Clinical trials: Infections, Coronavirus
COVID-19
Characterising Transmission of SARS-CoV-2 in a Peri-urban Population in Mozambique
A population-based COVID19 surveillance in a household cohort will be set-up using an existing Household demographic surveillance system (HDSS).
- Trial name
- AfriCoVER (NCT04442165)
- Where
- Mozambique
- Volunteers
- 6,049 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Covid-19
Testing the Accuracy of a Digital Test to Diagnose Covid-19
The Covid-19 viral pandemic has caused significant global losses and disruption to all aspects of society. One of the major difficulties in controlling the spread of this coronavirus has been the delayed and mild (or lack of)…
- Trial name
- NCT04407585
- Testing
- Covid-19 swab PCR test
- Where
- United Kingdom
- Volunteers
- 1,000,000 people
- Sponsor
- King's College London
Covid19, Sars-CoV-2 Infection
Post Acute Sequelae of COVID-19
COVID-19, a novel coronavirus, has caused widespread mortality and morbidity since it emerged in 2019. There is ongoing research and growing literature describing severe acute respiratory syndrome (SARS-COV-2).
- Conditions
- Covid19, Sars-CoV-2 Infection, Dyspnea Caused by 2019-nCoV, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- PASC (NCT04964115)
- Testing
- Cohort study
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Vanderbilt University Medical Center
COVID-19
Passive Immunotherapy In Patients With SARS CoV-2
Plasma from convalescent individuals (convalescent plasma, CP) has been used for more than a hundred years for the treatment of infectious diseases.
- Trial name
- CoV-PlasGal (NCT05578391)
- Testing
- Convalescent plasma
- Where
- Spain
- Volunteers
- 61 people
- Sponsor
- Fundacin Biomedica Galicia Sur
COVID-19, Azvudine
The Real-world Clinical Study of Azvudine Tablets in the Treatment of COVID-19
To establish a real-world clinical cohort and database of Azvudine in the treatment of SARS-CoV-2 infection, and to provide stable and reliable evidence for the clinical efficacy and safety evaluation of azvudine in the treatment…
- Trial name
- NCT06349655
- Testing
- Azvudine, Paxlovid
- Where
- China
- Volunteers
- 32,864 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Coronavirus Infection
ODYSSEY: A Study to Investigate the Efficacy of Tradipitant in Treating Severe or Critical COVID-19 Infection
This is a randomized, double-blind placebo-controlled trial to investigate the efficacy and safety of tradipitant 85 mg orally given twice daily to treat inflammatory lung injury associated with severe or critical COVID-19…
- Trial name
- NCT04326426
- Testing
- Tradipitant
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Vanda Pharmaceuticals
Covid19
Respiratory Muscle Function, Dyspnea, Exercise Capacity and Quality of Life in Severe COVID19 Patients
Further knowledge regarding sequelae in severe COVID-19 patients who have required ICU admission for invasive mechanical ventilation is still needed.
- Trial name
- NCT04853940
- Testing
- Data collection and clinical testing of subjects
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
COVID-19, ARDS
Losartan and Spironolactone Treatment for ICU Patients With COVID-19 Suffering From ARDS
Coronavirus disease (COVID-19) is a current pandemic infection caused by an RNA virus called Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2).
- Trial name
- COVIDANCE (NCT04643691)
- Testing
- Losartan 50 mg and Spironolactone 25 mg pillules oral use
- Where
- France
- Volunteers
- 78 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Mucormycosis; Rhinocerebral (Etiology), COVID-19
World Health Organization (WHO) , COVID19 Case Series of Post Covid 19 Rhino Orbito Cerebral Mucormycosis in Egypt
Objectives: identify and recognize clinical Characteristics, Pathophysiology, and management of a group of patients with rhino Rhino-Orbito-Cerebral Mucormycosis infection associated with Covid 19 viral infection
- Trial name
- NCT06267326
- Testing
- debridment
- Where
- Egypt
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Nasser Institute For Research and Treatment
COVID-19
The Efficacy and Safety of TADIOS as an Adjuvant Therapy in Patients Diagnosed With Mild to Moderate COVID-19
This study will assess the safety and efficacy and tolerability of TADIOS compared to placebo in patients with mild to moderate COVID-19.
- Trial name
- NCT05552625
- Testing
- TADIOS
- Where
- 6 sites in India
- Sponsor
- Helixmith Co., Ltd.
Cystic Fibrosis, COVID-19
COVID-19 Antibody Responses in Cystic Fibrosis
Coronavirus disease 2019 (COVID-19) which is caused by the virus SARS-CoV-2 has resulted in an ongoing global pandemic. It is unclear whether the relatively low number of reported cases of COVID-19 in people with CF (pwCF) is due…
- Trial name
- CAR-CF (NCT05561868)
- Where
- 2 sites in Ireland
- Volunteers
- 70 people
- Sponsor
- Children's Health Ireland
Acute Respiratory Distress Syndrome
Pilot Clinical Study of NOA-001 for ARDS (Acute Respiratory Distress Syndrome)
The primary object of this clinical study is to investigate the efficacy and the safety of NOA-001 in patients with ARDS (ARDS caused by Non-COVID-19 or COVID-19).
- Trial name
- NCT04804943
- Testing
- NOA-001
- Where
- Japan
- Volunteers
- 45 people
- Sponsor
- Toray Industries, Inc
Coronavirus Infection, Intensive Care Patients
Effects on the Qt Interval of COVID-19 Coronavirus Infection
The present study aims to evaluate the impact of COVID-19 disease and its treatment on ventricular repolarization, assessed by measuring the QTc interval, in patients admitted to the critical care unit.
- Trial name
- QT-COVID-19 (NCT04422535)
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Matilde Zaballos
Stress, Anxiety
Effects of Open-label Placebos on COVID-related Psychological Health
This project aimed to test the efficacy of a telehealth-administered placebo without deception intervention on stress, anxiety, and depression related to the COVID-19 pandemic.
- Conditions
- Stress, Anxiety, Depression
- Trial name
- NCT05035550
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Sepsis, Pneumonia
Comparative Effectiveness of Readmission Reduction Interventions for Individuals With Sepsis or Pneumonia
An adaptive platform trial to compare effectiveness of different care models to prevent readmissions for patients hospitalized with sepsis or lower respiratory tract infection.
- Conditions
- Sepsis, Pneumonia, Lower Resp Tract Infection, Covid19
- Trial name
- ACCOMPLISH (NCT04829188)
- Testing
- Structured Telephone Support (STS), Low-intensity Remote Patient Monitoring (RPM-Low), High-intensity Remote Patient Monitoring (RPM-High)
- Where
- United States
- Volunteers
- 1,296 people
- Sponsor
- University of Pittsburgh
COVID-19
A Phase Ⅲ Clinical Trial of Recombinant COVID-19 Trivalent (XBB+BA.5+Delta) Protein Vaccine (Sf9 Cell) in Booster Vaccination
A Phase Ⅲ Clinical Trial of Recombinant COVID-19 Trivalent (XBB+BA.5+Delta) Protein Vaccine (Sf9 Cell) in Booster Vaccination to Evaluate Efficacy, Safety and Immunogenicity
- Trial name
- NCT05911061
- Testing
- High dose of Recombinant COVID-19 Trivalent (XBB+BA.5+Delta) Protein Vaccine (Sf9 Cell), Low dose of Recombinant COVID-19 Trivalent (XBB+BA.5+Delta) Protein Vaccine (Sf9 Cell), control group
- Volunteers
- 4,950 people, healthy volunteers welcome
- Sponsor
- WestVac Biopharma Co., Ltd.
Coronavirus Infection
Convalescent Plasma Compared to the Best Available Therapy for the Treatment of SARS-CoV-2 Pneumonia
In early December 2019, cases of pneumonia of unknown origin were identified in Wuhan, China. The causative virus was called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Trial name
- COP-COVID-19 (NCT04358783)
- Testing
- Plasma, Best Available Therapy
- Where
- Mexico
- Volunteers
- 31 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Covid19
Analysis of the Pathophysiology and Pathology of Coronavirus Disease 2019 (COVID-19), Including Chronic Morbidity
NAPKON-HAP is the deep phenotyping platform of the National Pandemic Cohort Network (NAPKON) in Germany. NAPKON is a data and biospecimen collection of patients with COVID-19 and is part of the University Medicine Network (NUM)…
- Trial name
- NCT04747366
- Where
- 11 sites in Germany
- Volunteers
- 750 people
- Sponsor
- Charite University, Berlin, Germany
Susceptibility to Viral and Mycobacterial Infection
Efficacy of a Self-test and Self-alert Mobile Applet in Detecting Susceptible Infection of COVID-19
The "COVID-19 infection self-test and alert system" (hereinafter referred to as "COVID-19 self-test applet") jointly developed by Beijing Tsinghua Changgung Hospital, Institute for precision medicine, artificial intelligence of…
- Trial name
- COVID-19 (NCT04256395)
- Testing
- mobile internet survey on self-test
- Where
- China
- Volunteers
- 102,456 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Covid19, Functional Capacity
Comparison of Functional Capacities of Healthcare Workers With and Without Covid-19
This study aimed to investigate if the functional capacity of health workers sustained covid 19 infection effects functional capacity , quality of life and mood of health workers when comparing healthy health workers.
- Trial name
- NCT04834739
- Testing
- 6 minute walk test, 1 minute Sit to Stand Test, Fatigue Severity Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
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