Clinical trials: Infections Joint Prosthetic
Aseptic Loosening of Prosthetic Joint, Instability of Prosthetic Joint
The Use of CCK vs PS in Revision TKAs
This study aims to compare the clinical impact of Constrained Condylar versus Posterior Stabilized Knee (PS) bearings on patient satisfaction and surgical outcomes including mid-term survivorship among patients undergoing…
- Conditions
- Aseptic Loosening of Prosthetic Joint, Instability of Prosthetic Joint, Reimplantation for Periprosthetic Joint Infection, Femoral Revision Indicated
- Trial name
- NCT06782295
- Testing
- Constrained Condylar bearing, posterior stabilized bearing
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Rush University Medical Center
Periprosthetic Joint Infection (PJI)
Is the EBJIS Definition of Prosthetic Joint Infection Meaningful in Our Clinical Practice?
This retrospective multi-center, multi-national cohort study is to validate the European Bone and Joint Infection Society (EBJIS) Definition of Prosthetic Joint Infection.
- Trial name
- NCT05117671
- Testing
- data collection to classify infection status
- Where
- 2 sites in Portugal, Switzerland
- Volunteers
- 1,554 people
- Sponsor
- University Hospital, Basel, Switzerland
Prosthetic Joint Infection, Surgical Skin Infection
Efficacy of InteguSeal for Surgical Skin Preparation in Patients Undergoing Total Joint Replacement
This study is being conducted to investigate the potential benefits of using a special type of fluid that can be applied to the skin (Integuseal) in addition to standard surgical skin preparation in patients undergoing total hip…
- Trial name
- NCT00829556
- Testing
- Integuseal
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Rothman Institute Orthopaedics
Infected of Hip or Kneeprosthesis
β-lactam Use in Single-stage Exchange of ProstheTic Infections (Knee / Hip) in a Center of Reference (β-SEPTIC)
According to the official recommendations, infected prosthesis can be surgically treated by one or two-stage replacement. In Strasbourg, the investigators only perform one-stage surgery, which means that the new materiel is put…
- Trial name
- β-SEPTIC (NCT04123964)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Prosthetic Joint Infections
[124I]FIAU PET-CT Scanning in Patients With Pain in a Prosthetic Knee or Hip Joint
This protocol will evaluate the sensitivity and specificity of [124I]FIAU as a diagnostic imaging agent for the detection of prosthetic joint infections in patients.
- Trial name
- PJI (NCT01705496)
- Testing
- [124I]FIAU
- Where
- 10 sites in United States
- Volunteers
- 23 people
- Sponsor
- BioMed Valley Discoveries, Inc
Peri-Prosthetic Joint Infection
IP-coated Revision Hip Implants
The primary aim of the clinical investigation is to demonstrate the efficacy of a silver-based antimicrobial coating on hip implants in the reduction of periprosthetic infections in revision hip arthroplasty due to periprosthetic…
- Trial name
- HIPrevision (NCT06737809)
- Testing
- IP Plasmafit® Revision cup (and stem) system
- Where
- 2 sites in Germany, Poland
- Volunteers
- 268 people
- Sponsor
- Aesculap AG
Osteoarthritis, Hip, Osteoarthritis, Knee
Total Joint Arthroplasty (TJA) Weight Loss Study
This is a randomized clinical trial (RCT) to assess the efficacy of bariatric surgery vs medical weight loss vs. the "usual standard of care" to optimize a morbidly obese patient with end-stage osteoarthritis of the hip or knee…
- Conditions
- Osteoarthritis, Hip, Osteoarthritis, Knee, Obesity, Morbid
- Trial name
- NCT05156762
- Testing
- Bariatric surgery, Medical weight loss, Patient research surveys
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Boston Medical Center
Osteoarticular Infections
Molecular Microbiology in Osteo-arthritis Infection
Osteoarticular infections are painful and disabling diseases that require antimicrobial treatment adapted to the microorganisms implicated.
- Trial name
- MOLOS (NCT01193803)
- Testing
- Microbiological cultures and Molecular biology
- Where
- France
- Volunteers
- 229 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prosthetic Joint Infection
Bacteriological Setting Before Prosthesis Implantation With One Stage Surgery in Prosthetic Joint Infection
Chronic prosthetic joint infection (PJI) is a devastating complication of arthroplasty and its treatment continues to fuel the debate on how to manage it appropriately.
- Trial name
- Bac-UP (NCT02806063)
- Testing
- intraoperative samples
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Infection of Total Knee Joint Prosthesis, Aseptic Loosening of Prosthetic Joint
Surgical / Economic Effect of the Aquamantys System in Blood Management for Aseptic and Septic Revision TKA
To assess the surgical and economic effectiveness of the Aquamantys System in managing intra- and post-operative blood loss, and reducing transfusion needs in patients undergoing both aseptic and septic revision total knee…
- Trial name
- NCT02266407
- Testing
- Aquamantys System
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medtronic Surgical Technologies
Prosthetic Joint Infection
Identification of Molecular Marker of Coagulase-negative Staphylococci for the Diagnosis of Prosthetic Joint Infections
One of the major causes of prosthetic joint failure is infection. Recently, coagulase-negative Staphylococci (CoNS) have been identified as emergent, nosocomial pathogens involved in subclinical prosthetic joint infections…
- Trial name
- NCT04661345
- Testing
- Proteomic analysis of synovial fluids, Proteomic analysis of the isolated coagulase-negative Staphylococci
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Prosthetic-joint Infection
Expanded Access to Cyclic Irrigation in Patients Undergoing Exchange Arthroplasty
The objective of the protocol is to provide access to the VT-X7 (Vancomycin, Tobramycin Exchanged in 7 Days) system for subjects with periprosthetic joint infection (PJI) of the hip or knee who lack therapeutic treatment…
- Trial name
- APEX-EAP (NCT06383611)
- Testing
- VT-X7 Treatment System
- Where
- 14 sites in United States
- Sponsor
- Osteal Therapeutics, Inc.
Chronic PJIs
Heraeus MicroDTTect Lyon Pilot Studyprosthetic Joint Infections (PJIs)
Prosthetic joint infections (PJIs) are one of the main causes of implant failure after joint arthroplasty. Identification of the causal organism is crucial for successful treatment.
- Trial name
- NCT04371068
- Testing
- Culture of removed prosthesis using DTT
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Prosthetic Joint Infection
Bacteriophage Therapy in Patients With Prosthetic Joint Infections
This is a study designed to evaluate bacteriophage therapy in patients with chronic prosthetic joint infections.
- Trial name
- NCT04787250
- Testing
- Phage Therapy, Two-Stage Exchange Arthroplasty
- Where
- United States
- Sponsor
- Adaptive Phage Therapeutics, Inc.
Osteomyelitis, Prosthetic Joint Infection
Short or Long Antibiotic Regimes in Orthopaedics
Research question: If adults with bone or joint infection have local antibiotic therapy, can they do without prolonged treatment with antibiotics by mouth (oral) or injection? Adults with bone or joint infections are usually…
- Conditions
- Osteomyelitis, Prosthetic Joint Infection, Diabetic Foot
- Trial name
- SOLARIO (NCT03806166)
- Testing
- Shorter Systemic Antibiotics, Standard treatment
- Where
- 23 sites in Germany, Portugal and 2 more
- Volunteers
- 500 people
- Sponsor
- Oxford University Hospitals NHS Trust
Prosthetic Joint Infection
Leukocyte Esterase Sensor Test
The primary objective of this study is to assess the diagnostic efficacy of the quantitative electrochemical LE biosensor for periprosthetic joint infection (PJI).
- Trial name
- NCT04390607
- Testing
- leukocyte esterase electrochemical assay
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Rothman Institute Orthopaedics
Acute Bacterial Skin and Skin Structure Infection (ABSSSI), Prosthetic Joints Infection (PJI)
Phase 1, Single-Dose and Multiple-Dose Continuous Intravenous Infusions of TNP-2092 for Injection in Healthy Chinese Participants
This is a phase 1, single-center, randomized, double-blind, placebo-controlled, dose-escalation clinical trial of single and multiple intravenous doses of TNP-2092 for injection in healthy Chinese participants.
- Trial name
- NCT06394518
- Testing
- TNP-2092 for injection
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- TenNor Therapeutics Inc.
Lower Limb Megaprosthetis Infection
Epidemiology, Risk Factors, and Outcomes of Infections of Lower Limb MEGAprostheses
Retrospective, multicenter, non-profit observational study. The study will include consecutive patients who underwent lower-limb megaprosthesis implantation at the participating Centers between January 1, 2020, and June 30, 2023.
- Trial name
- EROMEGA (NCT07544212)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Arthroplasty, Replacement, Hip, Osteoarthritis, Hip
Antibiotic Impregnated Bone Graft to Reduce Infection in Hip Replacement.
Total hip replacement is the most successful treatment modern healthcare can offer patients to regain quality of life. Periprosthetic joint infection (PJI) is the most common and devastating complication after total hip…
- Conditions
- Arthroplasty, Replacement, Hip, Osteoarthritis, Hip, Antibiotic Resistant Infection, Prosthetic Joint Infection
- Trial name
- ABOGRAFT (NCT05169229)
- Testing
- Vancomycin + Tobramycin, Saline
- Where
- Sweden
- Volunteers
- 1,100 people
- Sponsor
- University Hospital, Linkoeping
Prosthesis-Related Infections
PRO-DIAG: Improved Diagnosis of Prosthetic Joint Infections
Implantation of joint prostheses is currently the second largest diagnosis-related group in the Danish health service, and in view of the demographic development and spread of lifestyle diseases, this type of intervention is…
- Trial name
- PRO-DIAG (NCT03444571)
- Testing
- revision surgery
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Aalborg University