Clinical trials: Infertility Unexplained
Sub Clinical Hypothyroidism, Pregnancy Loss
Thyroxin in Subclinical Hypothyroidism
Subclinical hypothyroidism(SCH) is the elevated thyroid stimulating hormone (TSH) with normal free Thyroxine levels and it is a mild or compensated form of primary hypothyroidism.
- Trial name
- NCT03712683
- Testing
- Thyroxine
- Volunteers
- 168 people
- Sponsor
- Hawler Medical University
Leiomyoma, Uterine
FRIEND: Fibroids and Unexplained Infertility Treatment With Epigallocatechin Gallate; A Natural CompounD in Green Tea
The objective of this study is to determine the effect of low caffeine green tea extract containing 45% epigallocatechin gallate (EGCG) on fibroids and subsequent pregnancy and live births in women seeking fertility treatment.
- Trial name
- FRIEND (NCT05364008)
- Testing
- Green Tea Extract
- Where
- 4 sites in United States
- Volunteers
- 33 people
- Sponsor
- Yale University
Infertility
Intracytoplasmic Sperm Injection Preparation in Infertile Women
Infertility is a common gynecological problem is women
- Trial name
- NCT03824340
- Testing
- Doxycycline before ICSI
- Where
- Egypt
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital
Unexplained Infertility
Varicocelectomy in Patients With Clinical Varicocele and Unexplained Infertility
This study was conducted to assess the efficacy of varicocelectomy in unexplained male infertility with clinical varicocele The primary objective was to assess the pregnancy outcomes in these group.
- Trial name
- NCT06491251
- Testing
- Bilateral Subinguinal microscopic varicocelectomy
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
ICSI
Retrieval Versus Mid-luteal Endometrial Scratching (ES) for Intra Cytoplasmic Sperm Injection (ICSI)
ES is a procedure used to help embryos to implant more successfully after In-Vitro Fertilization (IVF) , ICSI in patients who had failed cycles in spite of transfer of good quality embryos.
- Trial name
- ICSI (NCT03470298)
- Testing
- Endometrial scratching
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Infertility, Pertubation
Effect of Pertubation on Pregnancy Rates Before Intrauterine Insemination Treatment
To demonstrate a possible beneficial impact of pertubation we designed a randomized prospective study, in which uterine washing was administered prior to insemination in patients diagnosed with unexplained infertility.
- Conditions
- Infertility, Pertubation, Insemination
- Trial name
- NCT01999959
- Testing
- Pertubation
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Gazi University
Infertility Unexplained
Modulation of Reproductive Microbiota by Ligilactobacillus Salivarius CECT5713
The objective of the project is to elucidate if the oral administration of Ligilactobacillus salivarius CECT5713 is capable of improving the rates of term pregnancies in couples with infertility problems of unknown cause.
- Trial name
- NCT06290518
- Testing
- Ligilactobacillus salivarius CECT5713
- Where
- 3 sites in Spain
- Volunteers
- 72 people
- Sponsor
- Biosearch S.A.
Unexplained Infertility
Dual FSH/HCG Trigger in Letrozole Stimulated Intrauterine Insemination Cycles in Women With Unexplained Infertility
The objective of this study was to evaluate the outcome of follicle stimulating hormone (FSH) co-administration with human chorionic gonadotrophins trigger for women with unexplained infertility (UEI) and assigned for letrozole…
- Trial name
- NCT02739516
- Testing
- Human chorionic gonadotropin, FSH co-trigger, Letrozole
- Volunteers
- 108 people
- Sponsor
- Benha University
Unexplained Infertility
Role of Routine Hysteroscopy in Management of Cases of Unexplained Infertility
The aim of this work is to assess the value of hysteroscopy in unexplained infertility.
- Trial name
- NCT03380364
- Testing
- hystroscope
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Infertility, Infertility, Female
Developmental Epidemiological Study of Children Born Through Reproductive Technology
DESCRT will be a long-term study that both looks back in time, at successful pregnancies, and forward in time at early pregnancy and long-term as these children grow.
- Conditions
- Infertility, Infertility, Female, Infertility, Male, Infertility Primary
- Trial name
- DESCRT (NCT03799107)
- Where
- United States
- Volunteers
- 2,020 people
- Sponsor
- University of California, San Francisco
Recurrent Implantation Failure
ERA in Young Primary Infertile RIF Patients
This study aims to evaluate the clinical efficacy of transcriptome-based endometrial receptivity analysis (tb-ERA) and investigate the molecular mechanisms of abnormal receptivity in young women with unexplained recurrent…
- Trial name
- ERA (NCT07767240)
- Testing
- tb-ERA and personalized embryo transfer
- Where
- China
- Volunteers
- 400 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Unexplained Infertility
The Predictive Value of the Sperm Chromatin Dispersion Test, Halosperm®, Before and After Sperm Preparation for Clinical Pregnancy in Cases of Unexplained Infertility Treated With Intra-uterine Insemination (First Cycle) and Ovulation Induction With Clomiphene Citrate.
Recent research has revealed that subtle abnormalities can be found in sperm samples that seem to be normal with conventional analysis techniques.
- Trial name
- DNAFRAG (NCT02235103)
- Testing
- Sperm Chromatin Dispersion Test
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- University Hospital, Ghent
Pregnancy
The Benefits of Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) in Couples With Unexplained Infertility
The (motile sperm organelle morphology examination) MSOME allows the detection of sperm vacuoles that seems to be related to sperm DNA damage.
- Trial name
- NCT01729533
- Testing
- ICSI, IMSI
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sapientiae Institute
Primary Ovarian Insufficiency, Unexplained Infertility
Study of Oral Dehydroepiandrosterone(DHEA) to Treat Previously Unexplained Infertility
The experimental focus of this project is on the interaction of DHEA treatment on pregnancy in women with otherwise unexplained infertility and evidence of premature ovarian aging (POA).
- Trial name
- DHEAFert (NCT00650754)
- Testing
- Dehydroepiandrosterone
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Female Infertility
Clomiphene Citrate, Estradiol and Sildenafil for Induction of Ovulation in Unexplained Infertility
Diagnosis of unexplained infertility is made after the recommended testing fails to reveal any abnormality. The treatment for unexplained infertility is empiric because it does not address a specific defect or functional…
- Trial name
- NCT03755037
- Testing
- Clomid, Respatio and Ethinyl estradiol
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Nesreen Abdel Fattah Abdullah Shehata
Hysteroscopy, Pregnancy Rate
Hysteroscopic Metroplasty in Unexplained Infertile Women With Dysmorphic Uterus
The correlation between dysmorphic uterus and infertility still remains enigmatic. We aim to evaluate the reproductive outcomes of metroplasty via office hysteroscopy in unexplained infertile women with dysmorphic uterus with…
- Conditions
- Hysteroscopy, Pregnancy Rate, Abortion, Ectopic Pregnancy
- Trial name
- COH/IUI (NCT03579550)
- Testing
- office hysteroscopic metroplasty intervention arm
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Bulent Haydardedeoglu
Subfertility
Assessment of Intralipid Efficacy in Women With Unexplained Recurrent Implantation Failure
The study will include 100 women with unexplained recurrent implantation failure undergoing IVF/ICSI cycle. Patients fulfilling the inclusion criteria will be randomised into two groups.
- Trial name
- NCT02487940
- Testing
- Intralipid 20%, Normal saline
- Volunteers
- 100 people
- Sponsor
- Dar El Teb Institute
Infertility Unexplained
Comparison of Recombinant Follicle Stimulating Hormone and the Combination of Recombinant Follicle Stimulating Hormone With Clomiphene Citrate in Stimulated Intrauterine Insemination Cycles
The aim of study is to evaluate the results of two different protocols for ovulation induction during IUI cycles. All patients undergo IUI cycles are randomly divided in to two groups.
- Trial name
- NCT05670795
- Testing
- Recombinant Follicle Stimulating Hormone, Recombinant Follicle Stimulating Hormone and Clomiphene Citrate
- Where
- Turkey (Türkiye)
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Pregnancy Related, Fertility Issues
Luteal Phase Support in IUI MOH Treatment Luteal Phase Support in IUI MOH Treatment
The LUMO study is a multicenter, randomized controlled trial that evaluates the effectivity of luteal phase support in MOH/IUI treatment.
- Conditions
- Pregnancy Related, Fertility Issues, Luteal Phase Defect, Infertility Unexplained
- Trial name
- LUMO (NCT05080569)
- Testing
- Progesterone Vaginal Product
- Where
- Netherlands
- Volunteers
- 1,008 people
- Sponsor
- UMC Utrecht
Unexplained Infertility
New Protocol in Unexplained Infertility
The new protocol ANTIUI provides good results regarding ovulation and pregnancy rates in patients with unexplained infertility
- Trial name
- NCT04754243
- Testing
- Gonadotropin, Standard protocol in IUI
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Tanta University