Clinical trials: Infertility/Sterility, open to volunteers
Subfertility
Oral Dydrogesterone as Luteal Phase Support in Natural Cycle FET
This randomised double-blinded controlled trial aims to compare the live birth rate in natural FET cycles with and without oral dydrogesterone as luteal phase support.
- Trial name
- NCT03859921
- Testing
- Dydrogesterone
- Where
- China
- Volunteers
- 716 people
- Sponsor
- The University of Hong Kong
Infertility
Hyaluronic Acid-enriched Transfer Medium in Single Blastocyst Transfer
The purpose of this study is to compare the live birth rates of high concentration of Hyaluronic Acid (0.5 mg/ml) transfer medium (EmbryoGlue®) to those containing low Hyaluronic Acid concentrations (0.125 mg/ml) (G2 medium) in…
- Trial name
- NCT06492785
- Testing
- High Hyaluronic Acid concentrations (0.5 mg/ml), Low Hyaluronic Acid concentrations (0.125 mg/ml)
- Where
- China
- Volunteers
- 858 people
- Sponsor
- Northwest Women's and Children's Hospital, Xi'an, Shaanxi
Poor Response to Ovulation Induction, Infertility, Female
Autologous Platelet Rich Plasma Intraovarian Infusion for Poor Responders
Autologous platelet rich plasma (PRP) intraovarian infusion may improve ovarian response to controlled ovarian stimulation as well as the hormonal profile of poor ovarian response infertile women subjected to intracytoplasmic…
- Conditions
- Poor Response to Ovulation Induction, Infertility, Female, Ovarian Insufficiency, Ovarian Failure
- Trial name
- PRPPOR (NCT05181748)
- Testing
- Autologous platelet rich plasma
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Genesis Athens Clinic
Infertility, Intrauterine Insemination (IUI)
Interest of Sperm Insemination at 42 Hours Post hCG Compared to 36h in Intrauterine Insemination
Intrauterine insemination (IUI) is a common therapeutic option to treate infertility. Typically performed 36 hours post-hCG injection to trigger ovulation.
- Trial name
- SYNcIU (NCT06804538)
- Testing
- Insemination between 42 and 43 hours post hCG, Insemination between 36 and 37 hours post hCG
- Where
- 4 sites in France
- Volunteers
- 692 people
- Sponsor
- University Hospital, Toulouse
Osteoarthritis
Clinical Investigation of Sensovisc Sterile Sodium Hyaluronate Gel
This clinical investigation aims to investigate the safety and performance of Sensovisc.Sensovisc is used to reduce osteoarthritis related pain in the joints by supporting synovial fluid by intra-articular injection and allowing…
- Trial name
- NCT07232199
- Testing
- SV-3-75: Sterile Sodium Hyaluronate Gel-3 mL Prefilled Syringe (2.5%)
- Volunteers
- 25 people
- Sponsor
- Ankara City Hospital Bilkent
Infertility
Implementing IVM for Fertility Treatment in Clinical Practice
The ovarian reserve consists of a finite pool of follicles that gradually declines throughout a woman's reproductive life. During conventional IVF, exogenous gonadotropins are administered for 10-14 days to support the growth and…
- Trial name
- IVM-DK 2-0 (NCT07894952)
- Testing
- In vitro maturation
- Where
- Denmark
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
Oligospermia
Hyperbaric Oxygen Therapy for Men Suffering From Infertility Due to Oligospermia.
Infertility in a couple is defined as the inability to achieve conception despite one year of frequent, unprotected intercourse. Infertility affects approximately 12% of couples attempting to conceive.
- Trial name
- NCT05842239
- Testing
- Hyperbaric oxygen therapy
- Where
- Israel
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Oligospermia, Azoospermia, Nonobstructive
Isotretinoin vs hCG for Male Infertility Due to Low or Absent Sperm
This study compares two medical treatments to see how well they improve sperm production in men with infertility due to low sperm counts (oligospermia) or no sperm in the semen due to non-obstructive causes (nonobstructive…
- Conditions
- Oligospermia, Azoospermia, Nonobstructive, Infertility
- Trial name
- NCT07481370
- Testing
- isotretinoin, Human chorionic gonadotrophin (hCG)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Nebraska
Infertility (IVF Patients), Oocyte Competence
The EPIC Study: Exploring Paternal Age and the Influence on Blastocyst Culture
This study aims to assess the effect of age of the male partner and the reproductive ability of sperm prepared via sperm selection devices (Zymot) compared to routine embryologist selected sperm after density gradient…
- Conditions
- Infertility (IVF Patients), Oocyte Competence, Sperm DNA Fragmentation, Paternal Age
- Trial name
- EPIC (NCT06629766)
- Testing
- Microfluidic sperm separation device, Density grade centrifugation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Infertility
Clinical Cohort Study on the Endocrinology and Vaginal/Endometrial Microbiome of the Luteal Phase in Assisted Reproduction
Rationale: The hormone progesterone has different functions. In pregnancy, it is vital for maintenance thereof. In early pregnancy, progesterone is synthesized by the Corpus luteum (CL).
- Trial name
- NCT03507673
- Testing
- Blood samples and microbiological swaps
- Where
- 5 sites in Germany
- Volunteers
- 1,200 people
- Sponsor
- University of Luebeck
ICSI, Testicular Sperm Extraction in Azoospermic Patients
Comparison of Two Types of Calcium (Ca²⁺) Ionophore Treatments for Oocyte Activation in Cases of Suboptimal Fertilization Potential
This study aims to investigate the effectiveness and safety of assisted oocyte activation (AOA) using Ca²⁺ ionophores in cases of total fertilization failure (TFF) due to oocyte activation deficiency (OAD).
- Conditions
- ICSI, Testicular Sperm Extraction in Azoospermic Patients, Male Infertility, PGT-A
- Trial name
- (Ca²⁺) (NCT07570342)
- Testing
- Group 1: Oocyte Activation (OA) CultActive, Group 2: Oocyte Activation (OA) Ionomycin, Group 3: Control
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Urologic Diseases, Urologic Cancer
Bank of Biological Material From Patients and Healthy Donors for the Study of Urological and Uro-oncological Pathologies
The project aims to collect fresh biological material derived both from surgical resections performed in diseases, neoplastic and otherwise, of urological relevance at the level of the prostate, bladder, kidney, testicle and…
- Conditions
- Urologic Diseases, Urologic Cancer, Infertility
- Trial name
- NCT06187870
- Testing
- Collection of biological data
- Where
- Italy
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Subfertility
GnRH Agonist for Dual Trigger in IVF and for Luteal Phase Support in FET
The objectives of this study are to compare the efficacy of the dual trigger group vs the hCG trigger group on the live birth rate in women undergoing IVF and the efficacy of the agonist in LP group vs the placebo group on the…
- Trial name
- NCT04064840
- Testing
- IVF: Decapeptyl and hCG, FET: Decapeptyl, IVF: hCG and normal saline
- Where
- China
- Volunteers
- 784 people
- Sponsor
- The University of Hong Kong
Polycystic Ovary Syndrome (PCOS), Obesity
Effects of GLP-1RAs on Fertility Outcomes in Obese Women With PCOS
The goal of this clinical trial is to examine whether GLP1-RA and healthy lifestyle education in women with PCOS and obesity prior to fertility treatment improves live birth rate and other reproductive, maternal and perinatal…
- Conditions
- Polycystic Ovary Syndrome (PCOS), Obesity, Infertility, Female
- Trial name
- NCT07687667
- Testing
- GLP-1 receptor agonist, Metformin
- Where
- China
- Volunteers
- 406 people
- Sponsor
- Peking University Third Hospital
Infertility, Failed in Vitro Fertilisation
An Intervention on Psychosocial Health in Women With Unsuccessful IVF Experience
The goal of this interventional study is to learn if web-based support program can improve the psychosocial health status in women with unsuccessful IVF experience.
- Trial name
- NCT06426472
- Testing
- Web-based support program
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Infertility, In Vitro Maturation of Oocytes
Aspire In Vitro Maturation Study
A study to assess the Capacitation - in-vitro maturation (CAPA-IVM) system as an option for patients with a good ovarian reserve to achieve pregnancy.
- Conditions
- Infertility, In Vitro Maturation of Oocytes, Assisted Reproduction Technologies
- Trial name
- AIM (NCT07789730)
- Testing
- CAPA-IVM
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Inception Fertility Research Institute, LLC
Infertility
Preimplantation Genetic Testing for Aneuploidy (PGT-A) in Women Aged 37-41 Years
A multinational multi-centre, randomized, controlled non-blinded trial with participation of three fertility clinics in Denmark and one in Spain to assess the efficacy and safety of preimplantation genetic testing for aneuploidy…
- Trial name
- NCT06358547
- Testing
- PGT-A
- Where
- Denmark
- Volunteers
- 590 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Infertility, Stress
Online and Mobile Support Program and Fertility
Our study is designed as a randomized controlled experimental study with a pre-test and post-test control group to determine the effects of online fertility preparation classes and fertility mobile application support, based on…
- Trial name
- NCT06824272
- Testing
- MOBIL AND ONLINE EDUCATION
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Mannose-Binding Lectin Deficiency, Recurrent Pregnancy Loss
Association Between Plasma Level of Mannose Binding Lectin and Human Reproduction
A low plasma level of mannose binding lectin (p-MBL) is associated with unexplained recurrent pregnancy loss (RPL), but it is not investigated if it is associated with unexplained reproductive failure in general, including…
- Conditions
- Mannose-Binding Lectin Deficiency, Recurrent Pregnancy Loss, Recurrent Implantation Failure, Infertility
- Trial name
- NCT05169541
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Aalborg University Hospital
Infertile Patient Undergoing ICSI Procedure
Advanced Sperm Selection in ICSI: A Comparative Study of PICSI and ZyMot
our study explores the effectiveness of two advanced sperm selection techniques-PICSI and the ZyMot microfluidic device-in improving outcomes of Intracytoplasmic Sperm Injection (ICSI).
- Trial name
- NCT07240779
- Testing
- picsi dish
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sunrise Fertility Center