Clinical trials: Infertility,Male
Non-obstructive Azoospermia
Intra-Testicular Transplantation of Autologous Stem Cells for Treatment of Non-Obstructive Azoospermia Male Infertility.
This is an open label, single arm, single center investigation to assess the safety and efficacy of purified adult autologous, bone marrow derived, highly specialized, differentiation specific into spermatogonial lineages, and…
- Trial name
- NCT02641769
- Testing
- Stem Cell Transplantation
- Where
- Jordan
- Volunteers
- 600 people
- Sponsor
- Stem Cells Arabia
Male Infertility Due to Antisperm Antibody
Influence of Inguinal Hernia Repair on Sperm Autoimmunity
Influence of inguinal hernia repair on sperm autoimmunity using MAR test
- Trial name
- SPERMAR (NCT04591470)
- Testing
- Mar test
- Where
- Italy
- Volunteers
- 2,415 people
- Sponsor
- Istituto Clinico Humanitas
Male Infertility
Comparison of the Effect of Gonadotropin and Clomiphene Citrate Treatment on Sperm Parameters and the Outcome of Assisted Reproductive Procedures in Subfertile Men Based on the APHRODITE Groups
Men enrolled in the study are assigned to each APHRODITE group. Group 2,3,4 are treated with either gonadotropin preparations or clompihene-citrate (except group 4).
- Trial name
- GONACLO (NCT07523022)
- Testing
- recFSH, HCG injection, Clomiphene Citrate 50 mg
- Where
- Hungary
- Volunteers
- 500 people
- Sponsor
- Szeged University
Infertility, Male, Cancer
Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting
Spermatogonial stem cell transplantation through ultrasound guided rete testis injection and testicular tissue grafting will be performed for participants who have frozen testicular tissue prior to gonadotoxic therapy.
- Conditions
- Infertility, Male, Cancer, Autoimmune Disorder
- Trial name
- NCT04452305
- Testing
- Spermatogonial Stem Cell Transplant and Testicular Tissue Grafting
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pittsburgh
Embryo Aneuploidies, Implantation Rates
Preimplantation Genetic Screening (PGS) in Advanced Female Age and Male Severe Factor
Preimplantation Genetic Screening (PGS) is used for the selection of chromosomally normal embryos before the transfer in IVF treatments in many cases.
- Conditions
- Embryo Aneuploidies, Implantation Rates, Infertility
- Trial name
- NCT01571076
- Testing
- PGS, Prolonged culture
- Where
- Spain
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Igenomix
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
Effect of Hyperandrogenism on IVF Outcomes in PCOS Patients
Ovulatory dysfunction affects 18 to 25% of infertile women, the most common identifiable condition is polycystic ovarian syndrome (PCOS).
- Trial name
- HIP (NCT05555680)
- Testing
- Ferriman-Gallwey Score
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- Clinique Ovo
Infertility, Male
Sperm Separation Efficiency to Maximize Pregnancy Rates: MACS vs. FERTILE Chip
The goal of this observational study is to compare clinical outcomes of two techniques for sperm cell sorting, microfluidic sorting and magnetic activated cell sorting (MACS) technique, in males with high DNA fragmentation within…
- Trial name
- FERTIMACS (NCT04061486)
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Vida Recoletas Sevilla
Male Infertility, Heart Valve Disease
Warfarin Effects on Male Fertility After Cardiac Surgery
Young male patients undergoing cardiac surgery may require oral anticoagulation with warfarin either lifelong, such as after mechanical valve replacement, or for a limited postoperative period, for example following valve repair…
- Trial name
- NCT07330869
- Testing
- Semen analysis, sperm DNA fragmentation and hormonal evaluation
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Città di Lecce Hospital, GVM Care & Research
HPV - Anogenital Human Papilloma Virus Infection, Infertilities
Effect of a Dietary Supplement Containing EGCG, Folic Acid, Vitamin B12 and Hyaluronic Acid in Supporting Male Genital Balance in Subjects Exposed to HPV Risk
Pilot interventional study aimed at evaluating the effect of a dietary supplement containing EGCG, vitamin B12, hyaluronic acid, and folic acid on the maintenance of physiological balance of the genital mucosa and natural…
- Trial name
- PERVI-M (NCT07320183)
- Testing
- pervistop
- Volunteers
- 96 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Infertility, Male
Sperm Selection Using Microfluidic Technology
This clinical study has been organised to investigate whether microfluidic technology may be considered as a new procedure for routine sperm preparation during assisted reproduction.
- Trial name
- MSS (NCT04997070)
- Where
- Belgium
- Volunteers
- 1,038 people, healthy volunteers welcome
- Sponsor
- CRG UZ Brussel
Infertility, Male, Diagnosis, Preimplantation
Preimplantation Genetic Screening in Patients With Male Factor Infertility
This will be a prospective, randomized (1:1 ratio) clinical trial for patients with severe male-factor infertility with or without preimplantation genetic screening (PGS).
- Trial name
- NCT02941965
- Testing
- ICSI without PGS, ICSI with PGS
- Where
- China
- Volunteers
- 450 people
- Sponsor
- International Peace Maternity and Child Health Hospital
Oligospermia
A Preliminary Study on Effect of Omega-3 on Human Sperm
The phospholipids of mammalian spermatozoa possess a distinctive fatty acid composition with high proportion of long chain polyunsaturated fatty acids.
- Trial name
- NCT00479960
- Testing
- commercially available omega-3 fatty acids supplementation
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Infertility, Male
Male Reproduction COVID Sequelae Study (MARCOS).
The purpose of this study is to investigate the effects of COVID-19 Vaccination on semen parameters and to determine how long these possible changes may last following vaccination.
- Trial name
- NCT04665258
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Miami
Oligozoospermia
A Study to Evaluate the Safety and Tolerability of Single and Multiple Dose of STSP-0902 in Healthy Subjects
This is a Phase 1b, randomized, double-blind, placebo-controlled, single and multiple ascending dose (MAD) study to evaluate the safety, tolerability, pharmacokinetics (PK), and immunogenicity of STSP-0902
- Trial name
- NCT06948799
- Testing
- STSP-0902 injection
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Staidson (Beijing) Biopharmaceuticals Co., Ltd
Infertility, Infertility, Female
Aftificial Inteligence in Assisted Reproductive Techniques to Assess Oocyte Quality and Embryo Ploidy
The assisted reproduction success rate is affected by several factors including the age of the women, oocyte quality and maturation state, as well as sperm quality.
- Conditions
- Infertility, Infertility, Female, Infertility, Male, Infertility Unexplained
- Trial name
- SMARTAI (NCT06539104)
- Testing
- arteficial inteligence evaluation of oocyte and embryo development
- Where
- 4 sites in Czechia
- Volunteers
- 1,000 people
- Sponsor
- Charles University, Czech Republic
Sperm DNA Fragmentation, Infertility, Male
Impact of Escitalopram on Sperm DNA Fragmentation
Double-blind placebo-controlled randomized trial of daily escitalopram for 6 weeks in healthy men with normal semen analyses and no psychiatric history of depression, bipolar, mania or suicidal ideation.
- Trial name
- NCT03527043
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Male Infertility, Klinefelter's Syndrome
RA-2 13-cis Retinoic Acid (Isotretinoin)
Men with infertility and normal hormone levels have few options for fertility treatment. Previous research work has suggested that men with infertility may have low levels of the active form of Vitamin A, called retinoic acid, in…
- Conditions
- Male Infertility, Klinefelter's Syndrome, Y-chromosome Microdeletions
- Trial name
- RA-2 (NCT02061384)
- Testing
- 13-cis retinoic acid, Calcitriol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
Male Infertility
Use of Testicular Spermatozoa in Non-azoospermic Patients
Use of testicular spermatozoa in non-azoospermic patients.
- Trial name
- NAZOSPERM (NCT05203211)
- Testing
- Testicular sperm extraction (TESE)
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Istituto Clinico Humanitas
Male Infertility
The Acceptance, Safety, and Efficacy of MadaJet Versus Needle Injection for Sperm Retrieval in Patients With Azoospermia
To compare the acceptance, safety, and efficacy of needle-free jet anaesthetic technique (MadaJet) versus needle injection for sperm retrieval in patients with azoospermia.
- Trial name
- NCT03181243
- Testing
- Madajet, Needle injection
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Vietnam National University
Varicocele, Infertility, Male
Assessment of Seminal Levels of Cystatin C and Endoglin in Infertile Men With Varicocele
Varicocele is a major contributor in male infertility. The improvement of sperm parameters after varicocelectomy supports this contribution.
- Trial name
- NCT04856579
- Testing
- Varicocelectomy
- Where
- 2 sites in Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Benha University