Clinical trials: Inflammaging
Periodontal Diseases, Old Age
Effect of Low-Level Laser on Crevicular Interleukin-1β Concentration in Patients With Periodontal Disease: A Relation to Periodontal Inflammaging
This study is done to compare between young age and old age patients with periodontitis (inflammaging) and the effect of diode laser as adjunctive to scaling and debridement
- Trial name
- NCT06677385
- Testing
- diode laser as adjunctive to conventional scaling and debridement, conventional scaling and debridement
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Chronic Inflammation, Inflammaging
2021 PMT iAge® Intervention Trial by Edifice Health
This is a decentralized, double-blind, randomized, placebo-controlled study to assess the effectiveness of different dietary supplements in decreasing systemic chronic inflammation (SCI) and lowering inflammatory age (iAge®).
- Trial name
- NCT04983017
- Testing
- Dietary supplement
- Where
- 2 sites in United States
- Volunteers
- 781 people, healthy volunteers welcome
- Sponsor
- Edifice Health
Aging
Ecosystem Nourishment for Gut Restoration After Fecal Transplantation
The purpose of this study is to test whether young-donor fecal microbiome transplantation (FMT) and a fermented, plant-rich high-fiber, microbiome rejuvenating diet (MRD) reduce inflammatory and biological aging markers.
- Trial name
- ENGRAFT (NCT07826793)
- Testing
- Fecal Microbiota Transplant Capsules, Microbiome Rejuvenating Diet
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Stanford University
Acute Coronary Syndromes (ACS)
Evaluation Through Innovative Examinations of Intestinal Dysbiosis Status in Patients Diagnosed With Cardiovascular Diseases and Evaluation of the Efficacy of Natural and Probiotic Extracts in the Non-pharmacological Approach to Improving Intestinal Dysbiosis Status.
The prospective experimental study aims to take an instantaneous photograph of the subject at time T0 and after 24 hours of intestinal permeability and dysbiosis indices in patients with acute coronary syndromes (ACS) which…
- Trial name
- DISBIO (NCT07429227)
- Testing
- Tea tree (Melaleuca alternifolia), Cinnamon (Cynnamomum zeylanicum) bark, Clove carnation (Eugenia caryopyllus) flowers, Red thyme (Thymus vulgaris) plant
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Casa di Cura Dott. Pederzoli
Aging, Inflammation
Cocoa Supplementation, Inflammaging, and Epigenetic Aging
The COcoa Supplement and Multivitamin Outcomes Study (COSMOS; NCT02422745) is a randomized clinical trial of cocoa extract supplement (containing a total of 500 mg/d flavanols, including 80 mg.
- Conditions
- Aging, Inflammation, Cardiovascular Diseases
- Trial name
- NCT05510375
- Testing
- Cocoa extract, Multivitamin
- Volunteers
- 21,442 people, healthy volunteers welcome
- Sponsor
- Augusta University
Inflammatory Disease, Aging Problems
Umbilical Cord Mesenchymal Stem Cell for Aging-related Low-grade Inflammation
The goal of this single-group, open-label, phase I/II clinical trial is to evaluate the safety and efficacy of the transplantation of umbilical cord mesenchymal stem cells in aging-related low-grade inflammation patients'…
- Conditions
- Inflammatory Disease, Aging Problems, Obese, Lipid Metabolism Disorders
- Trial name
- NCT06448052
- Testing
- umbilical cord mesenchymal stem cell
- Where
- Vietnam
- Volunteers
- 72 people
- Sponsor
- Nguyen Ton Ngoc Huynh
Periodontal Disease
Effect of Low-Level Laser Therapy on Salivary Toll Like Receptor- 4 Concentration of Periodontitis Patients: a Relation to Periodontal Inflammaging
Effect of Low-Level Laser Therapy on Salivary Toll Like Receptor- 4 Concentration of Periodontitis Patients: A Relation to Periodontal Inflammaging
- Trial name
- NCT06677736
- Testing
- conventional scaling and debridement, Diode laser as adjunctive to conventional scaling and debridement
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Rawda Saleh Saad Alashmawy
Menopause, Gut Microbiome
AGEWISE: Unravelling the Gut-Hormone Axis in Women's Ageing
AGEWISE is an observational study that aims to understand how changes in gut microbiome are related to hormonal changes during women's ageing, particularly across the different stages of menopause.
- Conditions
- Menopause, Gut Microbiome, Hormonal Changes, Chronic Low-Grade Inflammation
- Trial name
- NCT07614542
- Where
- Portugal
- Volunteers
- 300 people
- Sponsor
- Gulbenkian Institute for Molecular Medicine
Periodontitis, Periodontitis Stage I
Relationship Between NLRP3 Inflammasome Activation and Stages of Periodontitis: An Association With Inflammaging
This study aims to investigate the relationship between NLRP3 inflammasome activation and different stages of periodontitis, with a focus on its association with inflammaging.
- Conditions
- Periodontitis, Periodontitis Stage I, Periodontitis Stage II, Periodontitis Stage III
- Trial name
- NCT07590089
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Sarcopenia, Diabetes Mellitus
Glucose Metabolism, Muscle Mass/Function and Inflammation in the Elderly
A thorough characterization of glucose metabolism and "inflammaging" in elderly subjects will help determine to what extent each of these factors affects muscle mass/function and contributes to age-related muscle wasting.
- Trial name
- NCT02426073
- Where
- 2 sites in Italy
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Immunity Disorders, Aging
The Impact of a Polyphenol-Rich Supplement on Epigenetic and Cellular Markers of Immune Age
This is a prospective, interventional, single-arm, open-label pilot study of 50 patients to evaluate the effect of a polyphenol-rich nutritional supplement on epigenetic and cellular markers of immune age.
- Conditions
- Immunity Disorders, Aging, Inflammation
- Trial name
- NCT05234203
- Testing
- HTB Rejuvenate
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Big Bold Health, PBC