Clinical trials: Infectious Respiratory Diseases
COPD, HIV/AIDS
Determining Bacterial Communities in the Lungs of HIV-infected Individuals With COPD in Uganda.
Research question Is there any association between altered lung bacterial communities and HIV-associated Chronic Obstructive Pulmonary Disease (COPD)? Rationale Sub-Saharan Africa has experienced dramatic increases in COPD…
- Trial name
- LMB (NCT04070248)
- Testing
- No intervention
- Where
- Uganda
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Makerere University
COVID-19 Infection, COVID-19 VACCINE
Third Dose Vaccination With AstraZeneca or Pfizer COVID-19 Vaccine Among Adults Received Sinovac COVID-19 Vaccine
This prospective, multi-center, randomized, observer-blind Phase 2 study. A total of 1320 participants will be divided into 2 groups (660 each) receiving either full dose or half dose of either AZ or PF.
- Trial name
- NCT05049226
- Testing
- AstraZeneca ChAdOx1 AZD1222 vaccine (AZ) full dose, Pfizer/BioNTech BNT162b2 vaccine (PF) full dose, AstraZeneca ChAdOx1 AZD1222 vaccine (AZ) half dose
- Where
- 7 sites in Thailand
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Covid19
Impact of the COVID-19 Pandemic on Vaccination
The vaccination policy is drawn up in France by the French Minister of Health, who makes public the vaccination schedule after the opinion of the High Authority of Health.
- Trial name
- COVIDVacImpac (NCT04657263)
- Testing
- Vaccine coverage assessment
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Respiratory Syncytial Virus Infection
Effectiveness of Synagis (Palivizumab) Immunoprophylaxis in Preterm Infants With High Risk of Severe Respiratory Syncytial Virus (RSV) Infection
Published data by the Organización panamericana de la Salud shows that Peru's mortality rate from acute respiratory infections (ARI) in infants less than one year of life is second only to Haiti (14,150/100,000).
- Trial name
- INSPIRA (NCT01107535)
- Testing
- Synagis (palivizumab), monoclonal antibody for passive immunoprophylaxis against severe RSV disease administered according to usual clinical practice.
- Where
- 4 sites in Peru
- Volunteers
- 82 people
- Sponsor
- Abbott
Influenza
Detection of Influenza or SARS-CoV-2 Infection by IMS of Nasal Air Sampling
Multicapillary Ion mobility spectrometry of nasal air aspirates shall be investigated as screening tool for the detection of Influenza and SARS-CoV-2- infection.
- Trial name
- NCT04282135
- Testing
- MCC IMS
- Where
- Germany
- Volunteers
- 76 people
- Sponsor
- Klinikum Bayreuth GmbH
Staphylococcal Infections, Meningitis
Cotrimoxazole Versus Vancomycin for Invasive Methicillin-resistant Staphylococcus Aureus Infections
Methicillin-resistant Staphylococcus aureus (SA) is a major pathogen causing mainly health-care associated infections and, lately, also community acquired infections. Few treatment choices exist to treat these infections.
- Conditions
- Staphylococcal Infections, Meningitis, Sepsis, Pneumonia
- Trial name
- NCT00427076
- Testing
- Cotrimoxazole, Vancomycin
- Where
- 2 sites in Israel
- Volunteers
- 252 people
- Sponsor
- Rabin Medical Center
Long COVID
A Practical RCT of TCM in the Treatment of LCOVID and Analysis of Syndrome Types and Medication Characteristics.
This is a multi-center, outcome assessor-blinded, practical randomized controlled trial, aiming to compare the actual clinical effectiveness of individualized traditional Chinese medicine and conventional Western medicine in the…
- Trial name
- NCT06095258
- Testing
- Traditional Chinese medicine treatment, Western medicine treatment
- Volunteers
- 162 people
- Sponsor
- Chinese University of Hong Kong
Pneumonia Childhood
Acute Respiratory Infection Diagnostic Aids (ARIDA) Controlled Accuracy Evaluation Protocol
Pneumonia is the leading infectious cause of death among children under 5 years of age globally. Many pneumonia deaths result from late care seeking and inappropriate treatment due to misdiagnosis of symptoms.
- Trial name
- NCT03067558
- Testing
- Children's automated respiratory rate monitor, MK2 Acute Respiratory Infection (ARI) Timer
- Where
- Ethiopia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Malaria Consortium
Urinary Tract Infection, Acute Pyelonephritis
Efficacy and Safety of CAZ-AVI in the Treatment of Infections Due to Carbapenem-resistant G- Pathogens in Chinese Adults
This is an open-label, randomized, multi-center, interventional, active-controlled Phase 4 study to evaluate the efficacy and safety of CAZ-AVI versus BAT in the treatment of infected participants with selected infection types…
- Conditions
- Urinary Tract Infection, Acute Pyelonephritis, Hospital Acquired Pneumonia, Ventilator-associated Pneumonia
- Trial name
- NCT04882085
- Testing
- Zavicefta, Ceftazidime-Avibactam, Best Available Treatment
- Where
- 37 sites in China
- Volunteers
- 60 people
- Sponsor
- Pfizer
Virus Diseases, RNA Virus Infections
Lot-to-lot Consistency of a Plant-Derived Quadrivalent Virus-Like Particles Influenza Vaccine in Healthy Adults
This Phase 3 study is intended to assess the clinical lot-to-lot consistency in manufacturing by evaluating and comparing the immunogenicity of three consecutively manufactured lots of the Quadrivalent Virus-Like Particles (VLP)…
- Conditions
- Virus Diseases, RNA Virus Infections, Respiratory Tract Infections, Respiratory Tract Disease
- Trial name
- NCT03321968
- Testing
- Quadrivalent VLP Influenza Vaccine
- Where
- 10 sites in Canada
- Volunteers
- 1,202 people, healthy volunteers welcome
- Sponsor
- Medicago
Long COVID Syndrome
A Fasting Pilot Study for Long COVID
Background Long COVID (LC) is a chronic multisystemic condition which substantially impact the quality of life. Despite the staggering burden of LC, there is still no effective treatment.
- Trial name
- NCT07418567
- Testing
- prolonged fasting
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Université de Sherbrooke
Covid19, Humoral Acquired Immunodeficiency
Antibody Detection of Vaccine-Induced Secretory Effects
The purpose of this research study is to conduct a prospective longitudinal surveillance research study, enrolling approximately 60 lactating mothers who receive the SARS-CoV-2 vaccine, and then following their clinical and…
- Conditions
- Covid19, Humoral Acquired Immunodeficiency, Coronavirus, SARS-CoV Infection
- Trial name
- ADVISE (NCT04895475)
- Testing
- SARS-CoV-2 vaccine
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Pneumonia - Bacterial, Pseudomonas Aeruginosa Infection
MP101 in Adults With Acute Pseudomonas Aeruginosa Pneumonia
The purpose of this study is to evaluate the safety and tolerability of a single intravenous dose of MP101 administered in addition to standard antibiotic therapy in adult patients with acute Pseudomonas aeruginosa pneumonia.
- Trial name
- MP101-1001 (NCT07492771)
- Testing
- MP101, Antibiotics
- Where
- South Korea
- Volunteers
- 18 people
- Sponsor
- MicrobiotiX Co., Ltd
Acute Respiratory Failure, Shock
Impact of Early Enteral vs. Parenteral Nutrition on Mortality in Patients Requiring Mechanical Ventilation and Catecholamines
The purpose of this study is to assess the hypothesis that, as compared to early intravenous feeding, early nutrition via the enteral route is associated with reduced Day 28-mortality in critically ill patients treated with…
- Trial name
- NUTRIREA2 (NCT01802099)
- Testing
- Enteral nutrition, Parenteral nutrition
- Where
- 41 sites in France
- Volunteers
- 2,410 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Pertussis
Establishing a Controlled Human Infection Model of Bordetella Pertussis
This study aims to establish a Controlled Human Infection Model of Bordetella pertussis by determining a reproducible and safe infectious bacterial dose (challenge inoculum) that achieves colonization and mild symptomatic…
- Trial name
- NCT05136599
- Testing
- Bordetella pertussis D420
- Where
- Canada
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Dalhousie University
COVID-19 Acute Respiratory Distress Syndrome, Cytokine Release Syndrome
Tazemetostat for the Treatment of Moderate to Severe COVID-19 Infection
The purpose of this study is to assess the safety and efficacy of repurposing tazemetostat for the treatment of Acute Respiratory Distress Syndrome (ARDS) or Systemic Cytokine Release Syndrome (SCRS) in COVID-19 patients.
- Trial name
- IST (NCT05018975)
- Testing
- Tazemetostat
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Diphtheria, Tetanus
Assess Immune Response Following Primary Vaccination With Tritanrix™-HepB Vaccine Mixed With 3 Formulations of Hib-MenAC Vaccine to Infants
To compare three formulations of Hib-MenAC vaccines mixed with Tritanrix™-HepB vaccine with that of Tritanrix™-HepB vaccine concomitantly administered with GSK Biologicals' Hiberix™ vaccine and Tritanrix™-HepB vaccine mixed with…
- Conditions
- Diphtheria, Tetanus, Pertussis, Hepatitis B
- Trial name
- NCT00291967
- Testing
- DTPw-HBV/Hib-MenAC conjugate vaccine
- Where
- Philippines
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Long COVID, Long COVID-19 Syndrome
Quality of Life After Hyperbaric Oxygen Therapy in Post-COVID Patients
Post-Covid syndrome, also known as long Covid, is a clinical condition in which patients experience long term symptoms after Covid-19 infection. Treatment options for post-Covid are not effective.
- Conditions
- Long COVID, Long COVID-19 Syndrome, Long Covid19, Long Covid 19
- Trial name
- QoL COVID HBOT (NCT06159309)
- Testing
- Hyperbaric oxygen therapy
- Where
- 6 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Rutger Lalieu
Long COVID, Long Covid19
Narrative Intervention for Long COVID-19 (NICO)
This T1 proof of concept trial is designed to test the Narrative Intervention for Long COVID-19 intervention.
- Trial name
- NICO (NCT06091293)
- Testing
- Narrative Intervention for Long COVID-19 (NICO)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Colorado, Denver
COVID, Corona Virus Infection
Coronavirus 2019 (COVID-19)- Using Ascorbic Acid and Zinc Supplementation
The purpose of this study is to examine the impact of ascorbic acid (vitamin c) and zinc gluconate in reducing duration of symptoms in patients diagnosed with coronavirus disease 2019 (COVID-19).
- Trial name
- COVIDAtoZ (NCT04342728)
- Testing
- Ascorbic Acid, Zinc Gluconate, Ascorbic Acid and Zinc Gluconate
- Where
- 2 sites in United States
- Volunteers
- 214 people
- Sponsor
- The Cleveland Clinic
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