Clinical trials: Inflammation, Brain
Primary Mitochondrial Disease
OMT-28 in Patients With Primary Mitochondrial Disease (PMD) (PMD-OPTION)
The goal of this clinical trial is to learn about the treatment effects of the investigational new drug OMT-28 in patients with Primary Mitochondrial Disease.
- Trial name
- PMD-OPTION (NCT05972954)
- Testing
- OMT-28
- Where
- 9 sites in Germany, Italy and 1 more
- Volunteers
- 28 people
- Sponsor
- Omeicos Therapeutics GmbH
Venezuelan Equine Encephalitis Virus Infection
Study of a DNA-based Venezuelan Equine Encephalitis Virus DNA Vaccine Administered by Electroporation in Healthy Volunteers
The Phase I study will assess the basic safety, tolerability, and immunogenicity of a DNA-based Venezuelan equine encephalitis virus (VEEV)vaccine candidate delivered by electroporation .
- Trial name
- NCT01984983
- Testing
- Venezuelan Equine Encephalitis Virus DNA Vaccine Candidate
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Ichor Medical Systems Incorporated
Obesity, Bariatric Surgery Candidate
Effects of Change in Insulin Resistance and Systemic Inflammation on Brain Structure and Function
Obesity is associated with alterations in brain structure and cognitive impairment and is a risk factor for Alzheimer's disease and vascular dementia.
- Trial name
- NCT03215888
- Testing
- bariatric surgery
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Minnesota
Alzheimer Disease, Mild Cognitive Impairment
A Study of NTRX-07 in Participants With Alzheimer's Disease
1. Study Overview NeuroTherapia Inc. is conducting a clinical study to explore the safety and effects of a new drug called NTRX- 07.
- Trial name
- SPPN-AD (NCT07058688)
- Testing
- NTRX-07
- Where
- 6 sites in Czechia, Hungary and 1 more
- Volunteers
- 48 people
- Sponsor
- NeuroTherapia, Inc.
Normal Physiology
Evaluation of a Novel PET Radioligand to Image Cyclooxygenase-1 (COX-1)
Background: A radioligand is a radioactive substance that is used to diagnose diseases. A new ligand is called [11C]PS13. This has a small amount of radioactivity that can be detected by a positron emission tomography (PET) scan.
- Trial name
- NCT03324646
- Testing
- [11C]PS13
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- National Institute of Mental Health (NIMH)
Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Efficacy and Safety of Taitacept in Treatment of Refractory or Recurrent Anti-NMDAR/anti-LGI1 Encephalitis
The main objective is to explore the efficacy and safety of Telitacicept in the treatment of refractory/recurrent anti-NMDAR and anti-LGI1 encephalitis.
- Trial name
- NCT06510283
- Testing
- Taitacept
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Beijing Tongren Hospital
Autoimmune Encephalitis (AE)
Plasma Exchange in Pediatric Autoimmune Encephalitis
The aim of the study will be to compare the efficacy of daily plasma exchange (PLEX) versus alternate-day PLEX in achieving a favorable functional outcome in children with autoimmune encephalitis.
- Trial name
- PE/AIE (NCT07707739)
- Testing
- Plasma exchange (PE)
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Menoufia University
Encephalitis, Japanese B
Immunogenicity and Safety of Inactivated Vero Cell Derived Japanese Encephalitis Vaccine in Thai Children
Japanese encephalitis (JE) is the main cause of viral encephalitis in many countries of Asia including Thailand. Estimated annual mortality ranges from10,000-15,000 deaths, while the total number of clinical cases is about…
- Trial name
- JE0153 (NCT01408537)
- Testing
- JEVAC
- Where
- Thailand
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Diffuse Lewy Body Disease, Dementia With Lewy Bodies
Imaging Inflammation in Patients With Parkinson's Disease Dementia or Dementia With Lewy Bodies
This study uses a special type of scan called a positron emission tomography (PET) scan to take pictures of the brain. During the PET scan, a special dye called 11C-PBR28 is injected into the body.
- Conditions
- Diffuse Lewy Body Disease, Dementia With Lewy Bodies, Parkinson's Disease Dementia
- Trial name
- NCT02702102
- Testing
- 11C-PBR28
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Columbia University
Major Depressive Disorder, Inflammatory Response
Cerebral and Anti-inflammatory Response Through Exercise - Mechanisms In Depressive Disorders
The goal of this clinical trial is to study how physical exercise works when applied to patients diagnosed with Major Depressive Disorder (MDD).
- Trial name
- CARE-MIND (NCT06450704)
- Testing
- Physical Exercise, Antidepressant medication (ADM)
- Where
- 5 sites in Spain
- Volunteers
- 124 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Cardiovascular Diseases, Heart Diseases
Plaque Inflammation and Dysfunctional HDL in AIM-HIGH
Coronary heart disease (CHD) is a serious health concern that affects millions of people in the United States. It is usually caused by atherosclerosis-a condition that occurs when fatty material and plaque build up on the walls…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Atherosclerosis
- Trial name
- HDL Proteomics (NCT00880178)
- Testing
- Simvastatin and Extended-Release niacin, Simvastatin
- Where
- 29 sites in United States, Canada
- Volunteers
- 324 people
- Sponsor
- University of Washington
Brain, Aging
Biobank and Brain Health in Bordeaux.
B cube is a new generation cohort to study the determinants and natural history of brain aging, using molecular epidemiology, in a representative sample (N=2000) of the general population from the age of 55 (the approximate age…
- Conditions
- Brain, Aging, Cognitive Aging, Immunosenescence
- Trial name
- B-cube (NCT05322343)
- Testing
- Questionnaires, Fasting blood sampling., Saliva collection and nasal or nasopharyngeal swab
- Where
- France
- Volunteers
- 2,050 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Alzheimer Disease
Effect of Indomethacin on the Progression of Alzheimer's Disease
The purpose of this study is determine whether indomethacin is able to retard disease progression in patients with mild to moderate Alzheimer's disease.
- Trial name
- NCT00432081
- Testing
- indomethacin
- Where
- 2 sites in Netherlands
- Volunteers
- 160 people
- Sponsor
- Radboud University Medical Center
Insomnia, Nonorganic, Chronic Insomnia Disorder
Individualized TCM Pattern-Based Thread-Embedding Acupuncture Plus Auricular Acupressure for Chronic Insomnia
Chronic insomnia disorder is a common sleep disorder associated with impaired daytime functioning and may be accompanied by alterations in immune-inflammatory and gut-related biological processes.
- Trial name
- NCT07552714
- Testing
- Thread embedding acupuncture, Auricular acupressure
- Where
- Vietnam
- Volunteers
- 70 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Autoimmune Encephalitis, Paraneoplastic Syndromes
Characterisation of Clinical Phenotypes and Outcomes of Ma2 Patient
Paraneoplastic neurological syndromes (PNS) are rare complications of cancer occurring in 0.01% of cases. Their clinical, biological and radiological presentation is heterogeneous and may constitute a diagnostic challenge.
- Trial name
- CarMa2 (NCT05645185)
- Testing
- Diagnosis test
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Hospices Civils de Lyon
Schizophrenia
Inflammatory Response In Schizophrenia
Schizophrenia affects a significant proportion of the population and current levels of understanding of the illness is inadequate to treat it effectively.
- Trial name
- IRIS (NCT03093064)
- Testing
- Natalizumab
- Where
- United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- King's College London
Respiratory Tract Infections, Urinary Tract Infections
Sepsis Prognosis and Diagnosis in the Emergency Department (SPEED)
This study aims to evaluate the diagnostic and prognostic performance of a novel mRNA diagnostic/prognostic classifier (interprets the expression of 29 host response mRNA biomarkers) from whole blood in adult patients presenting…
- Conditions
- Respiratory Tract Infections, Urinary Tract Infections, Intra-Abdominal Infections, Skin and Soft Tissue Infection
- Trial name
- NCT05639504
- Testing
- IMX-BVN-4 and IMX-SEV-4
- Sponsor
- Inflammatix
HIV Associated Cognitive Motor Complex
Effect of Galantamine on Inflammation and Cognition
This study tests whether galantamine (GAL) reduces HIV-related inflammation and cognitive deficits. In this double-blind placebo-controlled crossover study, HIV-infected individuals (N=120; 60 smokers and 60 non-smokers) will be…
- Trial name
- CHI (NCT03384784)
- Testing
- Galantamine
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Pennsylvania
Healthy Infants
Immunogenicity of SA 14-14-2 JE Vaccine
The proposed Japanese Encephalitis (JE)Vaccine study is a four-arm double-blind randomized controlled single center trial to evaluate, by examining post-vaccination seroprotection titers, the lot-to-lot consistency of three lots…
- Trial name
- NCT01635816
- Testing
- JE Vaccine existing facility, JE vaccine new plant lot 1, JE vaccine new plant lot 2
- Where
- Bangladesh
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Alzheimer Disease
Investigation of Inflammation Using [C-11]-CS1P1
There is a compelling need for a noninvasive imaging approach to measure S1P1 in both preclinical models of diseases and humans.
- Trial name
- CS1P1 (NCT04517552)
- Testing
- [11C]-CS1P1
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tammie L. S. Benzinger, MD, PhD