Clinical trials: Inflamed Gums
Gingivitis
Atlas of Experimental Gingivitis in Humans
Pilot case series with a split-mouth design to track subjects with known exposure (dental biofilm accumulation) over 21 days. Descriptive design, using single cell RNA sequencing as a "digital biopsy" to catalog and contrast…
- Trial name
- ATL (NCT04105569)
- Testing
- Stent-Induced Biofilm Overgrowth
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Periodontitis, Gingivitis
Effect of a Liquid Toothpaste on Periodontal Disease
The aim of the present clinical study is to evaluate the efficacy and safety of the novel toothpaste in patients diagnosed with gingivitis and/or periodontitis.
- Trial name
- NCT03117153
- Testing
- DA-5502 liquid toothpaste
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Dong-A Pharmaceutical
Plaque Ph Lowering After Use of Probiotics, Caries
Effect of Probiotic on the Plaque pH. A Randomized Double Blind Interventional Study
The aim of the present research protocol was to evaluate the effect of probiotics daily used, on the plaque acidogenicity of children.
- Conditions
- Plaque Ph Lowering After Use of Probiotics, Caries, Gingivitis
- Trial name
- NCT01601145
- Testing
- consumption of lozenges
- Where
- Italy
- Volunteers
- 192 people
- Sponsor
- Università degli Studi di Sassari
Gingivitis
Effect of Miswak Chewing Sticks on Periodontal Pathogens and Its Impact on the Progression of Gingivitis
A cross over randomized clinical trial Group A- Tooth Brush and Paste only Group B- Tooth Brush and Paste and Miswak chewing sticks
- Trial name
- NCT04123002
- Testing
- Miswak chewing sticks
- Where
- 2 sites in Kuwait
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- King Saud Bin Abdulaziz University for Health Sciences
Gingivitis
Powertoothbrushing for Treating Gingivitis
In this three-month interventional clinical trial for the treatment of gingivitis the investigators will assess the use of an oscillating-rotating powered toothbrush in comparison to the use of a manual toothbrush over 12-weeks…
- Trial name
- NCT03381339
- Testing
- Oscillating rotating power toothbrush
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Marquette University
Gingivitis
The Efficacy of Different Adjunctive Plaque Control Modalities in Orthodontic Patients
Bacterial plaque is the primary etiological factor for periodontal disease ranging from mild gingival inflammation to severe periodontitis.The fixed appliance can alter the microbial composition of the oral environment.Patients…
- Trial name
- NCT05889975
- Testing
- interdental brush, single tufted brush, water irrigator
- Where
- Iraq
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Plaque Induced Gingivitis
Topical Chlorhexidine and Metronidazole Gels for Gingival Inflammation
This randomized controlled clinical trial was undertaken to evaluate and compare the effectiveness of chlorhexidine gluconate gel (1%) alone and a combination gel containing chlorhexidine gluconate (0.5%) with metronidazole…
- Trial name
- NCT07776197
- Testing
- Chlorhexidine Gluconate Gel 1%, Chlorhexidine Gluconate 0.5% + Metronidazole 1.5% Gel
- Where
- India
- Volunteers
- 120 people
- Sponsor
- H.P. Government Dental College and Hospital Shimla
Down Syndrome, Gingival Bleeding
Clinical Comparison of a Postbiotic-gel With Placebo Gel for Gingival Inflammation in Patients With Down Syndrome
The aim of the study is to evaluate the efficacy of home treatment with a postbiotic-based gel for the management of periodontal inflammation in patients with Down syndrome. Patients will be enrolled at the S.C.
- Trial name
- NCT06293911
- Testing
- Biorepair Plus Parodontgel Intensive
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Dental Plaque, Gingivitis
Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis
The objective of this clinical research study is to evaluate the efficacy of floss to an essential oil alcohol-containing mouthwash, an essential oil alcohol-free mouthwash, and a CPC+Zn alcohol-free mouthwash in reducing dental…
- Trial name
- NCT07029438
- Testing
- Mouthwash, Floss, Toothbrush
- Where
- United States
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis, Plaque, Dental
Clinical Investigation Examining Plaque and Gingivitis Connected Toothbrush Compared to Non-Connected Toothbrush
The objective of this clinical research study is to assess plaque and gingivitis reductions of Connected Toothbrush compared to Non-Connected Toothbrush over a six-week clinical study.
- Trial name
- Connected (NCT04221334)
- Testing
- Electric Toothbrush, oral health care application
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Oral Health
Effect of Aloe Vera Mouthwashes on the Oral Health of Children
Prevention of dental problems by controlling plaque is the best solution to maintain oral health and prevent high cost of dental treatments.
- Trial name
- NCT04009616
- Testing
- Aloe Vera mouthwash, Chlorhexidine mouthwash
- Where
- Syria
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Damascus University
Gingivitis
Efficacy of Matcha Tea on Patients With Biofilm-induced Gingivitis
1. Evaluate the salivary level of antioxidants (malondialdehyde "MDA," superoxide dismutase "SOD," and glutathione peroxidase-1 "GPX-1") by enzyme-linked immunosorbent assay test (ELISA). 2.
- Trial name
- NCT06912958
- Testing
- Drinking of matcha tea, Organic Japanese Matcha, Jade Leaf, Japan
- Where
- Iraq
- Volunteers
- 50 people
- Sponsor
- Ahmed Talib
Dental Plaque (Diagnosis), Dental Plaque Imaging Methods
Digital Quantification of Dental Plaque Based on Intraoral Scanner Images
This diagnostic validation study aims to develop and validate a digital method for dental biofilm quantification using three-dimensional images obtained by an intraoral scanner.
- Conditions
- Dental Plaque (Diagnosis), Dental Plaque Imaging Methods, Dental Plaque, Gingivitis
- Trial name
- NCT07152314
- Testing
- Digital plaque quantification using intraoral scanner
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Guarulhos
Plaque, Gingivitis
A Pilot Study to Evaluate a Molecular Method for Plaque
This study is to evaluate the sensitivity of the molecular method and its ability to split a stannous fluoride toothpaste versus a negative control.
- Trial name
- NCT02574221
- Testing
- stannous fluoride toothpaste, cavity protection toothpaste
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Dental Caries, Gingivitis
Shifts in the Oral Biofilm of Patients With Known Oral Health Risk Factors
This study is observational only and is intended to evaluate changes in the makeup and function of bacteria naturally present in the mouth during treatment with braces to straighten teeth.
- Trial name
- NCT02885064
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Tooth Decay, Cavities of Teeth
Plaque Removal Effectiveness of a Flossing Device Compared to the Conventional Flossing in Adults
Objective: To evaluate the effectiveness in plaque removal of the new device; Dental floss holders and compare the results to the conventional way of flossing.
- Conditions
- Tooth Decay, Cavities of Teeth, Gingivitis, Plaque
- Trial name
- NCT06318819
- Testing
- Dental Floss Holders
- Where
- Saudi Arabia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Maha A. Bahammam
Healthy
A Twelve Week Study of Supervised Mouth Rinse and Flossing
The purpose of this study is to evaluate the efficacy of twice daily alcohol containing essential oil mouth rinse and brushing versus dental flossing and brushing under once daily supervision for the prevention and reduction of…
- Trial name
- NCT04696536
- Testing
- Colgate Cavity Protection Toothpaste, American Dental Association (ADA) Referenced Toothbrush, 5% Hydroalcohol Mouth Rinse
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Bacteremia, Infective Endocarditis
Reducing Risk for Infective Endocarditis
This clinical trial is studying if bacteria found in a participant's bloodstream after brushing their teeth can be prevented with a dental cleaning and more education on how to best brush and care for their teeth.
- Trial name
- PIE-B (NCT05721781)
- Testing
- Oral Hygiene instruction, Dental Cleaning
- Where
- 6 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Obesity, Obesity, Childhood
Associations Between Obesity, Dental Caries, Erosive Tooth Wear and Periodontal Disease in Adolescents: A Case Control-study
Objectives To compare oral health (dental caries, periodontal status, and erosive tooth wear (ETW)), diet and oral hygiene habits between obese and normal weight adolescents, and to explore possible risk associations.
- Conditions
- Obesity, Obesity, Childhood, Tooth Wear, Tooth Erosion
- Trial name
- NCT05146557
- Testing
- Dental examination
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University Ghent
Periodontal Diseases, Periodontal Inflammation
Oral and Systemic aMMP-8 in Periodontal Disease
Periodontal disease is an inflammatory process that can result in tooth loss and also is considered a modifying factor for systemic health.
- Trial name
- NCT04268381
- Testing
- Biochemical analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University