Clinical trials: Infertility
Infertility
MENOPUR® in a Gonadotropin-Releasing Hormone (GnRH) Antagonist Cycle With Single-Blastocyst Transfer in a High Responder Subject Population
The purpose of this trial is to demonstrate non-inferiority of MENOPUR® versus recombinant Follicle Stimulating Hormone (rFSH) (Gonal-f®) with respect to ongoing pregnancy rate in women undergoing controlled ovarian stimulation…
- Trial name
- MEGASET HR (NCT02554279)
- Testing
- menotropin, recombinant FSH
- Where
- 35 sites in United States
- Volunteers
- 620 people
- Sponsor
- Ferring Pharmaceuticals
Metastatic Cancer, Cancer
BP31510 (Ubidecarenone,USP) Nanosuspension for Intravenous Injection to Patients With Solid Tumors
This is a Phase 1a/b multicenter, open-label, non-randomized, dose-escalation study to examine the dose limiting toxicities (DLT) of BPM31510 administered as a 144-hour continuous intravenous (IV) infusion as…
- Conditions
- Metastatic Cancer, Cancer, Solid Tumor
- Trial name
- NCT01957735
- Testing
- BP31510 monotherapy, BP31510 in combination with chemotherapy
- Where
- 3 sites in United States
- Volunteers
- 97 people
- Sponsor
- BPGbio
Infertility
Automation of Gamete Preparation, Intracytoplasmic Sperm Injection (ICSI), Embryo Culture, and Vitrification
Patients suffering from infertility may seek assisted conception treatment. In a full treatment cycle, the sperm and eggs (gametes) from the intended parents will be looked after by skilled laboratory staff (embryologists) who…
- Trial name
- NCT06074835
- Testing
- Gamete preparation, ICSI, embryo culture and vitrification robot assistant, Routine Manual ICSI Workflow
- Where
- Mexico
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Conceivable Life Sciences
Infertility
Prospective Paired Study on the Effectiveness of MitoGrade
Chromosomal abnormalities are a major cause of pregnancy loss. Preimplantation Genetic Screening (PGS) using Next Generation Sequencing (NGS) allows the effective detection of these abnormalities and improves clinical outcomes.
- Trial name
- NCT02673125
- Testing
- MitoGrade
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Reprogenetics
Infertility, Female
GEnetic Testing in Elective Single Embryo Transfer (GETSET): A Randomized Clinical Trial
The GETSET trial is a prospective randomized trial designed to evaluate the clinical outcomes of incorporating preimplantation genetic testing for aneuploidies (PGT-A) in elective single embryo transfer in women between 35 and 40…
- Trial name
- GETSET (NCT06141135)
- Testing
- Preimplantation genetic testing for aneuploidy (PGTA)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Genomic Prediction Inc.
Infertility
GONAL-f CONSORT (Consistency in r-hFSH Starting Doses for Individualised Treatment)
This non-interventional study (NIS) is planned to examine the consistency of the dose recommended by the doctor for the first stimulation day with the dose recommended by the CONSORT calculator.
- Trial name
- NCT01100333
- Testing
- Recombinant human follicle stimulating hormone (r-hFSH)
- Where
- Germany
- Volunteers
- 2,552 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Non-obstructive Azoospermia, Male Infertility
Preimplantation Genetic Testing for Aneuploidy (PGT-A) in Couples With Non-obstructive Azoospermia (NOA)
Objective: To examine the rate of embryo aneuploidy in patients with non-obstructive azoospermia (NOA) who utilize in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) and compare live birth rates with the…
- Trial name
- NCT06566599
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Inception Fertility Research Institute, LLC
Infertility, Male
The Effect of Supplementation With Fish Oil (EPAX EVOLVE 05) on Sperm Quality
The study will enrol men that have a poor sperm quality. They will take either a placebo or fish oil capsule (2 per day) for 3 months.
- Trial name
- NCT06950203
- Testing
- Very Long Chain Polyunsaturated Fatty Acids, Comparator arm (DHA)
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Epax Norway AS
Infertility
To Investigate REKOVELLE in Chinese Women Undergoing Assisted Reproductive Technologies: Effectiveness, Safety, and Patterns of Use in Real-world Practice
This is a multi-centre prospective non-interventional trial to assess the pattern of use of REKOVELLE® in Women Undergoing In Vitro Fertilisation (IVF) or Intracytoplasmic Sperm Injection (ICSI) Procedures in Routine Clinical…
- Trial name
- LYCHEE (NCT07029451)
- Where
- 28 sites in China
- Volunteers
- 2,549 people
- Sponsor
- Ferring Pharmaceuticals
Polycystic Ovary Syndrome, Infertility, Female
The REBALANCE Study - a Prospective, Multicenter, Randomized, Pivotal Study of the May Health System
A Prospective, Multicenter, Randomized, Pivotal Study of the May Health System in Transvaginal Ablation of Ovarian Tissue under Ultrasound Guidance in Women with Infertility due to Polycystic Ovary Syndrome
- Trial name
- NCT06206746
- Testing
- May Health System
- Where
- 19 sites in United States
- Volunteers
- 93 people
- Sponsor
- May Health
Infertility, Ovulation Induction
SJ-0021 (Gonalef®) Versus Purified Pituitary Gonadotropin (Fertinorm-P®) for Ovulation Induction in Japanese Infertile Women
Efficacy and safety studies in the past have suggested that a starting dose of 75 International Unit (IU) of SJ-0021, and an increase in the dose by 37.5 IU every 7 days, are safe for treatment of subjects with ovulatory…
- Trial name
- NCT01185782
- Testing
- Gonalef® (Follitropin alfa), Purified pituitary gonadotropin (Fertinorm-P®)
- Where
- Japan
- Volunteers
- 300 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility
Efficacy and Safety of FE 999049 in Controlled Ovarian Stimulation in Japanese Women
To demonstrate non-inferiority of FE 999049 compared to FOLLISTIM with respect to number of oocytes retrieved in Japanese IVF/ICSI patients undergoing controlled ovarian stimulation.
- Trial name
- NCT03228680
- Testing
- Follitropin delta, Follitropin beta
- Where
- 17 sites in Japan
- Volunteers
- 373 people
- Sponsor
- Ferring Pharmaceuticals
InFertility
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Three Dosage Strengths of Pulsatile GnRH
This study will be performed in approximately 132 women with anovulatory/oligoovulatory infertility.
- Trial name
- NCT00296465
- Testing
- Pulsatile gonadotropin-releasing hormone (GnRH), Clomiphene Citrate
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Infertility
A Post Marketing Assessment of Gonal f Solution for Injection in a Prefilled Pen for Follicular Stimulation in in Vitro Fertilisation/Embryo Transfer (IVF-ET) Cycles
The development of recombinant DNA technology, culminated in the introduction of the first recombinant human follicle stimulating hormone (r hFSH), Gonal-f, which further developed to become Gonal-f Filled-by-Mass (FbM) pen has…
- Trial name
- POINT (NCT01125462)
- Testing
- Quality of Life Questionnaire (FertiQoL)
- Where
- 3 sites in Serbia
- Volunteers
- 61 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Endometriosis
A Study to Evaluate the Safety and Effectiveness of Three Asoprisnil Doses in the Treatment of Women With Endometriosis
The objective of this study is to determine the safety and effectiveness of three doses of asoprisnil, compared to placebo, in the treatment of women with endometriosis.
- Trial name
- NCT00160446
- Testing
- Asoprisnil
- Volunteers
- 130 people
- Sponsor
- Abbott
Controlled Ovarian Stimulation
To Compare and Evaluate the Efficacy and Safety of Ganilever PFS(Prefilled Syringe) and Orgalutran®
to compare and evaluate the efficacy and safety of Ganilever PFS and Orgalutran® in infertility women for assisted reproductive technologies
- Trial name
- NCT03051087
- Testing
- Ganirelix acetate
- Where
- 2 sites in South Korea
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- LG Life Sciences
Infertility
Safety and Tolerability of TWP-201 in Healthy Female Subjects
This study is a randomized, double-blind, placebo-controlled, single dose, escalation, phase I clinical trial to evaluate the safety and tolerability of recombinant human follicle stimulating hormone Fc fusion protein injection…
- Trial name
- NCT04878705
- Testing
- TWP-201
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Shandong TheraWisdom Biopharma Co., Ltd.
Infertility
Barusiban Subcutaneously for Reducing Implantation Failure Due to Uterine Contractions
This trial investigates the effects of FE 200440 compared to placebo on implantation rate in women undergoing IVF/ICSI treatment
- Trial name
- BASIC (NCT01723982)
- Testing
- Barusiban (FE 200440)
- Where
- 14 sites in Australia, Belgium and 4 more
- Volunteers
- 256 people
- Sponsor
- Ferring Pharmaceuticals
Oligozoospermia, Asthenozoospermia
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of STSP-0902 in Healthy Subjects
This is a Phase 1a, randomized, double-blind, placebo-controlled, single ascending dose (SAD) study to evaluate the safety, tolerability, pharmacokinetics (PK), and immunogenicity of STSP-0902.
- Trial name
- NCT06563713
- Testing
- STSP-0902 injection
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Staidson (Beijing) Biopharmaceuticals Co., Ltd
Infertility, Female
Lovenox With Aspirin in Thawed Blastocyst Transfer
This prospective randomized trial will compare outcomes in patients receiving aspirin in combination with a low-molecular weight heparin and those under this center's standard protocol receiving neither medication, in order to…
- Trial name
- NCT06133803
- Testing
- Lovenox, Aspirin, Embryo transfer
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Fertility Center of Las Vegas