Clinical trials: Infertility
Multidimensional Tubal Function Assessment and Individualized Treatment Strategies for Tubal Factor Infertility
Comprehensive Assessment System for Fallopian Tube Function and Clinical Study on Individualized Treatment Strategies
This clinical study aims to develop a comprehensive system to evaluate tubal function and to optimize individualized treatment strategies for patients with tubal factor infertility (caused by hydrosalpinx, obstruction, or…
- Trial name
- NCT07808229
- Testing
- Optimize the techniques and plans for fallopian tube reconstruction surgery
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Peking University People's Hospital
Male Infertility Due to Azoospermia
Seminal Levels of PGK2 and ACRV1 as Predictors of Micro-TESE Results in NOA
Measurement of PGK2 and ACRV1 levels in the semen of infertile males undergoing testicular sperm extraction (TESE). Correlate seminal levels of PGK2 and ACRV1 with sperm retrieval results and histopathology analysis of testicular…
- Trial name
- NCT06307639
- Testing
- Measurement of PGK2 and ACRV1 levels in the semen of infertile males undergoing testicular sperm extraction (TESE).
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Assiut University
Infertility, Female
Post-Marketing Surveillance (PMS) Protocol of REKOVELLE Pre-Filled Pen (Follitropin Delta)
This post-marketing surveillance study was conducted in accordance with the regulations for re-examination of domestic new drugs (Standard for Re-Examination of New Drugs: Ministry of Food and Drug Safety [MFDS]: Notification No.
- Trial name
- NCT04654039
- Testing
- Other: Non intervention
- Where
- 15 sites in South Korea
- Volunteers
- 728 people
- Sponsor
- Ferring Pharmaceuticals
Infection, Bacterial
Comparison of Sterile Gauze and Semi-permeable Film Dressing for Hemodialysis Central Venous Catheter
This prospective single center RCT aims to compare sterile gauze and tape versus Semi-permeable film dressing on the incidence of exit-site infection, CRBSIs (catheter-related bloodstream infections), skin irritation, total…
- Trial name
- NCT04800575
- Testing
- semi-permeable film, sterile gauze and tape
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Peking University People's Hospital
Infertility, Recurrent Pregnancy Loss
Comparison of Standard ART Practice vs. Trophectoderm Biopsy and Whole Chromosome Analysis
We propose to perform a clinical randomized trial to evaluate the effect of blastocyst biopsy and whole chromosome analysis by Next Generation Sequencing (NGS) in comparison to standard Assisted Reproductive Technologies (ART)…
- Trial name
- NCT01946945
- Testing
- Next Generation Sequencing after Blastocyst biopsy
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Reprogenetics
Culture Media, DNA
Cell-free DNA: a Non-invasive Test for Assessing Embryo Quality
In the present project we propose to deeply characterize nuclear and/or mitochondrial DNA in embryo culture medium, in order to investigate whether both cell-free nucleic acid types may provide additional, reliable, predictive…
- Trial name
- NCT01397136
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Infertility, Assisted Reproductive Technology
Does the Embryo Transfer Technique Affect the Success of in Vitro Fertilization?
Prospective, open, randomized, parallel, two-arm trial to compare the clinical pregnancy rate between most commonly used two embryo transfer techniques: trial followed by transfer technique and afterloading technique
- Conditions
- Infertility, Assisted Reproductive Technology, IVF
- Trial name
- NCT03756857
- Testing
- Afterload Transfer, Trial followed by transfer
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Acibadem Kadiköy Hospital
Infertility, Female
Transcriptomic Profile of Endometrium in Different Histological Dating of Natural Cycle
At present, the evaluation criterion of endometrial receptivity is controversial. The development of a molecular diagnostic tool, the endometrial receptivity array (ERA) for diagnosis of endometrial receptivity .
- Trial name
- NCT03222830
- Testing
- personal embryo transfer
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Infertility
Using Cumulase for Denudation of Cycles With ≤ 8 Cumulus-oocytes Complexes
The cumulus-corona-oocyte complex (COCs) surrounds each oocyte and must be removed prior to intracytoplasmic sperm injection (ICSI).
- Trial name
- NCT03778736
- Testing
- Cumulase denudation
- Where
- 3 sites in Egypt
- Volunteers
- 586 people
- Sponsor
- Ibn Sina Hospital
Male Infertility, Male Subfertility
Assessing the Correlation Between Phospholipase C Zeta Measurements and Semen Parameters
With declining fertility rates Worldwide, Assisted Reproductive Technology is seen as a viable solution for infertility, however, individual success rates following ART remain relatively low, rarely exceeding ~50%.
- Trial name
- PLCZeta (NCT07684339)
- Testing
- No Intervention: Observational Cohort
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 200 people
- Sponsor
- Fakih IVF Fertility Center
Infertility Unexplained
Only Gonadotropin Vs. Letrozole Combined Gonadotropin Stimulation in IUI Cycles
The present randomized controlled study aims to investigate the effectiveness of a combined regimen of letrozole and gonadotropin with dose adjustments based on body mass index (BMI) compared to a conventional only gonadotropin…
- Trial name
- NCT06413771
- Testing
- Letrozole 2.5mg, Gonadotropin
- Where
- Turkey (Türkiye)
- Volunteers
- 131 people
- Sponsor
- Uludag University
Infertility, Female, Reproductive Sterility
Evaluation of Salivary ELISA for Hormone Monitoring in IVF Patients
In assisted reproductive treatment (ART), it is necessary to follow closely the stimulation cycles of patients undergoing these treatments in order to monitor the number and size of developing follicles.
- Trial name
- SALIVA_MINT (NCT05184777)
- Testing
- Determination of progesterone and oestradiol
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Hand Fracture, Infection Due to Internal Fixation Pin
Hand K-wire Infections in Operating Room Versus Ambulatory Setting
The main objective of this non-interventional, observational study is to analyze the rate and type of infection complications while performing closed reduction internal fixation (CRIF) of hand fractures in the operating room…
- Trial name
- NCT02870465
- Testing
- Closed Reduction Internal Fixation
- Where
- 15 sites in Canada, Philippines
- Volunteers
- 1,042 people
- Sponsor
- Horizon Health Network
Polycystic Ovary Syndrome, Infertility
New Application of Sequential in Vitro Muturation System for Infertility Patients With Polycystic Ovary Syndrome
Oocyte in vitro maturation (IVM) is an artificial reproductive technologies (ART) in which cumulus-oocyte complex (COC) are collected at the immature germinal vesicle (GV) stage from unstimulated or FSH-primed ovaries and matured…
- Trial name
- NCT03773263
- Testing
- sequential IVM system, intracytoplasmic sperm injection (ICSI), Thawed embryo transfer (TET)
- Where
- 5 sites in China
- Volunteers
- 300 people
- Sponsor
- Sun Yat-sen University
Infertility
IVF Hyper-responders: Oocyte Vitrification Compared With Embryo Freezing
The chances to achieve pregnancy after retrieving >15 oocytes are not good, probably because of bad effect on the endometrium (uterine inner lining).
- Trial name
- NCT02026193
- Testing
- oocyte vitrification, embryo freezing
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- Rambam Health Care Campus
Infertility, Female
The Effectiveness and Safety of the Prolonged Down-regulation Protocol for Controlled Ovarian Hyperstimulation
Since the first "tube baby", Louise Brown, was born in the United Kingdom in 1978, many infertile couples have been benefitted from in vitro fertilization and embryo transfer (IVF-ET) and intracytoplasmic sperm injection (ICSI).
- Trial name
- NCT03809221
- Testing
- Triptorelin acetate
- Volunteers
- 1,892 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
IVF, Infertility, Female
Inhibin B/AFC Ratio for Ovarian Response
Ovarian response to gonadotropin stimulation plays a major role in the success of in vitro fertilization (IVF). Anti-müllerian hormone (AMH), inhibin B, and antral follicle count (AFC) are ovarian reserve markers and also…
- Conditions
- IVF, Infertility, Female, Ovulation Disorder
- Trial name
- NCT06292806
- Testing
- FSH-R
- Volunteers
- 144 people
- Sponsor
- Insemine Humen Reproduction Centre
Infertility, Infertility, Female
Developmental Epidemiological Study of Children Born Through Reproductive Technology
DESCRT will be a long-term study that both looks back in time, at successful pregnancies, and forward in time at early pregnancy and long-term as these children grow.
- Conditions
- Infertility, Infertility, Female, Infertility, Male, Infertility Primary
- Trial name
- DESCRT (NCT03799107)
- Where
- United States
- Volunteers
- 2,020 people
- Sponsor
- University of California, San Francisco
Male Infertility, Klinefelter's Syndrome
RA-2 13-cis Retinoic Acid (Isotretinoin)
Men with infertility and normal hormone levels have few options for fertility treatment. Previous research work has suggested that men with infertility may have low levels of the active form of Vitamin A, called retinoic acid, in…
- Conditions
- Male Infertility, Klinefelter's Syndrome, Y-chromosome Microdeletions
- Trial name
- RA-2 (NCT02061384)
- Testing
- 13-cis retinoic acid, Calcitriol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
Infertility, Frozen Embryo Transfer (FET)
Platelet-Rich Plasma vs. Granulocyte Colony-Stimulating Factor vs. Placebo and Outcomes in Frozen Embryo Transfer
The goal of this clinical trial is to assess the impact of using Platelet-Rich Plasma (PRP) vs. Granulocyte Colony-Stimulating Factor (GCSF) vs.
- Trial name
- NCT03945812
- Testing
- Granulocyte Colony Stimulating Factor, Platelet Rich Plasma Arm, Saline
- Where
- Egypt
- Volunteers
- 665 people
- Sponsor
- Wael Elbanna Clinic