Clinical trials: Infectious Gastroenteritis
Nosocomial Infection, Necrotizing Enterocolitis
Effect of Oral Probiotic Supplementation on The Rate of Hospital Acquired Infection and Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants
The purpose of this study is to determine whether oral probiotic supplementation could reduce the incidence of nosocomial infections in preterm infants.
- Trial name
- NCT01340469
- Testing
- probiotics
- Where
- Thailand
- Volunteers
- 160 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Herpes Zoster, Inflammatory Bowel Diseases
Identifying Young Inflammatory Bowel Disease Patients at Risk for Herpes Zoster
Inflammatory bowel disease (IBD) patients under the age of 50 can have a greater risk than the general population above age 50. IBD patient are commonly treated with immunosuppression that increases the risk for Herpes Zoster.
- Conditions
- Herpes Zoster, Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT03553472
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Rotavirus Infection of Children
A Trial to Assess the Safety, Immunogenicity and Efficacy of a Trivalent Rotavirus P2-VP8 Subunit Vaccine in Prevention of Severe Rotavirus Gastroenteritis in Healthy Infants in Africa and India
The trial will be a multinational, randomized, double-blind, double-dummy, endpoint driven, group-sequential, active comparator-controlled study, in which participating infants will be randomized 1:1 to receive either: 1) 90 µg…
- Trial name
- NCT04010448
- Testing
- TV P2-VP8, Rotarix
- Where
- Zambia
- Volunteers
- 8,200 people, healthy volunteers welcome
- Sponsor
- PATH
Appendicitis, Yersinia Enterocolitica Infection
Explanations for Negative Laparoscopic Appendectomies and Normal Laparoscopies
Trial The aim of the study is to investigate which infectious diseases might mimic the symptoms of acute appendicitis to a degree to cause a diagnostic laparoscopy or laparoscopic appendectomy.
- Conditions
- Appendicitis, Yersinia Enterocolitica Infection, Yersinia Pseudotuberculosis Infections, Appendectomy
- Trial name
- NCT03349814
- Testing
- Diagnostic laparoscopy without appendectomy, Diagnostic laparoscopy with appendectomy
- Where
- Denmark
- Volunteers
- 225 people
- Sponsor
- Herlev Hospital
Healthy
Infectivity of Norovirus in Groundwater-Human Challenge Study
Norwalk virus and related "Norwalk-like viruses" are the most common cause of outbreaks of stomach sickness (nausea, vomiting, diarrhea) in older children and adults in the United States.
- Trial name
- NCT00313404
- Testing
- Safety tested norovirus inoculum
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Emory University
H Pylori Gastritis, H Pylori Infection
Efficacy of Carminal in Helicobacter Pylori Gastritis
Eighty patients will be included and randomized in two groups, one group (40 patients) will be administered 30 ml of the supplement Carminal, once a day, plus therapy for HP gastitis and the control group (40 patients) will be…
- Conditions
- H Pylori Gastritis, H Pylori Infection, H Pylori Eradication, Gastritis Associated With Helicobacter Pylori
- Trial name
- NCT07179237
- Testing
- Carminal Oral solution
- Where
- 2 sites in Serbia
- Volunteers
- 80 people
- Sponsor
- Catalysis SL
Diarrhea Infectious, Shigella
The Impact of Shigellosis and Recommended Treatment in Children
The purpose of this study is to evaluate whether antibiotic treatment of non-dysentery Shigella associated watery diarrhea (NDSD) cases improves clinical outcomes and growth in children.
- Conditions
- Diarrhea Infectious, Shigella, Growth & Development
- Trial name
- TrtNDSD (NCT07433426)
- Testing
- Azithromycin
- Where
- 4 sites in Bangladesh, Zambia
- Volunteers
- 700 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Otitis, Bronchiolitis
Pediatric and Ambulatory Research in Infectious Diseases
Many ambulatory networks are mainly based on diagnoses made by first-line physicians not specifically trained to join the network.
- Conditions
- Otitis, Bronchiolitis, Influenza, Pharyngitis
- Trial name
- PARI (NCT04471493)
- Where
- France
- Volunteers
- 400,000 people
- Sponsor
- Association Clinique Thérapeutique Infantile du val de Marne
Malnutrition Pregnancy, Malnutrition in Children
Early Life Malnutrition, Environmental Enteric Dysfunction and Microbiome Trajectories
Malnutrition in women of reproductive age remains a public health concern in Sub-Saharan Africa (SSA). Malnutrition during pregnancy affects foetal growth with a tendency of the exposed infants to also develop it.
- Conditions
- Malnutrition Pregnancy, Malnutrition in Children, Malnutrition (Calorie), Environmental Enteric Dysfunction
- Trial name
- UZBCS-2 (NCT07195006)
- Testing
- Malnutrition in pregnancy as exposure, Poor WASH living conditions as exposure
- Where
- Zimbabwe
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Psoriasis, Inflammatory Bowel Diseases
On the Impact of Therapeutic Tumor Necrosis Factor-alpha Inhibition on Anogenital Human Papillomavirus Infection
In this prospective, open, controlled, cross-sectional observational study patients with psoriasis or IBD, who received either anti-TNF-alpha inhibitors or alternates (purine-, folic acid analogues, phototherapy, fumaric ester…
- Trial name
- NCT02376478
- Testing
- TNF-alpha inhibitors, Alternative/no medication, Purine/folic acid analogues
- Volunteers
- 222 people
- Sponsor
- Medical University of Vienna
Appendicitis, Perforated Appendicitis
Comparative Study Between Laparoscopic and Open Appendectomy of Complicated Appendicitis
Acute appendicitis is one of the most common surgical emergencies in children. In complicated cases, where the appendix has perforated, become gangrenous, or caused peritonitis and purulent contamination, determining the optimal…
- Conditions
- Appendicitis, Perforated Appendicitis, Gangrenous Appendicitis, Peritonitis
- Trial name
- NCT07879235
- Testing
- Laparoscopic Appendectomy, Open Appendectomy
- Volunteers
- 100 people
- Sponsor
- Assiut University
Abscess, Intra-Abdominal, Cholecystitis
Cefoperazone/Sulbactam In The Treatment Of Serious Intra-Abdominal And Hepatobiliary Infections.
The primary objective is to collect data on treatment outcomes (clinical and microbiological cure), safety and tolerability of treatment with cefoperazone/sulbactam in patients with serious intra-abdominal and hepatobiliary…
- Conditions
- Abscess, Intra-Abdominal, Cholecystitis, Wound Infections, Peritonitis
- Trial name
- NCT00463762
- Testing
- CP-75385-02 Cefoperazone/sulbactam
- Sponsor
- Pfizer
Urologic Injuries, Urologic Diseases
Bladder Morphology Using 2 Different Catheter Designs
Demonstrate and compare the 3D morphology of the bladder wall in full and drained states with 2 different kinds of bladder catheters in place. (Foley Catheter vs. Cystosure Catheter)
- Conditions
- Urologic Injuries, Urologic Diseases, Bladder Infection, Urinary Tract Infections
- Trial name
- NCT03108079
- Testing
- Cystosure Urinary Access System, Foley Catheter
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- The Pelvic Floor Institute
Abscess, Intra-Abdominal, Abdominal Abscess
A Safety and Tolerability Study of Doripenem Compared With Meropenem in Children Hospitalized With Complicated Intra-abdominal Infections
The purpose of the study is to evaluate the safety and tolerability of doripenem compared with meropenem in children hospitalized with complicated intra-abdominal infections.
- Conditions
- Abscess, Intra-Abdominal, Abdominal Abscess, Abdomen, Acute, Abdominal Pain
- Trial name
- NCT01110382
- Testing
- Doripenem, Meropenem, Amoxicillin/clavulanate potassium
- Where
- 19 sites in United States, Argentina and 6 more
- Volunteers
- 41 people
- Sponsor
- Janssen Research & Development, LLC
Infection, Enterocolitis, Necrotizing
Oropharyngeal Administration of Mother's Colostrum for Premature Infants (NS-72393-360)
Extremely premature (BW<1250g) infants are at high risk for morbidity and mortality. Own mother's colostrum (OMC) and milk (OMM) protect against neonatal morbidity and are rich in immune factors which may provide…
- Conditions
- Infection, Enterocolitis, Necrotizing, Ventilator-associated Pneumonia
- Trial name
- NCT02116699
- Testing
- oropharyngeal mother's milk, oropharyngeal sterile water
- Where
- 5 sites in United States
- Volunteers
- 260 people
- Sponsor
- Endeavor Health
Acute Gastroenteritis, Norwalk Virus Infection
Norwalk Vaccine Study
The purpose of this study was to evaluate the efficacy of the Norwalk virus-like particle (VLP) vaccine as determined by the illness rate of viral acute gastroenteritis (AGE) during the inpatient stay.
- Trial name
- NCT00973284
- Testing
- Norwalk VLP vaccine, mannitol and sucrose, Norwalk virus
- Where
- 3 sites in United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Takeda
Mixed Flora; Infection
Preterm Infant Gut (PINGU) - a Norwegian Multi Centre Study
Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality among infants in the neonatal intensive care unit (NICU).
- Trial name
- PINGU (NCT02197468)
- Where
- 7 sites in Norway
- Volunteers
- 60 people
- Sponsor
- University Hospital of North Norway
Inflammatory Bowel Diseases, Crohn Disease
Immunogenicity of Herpes Zoster Subunit Vaccine in Inflammatory Bowel Disease Patients Treated With Vedolizumab
Inflammatory bowel disease (IBD) is a chronic inflammatory state of the gastrointestinal tract affecting 1.6-3.1 million people in the United States.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Herpes Zoster
- Trial name
- NCT03798691
- Testing
- Shingrix
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Wisconsin, Madison
Helicobacter Pylori Infection
Control of Helicobacter Pylori Infection by Probiotics
Helicobacter pylori colonises an estimated 50% of the world´s population (Taylor \& Blaser, 1991; Go, 2002). Despite clear clinical guidelines on the treatment of this infection (Malfertheiner et al.
- Trial name
- NCT01115296
- Testing
- L. reuteri DSM 17938 and ATCC PTA 6475
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Bari
H. Pylori Infection
Effect of Vitamin D on Drug Resistant Helicobacter Pylori (HP) Eradication Study
Background: Helicobacter pylori infection, which affects over 50% of the global population, is one of the most prevalent infectious diseases in the world. H.
- Trial name
- vDHp (NCT03142620)
- Testing
- Esomeprazole, Amoxicillin-Potassium Clavulanate Combination, Clarithromycin
- Where
- Hong Kong
- Volunteers
- 96 people
- Sponsor
- Chinese University of Hong Kong