Clinical trials: Infertility,Male, open to volunteers
Spermatogenesis and Semen Disorders, Infertility, Male
Power Prenatal Supplements for Sperm Quality
Male factor infertility is a leading cause of primary and secondary infertility. Poor sperm quality is defined as having an abnormal semen analysis [WHO 2020 - https://www.who.int/publications/i/item/9789240030787].
- Trial name
- NCT05410782
- Testing
- Power Prenatal for Sperm
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Bird and Be Co Inc
Male Infertility, Nonobstructive Azoospermia
Platelet Rich Plasma Testis Treatment for Infertile Men
Investigate the effect of intratesticular injection of autologous platelet rich plasma (PRP) on sperm retrieval rates and IVF outcomes in infertile men who already underwent a negative sperm retrieval.
- Conditions
- Male Infertility, Nonobstructive Azoospermia, Azoospermia
- Trial name
- NCT05479474
- Testing
- Platelet rich plasma
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Aging, Epigenetic Aging
Human Sperm Cryopreservation as an Alternative to the Decline of Sperm Quality With Aging
This observational study will evaluate whether sperm cryopreservation can help preserve sperm quality and molecular characteristics that may be affected by increasing paternal age.
- Conditions
- Aging, Epigenetic Aging, Infertility, Assisted Reproduction Technologies
- Trial name
- NCT07814235
- Where
- Spain
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- IVI Murcia
Varicocele, Male Infertility
Intratesticular Artery Resistive Index Changes After Varicocelectomy
This study aims to evaluate how blood flow inside the testicles changes after surgery to correct a varicocele, and whether these changes correlate with improvements in semen quality and testosterone levels.
- Conditions
- Varicocele, Male Infertility, Secondary Hypogonadism
- Trial name
- NCT07517952
- Testing
- Microscopic Sub-inguinal Varicocelectomy
- Volunteers
- 40 people
- Sponsor
- Assiut University
HPV - Anogenital Human Papilloma Virus Infection, Infertilities
Effect of a Dietary Supplement Containing EGCG, Folic Acid, Vitamin B12 and Hyaluronic Acid in Supporting Male Genital Balance in Subjects Exposed to HPV Risk
Pilot interventional study aimed at evaluating the effect of a dietary supplement containing EGCG, vitamin B12, hyaluronic acid, and folic acid on the maintenance of physiological balance of the genital mucosa and natural…
- Trial name
- PERVI-M (NCT07320183)
- Testing
- pervistop
- Volunteers
- 96 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Infertility Due to Azoospermia
PKB171 Against Placebo in Couples With Mild Male Factor Infertility
The test medication Gel PKB171 is a vaginal gel that has not yet been licensed by the regulatory authorities. However, the active substance pentoxifylline has been available as tablets for decades and is used to increase…
- Trial name
- NCT07669584
- Testing
- Intravaginal gel, Vaginal Gel with Applicator
- Where
- 12 sites in Spain
- Volunteers
- 732 people
- Sponsor
- Prokrea BCN, S.L.
Genetic Disorder, Infertility
Inherited Reproductive Disorders
Background: During puberty, children begin to develop into adults. Problems with the hormones released during puberty can affect the reproductive system. Some people have low hormone levels that severely delay or prevent puberty.
- Conditions
- Genetic Disorder, Infertility, Hypogonadism, Amenorrhea
- Trial name
- NCT01500447
- Where
- 2 sites in United States
- Volunteers
- 850 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Myo-inositol, Post Varicocelectomy
Comparative Study of Post-Varicocelectomy Myo-inositol vs. Antioxidants vs. Surgery Alone in Infertile Men
The purpose of this open-label, 3-arm randomized controlled trial is to compare the clinical efficacy and safety of adding oral myo-inositol versus conventional oral antioxidants (vitamin C, L-carnitine, and zinc) versus surgery…
- Conditions
- Myo-inositol, Post Varicocelectomy, Infertile Men, Varicocele
- Trial name
- MYO-VAR (NCT07915388)
- Testing
- Experimental Arm Intervention: Myo-inositol, Conventional Antioxidants, Group C (Control)
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Fayoum University Hospital
Urologic Diseases, Urologic Cancer
Bank of Biological Material From Patients and Healthy Donors for the Study of Urological and Uro-oncological Pathologies
The project aims to collect fresh biological material derived both from surgical resections performed in diseases, neoplastic and otherwise, of urological relevance at the level of the prostate, bladder, kidney, testicle and…
- Conditions
- Urologic Diseases, Urologic Cancer, Infertility
- Trial name
- NCT06187870
- Testing
- Collection of biological data
- Where
- Italy
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Azoospermia
Testis Needle Aspiration of Sperm in Men With Azoospermia
Needle aspiration of the epididymis causes rupture and irreversible damage to the duct. Recurring punctures and needle aspirations of fluid and tissue during Testicular Fine Needle Aspiration (TEFNA) procedure cause irreparable…
- Trial name
- NCT02418832
- Testing
- Sperm cell aspiration and TEFNA
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Hadassah Medical Organization
Cancer, Infertility
Late Effects of Cancer Therapies on Gonadal Function, Fertility, Efficiency of Fertility Preservation Procedures and Pregnancy Outcomes
In the past two decades, evidence-based knowledge on the prevalence and risk factors for fertility impairment, including infertility, following cancer and numerous cancer treatment regimens has significantly increased.
- Conditions
- Cancer, Infertility, Late Effects, Female Fertility
- Trial name
- Follow-AYA (NCT07622537)
- Volunteers
- 4,000 people
- Sponsor
- Karolinska Institutet
Infertility (IVF Patients), Male Fertility
Functional Development and Clinical Validation of a Diagnostic Tool Based on Artificial Intelligence for the Assessment of Sperm Quality and the Selection of the Optimal In Vitro Fertilisation (IVF) Treatment
Infertility is a growing global health problem affecting millions of couples worldwide, with male infertility accounting for approximately half of all cases.
- Conditions
- Infertility (IVF Patients), Male Fertility, Sperm Selection
- Trial name
- NCT07185984
- Testing
- Sperm sellection, DIAGNOSIS TOOL
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Endometriosis
ENDOMET - Novel Diagnostic Tools and Treatments for Endometriosis
Endometriosis is a chronic disease characterized by the presence of functional endometrial glands and stroma in ectopic locations outside the uterine cavity.
- Trial name
- ENDOMET (NCT01301885)
- Testing
- Laparoscopy/laparotomy
- Where
- 4 sites in Finland
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Cystic Fibrosis, Congenital Bilateral Absence of Vas Deferens
Establishment of a Primary Epididymal Cell Model From Epididymal Samples to Study CFTR Gene Regulation
The aim of this observational study is to better understand the role and involvement of the regulatory elements of the CFTR gene, with the aim of better describing the 3D organisation of chromatin at the CFTR locus in epididymal…
- Conditions
- Cystic Fibrosis, Congenital Bilateral Absence of Vas Deferens, Sterility, Male
- Trial name
- CFTR-EP (NCT06045702)
- Testing
- Epididymal sample
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Adenomyosis of Uterus
Association of Ultrasound Features of the Myometrium Suggestive of Adenomyosis and Clinical Symptoms
The goal of this study/research is to assess the relationship between ultrasound features of the myometrium suggestive of adenomyosis and clinical symptoms of adenomyosis and to establish a reporting system for adenomyosis…
- Trial name
- MUSA3 (NCT07397715)
- Where
- 5 sites in Belgium, Poland and 2 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Swiss GO Trial Group
Infertility, Female, Reproductive Techniques, Assisted
SISTER: Sibling Oocyte Insemination With Frozen Sperm From Third Party Donors: Evaluation of Reproductive Techniques
The goal of this clinical trial is to learn whether two different methods of helping eggs and sperm join-intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF)-lead to better embryo development when…
- Conditions
- Infertility, Female, Reproductive Techniques, Assisted, Fertilization in Vitro
- Trial name
- SISTER (NCT07175571)
- Testing
- Intracytoplasmic Sperm Injection (ICSI), Conventional Insemination (IVF)
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Spermatogenesis and Semen Disorders, Infertility, Male
Prospective Study on Power Prenatal Vitamins for Males on YO Score At-home Sperm Test Results
Male factor infertility is a leading cause of primary and secondary infertility. Poor sperm quality is defined as having an abnormal semen analysis.
- Trial name
- NCT05951075
- Testing
- Power Prenatal for Sperm
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- The Bird and Be Co Inc
Male Infertility, Heart Valve Disease
Warfarin Effects on Male Fertility After Cardiac Surgery
Young male patients undergoing cardiac surgery may require oral anticoagulation with warfarin either lifelong, such as after mechanical valve replacement, or for a limited postoperative period, for example following valve repair…
- Trial name
- NCT07330869
- Testing
- Semen analysis, sperm DNA fragmentation and hormonal evaluation
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Città di Lecce Hospital, GVM Care & Research
Satisfaction Survey, Fertility Perservation
Survey of Patients Who Received Fertility Preservation Counseling and Underwent Testicular Tissue Cryopreservation Prior to Gonadotoxic Treatment During Childhood or Peripuberty
Chemotherapy and radiotherapy can lead to spermatogonial stem cell depletion in pre- and peripubertal boys, potentially resulting in infertility during adulthood A testicular biopsy is considered a safe procedure performed in…
- Trial name
- QUALIFERT (NCT07140549)
- Testing
- Survey using a questionnaire.
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
ICSI, Testicular Sperm Extraction in Azoospermic Patients
Comparison of Two Types of Calcium (Ca²⁺) Ionophore Treatments for Oocyte Activation in Cases of Suboptimal Fertilization Potential
This study aims to investigate the effectiveness and safety of assisted oocyte activation (AOA) using Ca²⁺ ionophores in cases of total fertilization failure (TFF) due to oocyte activation deficiency (OAD).
- Conditions
- ICSI, Testicular Sperm Extraction in Azoospermic Patients, Male Infertility, PGT-A
- Trial name
- (Ca²⁺) (NCT07570342)
- Testing
- Group 1: Oocyte Activation (OA) CultActive, Group 2: Oocyte Activation (OA) Ionomycin, Group 3: Control
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC