Clinical trials: Infectious Keratitis
Bacterial Keratitis
Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction II
Rose Bengal Electromagnetic Activation with Green light for Infection Reduction II (REAGIR II) is a randomized, double-masked feasibility study.
- Trial name
- REAGIR II (NCT06271772)
- Testing
- Difluprednate Ophthalmic, Rose Bengal, Moxifloxacin Ophthalmic
- Where
- 2 sites in Brazil, India
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Infection, Fungal
Combination Treatment of 5% Natamycin and 1% Voriconazole in Fungal Keratitis
OBJECTIVE To evaluate the efficacy and safety of the concurrent treatment of 5% Natamycin and 1% Voriconazole in patients affected by fungal keratitis METHODS AND MATERIALS STUDY POPULATION Patients with smear and or culture…
- Trial name
- NATA_VORI (NCT03230058)
- Testing
- Group 1 Natamycin 5% Suspension + voriconazole 1% eye drops; Group 2 Natamycin 5% Suspension + Vehicle eye drops
- Where
- India
- Volunteers
- 55 people
- Sponsor
- L.V. Prasad Eye Institute
Keratitis
Tolerance to Light for Patients Suffering From Keratitis
In order to develop an innovative device to study infectious keratitis, we need to illuminate the cornea of patients suffering from an infectious keratitis with red or near-infrared light.
- Trial name
- EBLOUI (NCT03586505)
- Testing
- Light exposure
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Corneal Ulcer
The Asia Cornea Society Infectious Keratitis Study
Corneal diseases are a major cause of blindness worldwide, and corneal infections are a substantial cause of blindness in Asia. The aim of the Asia Cornea Society Infectious Keratitis Study (ACSIKS) is to study infectious…
- Trial name
- ACSIKS (NCT01560208)
- Where
- 11 sites in China, India and 6 more
- Volunteers
- 6,750 people
- Sponsor
- Asia Cornea Society
Keratitis
Microbiological Keratitis in a Countryside City of Brazil
The purpose of this study is to identify the predisposing factors, epidemiological features and clinical and microbiological diagnosis of infectious keratitis in two public referral centers of ophthalmology in a countryside city…
- Trial name
- NCT00949468
- Where
- Brazil
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Sao Jose do Rio Preto Medical School
Fusarium Keratitis
RB-PDT for Fusarium Keratitis: The LUMIERE Study
This is a multicenter trial with recruitment planned at ophthalmology clinics specializing in corneal diseases in India, Brazil, and at Stanford University and Bascom Palmer Eye Institute in the United States.
- Trial name
- NCT07743489
- Testing
- Rose Bengal Photodynamic Therapy
- Where
- 4 sites in United States, Brazil and 1 more
- Volunteers
- 434 people
- Sponsor
- Stanford University
Endophthalmitis, Keratitis
Complex Ocular Infection, Optimization of Microbiological Diagnosis
The purpose of this study is to evaluate the impact of different technique to optimize the microbiological diagnosis of the COI. Metagenomic for the endophtalmitis Multiplex polymerase chain reaction for corneal abscesses
- Trial name
- ICODIA (NCT05432336)
- Testing
- NGS for endohtalmitis / Multiplex PCR for keratitis
- Where
- France
- Volunteers
- 153 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infected Corneal Ulcers, CXL
Effectiveness of Riboflavin-Moxifloxacin Amniotic Membrane as an Adjuvant for PACK-CXL in Moderate to Severe Infectious Keratitis
This study aims to evaluate the effectiveness of a specialized amniotic membrane preparation as an adjuvant therapy for patients with moderate-to-severe infected corneal ulcers.
- Trial name
- NCT07559149
- Testing
- Riboflavin-Moxifloxacin Amniotic Membrane, Standard PACK-CXL
- Where
- Indonesia
- Volunteers
- 32 people
- Sponsor
- Gadjah Mada University
Keratitis
Evaluation of Next-Generation Sequencing-based Metabarcoding Versus Culturing for Microbiological Assessment in Infectious Keratitis
Infectious keratitis is a potential sight threatening condition. In conventional clinical practice culturing is performed in order to identify the causative microbial organism; however in recent years Next Generation Sequencing…
- Trial name
- NCT05183906
- Testing
- Next generation sequencing
- Where
- Denmark
- Volunteers
- 57 people
- Sponsor
- Aarhus University Hospital
Infectious Keratitis, Bacterial Keratitis
Collagen Cross-linking in Infectious Keratitis Trial
The purpose of this study is to evaluate the efficacy of collagen cross-linking for treatment of infectious keratitis.
- Conditions
- Infectious Keratitis, Bacterial Keratitis, Fungal Keratitis
- Trial name
- NCT01831206
- Testing
- Collagen cross-linking
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University
Corneal Ulcers
Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Refractory Corneal Infection
This study will evaluate the Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes with Corneal Infection.
- Trial name
- NCT02068430
- Testing
- Riboflavin 0.1%, UV-X™ Illumination System
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Stephen Trokel
Ocular Inflammation, Infection Associated Blepharitis
Antibiotic Steroid Combination Compared With Individual Administration in the in the Treatment of Ocular Inflammation and Infection
To evaluate the efficacy and safety of fixed combination of azithromycin 1.5% + 0.5% Loteprednol eye drops for the treatment of ocular inflammation and infection associated bacterial blepharitis and / or keratitis and / or…
- Conditions
- Ocular Inflammation, Infection Associated Blepharitis, Keratitis, Conjunctivitis, Bacterial
- Trial name
- NCT01721694
- Testing
- azithromycin 1.5% + Loteprednol 0,5% (separately)
- Where
- Brazil
- Sponsor
- Adapt Produtos Oftalmológicos Ltda.
Corneal Ulcer, Fusarium Infection
Fusarium Keratitits in Spain 2012 to 2014
The aim of this study was to describe the clinical-epidemiological characteristics of a series of cases of fungal keratitis associated with Fusarium spp., In Spain during the years 2012 to 2014.
- Trial name
- NCT02984904
- Testing
- survey
- Volunteers
- 23 people
- Sponsor
- Miguel Armando Mosquera Gordillo, MD
Keratitis; Infectious Disease (Manifestation)
Swiss PACK-CXL Multicenter Trial for the Treatment of Infectious Keratitis
To assess the safety and efficacy of PACK-CXL (photoactivated chromophore for infectious keratitis cross-linking) as a firstline treatment for infectious corneal infiltrates and early corneal ulcers, and compare it to the current…
- Trial name
- NCT02717871
- Testing
- PACK-CXL, Cefazolin in combination with either tobramycin or gentamicin, Cycloplegic agents (cyclopentolate 1% eye drops)
- Where
- Switzerland
- Volunteers
- 35 people
- Sponsor
- University Hospital, Geneva
Corneal Ulcer, Infectious Keratitis
Cross-linking for Corneal Ulcers Treatment Trial
The primary purpose of this study is to determine if patients randomized to corneal collagen cross-linking plus medical therapy will have a lower prevalence of positive bacterial or fungal cultures immediately after the procedure…
- Conditions
- Corneal Ulcer, Infectious Keratitis, Bacterial Ulcer, Fungal Ulcer
- Trial name
- CLAIR (NCT02570321)
- Testing
- Corneal Cross-linking, Anti Fungal Drug
- Where
- 2 sites in United States, India
- Volunteers
- 147 people
- Sponsor
- University of California, San Francisco
Infectious Keratitis, Adjuvant Treatment Bacterial Infectious Keratitis
Effect of Sodium Chloride 5% Solution as an Adjuvant Treatment With Antimicrobial Therapy in the Treatment of Bacterial Infectious Keratitis
This study aims to detect the effect of sodium chloride 5% solution as an adjuvant treatment with antimicrobial therapy in treatment of bacterial infectious keratits and to assess whether NaCl 5% accelerates epithelial healing…
- Conditions
- Infectious Keratitis, Adjuvant Treatment Bacterial Infectious Keratitis, Sodium Chloride 5% Solution
- Trial name
- keratitis (NCT07452588)
- Testing
- Sodium chloride 5% solution, quinolones
- Volunteers
- 40 people
- Sponsor
- Sohag University
Infective Keratitis
Role of Anterior Segment Optical Coherence Tomography in Infectious Keratitis
To evaluate the role of anterior segment optical coherence tomography in follow up of infectious keratitis and assessment of response to treatment.
- Trial name
- NCT04969640
- Testing
- Optical coherence tomography
- Where
- Egypt
- Volunteers
- 23 people
- Sponsor
- Minia University
Acanthamoeba Keratitis, Fungal Keratitis
Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction
Rose Bengal Electromagnetic Activation with Green light for Infection Reduction (REAGIR ) is an international, randomized, doubled masked, clinical trial.
- Trial name
- REAGIR (NCT05110001)
- Testing
- Moxifloxacin Ophthalmic, Chlorhexidine Gluconate, Natamycin
- Where
- 2 sites in Brazil, India
- Volunteers
- 330 people
- Sponsor
- University of California, San Francisco
Infectious Keratitis, Microbial Keratitis
Use of a New Method for the Microbiological Diagnosis of Severe Corneal Infection
Microbial keratitis is a severe and often blindness-inducing pathology which represents today the first reason for long-term hospitalization (more than 5 days) in ophthalmology.
- Conditions
- Infectious Keratitis, Microbial Keratitis, Corneal Infection
- Trial name
- ABCORFILM (NCT05888987)
- Testing
- PCR multiplex by FilmArray
- Where
- France
- Volunteers
- 46 people
- Sponsor
- CHU de Reims
Endophthalmitis, Keratitis
Multiplex Strip Polymerase Chain Reaction for Diagnosis of Eye Infection Diseases From Corneal Scraping Samples
The aim of this study is to see if multiplex strip PCR will detect the pathogen that causing eye infection from the corneal scraping samples with higher sensitivity and specificity than the current gold standard.
- Conditions
- Endophthalmitis, Keratitis, Corneal Ulcer, Eye Infections
- Trial name
- NCT04075669
- Testing
- Multiplex Strip PCR
- Where
- Indonesia
- Volunteers
- 65 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia