Clinical trials: Infectious Respiratory Diseases
Coronavirus, Coronavirus Infection
BCG Vaccine for Health Care Workers as Defense Against COVID 19
SARS-CoV-2 spreads rapidly throughout the world. A large epidemic would seriously challenge the available hospital capacity, and this would be augmented by infection of healthcare workers (HCW).
- Conditions
- Coronavirus, Coronavirus Infection, Coronavirus as the Cause of Diseases Classified Elsewhere
- Trial name
- BADAS (NCT04348370)
- Testing
- BCG Vaccine
- Where
- 6 sites in United States
- Volunteers
- 659 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Respiratory Distress Syndrome, Adult, COVID-19
Coronavirus Studied by Metagenomics in ARDS COVID-19 Patients
Pandemic SARS-CoV-2 (COVID-19) respiratory infection is responsible for more than 4,000 deaths, mainly (67%) secondary to acute respiratory distress syndromes (ARDS).
- Trial name
- COMETS (NCT04516486)
- Testing
- retrospective metagenomics on clinical samples collected during hospitalization
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infectious Disease of Lung
Tracheobronchitis in Respiratory Involvement on the Lung SPECT/CT Images of Coronavirus Disease (COVID-19) Patients
Tracheobronchitis signs may be observed on ventilation lung scintigraphy during coronavirus disease (COVID-19) infection. This case report study aimed to analyze the rates and associated factors of such tracheobronchitis in…
- Trial name
- NCT04629222
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Central Hospital, Nancy, France
Ventilator-associated Pneumonia, Hospital-acquired Pneumonia
Identifying Risk Factors for Gram-negative Resistance for HAP/VAP in the Intensive Care Unit
Single center, retrospective chart review. Patients admitted to MDMC ICU from 4/1/2017 to 6/30/2020 will be identified through the electronic medical record utilizing ICD codes for HAP and VAP.
- Trial name
- NCT04700202
- Testing
- Observational
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Methodist Health System
Cystic Fibrosis Pulmonary Exacerbation
Pharmacokinetic Study of Extended Infusion Meropenem in Adult Cystic Fibrosis Patients
Meropenem is an intravenous antibiotic commonly used to treat acute exacerbation of respiratory infections in cystic fibrosis. The research study aims to determine if a different method of infusing the drug over 3 hours or…
- Trial name
- NCT01158937
- Testing
- Meropenem Infusion
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Unity Health Toronto
Cystic Fibrosis, Lung Inflammation
TAAI Erasmus Research Initiative to Fight CF: Monitoring Inflammation in CF Lung Disease Into a New Era
Progressive destruction of the lungs is the main cause of shortened life expectancy in people with cystic fibrosis (pwCF). Inflammation and respiratory infections play a key role in CF lung disease.
- Conditions
- Cystic Fibrosis, Lung Inflammation, Lung Infection, Lung Disease; Cystic
- Trial name
- TERRIFIC-MILE (NCT05752019)
- Where
- Netherlands
- Volunteers
- 103 people
- Sponsor
- Erasmus Medical Center
Respiratory Syncytial Virus Infection, Respiratory Syncytial Virus Infections
Genotype and Disease Burden of RSV in Older Vietnamese Adults (RSV: Respiratory Syncytial Virus )
This observational, prospective, multicenter study aims to estimate the proportion of RSV infection in adults aged 60 years and older hospitalized due to acute respiratory infections or exacerbation of cardiopulmonary disease.
- Trial name
- RSV-VN-Elderly (NCT07239583)
- Where
- Vietnam
- Volunteers
- 1,000 people
- Sponsor
- Tam Anh Research Institute
Idiopathic Pulmonary Fibrosis
A Pilot Trial of Herpesvirus Treatment in Idiopathic Pulmonary Fibrosis (IPF)
The investigators will conduct a single-center, prospective, randomized, placebo-controlled, double-blind pilot study of anti-herpesvirus therapy in patients with idiopathic pulmonary fibrosis (IPF).
- Trial name
- NCT02871401
- Testing
- Valganciclovir
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Vanderbilt University Medical Center
COVID-19
Safety and Immunogenicity Study of EgyVax Vaccine Candidate for Prophylaxis of COVID-19 Infection
This is a phase I, prospective, three-arm, open-label, randomized, first in human (FIH) clinical trial to assess the safety and immunogenicity of EgyVax vaccine candidate for prophylaxis of SARS-CoV-2 infection (COVID-19).
- Trial name
- Sphinx (NCT05218070)
- Testing
- EgyVax Vaccine Candidate
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Eva Pharma
COVID-19, Sleep Disorder
Investigation of Respiratory Muscle Strength, Exercise Capacity, Physical Activity and Sleep Quality Level in Individuals With Covid-19 Infection
COVID-19 infection was identified in Wuhan, China at the end of 2019 and turned into a pandemic in a short time. In our country, the pandemic continues at full speed and patients are being treated in various clinical pictures.
- Conditions
- COVID-19, Sleep Disorder, Respiratory Failure
- Trial name
- NCT06008470
- Testing
- observational tests
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Respiratory Syncytial Virus Infections
Ribavirin to Prevent RSV Pneumonia in Bone Marrow Transplant Patients
The purpose of this study is to test the safety and effectiveness of ribavirin, administered as an aerosol, in preventing progression of upper respiratory tract RSV infection to RSV pneumonia in bone marrow and peripheral blood…
- Trial name
- NCT00031473
- Testing
- Virazole (Ribavirin) Inhalation Solution
- Where
- 11 sites in United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19, COVID-19 Drug Treatment
Combination Therapies to Reduce Carriage of SARS-Cov-2 and Improve Outcome of COVID-19 in Ivory Coast: a Phase Randomized IIb Trial
In January 2020, the new SARS-CoV-2 coronavirus was identified in China. The disease caused by this coronavirus was named COVID-19 by the World Health Organization (WHO).
- Conditions
- COVID-19, COVID-19 Drug Treatment, Severe Acute Respiratory Syndrome Coronavirus 2
- Trial name
- INTENSE-COV (NCT04466241)
- Testing
- Lopinavir/Ritonavir 200 MG-50 MG Oral Tablet, Telmisartan 40Mg Oral Tablet, Atorvastatin 20 Mg Oral Tablet
- Where
- 2 sites in Côte d’Ivoire
- Volunteers
- 294 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Coronavirus Infectious Disease (COVID-19), Nosocomial Infection
NOSOcomial COVID-19 in ICU (NOSOCOVID)
The current global pandemic at COVID-19 is a major public health issue. Transmission of the virus is primarily through direct and close person-to-person contact.
- Conditions
- Coronavirus Infectious Disease (COVID-19), Nosocomial Infection, Nosocomial COVID-19
- Trial name
- NOSOCOVID (NCT04659356)
- Testing
- Patients admitted in Intensive Care Units
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Nantes University Hospital
Long COVID
Cognitive Impairment and Return to Work in Long COVID
This retrospective, single-center observational study investigates the relationship between cognitive performance and return to work in patients with Long COVID.
- Trial name
- REWORK-COV (NCT07881029)
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Hopitaux de Saint-Maurice
Long COVID
Water-based Activity to Enhance Recovery in Long COVID-19
This two-year study will evaluate the feasibility and safety of an exercise + cognitive training program to improve neurological symptoms of long-COVID.
- Trial name
- NCT06142253
- Testing
- WATER+CT, Usual Care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
COVID-19 Respiratory Infection, SARS-CoV-2 Acute Respiratory Disease
Photodynamic Therapy for COVID-19 Prevention
This is a single-center open-label study to evaluate antimicrobial photodynamic therapy (aPDT) for upper airway decolonization in patients presenting with SARS-CoV-2 positive antigen test with mild or no symptoms of COVID-19.
- Trial name
- NCT05184205
- Testing
- Nasal Photodisinfection
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Ondine Biomedical Inc.
Long COVID, COVID-19 Pandemic
Long COVID and Its Associations With Health Outcomes in Older Adults
The Peking University Health Cohort in Anning, Yunnan (PKUHC-AN) is a prospective cohort study carried out in Anning, Yunnan. The primary aim of this study is to investigate the impact of COVID-19 on older adults' health, and to…
- Conditions
- Long COVID, COVID-19 Pandemic, Elderly Infection, Vaccine Reaction
- Trial name
- NCT05825651
- Testing
- no interventions
- Where
- China
- Volunteers
- 11,527 people, healthy volunteers welcome
- Sponsor
- Peking University
Covid19, Hiv
Effects of COVID-19 on Endothelium in HIV-Positive Patients in Sub-Saharan Africa
Background: Coronavirus disease 2019 (COVID-19) has affected almost every country in the world, especially in terms of health system capacity and economic burden.
- Conditions
- Covid19, Hiv, ART
- Trial name
- ENDOCOVID (NCT04709302)
- Testing
- COVID-19, HIV, ART
- Where
- 3 sites in Nigeria, South Africa
- Volunteers
- 342 people
- Sponsor
- Medical University of Graz
Bacteria Infection, Respiratory Tract Infections
Early Versus Expectant Treatment of Ureaplasma Infection in Very Low Birth Weight Neonates
Our hypothesis is that treatment of known Ureaplasma spp. infection of the airways in very low birth weight (VLBW) infants with azithromycin will eradicate the organisms and lessen the proinflammatory state caused by infection…
- Trial name
- NCT00599053
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Alabama at Birmingham
SARS-CoV-2 Infection
Evusheld Japan PMS_Japan Post-Marketing Surveillance (PMS)
To investigate intends to evaluate the incidence of adverse drug reactions (ADRs) in individuals who receive Evusheld in clinical practice to determine its post-marketing safety profile in Japanese.
- Trial name
- NCT05687877
- Where
- 18 sites in Japan
- Volunteers
- 366 people
- Sponsor
- AstraZeneca
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