Clinical trials: Infectious Disease of Abdomen
Acute Abdomen, Acute Appendicitis
Diagnostic Accuracy of Emergency Physician Performed Bedside Ultrasound in Suspected Acute Appendicitis
The aim of the study is to evaluate the diagnostic yield and accuracy of bedside emergency physician performed ultrasound in the diagnosis of acute appendicitis.
- Trial name
- NCT02467959
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Antalya Training and Research Hospital
Sepsis, Intra-Abdominal Infections
Gelaspan vs Crystalloid Therapy in Sepsis
The goal of this randomized clinical trial is to evaluate whether balanced gelatin solution is more effective and safe than balanced crystalloid solution for perioperative fluid management in adults with sepsis undergoing…
- Trial name
- SPACES (NCT07172451)
- Testing
- Balanced Gelatin Solution, Acetate Ringer's Solution
- Where
- 9 sites in China
- Volunteers
- 318 people
- Sponsor
- Shanghai Zhongshan Hospital
Peritonitis Infectious
Capillary Leak Index Versus Conventional Biomarkers in Predicting Sepsis-Related Outcomes
This study aims to evaluate the prognostic significance of CLI in predicting 28-day mortality and other outcomes in critically ill patients who develop post-operative abdominal sepsis.
- Trial name
- NCT07232342
- Testing
- Capillary Leak Index Versus
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Appendicitis, Other and Unspecified Acute Appendicitis
The Optimization of a Low-dose Computed Tomography Protocol in Patients With Suspected Uncomplicated Acute Appendicitis
This study focuses on the use of contrast enhanced low-dose CT imaging as a modality to differentiate between uncomplicated and complicated acute appendicitis.
- Conditions
- Appendicitis, Other and Unspecified Acute Appendicitis, Acute Disease, Gastrointestinal Diseases
- Trial name
- OPTICAP (NCT02533869)
- Testing
- Low-dose CT, Laparoscopic appendectomy
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Turku University Hospital
Infection
A Pharmacovigilance Evaluation And Assessment Of The Prescribing Practice For Tygacil In Usual Health Care Setting
To assess the efficacy and safety of Tygacil in the usual German hospital setting. The main goals are: to assess the efficacy of Tygacil under usual care conditions (cure rate); to assess the main side effects observed in daily…
- Trial name
- NCT00488488
- Testing
- tigecycline
- Volunteers
- 1,028 people
- Sponsor
- Pfizer
Appendicitis Acute
Investigation of Oxidative Stress in Appendectomy - Open Versus Laparoscopic in Childhood and Adolescence
In the planned prospective randomized study, oxidative stress will be investigated by analyzing volatile organic compounds in the exhaled air in children.
- Trial name
- OSAE (NCT03723642)
- Testing
- Initial serum malondialdehyde level, Final serum malondialdehyde level, Initial differential white blood cell count
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Graz
Appendicitis
Diagnostic Performance of C Reactive Protein and Delta CRP in Acute Appendicitis
The diagnosis of acute appendicitis is difficult and despite important advances in medical sciences, detailed patient questioning and precise medical examination are the main keystones of the diagnosis of acute appendicitis and…
- Trial name
- dCRPappend (NCT02730585)
- Testing
- C-reactive protein measurement
- Where
- Tunisia
- Volunteers
- 500 people
- Sponsor
- University of Monastir
Complicated Intra-Abdominal Infection
Impact Of Bacterial Resistance On Healthcare Costs For Hospitalized Patients With Complicated Intra-Abdominal Infections
The objective of this study is to estimate the costs of empiric antibiotic therapy and hospitalization costs for patients with a complicated intra-abdominal infection, and to assess the impact of treatment failure of initial…
- Trial name
- NCT00929643
- Testing
- no intervention
- Where
- 13 sites in Greece
- Volunteers
- 203 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Peritonitis
Prospective Comparison of Primary Abdominal Closure and Vacuum Assisted Laparostomy in Treatment of Severe Peritonitis
The aim of the project was to optimalize the process in severe peritonitis which is generally inflicted with high mortality and morbidity with long term costly therapy.
- Trial name
- NCT01531543
- Testing
- V.A.C.- Vacuum assisted closure laparostomy (KCI)
- Where
- Czechia
- Volunteers
- 57 people
- Sponsor
- The Faculty Hospital Na Bulovce
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Appendicitis
TRIAD Appendicitis Decision-making Surveys
While appendectomy has been the main treatment of appendicitis for over 100 years, recent European studies found that, at least among highly selected patients, antibiotics alone can be an effective alternative.
- Trial name
- TRIAD (NCT05887414)
- Testing
- Baseline, 30 Day Follow Up
- Where
- 17 sites in United States
- Volunteers
- 2,542 people
- Sponsor
- University of Washington
Peritonitis, Catheter-related Infections
Taurolock for Preventing Bacterial Peritonitis During Renal Insufficiency
Dialysis catheters are sites of bacterial proliferation. The purpose of this study is to determine whether or not the use of Taurolock (a catheter lock solution) can prevent bacterial peritonitis in patients undergoing peritoneal…
- Conditions
- Peritonitis, Catheter-related Infections, Renal Insufficiency
- Trial name
- NCT01101087
- Testing
- Taurolock
- Where
- 15 sites in France, French Polynesia
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Appendicitis, Surgery
Serum Hyperbilirubinemia as an Early Predictive Factor for Complicated Appendicitis: Single Center Experience
Serum total bilirubin provides a practical guide to early assessment of suspected appendicitis, supporting faster and more proportionate decisions-earlier escalation when overall risk is high and safe observation when it is low.
- Trial name
- NCT07291882
- Testing
- Appendectomy
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Minia University
Acute Appendicitis
The Role of Contrast Enhanced Ultrasound in Appendicitis
This study seeks to determine the efficacy of Contrast Enhanced Ultrasound (CEUS) in improving the diagnosis of acute appendicitis in children, when compared to the standard grey-scale ultrasound.
- Trial name
- NCT03687502
- Testing
- Sulfur hexafluoride lipid-type A microspheres
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Children's Mercy Hospital Kansas City
Gastroschisis, Anorectal Malformation
Children's Surgery in Sub-Saharan Africa
Background: Five billion people worldwide do not have access to safe, affordable surgical care. A significant proportion live in sub-Saharan Africa (SSA), where up to 50% of the population are children.
- Conditions
- Gastroschisis, Anorectal Malformation, Appendicitis, Intussusception
- Trial name
- PaedSurgAfrica (NCT03185637)
- Testing
- Various interventions for each of the conditions.
- Where
- United Kingdom
- Volunteers
- 1,407 people
- Sponsor
- King's College London
Peritonitis
Point-of-care Test for Diagnosis of Peritonitis in Peritoneal Dialysis Patients
Peritoneal dialysis (PD) is a home-based dialysis therapy and peritonitis is a serious complication in PD. A reliable point-of-care test to detect peritonitis is important for patients to self-detect peritonitis at home as…
- Trial name
- Periplex (NCT04070196)
- Testing
- Periplex
- Where
- Singapore
- Volunteers
- 120 people
- Sponsor
- Singapore General Hospital
Acute Appendicitis
A Trial on Laparoscopic Appendectomy Versus Single Port Appendectomy
The aim of this study is to compare patients who undergone single-port access laparoscopic appendectomy to those who underwent conventional three-port laparoscopic appendectomy (TPLA) in a prospective randomized trial
- Trial name
- NCT01348464
- Testing
- single port appendectomy, three port appendectomy
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Gachon University Gil Medical Center
Acute Abdomen, Emergency Surgery
Primary Cecal Pathologies Presenting as Acute Abdomen
Background: The importance of cecal pathologies lie in the fact that being the first part of large intestine, any disease involving the cecum affects overall functioning of the large bowel.
- Conditions
- Acute Abdomen, Emergency Surgery, Laparotomy, Amoebic Colitis
- Trial name
- NCT03262025
- Testing
- Operated
- Volunteers
- 43 people
- Sponsor
- Jawaharlal Nehru Medical College
Complicated Intra-abdominal Infections
Italian Register for the Study of Complicated Intra-Abdominal Infections
The study will identify the epidemiological and treatment profiles of acute peritonitis in Italy
- Trial name
- IRCA (NCT03678298)
- Testing
- Epidemiological/treatment profiles
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- World Society of Emergency Surgery
Incisional Ventral Hernia, Recurrent Ventral Hernia
Modified "Open Intraperitoneal Mesh" Technique of Incisional Ventral Hernia Repair
Ventral hernias, primary and recurrent, are major surgical challenge. We aim to investigate efficacy of modified technique of ventral hernias repair: an "open intraperitoneal mesh" technique.
- Trial name
- NCT01953302
- Testing
- modified "open mesh technique"
- Where
- Croatia
- Volunteers
- 124 people
- Sponsor
- Varazdin General Hospital