Clinical trials: Infections, Nosocomial
Nosocomial Infections
Reduction of Infection in Neonatal Intensive Care Units Using the Evidence-based Practice for Improving Quality
This 4-year cluster randomized controlled trial aims to determine whether implementation of Evidence-based Practice for Improving Quality (EPIQ) method can reduce hospital-acquired infection in Chinese Neonatal Intensive Care…
- Trial name
- NCT02600195
- Testing
- Evidence-based Practice for Improving Quality (EPIQ) method
- Where
- 24 sites in China
- Volunteers
- 15,600 people
- Sponsor
- Children's Hospital of Fudan University
Bacterial Resistance, Infection Resistant to Multiple Drugs
SATURN 04 Nosocomial Acquisition Study
The study is the WP4 of the EU-funded (7th FW) project SATURN (Impact of Specific Antibiotic Therapies on the prevalence of hUman host ResistaNt bacteria). A total of 6 surgical and 6 medical wards will participate in the study.
- Conditions
- Bacterial Resistance, Infection Resistant to Multiple Drugs, Staph Aureus Methicillin Resistant Colonization, Infection Due to ESBL Bacteria
- Trial name
- SATURN (NCT01208519)
- Where
- 3 sites in Italy, Romania and 1 more
- Volunteers
- 16,680 people
- Sponsor
- Catholic University of the Sacred Heart
Nosocomial Infection, Infection Control
Can Environmental Cleanliness be Assessed by BCA (Bicinchoninic Acid) Method
Effective cleaning of surfaces in the hospital environment is an absolute necessity to reduce pathogen transmission. Multi Drug Resistant Organisms (MDRO) in ICU are among the leading causes of hospital-acquired infections.
- Conditions
- Nosocomial Infection, Infection Control, Multi-antibiotic Resistance
- Trial name
- BCA (NCT04212130)
- Testing
- BCA method for assessing environmental cleanliness
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Cumhuriyet University
Coagulopathy, Nosocomial Pneumonia
Effect of Antioxidant Vitamins on Coagulopathy and Nosocomial Pneumonia After Severe Trauma
The purpose of this study is to determine the effect of antioxidant vitamins (vitamins C and E) on the development of coagulation derangements and nosocomial pneumonia after severe trauma in patients.
- Trial name
- NCT01897792
- Testing
- Vitamin C, Vitamin E, Saline (for Vitamin C)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Alabama at Birmingham
Nosocomial Pneumonia
International Study on NoSocomial Pneumonia in Intensive CaRE (PneumoINSPIRE)
The International study on NoSocomial Pneumonia in Intensive CaRE (PneumoINSPIRE) is a prospective, international, multicentre, observational, cohort study.
- Trial name
- PneumoINSPIRE (NCT02793141)
- Testing
- No intervention
- Where
- 2 sites in Australia, Greece
- Volunteers
- 1,657 people
- Sponsor
- The University of Queensland
Candidemia
Early- and Late-onset Candidemia
A timing diagnosis of candidemia is as important as the correct choice of empiric or targeted antifungal therapy. In the last years a growing body of knowledge has better characterized health-care associated (HCA) infections…
- Trial name
- NCT01406093
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Giovanni Di Perri
Nosocomial Infection, Sepsis
Application of an Antimicrobial Stewardship Program in Brazilian ICUs Using Machine Learning Techniques and an Educational Model
Antimicrobial agents are frequently used empirically and include therapy for both Gram-positive and Gram-negative bacteria. In Brazil, multidrug-resistant Gram-negative pathogens are the cause of most nosocomial infections in…
- Trial name
- NCT05312034
- Testing
- Implementation of the predictive model for an antimicrobial management program
- Volunteers
- 100 people
- Sponsor
- D'Or Institute for Research and Education
Healthy Volunteer
An Open Study to Assess the Safety and Pharmacokinetics of Fluorothyazinone as a Single-Dose Administration or a Treatment Course in Healthy Volunteers
The current Phase I clinical trial has been developed to assess the safety and tolerability of the Fluorothyazinone drug used as a single-dose administration and a treatment course in healthy volunteers.
- Trial name
- NCT03205462
- Testing
- Fluorothyazinone 300 mg, Fluorothyazinone 600 mg, Fluorothyazinone 3900 mg
- Where
- Russia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
MRSA, VRE
Benefits of Universal Glove and Gowning
This study will test if doctors, nurses and other people who take care of patients in hospitals wearing gloves and gown for all contact with patients in an intensive care unit (ICU) will: Decrease the chance of patients getting…
- Trial name
- BUGG (NCT01318213)
- Where
- United States
- Volunteers
- 19,856 people
- Sponsor
- University of Maryland, Baltimore
Nontuberculous Mycobacterial Pulmonary Infection, Outbreak Investigation
Transmission and Acquisition of Nontuberculous Mycobacteria Outbreak Investigation (TrANsMIt)
The goal of this observational study is to support U.S. healthcare centers in determining if they may have an NTM outbreak among patients receiving care at the healthcare center.
- Conditions
- Nontuberculous Mycobacterial Pulmonary Infection, Outbreak Investigation, Healthcare Associated Infection, Mycobacterium Infections
- Trial name
- TrANsMIt (NCT06155747)
- Testing
- Epidemiologic investigation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Surgical Site Infections, Nosocomial Infection
Nasal Photodisinfection in All Patients Presenting for Surgery for a Wide Range of Surgical Procedures
This is a Phase 2 single-center, open-label, single-arm, study of a microbiological endpoint using antimicrobial photodynamic therapy (aPDT) for nasal disinfection in all patients (universal) presenting for surgery at an acute…
- Conditions
- Surgical Site Infections, Nosocomial Infection, Healthcare Associated Infections
- Trial name
- BENEFIT-PDT (NCT05090657)
- Testing
- methylene blue 0.01%/chlorhexidine gluconate 0.25% + light activation
- Where
- United States
- Volunteers
- 322 people
- Sponsor
- Ondine Biomedical Inc.
Antibiotic, Healthcare Associated Infection
Evaluating Antibiotic Stewardship Assisted by Computer in the University Hospital of Nancy (MACABAO)
Antibiotic resistance is one of the most pressing health threats that mankind faces now and in the coming decades. Antibiotic resistance leads to longer hospital stays, higher medical costs and increased mortality.
- Trial name
- MACABAO (NCT04976829)
- Testing
- Antibiotic stewardship and healthcare-associated infections surveillance assisted by computer
- Volunteers
- 100,000 people
- Sponsor
- Central Hospital, Nancy, France
Nosocomial Pneumonia
Optimizing Dosing Regimen of Piperacillin/Tazobactam for Nosocomial Pneumonia
1. To observe clinical and bacteriologic responses of different regimens of piperacillin/tazobactam (4.5g q6h, prolonged or intermittent infusion) for treatment of nosocomial pneumonia. 2.
- Trial name
- NCT01796717
- Testing
- C Group, E Group
- Where
- 2 sites in China
- Volunteers
- 50 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Hospital-Acquired Infection, Influenza
Nosocomial Influenza Surveillance 2018 - 2022
Hospital-acquired influenza is associated with significant morbidity and mortality in hospitalized patients notably elderly patients. Furthermore, it is also associated with a large economic impact for the hospitals.
- Trial name
- NOSOGRIPPE (NCT03413228)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Hospices Civils de Lyon
Nosocomial Infection, Nosocomial Pneumonia
Mechanical Insufflation-exsufflation and Hypertonic Saline in Nosocomial Bacterial Respiratory Tract Infection
Multicenter, randomized open label clinical trial to evaluate IEM and HS as concomitant therapy for respiratory tract infection in patients under artificial ventilation in the ICU.
- Conditions
- Nosocomial Infection, Nosocomial Pneumonia, Tracheobronchitis, Mechanical Ventilation Complication
- Trial name
- ABSENTA (NCT06310941)
- Testing
- Mechanical insufflation-exsufflation, Standard of Care, Hypertonic saline with hyaluronic acid
- Where
- 8 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Hospital San Carlos, Madrid
Tuberculosis, Multidrug-resistant
Nosocomial Transmission of MDR-TB in Bucharest, Romania
It is a single-center, observational, prospective cohort study recruiting patients hospitalized at the multidrug-resistant tuberculosis ward at Marius Nasta Institute.
- Trial name
- NCT02413931
- Testing
- Routine management practices applied
- Where
- Romania
- Volunteers
- 53 people
- Sponsor
- Research Center Borstel
Cross Infection, Infection Control
A Randomized Trial Comparing Matt and Antimicrobial Cellomed Laminates
Sepsis contributes to nearly 20% of all hospital deaths and is the leading cause of death on non-coronary intensive care units. Contamination of the patient environment is common with organisms such as MRSA, VRE and C.difficile…
- Trial name
- NCT01245829
- Testing
- Swabbing of observation chart
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- County Durham and Darlington NHS Foundation Trust
Gram Negative Pneumonia, Gram-Negative Bacterial Infections
Clinical Trial to Study the Efficacy and Safety of Fluorothiazinone (N.F. Gamaleya NRCEM) in Prophylaxis of Nosocomial Bacterial Infections With Participation of Patients on MV
This study is designed to evaluate the clinical and antibacterial efficacy, safety and pharmacokinetics of the drug Fluorothiazinone compared to placebo to prevent nosocomial gram-negative bacterial infections with participation…
- Conditions
- Gram Negative Pneumonia, Gram-Negative Bacterial Infections, Bacteremia Caused by Gram-Negative Bacteria
- Trial name
- NCT06135350
- Testing
- Fluorothiazinone, tablets 300 mg at a dose of 2400 mg/day
- Where
- 2 sites in Russia
- Volunteers
- 234 people
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
Cross Infection, Bacteriuria
Prevention of Nosocomial E. Coli Infections After Placement of an Indwelling Catheter During Pelvic Surgery: an Evaluation of Cranberry Gel Capsules
Indwelling urinary catheters are a primary site for nosocomial infections. The purpose of this study is to evaluate the anti-adhesive properties of Cranberry type A pro anthocyanidine gel capsules in the prevention Escherichia…
- Trial name
- NosoPink (NCT01114347)
- Testing
- cranberry type A pro anthocyandines
- Where
- France
- Volunteers
- 270 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Cirrhosis, Ascites
Daptomycin + Meropenem Versus Ceftazidime in the Treatment of Nosocomial Spontaneous Bacterial Peritonitis
Nosocomial spontaneous bacterial peritonitis (SBP) is frequently caused by multi drug resistant bacteria. Standard treatment of SBP could be ineffective.
- Conditions
- Cirrhosis, Ascites, Nosocomial Spontaneous Bacterial Peritonitis
- Trial name
- NCT01455246
- Testing
- Daptomycin + Meropenem, Ceftazidime
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- University of Padova