Clinical trials: Infertility,Male
Male Infertility, Obesity
Investigating the Physiological Effects of Weight Loss on Male Fertility
The purpose of this study is to determine the physiological effects of weight loss on seminal parameters in male participants with reduced reproductive capacity.
- Conditions
- Male Infertility, Obesity, Weight Loss
- Trial name
- NCT03553927
- Testing
- Low Energy Diet, NHS advice on healthy eating
- Where
- United Kingdom
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Primary Ovarian Insufficiency, Azoospermia
Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI)
Background: Infertility affects 1 in 6 people. Often, the causes of infertility are unknown. Treatments are successful in only about 50% of cases.
- Conditions
- Primary Ovarian Insufficiency, Azoospermia, Oligospermia
- Trial name
- NCT07357701
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infertility, Female, Infertility, Male
Cell Free Preimplantation Genetic Testing
This study aims to develop preimplantation genetic testing methods from embryo culture media (cell free). Genetic testing of culture media will be compared to conventional methods based on embryo biopsies.
- Trial name
- NCT04628507
- Testing
- Spent media collection
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Genomic Prediction Inc.
Polycystic Ovary Syndrome
History of Polycystic Ovary Syndrome in First-degree Relatives
The aim of this study was to investigate the semen analysis results of male patients with first-degree relatives meeting the diagnostic criteria for PCOS.
- Trial name
- PCOS (NCT06442228)
- Testing
- spermiogram test
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital
Male Infertility
Effect of Sorting of Apoptotic Spermatozoa on the Outcome of Assisted Reproduction
In assisted reproductive technology (ART) semen needs to be processed. Commonly used methods rely on physical properties of the spermatozoa, such as the swim-up methods and density gradient centrifugation.
- Trial name
- Spermsorting (NCT02166567)
- Testing
- Staining of spermatozoa with the YoPro dye and sorting of the stained spermatozoa with FACS, Swim-up
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Basel, Switzerland
Kallmann Syndrome, Hypogonadotropic Hypogonadism
Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or Palate
The purpose of this study is to explore the genetic basis of reproductive disorders and cleft lip and/or palate.
- Conditions
- Kallmann Syndrome, Hypogonadotropic Hypogonadism, Hypothalamic Amenorrhea, Polycystic Ovarian Syndrome
- Trial name
- NCT01601171
- Where
- Switzerland
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Male Infertility
Vitamin E and Male Infertility
The goal of this study is to determine whether there is a correlation between the levels of Vitamin E in sperm and sperm DNA fragmentation.
- Trial name
- NCT00178516
- Testing
- behavior, procedure
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Male Infertility
Trial to Improve Fertilization Rate and Embryo Development in Intracytoplasmic Sperm Injection (ICSI) Cycles
The Aim of the trial: Assess if a consecutive second ejaculate contains an equal, or even higher number of motile sperm and produces high-quality sperm for intracytoplasmic sperm injection (ICSI) in male factor patients and if it…
- Trial name
- NCT07056400
- Testing
- First Ejaculate for ICSI, Second Ejaculate for ICSI
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Ain Shams University
Male Sterility Due to Y-chromosome Deletions
Aneuploidies in Embryos and Spermatozoa From Patients With Y-chromosome Microdeletions
In this study, investigators assess, using Fluorescence in situ Hybridization (FISH) and Comparative Genomic Hybridization (CGH) arrays for Preimplantation Genetic Screening (PGS), the incidence of aneuploidies in spermatozoa and…
- Trial name
- NCT02527954
- Where
- 3 sites in Spain
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI Alicante
Endometriosis
A Long-Term Study to Evaluate the Safety of Asoprisnil in the Treatment of Women With Endometriosis From Study M01-398
The objective of this study is to determine the long-term safety of asoprisnil 5 mg for 12 months in women with endometriosis from study M01-398.
- Trial name
- NCT00160420
- Testing
- Asoprisnil
- Volunteers
- 73 people
- Sponsor
- Abbott
Male Factor Infertility
Effectiveness of the Use of the PICSI Dish (Hyaluronan Microdot) in the Selection of Sperm for Intracytoplasmic Sperm Injection (ICSI)
The purpose of this study is to determine if using microdots of hyaluronan (PICSI) to select sperm for ICSI will result in increased pregnancies especially with men that have a low hyaluronan binding score (HBA).
- Trial name
- NCT00741494
- Testing
- PICSI dish
- Where
- 9 sites in United States
- Volunteers
- 801 people
- Sponsor
- Biocoat
Infertility, Male, Sperm Count, Low
Study of the ZyMōt Sperm Selection Method and Its Effect on Embryo Ploidy.
It has been described that 11% of men with semen values within the normal range established by the World Health Organization (WHO) have sperm DNA fragmentation.
- Trial name
- ZYMOT2 (NCT06384794)
- Testing
- Sperm capacitation through the ZyMōt®Sperm Separation Device®, Swim-up
- Where
- 2 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Asthenozoospermia
The Effect of Royal Vaginal Gel Compared to IUI Technique on Fertility Rate of Women With Low-fertility Husbands
The present Pocock clinical trial study was conducted In the city of Mashhad in Iran between 2015 and 2016. The study inclusion criteria were men with low fertility of sperm motility<25% and total motility <50%…
- Trial name
- NCT03463005
- Testing
- Royal jelly, IUI
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Gonabad University of Medical Sciences
Periodontitis, Sub-fertility
Association Study Between Periodontal Disease and Male Infertility
The aim of the present study is to examine the association between fertility parameters and the periodontal status of men attending fertility and in vitro fertilization clinic.
- Trial name
- NCT01140945
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Infertility, Male
PKB171 Against Placebo in Couples With Asthenozoospermia Who Wish to Conceive
The test medication Gel PKB171 is a vaginal gel that has not yet been licensed by the regulatory authorities. However, the active substance pentoxifylline has been available as tablets for decades and is used to increase…
- Trial name
- PKB171 (NCT06986031)
- Testing
- Vaginal product
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Prokrea BCN, S.L.
Male Infertility, Benign Prostatic Hyperplasia
The Effectiveness of Spermotrend Food Supplement in the Treatment of Male Infertility
Spermotrend is a natural based product manufactured by Catalysis Laboratories. Its composition contains different essential elements for spermatogenesis: selenium, zinc and fructose.
- Conditions
- Male Infertility, Benign Prostatic Hyperplasia, Spermatogenesis and Semen Disorders
- Trial name
- NCT05222841
- Testing
- Spermotrend
- Where
- Nicaragua
- Volunteers
- 150 people
- Sponsor
- Catalysis SL
Infertility, Male
To Study the Effect of Magnetic Activated Sperm Sorting on the Outcome of in Vitro Fertilization-embryo Transplantation
Recent studies have evaluated the use of magnetic-activated sperm sorting (MASS) to reduce apoptotic spermatozoa and improve the outcome of infertile male with assisted reproductive technology (ART).
- Trial name
- MASS (NCT03968367)
- Testing
- Magnetic activated sperm sorting
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Li-jun Ding
Male Infertility Due to Azoospermia
Seminal Levels of PGK2 and ACRV1 as Predictors of Micro-TESE Results in NOA
Measurement of PGK2 and ACRV1 levels in the semen of infertile males undergoing testicular sperm extraction (TESE). Correlate seminal levels of PGK2 and ACRV1 with sperm retrieval results and histopathology analysis of testicular…
- Trial name
- NCT06307639
- Testing
- Measurement of PGK2 and ACRV1 levels in the semen of infertile males undergoing testicular sperm extraction (TESE).
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Assiut University
Asthenozoospermia, Mitochondrial Damage
Evaluation of the Effects of Semen Incubation With ANDROSITOL®DGN on Sperm Motility and Mitochondrial Membrane Potential
Mitochondria is the cellular organelle responsible for the production of the energy necessary to fuel sperm motility. It has been demonstrated that mitochondrial efficiency is correlated to the fertilizing capacity of the…
- Trial name
- Androsi-Test (NCT04291495)
- Testing
- ANDROSITOL®TEST
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Catania
Unexplained Infertility, Male Infertility
Royal Jelly Supplementation in Unexplained Male Infertility
This randomized, double-blind, placebo-controlled clinical trial investigates the effects of oral Royal Jelly supplementation on sperm DNA fragmentation and pregnancy rates in couples with unexplained infertility.
- Conditions
- Unexplained Infertility, Male Infertility, Sperm DNA Fragmentation
- Trial name
- NCT07337265
- Testing
- Lyophilized Royal Jelly
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Medipol University