Clinical trials: Infections, Coronavirus
Coronavirus Disease (COVID-19)
Plasma Rich Antibodies From Recovered Patients From COVID19
Prospective interventional study, single arm of purified convalescent plasma transfusion as an add on therapy for the standard of care treatment (national guideline) (Oseltamivir (75mg/12 hours for 5-10 days) and hydroxychroquine…
- Trial name
- PRA-001 (NCT04348877)
- Testing
- Antibody-Rich Plasma from COVID-19 recovered patients
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Covid19
A Phase 2b Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study, Evaluating Efficacy and Safety of Allocetra-OTS in Patients With Severe or Critical COVID-19 With Associated Acute Respiratory Distress Syndrome (ARDS)
This is a Phase 2b multi-center, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of intravenous (IV) Allocetra-OTS 10x10^9 cells vs placebo (1:1) in adult hospitalized patients with severe or…
- Trial name
- NCT04922957
- Testing
- ALLOCETRA-OTS
- Where
- Israel
- Volunteers
- 12 people
- Sponsor
- Enlivex Therapeutics Ltd.
COVID-19
Efficacy and Safety of Favipiravir in the Treatment of COVID-19 Patients Over 15 Years of Age
This study is an observational study (Non-interventional study) to evaluate the safety and efficacy of favipiravir in patients older than 15 years of age, diagnosed with COVID-19 and initiated treatment with favipiravir before…
- Trial name
- NCT04474457
- Testing
- Favipiravir
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people
- Sponsor
- Ministry of Health, Turkey
Covid19
Assessment of Vitamin D Level in COVID-19
his a prospective observational study will be conducted on 100 patients who were diagnosed as SARS-CoV2 positive. The data will be collected from isolation hospital in Sohag governorate during the period from the start of June…
- Trial name
- COVID19 (NCT04949412)
- Testing
- Vitamin D
- Where
- Egypt
- Volunteers
- 98 people
- Sponsor
- Sohag University
Covid19
Thymic Function in Patients With COVID-19
The main clinical manifestation associated with SARS-CoV-2 infection is an influenza-like illness that follows the infection of the respiratory tract.
- Trial name
- COVITHYM (NCT04716907)
- Testing
- Single-Nucleotide Polymorphisms (SNP) within the TCRA/D region, Blood sample, CT Scan
- Where
- France
- Volunteers
- 85 people
- Sponsor
- CMC Ambroise Paré
SARS-CoV-2 Infection
Understanding the Long-term Impact of COVID on Children and Families
This is a combined retrospective and prospective, longitudinal, observational meta-cohort of individuals age 0-25 years who will enter the cohort with and without SARS-CoV-2 infection at varying stages before and after infection.
- Trial name
- NCT05172011
- Where
- 65 sites in United States
- Volunteers
- 15,028 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Cerebral Palsy, Covid19
Rehabilitation Status of Children With Cerebral Palsy and Anxiety of Their Caregivers During the Covid19 Pandemic
Rehabilitation status of children with cerebral palsy (CP) and anxiety of their caregivers during the covid19 pandemic were explored.
- Conditions
- Cerebral Palsy, Covid19, Anxiety
- Trial name
- CP (NCT04916873)
- Where
- Turkey (Türkiye)
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Corona Virus Infection
Differential Expression of Cytokines, Transcriptome and miRNA in Coronavirus Disease 2019 (COVID-19) Egyptian's Patients
The aim of this effort is to study host-pathogen interaction in Egyptian patients infected with COVID-19. The investigators will perform genome-wide miRNA and transcriptome screens in the infected patients along with healthy ones…
- Trial name
- NCT04583566
- Testing
- COVID-19 Diagnostic and Assessment Tests
- Where
- 2 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tanta University
Influenza, COVID-19
Enhancing Protection Against Influenza and COVID-19 for Pregnant Women and Medically at Risk Children
Pregnant women and children with chronic medical conditions are at increased risk of hospitalisation, intensive care admission and death from influenza and COVID-19 infections.
- Trial name
- NCT05613751
- Testing
- Nudge
- Where
- 7 sites in Australia
- Volunteers
- 1,038 people
- Sponsor
- University of Adelaide
COVID19, Herbal Medicine
Changing Susceptible Body Constitution for COVID-19 Prevention by Chinese Medicine in Hong Kong Residents
Chinese medicine has been used for thousands of years in the treatment of epidemic diseases. Through the long-term struggle with the epidemic, Investigators have accumulated and explored a lot of prevention and control…
- Trial name
- NCT04668222
- Testing
- Yu-Ping-Feng formula, Xiang-Sha-Liu-Jun formula, Liu-Wei-Di-Huang formula
- Where
- Hong Kong
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Tracheal Stenosis, COVID-19
Relationship Between Post-Intubation Tracheal Stenosis and Covid-19
Tracheal stenosis (TS) is a serious complication that occurs in approximately 6-22% of patients due to prolonged endotracheal intubation.
- Conditions
- Tracheal Stenosis, COVID-19, Post-Intubation Subglottic Stenosis, Intensive Care Unit
- Trial name
- NCT05682651
- Testing
- tracheal stenosis follow-up file
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Ankara City Hospital Bilkent
COVID-19
A Safety, Tolerability, and Efficacy Study of IBI314 in Ambulatory Patients With COVID-19
This is a dose-finding, inferentially seamless Phase 1/2 study evaluating the safety, tolerability and efficacy of IBI314 in Ambulatory Patients with COVID-19.
- Trial name
- NCT05162365
- Testing
- IBI314
- Where
- 19 sites in United States
- Volunteers
- 248 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Covid19
Sex-Informed Data in the COVID-19 Pandemic.
Sex and gender matter to health equity, especially in a pandemic. Sex (a biological attribute) and gender (a social construct) may influence an individual's susceptibility, vulnerability and exposure to infectious disease.
- Trial name
- G-COV (NCT04497402)
- Where
- Italy
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
COVID-19
Efficacy and Safety of Convalescent Plasma in Treating COVID-19 Hospitalized Patients
This is a Phase II study. This research study is being conducted to use convalescent donor plasma in seriously ill patients who have COVID-19.
- Trial name
- NCT04354831
- Testing
- anti-SARS-CoV-2 convalescent plasma
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- Medical College of Wisconsin
Severe Acute Respiratory Syndrome, COVID
Intermediate IND Severe Illness COVID-19 CP
Beyond supportive care, there are currently no proven therapeutic options for pneumonia due to coronavirus disease (COVID-19), the infection caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
- Trial name
- NCT04411602
- Testing
- SARS-CoV-2 plasma
- Where
- 3 sites in United States
- Sponsor
- Henry Ford Health System
Covid19, SARS-CoV Infection
An Efficacy and Safety Clinical Trial of an Investigational COVID-19 Vaccine (BBV152) in Adult Volunteers
The BBV152 vaccine is being developed to prevent COVID-19, the disease resulting from Severe Acute Respiratory Syndrome coronavirus (SARS-CoV-2) infection.
- Trial name
- NCT04641481
- Testing
- BBV152
- Where
- India
- Volunteers
- 25,800 people, healthy volunteers welcome
- Sponsor
- Bharat Biotech International Limited
Sars-CoV2, Coronavirus Infection
Prevention of COVID19 Infection in Nursing Homes by Chemoprophylaxis With Hydroxychloroquine (PREVICHARM)
Professionals and residents of nursing homes are one of the most vulnerable groups in this public health crisis of COVID-19, since they have the highest rate of positives for COVID-19, despite the restriction measures carried…
- Conditions
- Sars-CoV2, Coronavirus Infection, Prevention & Control, Nursing Home
- Trial name
- PREVICHARM (NCT04400019)
- Testing
- Hydroxychloroquine Only Product in Oral Dose Form
- Volunteers
- 1,930 people, healthy volunteers welcome
- Sponsor
- University of Malaga
Covid19
Hyperbaric Oxygen for COVID-19 Patients With Moderate to Severe Hypoxemia
Of the many treatments proposed for COVID-19, few directly address the severe hypoxia among COVID-19 patients. Interim results from our single-center, non-randomized clinical trial (NCT04332081) suggest that hyperbaric oxygen…
- Trial name
- NCT04619719
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- Legacy Health System
SARS-CoV-2 Infection
Evusheld Japan PMS_Japan Post-Marketing Surveillance (PMS)
To investigate intends to evaluate the incidence of adverse drug reactions (ADRs) in individuals who receive Evusheld in clinical practice to determine its post-marketing safety profile in Japanese.
- Trial name
- NCT05687877
- Where
- 18 sites in Japan
- Volunteers
- 366 people
- Sponsor
- AstraZeneca
COVID-19 Infection
Changes in Seroprevalence and Wellness Over Time in Healthcare Workers (CONSERVE-HCW)
The Investigators propose a multi-center, observational, longitudinal, cohort study of the serology and wellness of HCWs over a year of the COVID-19 pandemic.
- Trial name
- CONSERVE-HCW (NCT04595175)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Brian Tiffany, MD
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