Clinical trials: Infertility/Sterility, open to volunteers
Polycystic Ovary Syndrome, Obesity
Effects of GLP-1RAs on Reproductive Outcomes in PCOS and Obesity
The goal of this clinical trial is to examine whether benalutide combined with metformin and healthy lifestyle education in women with PCOS and obesity prior to fertility treatment improves live birth rate and other reproductive…
- Conditions
- Polycystic Ovary Syndrome, Obesity, Infertility, Female
- Trial name
- NCT06775093
- Testing
- GLP-1 receptor agonist, Metformin, healthy lifestyle education
- Where
- China
- Volunteers
- 392 people
- Sponsor
- Peking University Third Hospital
Infertility
Safety Evaluation of the HyperSperm Sperm Preparation Procedure for In Vitro Fertilization
Prospective, multicenter, randomized clinical study evaluating the safety of a novel sperm preparation method for in vitro fertilization (IVF), compared to standard sperm preparation procedures.
- Trial name
- NCT07478549
- Testing
- Standard Sperm Preparation, HyperSperm
- Where
- 2 sites in Argentina
- Volunteers
- 202 people
- Sponsor
- Fecundis Lab SL
Infertility, Transmission
Couples and Microbial Diversity
Couples and Microbial Diversity (CLARITY) - study is a prospective study that investigates the risks and dynamics of different microbes and transmission among couples to optimize the prevention and control strategies as well as…
- Conditions
- Infertility, Transmission, Infections
- Trial name
- CLARITY (NCT07315568)
- Volunteers
- 200 people
- Sponsor
- Tampere University Hospital
Endometriosis, Infertility Assisted Reproductive Technology
First Line Surgery or First Line Fertility Treatment Using Assisted Reproductive Technologies in Patients With Advanced Endometriosis
Endometriosis is a chronic disease affecting approximately 10% of women of reproductive age. It is strongly associated with pelvic pain and infertility.
- Trial name
- EndoSOFT (NCT07240363)
- Testing
- Endometriosis surgery
- Where
- 4 sites in Sweden
- Volunteers
- 350 people
- Sponsor
- Karolinska Institutet
Infertility
A Study to Compare the Efficacy and Safety of Follitropin Alfa/Lutropin Alfa Versus hMG in Japanese Participants With LH and FSH Deficiency Undergoing ART (HINATA)
The purpose of this study is to assess the efficacy and safety of follitropin alfa/lutropin alfa in Japanese participants with Luteinizing hormone (LH) and Follicle stimulating hormone (FSH) deficiency undergoing Assisted…
- Trial name
- NCT07340827
- Testing
- Follitropin alfa/lutropin alfa (MBJ-0011), hMG, Cetrorelix acetate
- Where
- 21 sites in Japan
- Volunteers
- 266 people
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Infertility, Infertility, Female
Half-dose vs Conventional-dose Cetrorelix in ICSI Cycles
This prospective cohort study aims to compare the effectiveness of half-dose (0.125 mg/day) versus conventional-dose (0.25 mg/day) cetrorelix in GnRH antagonist ICSI cycles regarding clinical pregnancy rate in women with BMI ≥25…
- Conditions
- Infertility, Infertility, Female, Anovulation
- Trial name
- NCT07836400
- Volunteers
- 160 people
- Sponsor
- Assiut University
Endometriosis, Adenomyosis
Clinical and Molecular Study of Endometriosis and Adenomyosis
The purpose of this study is to determine whether endometriosis and adenomyosis are progressive diseases, in terms of symptoms (pain, abnormal uterine bleeding and infertility), anatomical lesions size, and recurrences.
- Trial name
- ENDOCHAP (NCT04481321)
- Testing
- Biological/Vaccine
- Where
- France
- Volunteers
- 5,300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Subclinical Hypothyroidism
Best Treatment for Women With Both (Polycystic Ovary Syndrome) PCOS and Subclinical Hypothyroidism
The goal of this randomized controlled trial is to compare letrozole alone versus letrozole plus levothyroxine for ovulation induction in infertile women with both PCOS and subclinical hypothyroidism.
- Conditions
- PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Subclinical Hypothyroidism, Female Infertility
- Trial name
- NCT06041204
- Testing
- Letrozole 2.5mg, Levothyroxine 25 Mcg (0.025 Mg) Oral Tablet
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Muhamed Ahmed Abdelmoaty Muhamed Alhagrasy
Infertility (IVF Patients), Infertile Females or Females with Ovarian Insufficiency
Evaluation of Pregnancy Outcome with Usage of Drug-free In-vitro Activation of Follicles Ovary
This study is the pilot study to evaluate the effect of Drug-free in vitro activation to improve the outcomes of IVF in poor responder women
- Trial name
- NCT06769789
- Testing
- Drug free invitro activation Ovary
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Malihe Mahmoudinia
Anxiety, Stress
Aromatherapy for Mental Health Promotion in IVF Patients
The experience of infertility can cause significant emotional instability, especially for patients awaiting In Vitro Fertilization (IVF) treatment, generating anxiety, stress, and depressive symptoms.
- Conditions
- Anxiety, Stress, Depression Disorder, Quality of Life
- Trial name
- NCT07480668
- Testing
- Lavender essential oil Inhalation, Synthetic lavender aroma inhalation
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Federal University of Minas Gerais
Partial Meniscal Loss, Lateral Meniscus Partial Loss
Partial Meniscal Replacement with Spongioflex®
The purpose of this investigator-initiated trial is to evaluate whether the novel graft can prevent/reduce the disadvantages of the previously used replacement materials and shows better results than the group of patients, which…
- Conditions
- Partial Meniscal Loss, Lateral Meniscus Partial Loss, Medial Meniscal Partial Loss, Meniscus Lesion
- Trial name
- NCT06775197
- Testing
- partial meniscal replacement with Spongioflex®
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Maria-Josef-Hospital Greven
Infertility, In Vitro Maturation of Oocytes
Aspire In Vitro Maturation Study
A study to assess the Capacitation - in-vitro maturation (CAPA-IVM) system as an option for patients with a good ovarian reserve to achieve pregnancy.
- Conditions
- Infertility, In Vitro Maturation of Oocytes, Assisted Reproduction Technologies
- Trial name
- AIM (NCT07789730)
- Testing
- CAPA-IVM
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Inception Fertility Research Institute, LLC
Thin Endometrium, Female Infertility
Intrauterine G-CSF Infusion for Thin Endometrium
Thin endometrium is a condition in which the lining of the uterus is too thin during preparation for embryo transfer. This may reduce the chance of pregnancy and live birth in patients undergoing frozen-thawed embryo transfer.
- Trial name
- GIFT (NCT07692672)
- Testing
- Granulocyte Colony-Stimulating Factor(G-CSF), Normal Saline
- Volunteers
- 620 people
- Sponsor
- Nanjing University
Endometriosis, Infertility Unexplained
Endometriosis and Peritoneal Dysbiosis
Endometriosis is a complex clinical syndrome that impairs many aspects of a woman's life, characterized by a chronic estrogen-dependent inflammatory process, mainly affecting the pelvic organs, with ectopic presence of tissue…
- Trial name
- NCT05824819
- Testing
- Next Generation Sequencing (NGS)
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Jagiellonian University
Stress, Infertility, Female
The Effect of a Mindset Management Approach on Stress Levels in Women With Infertility
The goal of this clinical trial is to test the effect of a mindset management intervention on stress levels in women with infertility.
- Trial name
- NCT05997407
- Testing
- Organic Conceptions mindset management program
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Virginia Polytechnic Institute and State University
Pregnancy Related, Infertility, Female
Comparison of Live Birth Rate in Natural Cycle Single Euploid FET Versus Without Luteal Phase Support
To evaluate whether single euploid embryo transfer in NC without routinely administered LPS is non-inferior to NC with routinely administered LPS.
- Trial name
- NCT05969795
- Testing
- Transvaginal ultrasound, Serial serum LH, E2, P4, Progesterone 100 Mg Vaginal Insert
- Where
- 3 sites in United Arab Emirates
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
HPV Infection, Infertilities
Evaluation of the Effect of a Dietary Supplement Based on EGCG, Vitamin B12, Hyaluronic Acid, and Folic Acid on the Maintenance of Physiological Balance and the Natural Defenses of the Male Genital System in Subjects Exposed to HPV Infection.
This is a randomized pilot interventional study aimed at evaluating the effect of a dietary supplement containing EGCG, vitamin B12, hyaluronic acid, and folic acid on the maintenance of physiological balance and natural defenses…
- Trial name
- PERVI-I (NCT07344337)
- Testing
- Pervistop
- Volunteers
- 96 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Caesarean Scar Defect
Effectiveness of Transvaginal Niche Resection Versus Expectant Management in Patients with Secondary Infertility and a Large Uterine Caesarean Scar Defect
The goal of this clinical trial is to evaluate the efficacy and safety of transvaginal niche resection in improving pregnancy outcomes of a large uterine caesarean scar defect (niche) with secondary infertility.
- Trial name
- TVARES (NCT06599671)
- Testing
- Transvaginal niche resection
- Volunteers
- 100 people
- Sponsor
- International Peace Maternity and Child Health Hospital
Infertility, Female, Reproductive Techniques, Assisted
SISTER: Sibling Oocyte Insemination With Frozen Sperm From Third Party Donors: Evaluation of Reproductive Techniques
The goal of this clinical trial is to learn whether two different methods of helping eggs and sperm join-intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF)-lead to better embryo development when…
- Conditions
- Infertility, Female, Reproductive Techniques, Assisted, Fertilization in Vitro
- Trial name
- SISTER (NCT07175571)
- Testing
- Intracytoplasmic Sperm Injection (ICSI), Conventional Insemination (IVF)
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Cyberchondria, Stress
Cyberchondria and Stress in Women Undergoing Infertility Treatment
This study examines how searching for health information on the internet may affect stress and emotional well-being in women undergoing infertility treatment.
- Conditions
- Cyberchondria, Stress, Infertility
- Trial name
- NCT07126769
- Where
- Turkey (Türkiye)
- Volunteers
- 201 people
- Sponsor
- Acibadem University