Clinical trials: Infertility
Male Infertility
Home Semen Testing in Men Beginning Attempts to Conceive
The overall objective of the proposed study is to enhance early detection of male factor infertility and reduce cost and morbidity associated with delayed diagnosis through development of a universal screening model based on home…
- Trial name
- NCT05503862
- Testing
- YoSperm
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Northwestern University
Male Idiopathic Infertility
A Trial to Compare Efficacy and Safety of Follitropin Delta Versus Placebo (Inactive Treatment) in the Treatment of Men With Idiopathic Infertility (Unexplained Reduction of Semen Quality) (ADAM)
The primary purpose of this trial is to investigate whether men with idiopathic infertility (unexplained reduction of semen quality), after being treated with a daily dose of 12 µg recombinant follicle stimulating hormone (rFSH)…
- Trial name
- NCT05403476
- Testing
- FE 999049
- Where
- 22 sites in United States, Belgium and 5 more
- Volunteers
- 4 people
- Sponsor
- Ferring Pharmaceuticals
Infertility, Endometriosis
Pre-IVF Treatment With a GnRH Antagonist in Women With Endometriosis
A Phase 3 clinical trial of oral GnRH antagonist pre-treatment for women with endometriosis who are undergoing IVF, with a primary outcome of live birth rate.
- Trial name
- PREGnant (NCT04173169)
- Testing
- Elagolix 200 MG
- Where
- 5 sites in United States
- Volunteers
- 103 people
- Sponsor
- Yale University
Infertility, Male
Assessment of TetraSOD® Efficacy to Improve Semen Parameters in Men With Idiopathic Infertility
TetraSOD® is a unique marine phytoplankton (Tetraselmis chuii) SOD-rich ingredient that is grown under patent-protected technology exclusively designed by the company Fitoplancton Marino, S.L. (Spain).
- Trial name
- NCT04864314
- Testing
- Marine microalgae Tetraselmis chuii with high Superoxide Dismutase (SOD) activity
- Where
- 2 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Fitoplancton Marino, S.L.
Reproductive Disorder
Recall by Genotype: Neuropeptide Stimulation
The objective of this protocol is to assess response to kisspeptin and gonadotropin-releasing hormone (GnRH) stimulation testing as well as the baseline patterns of luteinizing hormone (LH) secretion in individuals who carry…
- Trial name
- NCT05901467
- Testing
- kisspeptin 112-121, GnRH
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Stephanie B. Seminara, MD
Obesity, Infertility
Reprometabolic Syndrome Mediates Subfertility in Obesity
Obesity plays an adverse role at every stage of conception and pregnancy and mounting evidence implicates relative hypogonadotropic hypogonadism, and reduced menstrual cycle hormone secretion as likely contributors to the…
- Conditions
- Obesity, Infertility, Hypogonadotropic Hypogonadotropism, Hyperinsulinemia
- Trial name
- NCT02653092
- Testing
- Insulin, Intralipid, Dextrose
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Infertility, Female
A Randomised Trial Comparing the Ovarian Response of a Starting Dose of Either 10 μg or 15 μg Follitropin Delta (FE 999049) to a Starting Dose of Either 150 IU or 225 IU Follitropin Alfa (GONAL-F) in Conventional Regimens in China
This is a phase 3b clinical trial with follitropin delta (FE 999049) and Gonal-F. The trial is a randomised, controlled, assessor-blind, parallel groups, multicentre trial comparing the ovarian response of a starting dose of…
- Trial name
- COCO (NCT06173869)
- Testing
- FE 999049, GONAL-F
- Where
- 11 sites in China
- Volunteers
- 301 people
- Sponsor
- Ferring Pharmaceuticals
Sperm DNA Fragmentation, Embryo Quality
Sperm Selection by Microfluidic Separation Improves Embryo Quality
This is a randomized controlled trial of couples with a history of poor embryo quality undergoing a repeat in vitro fertilization (IVF) cycle for unexplained infertility.
- Conditions
- Sperm DNA Fragmentation, Embryo Quality, Fertility Disorders, Infertility
- Trial name
- SPERM (NCT03085433)
- Testing
- Microfluidic Sperm Sorting, in vitro fertilization
- Where
- United States
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Infertility
Concomitant Administration of FSH With HCG Improves Oocyte Maturation and Quality Double -Blinded Randomized Trial
Marcelle Cedars, M.D., Victor Fujimoto, M.D., Mitch Rosen, M.D., Heather Huddleston, M.D., Paolo Rinaudo, M.D., Anthony Dobson, M.D., and Shehua Shen, M.D.
- Trial name
- NCT00854373
- Testing
- Bravelle(follicle stimulating hormone)
- Where
- United States
- Volunteers
- 232 people
- Sponsor
- University of California, San Francisco
Female Infertility
Effects of Intrauterine Flushing With Human Chorionic Gonadotropin on ICSI Outcome
a number of infertile women who were prepared for ICSI and immediately post ova pick up intrauterine flushing with human chorionic gonadotropin was done to study the effect of this drug on ICSI outcome and ultrasound parameter.
- Trial name
- NCT06684951
- Testing
- hCG
- Where
- Iraq
- Volunteers
- 90 people
- Sponsor
- Omayma Ismail Khalaf
Sperm DNA Fragmentation, Infertility, Male
Impact of Escitalopram on Sperm DNA Fragmentation
Double-blind placebo-controlled randomized trial of daily escitalopram for 6 weeks in healthy men with normal semen analyses and no psychiatric history of depression, bipolar, mania or suicidal ideation.
- Trial name
- NCT03527043
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Infertility, Male
Fertility Preservation in Male AYA With Cancer
Very little is known about how medical providers can help adolescent and young adults (AYAs) and their caregivers make decisions about fertility preservation (sperm banking) before beginning cancer treatment.
- Trial name
- NCT04268004
- Testing
- FP Decision Tool and Discussion
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Leena Nahata
Infertility
The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation in Poor Responders
The supplementation of Dehydroepiandrosterone (DHEA) has been used in some centers for patients with previous poor ovarian reserve and response in an attempt to improve pregnancy outcomes.
- Trial name
- DHEA (NCT02357472)
- Testing
- dehydroepiandrosterone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Fertility Issues
Continuous Double Ovarian Stimulation.
To evaluate the efficacy of the weekly use of corifollitropin alfa in double ovarian stimulation process and to compare it to the conventional protocol with daily medication administration.
- Trial name
- NCT05815719
- Testing
- Corifollitropin Alfa, Follitropin Alfa, Follitropin Alfa Biosimilar
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Instituto Bernabeu
Polycystic Ovary Syndrome, PCOS
Randomized Controlled Trial of Combined Letrozole and Clomid (CLC II) Versus Letrozole Alone for Women With Anovulation
This study evaluates the addition of clomiphene citrate (CC) to letrozole for the treatment of infertility in women with polycystic ovary syndrome across a course of two treatment cycles with stair step dosing of letrozole…
- Conditions
- Polycystic Ovary Syndrome, PCOS, Infertility
- Trial name
- CLC II (NCT05206448)
- Testing
- Letrozole, Clomiphene Citrate
- Where
- 4 sites in United States
- Volunteers
- 190 people
- Sponsor
- Rachel Mejia
Infertility
A Trial to Compare the Ovarian Response of REKOVELLE and GONAL-F in Conventional Dosing in Women Undergoing Controlled Ovarian Stimulation
Hormone preparations like REKOVELLE and GONAL-F are used to make the body produce multiple egg sacs, allowing more eggs to be collected from women undergoing infertility treatment.
- Trial name
- ADAPT-1 (NCT05263388)
- Testing
- REKOVELLE (Follitropin Delta), GONAL-F (Follitropin Alfa)
- Where
- 16 sites in Austria, France and 3 more
- Volunteers
- 302 people
- Sponsor
- Ferring Pharmaceuticals
Recurrent Pregnancy Loss, Unexplained Infertility
Assessing the Endometrial Environment in Recurrent Pregnancy Loss and Unexplained Infertility
The purpose of this study is to determine if patients with recurrent pregnancy loss or unexplained infertility have an altered uterine gene expression or uterine microbiome (micro-organism composition) during the window of embryo…
- Trial name
- NCT03401918
- Testing
- Uterine ERA and microbiome testing, Oral antibiotics and vaginal probiotics
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Stanford University
Asherman Syndrome, Intrauterine Adhesion
PREvention of Intrauterine Adhesion After Adhesiolysis With Novel Tri-block deGradable Polymer Film.
PREG2 is a randomized controlled trial that aims to evaluate efficacy in preventing intrauterine adhesion recurrence after hysteroscopic adhesiolysis of a novel intrauterine barrier film named Womed Leaf
- Trial name
- PREG2 (NCT04963179)
- Testing
- Womed Leaf
- Where
- 15 sites in Belgium, China and 5 more
- Volunteers
- 160 people
- Sponsor
- Womed
Infertility, Female
The Application of Zishen Yutai Pill in Aged Women Undergoing IVF-ET
To explore the application of Zishen Yutai Pill in controlled ovarian stimulation and effect on pregnancy outcome in aged women undergoing in vitro fertilization-embryo transfer.
- Trial name
- NCT03703700
- Testing
- Zishen Yutai Pill
- Where
- 12 sites in China
- Volunteers
- 1,467 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Weight Loss, Anovulation
Evaluation of Ovarian Morphology and Function in Overweight Women During Weight Loss
The objective of this study is to explore the effects of weight loss on body composition, metabolic status, reproductive hormones, and ovarian follicle development in obese women with regular menstrual cycles versus obese women…
- Conditions
- Weight Loss, Anovulation, Amenorrhea, Infertility
- Trial name
- NCT01785719
- Testing
- Commercial Weight Loss Program
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Cornell University