Clinical trials: Infectious Respiratory Diseases
Pneumonia, Ventilator-Associated
Human Recombinant Interferon Gamma in the Treatment of Ventilator-acquired Pneumonia in ICU Patients
Clinical presentation of patients after severe injury such as a severe infection, trauma or extensive burns is characterized by the simultaneous occurrence of dysregulation of the initial inflammatory response and…
- Trial name
- IGNORANT (NCT05843786)
- Testing
- Interferon gamma
- Where
- 9 sites in France
- Volunteers
- 132 people
- Sponsor
- Hospices Civils de Lyon
Covid19, SARS-CoV Infection
COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19)
1. The purpose of this trial is to conduct a 2x3 factorial randomized trials, which efficiently allows the parallel conduct of three randomized trials to understand whether metformin, ivermectin, or fluvoxamine, is superior to…
- Trial name
- NCT04510194
- Testing
- Metformin, Fluvoxamine, Ivermectin
- Where
- 7 sites in United States
- Volunteers
- 1,323 people
- Sponsor
- University of Minnesota
Covid19, Sars-CoV-2 Infection
Performance Study of SONA Saliva C-19 Rapid Test
The Sona Saliva C-19 Rapid Test is a bioassay intended for rapid point-of-care detection of the SARS-CoV-2 virus. Performance of the Sona Saliva C-19 Rapid Test assay will be assessed by comparison to a RT-PCR reference method
- Conditions
- Covid19, Sars-CoV-2 Infection, Corona Virus Infection
- Trial name
- NCT04877002
- Testing
- Sona Saliva C-19 Rapid Test
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Sona Nanotech Inc
Diphtheria, Tetanus
Study to Evaluate the Immunogenicity and Safety of LBVD(Hexavalent Vaccine), Given to Healthy Infants at Primary Series
The purpose of this study is to evaluate immunogenicity and safety of different doses of candidate hexavalent vaccine in comparison to co-administration of Pentavalent vaccine and Poliomyelitis Vaccine (Inactivated) in separate…
- Conditions
- Diphtheria, Tetanus, Pertussis, Hepatitis B
- Trial name
- NCT05457946
- Testing
- LBVD (Hexavalent vaccine), Pentavalent vaccine and Inactivated Polio vaccine (Sabin strains)
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- LG Chem
Post-Acute COVID-19 Syndrome, Dysautonomia
Post Covid-19 Dysautonomia Rehabilitation Randomized Controlled Trial
Dysautonomia in post-covid-19 condition appears to affect a significant number of patients, with reports raising the incidence up to 61%, having an overlap with myalgic encephalomyelitis/ chronic fatigue syndrome.
- Trial name
- LoCoDiRe-Dys (NCT05855356)
- Testing
- Rehabilitation, Standard of Care
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Evangelismos Hospital
Pneumocystis, HIV/AIDS
Short-term Steroid Therapy in Patients With P. Jirovecii Pneumonia Due to HIV / AIDS
The treatment guidelines for Pneumocystis pneumonia (PCP) suggest adding 40mg of prednisone (or its equivalent in methylprednisolone) twice per day on days 1 through 5, 40 mg days 6 through 10, and 20 mg daily on days 11 through…
- Conditions
- Pneumocystis, HIV/AIDS, Steroid
- Trial name
- NCT03856229
- Testing
- Conventional steroid regimen, Shortened steroid regimen
- Where
- Mexico
- Volunteers
- 196 people
- Sponsor
- Centro de Investigación en. Enfermedades Infecciosas, Mexico
Stroke, Lung Diseases
Acupuncture Therapy Combined With Breathing Training for Patients With Stroke Complicated
The goal of this prospective randomized controlled study is to explore the clinical efficacy of acupuncture therapy combined with breathing training in patients with stroke complicated with pulmonary infection.
- Trial name
- NCT05930262
- Testing
- TCM acupuncture therapy, Conventional drug therapy, Rehabilitation therapy
- Where
- China
- Volunteers
- 72 people
- Sponsor
- The Second Hospital of Hebei Medical University
Covid19
Phase 3 Open-Label Controlled Trial of Convalescent Plasma in Early COVID-19 Infection
The expanded access program for investigational convalescent plasma (CP) is being utilized nationwide despite its unproven benefit and optimal timing of transfusion.
- Trial name
- NCT06084351
- Testing
- Convalescent Plasma, Standard of Care
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Larkin Community Hospital
Respiratory Virus Infection, Fever of Unknown Origin
Rapid Viral Diagnostics in Adults to Reduce Antimicrobial Consumption and Duration of Hospitalization
Viral respiratory infections are common and often require use of health care resources. Patients receive inappropriate bacterial antibiotics, which has many problems including side-effects, development of resistance and costs.
- Conditions
- Respiratory Virus Infection, Fever of Unknown Origin, Dyspnea, Chest Pain
- Trial name
- NCT02538770
- Testing
- Rapid diagnostics using Anyplex TMII RV16 Detection, Delayed diagnostics Anyplex TMII RV16 Detection
- Where
- 2 sites in Finland
- Volunteers
- 900 people
- Sponsor
- University of Oulu
Respiratory Tract Infection
Effects of a Supplement on Acute Respiratory Infections
The purpose of this study is to determine whether the consumption of a nutritional supplement with micronutrients and herbal extracts has an effect on the incidence of acute respiratory infections in susceptible adults.
- Trial name
- NCT02210156
- Testing
- Omniplus Supreme
- Where
- Mexico
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Omnilife Manufactura, SA de CV
Influenza
Peramivir Treatment Response in Adults Hospitalized for Influenza-associated Lower Respiratory Tract Infections
Peramivir is the first intravenous neuraminidase inhibitor (NAI) available for treatment of uncomplicated influenza in adults. Data from placebo-controlled trials in outpatients have shown antiviral efficacy, safety, and…
- Trial name
- NCT02665351
- Testing
- Peramivir
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Chinese University of Hong Kong
Pneumonia, Viral, Corona Virus Infection
Convalescent Antibodies Infusion in COVID 19 Patients
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in Wuhan, China, has become a major concern all over the world.
- Trial name
- NCT04418531
- Testing
- Anti-coronavirus antibodies (immunoglobulins) obtained with DFPP form convalescent patients
- Sponsor
- Piero Luigi Ruggenenti
Covid19, Cardiopulmonary Disease
Physiological Studies in Post-COVID-19 Syndrome, and the Association With DNA Methylation
The physiological derangements in subjects suffering from long-term symptoms following a Covid-19 infection (Post-COVID-19 Syndrome) are poorly understood and evaluated.
- Conditions
- Covid19, Cardiopulmonary Disease, Dyspnea, Lung Function Decreased
- Trial name
- NCT04859894
- Testing
- Physiological testing
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Linkoeping University
New Coronavirus Disease (COVID-19), Infection With SARS-CoV-2
Study of Immune Response During SARS-CoV-2 Infection - (COVID-19)
Study of the cellular immune response during the SARS-CoV-2 infection and identify cytokinic profiles in caregivers exposed to the virus with asymptomatic forms of COVID19, patients with an asymptomatic form followed in…
- Trial name
- CovImmune (NCT04355351)
- Testing
- blood sampling, additional blood tubes
- Where
- 3 sites in France
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
COVID-19 Respiratory Infection, COVID-19
Efficacy and Safety Study of Essential Oil-Based Preparation Administered to COVID-19 Patients
The aim of this study was to compare the efficacy and safety of the essential oil-based product in patients with mild to moderate symptomatic COVID-19 Positive infection confirmed by PCR.
- Trial name
- NCT06452069
- Testing
- IMMUNO19
- Where
- 10 sites in Turkey (Türkiye)
- Volunteers
- 280 people
- Sponsor
- Biodex S.A
Long COVID, Post-Acute Sequelae of SARS-CoV-2 Infection
Long COVID Diagnostic Reactivity Assesment Test
This study is a diagnostic clinical investigation designed to evaluate bioelectrical response patterns assessed by electro-acupuncture-based medicament testing.
- Trial name
- EAV-LONGCOVID (NCT07343856)
- Testing
- Electrodiagnostic Bioelectrical Assessment
- Where
- Uzbekistan
- Volunteers
- 50 people
- Sponsor
- Oncology Center,Ministry Of Heath,Uzbekistan
Influenza, Orthomyxoviruses
Immunogenicity of a Split, Cell-Based, Inactivated, Trivalent Influenza Vaccine in Healthy Adult Subjects
Primary Objective: To describe the immune response to a single administration of 2 formulations of the investigational cell-based influenza vaccines in healthy adult subjects.
- Conditions
- Influenza, Orthomyxoviruses, Myxovirus Infection
- Trial name
- NCT00845429
- Testing
- Influenza virus vaccine - cell based (2007-2008 Formulation), Influenza virus vaccine - cell-based (2007-2008 Formulation), Influenza virus vaccine (2007-2008 Formulation)
- Where
- 15 sites in United States
- Volunteers
- 729 people, healthy volunteers welcome
- Sponsor
- Sanofi
Long COVID, Pain
Effects of an Active Coping Program in Patients With Persistent Post-Covid Pain.
Justification: among the sequelae of Covid-19 in clinical practice we frequently find persistent neuromusculoskeletal pain. Previous studies carried out by this research group and in the scientific literature have shown that…
- Trial name
- NCT05894629
- Testing
- Pain Neuroscience Education (PNE)+ Therapeutic Exercise (TE), Active Comparator: Usual treatment
- Where
- Spain
- Volunteers
- 89 people
- Sponsor
- University of Valladolid
Post-COVID-19 Syndrome
Psychosomatic, Physical Activity or Both for Post-covid19 Syndrom
Post-Covid(PoC)-patients with fatigue symptoms respond very differently to physical rehabilitation programs. While PoC-patients with psychological symptoms benefit little from physical interventions, fatigue and exercise capacity…
- Trial name
- TELPOCO (NCT06042751)
- Testing
- Exercise Therapy, Psychotherapy
- Where
- Germany
- Volunteers
- 195 people
- Sponsor
- Hannover Medical School
Pneumonia
Efficacy and Safety of Intrapulmonary Percussive Ventilation in Patients With Pulmonary Infection Receiving Invasive Mechanical Ventilation
The goal of this clinical trial is to learn whether adding intrapulmonary percussion ventilation (IPV) to standard airway clearance treatment improves clinical outcomes in invasively mechanically ventilated patients with…
- Trial name
- NCT07453966
- Testing
- Intrapulmonary percussion ventilation, usual care
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Zhongnan Hospital
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