double blind clinical trial will be conducted to evaluate the Device against placebo in COVID-19 positive…
- Trial name
- KONS-COVID19 (NCT04357990)
- Testing
- Viruxal Oral and Nasal Spray
- Where
- Iceland
- Volunteers
- 128 people
- Sponsor
- Kerecis Ltd.
Influenza, COVID-19
Comparative Immunogenicity of Concomitant vs Sequential mRNA COVID-19 and Influenza Vaccinations
This is a prospective, randomized randomized immunologic study of response to influenza and SARS-CoV-2 vaccination across four of the US Influenza Vaccine Effectiveness (Flu VE) Network study sites.
- Trial name
- NCT06020118
- Testing
- Simultaneous Vaccination (Influenza Vaccine and mRNA COVID booster), Sequential Vaccination (Influenza vaccine then mRNA COVID booster), Sequential Vaccination (mRNA COVID booster then Influenza vaccine)
- Where
- 8 sites in United States
- Volunteers
- 455 people, healthy volunteers welcome
- Sponsor
- Duke University
Covid19
To Evaluate the Safety and Efficacy of TQ Formula in Covid-19 Participants
This is a randomized (1:1), double-blind, placebo-controlled phase 2 study to assess safety and efficacy of Total TQ Formula (3 g daily dose of Nigella Sativa Oil) capsules versus placebo in treating patients who have tested…
- Trial name
- BOSS (NCT04914377)
- Testing
- TQ Formula/Tab
- Where
- 3 sites in United States
- Volunteers
- 55 people
- Sponsor
- Novatek Pharmaceuticals
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