Clinical trials: Inflammation, Brain
Tick-borne Encephalitis
New Study - Humoral Response to Tick-borne Encephalitis Vaccine in Elderly
The risk for tick borne encephalitis increases in Sweden. Together with an increased awareness of the possibility to acquire protection by vaccination, this has led to an increase in the number of doses of the vaccine distributed…
- Trial name
- NCT02318069
- Testing
- FSME-immune
- Where
- 2 sites in Finland, Sweden
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Sormland County Council, Sweden
Chronic Focal Encephalitis, Rasmussen's Encephalitis
A Pilot Study of the Use of Rituximab in the Treatment of Chronic Focal Encephalitis
The purpose of this study is to assess the safety, tolerability and effectiveness of rituximab in the treatment of chronic focal encephalitis.
- Trial name
- NCT00259805
- Testing
- Rituximab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- California Pacific Medical Center Research Institute
Neurocysticercosis, Healthy
PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Neurocysticercosis Using [F-18]FB
The purpose of this protocol is to measure peripheral benzodiazepine receptors in the brain using positron emission tomography (PET) and compare the imaging results between patients and healthy people.
- Trial name
- NCT00527579
- Testing
- [F-18]FBR
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Mental Health (NIMH)
Encephalitis, Tick-Borne
Tick-Borne Encephalitis (TBE) Seropersistence After First Booster and Response to a Second Booster in Children, Adolescents and Young Adults (Follow-Up to Study 700401)
The main purpose of this study is to assess the seropersistence of TBE virus antibodies in children, adolescents and young adults who received the first booster vaccination with either FSME-IMMUN 0.25 mL Junior or FSME-IMMUN 0.5…
- Trial name
- NCT00894686
- Testing
- FSME-IMMUN 0.25 mL Junior (1.2 µg TBE antigen/0.25 mL) or FSME-IMMUN 0.5 mL (2.4µg TBE antigen/0.5 mL)
- Where
- 4 sites in Austria, Germany and 1 more
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Pfizer
Cardiogenic Shock, Postresuscitation Disease
Role of Candidate Proteins in Capillary Leakage During Acute Circulatory Failure
Testing the association between circulating candidate proteins and the level of vascular leakage for three distinct forms of circulatory failure: cardiogenic shock, septic shock, and post-resuscitation syndrome.
- Conditions
- Cardiogenic Shock, Postresuscitation Disease, Septic Shock
- Trial name
- NCT05586282
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Inflammation, Psychosocial Functioning
Mindfulness Meditation Neuroimaging Study for Undergraduates
This study is designed to test the effectiveness of mindfulness meditation intervention classes on psychosocial health outcomes.
- Conditions
- Inflammation, Psychosocial Functioning, Depression, Anxiety
- Trial name
- NCT05304052
- Testing
- Mindfulness Meditation classes
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Stroke
Molecular Imaging of Inflammation With 18F-PBR06 to Identify Unstable Carotid Plaques in Patients With Stroke
Evaluating an innovative molecular imaging technique to visualize inflammation of the atherosclerotic plaque in patients with a recent ischemic stroke (<15 days) with carotid stenosis> 50%, by performing a Positron emission…
- Trial name
- PLAQINSTEP (NCT02513589)
- Testing
- 18F-PBR06
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Bordeaux
Autoimmune Encephalitis (AE)
Is [18F]-DPA-714 PET a Good Marker of Neuroinflammation in Autoimmune Encephalitis?
This study aims to evaluate the effectiveness of [18F]-DPA-714 PET imaging in detecting neuroimmune activity in patients with autoimmune encephalitis (AE).
- Trial name
- EAI-714 (NCT07488117)
- Testing
- TEP with radioligand EAI 714
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Sepsis, ARDS
Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit
As medicine advances, many lives can be saved in the intensive care unit. However, when multiple organ failure occurs, the mortality rate of patients increases dramatically.
- Conditions
- Sepsis, ARDS, Liver Failure, Renal Failure
- Trial name
- NCT00808691
- Testing
- Critical care
- Where
- Taiwan
- Volunteers
- 124 people
- Sponsor
- National Taiwan University Hospital
Mild Cognitive Impairment (MCI), Cognition
LpD3.5 Intervention Study in Older Adults- LISA-I Trial
This randomized placebo-controlled clinical study, called the LpD3.5 Intervention Study in Older Adults (LISA), aims to evaluate whether a heat-inactivated postbiotic of human origin (LpD3.5) can serve as a non-pharmacological…
- Conditions
- Mild Cognitive Impairment (MCI), Cognition, Brain Aging, Microbiome Dysbiosis
- Trial name
- Postbiotics (NCT07794956)
- Testing
- LpD3.5
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Infectious Disease, Yellow Fever
An Experimental Medicine Decipher of a Minimum Correlate of Cellular Immunity
We hypothesize that a high CD4+ and CD8+ T cell count will reduce viremia upon challenge with a structurally heterologous virus, and correspondingly result in reduced magnitude of host response to challenge infection.
- Conditions
- Infectious Disease, Yellow Fever, Japanese Encephalitis, Viral Infection
- Trial name
- NCT05568953
- Testing
- Stamaril, Imojev, Ixiaro
- Where
- Singapore
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Primary Mitochondrial Disease
OMT-28 in Patients With Primary Mitochondrial Disease (PMD) (PMD-OPTION)
The goal of this clinical trial is to learn about the treatment effects of the investigational new drug OMT-28 in patients with Primary Mitochondrial Disease.
- Trial name
- PMD-OPTION (NCT05972954)
- Testing
- OMT-28
- Where
- 9 sites in Germany, Italy and 1 more
- Volunteers
- 28 people
- Sponsor
- Omeicos Therapeutics GmbH
Stroke, Immunoregulation
Vinpocetine Inhibits NF-κB-dependent Inflammation in Acute Ischemic Stroke Patients
Immunity and inflammation play critical roles in the pathogenesis of acute ischemic stroke. Therefore, immune intervention, as a new therapeutic strategy, is worthy of exploration.
- Conditions
- Stroke, Immunoregulation, Inflammation, Vinpocetine
- Trial name
- NCT02878772
- Testing
- vinpocetine, Aspirin
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
AIDS-Related Opportunistic Infections, Meningo-encephalitis
Driving Reduced AIDS-associated Meningo-encephalitis Mortality
The DREAMM project is investigating whether the DREAMM interventions (1) Health system strengthening, 2) Co-designed education programs tailored to frontline healthcare workers, 3) Implementation of a diagnostic and treatment…
- Conditions
- AIDS-Related Opportunistic Infections, Meningo-encephalitis, Cryptococcal Meningitis, Bacterial Meningitis
- Trial name
- DREAMM (NCT03226379)
- Testing
- DREAMM
- Where
- 5 sites in Cameroon, Malawi and 1 more
- Volunteers
- 495 people
- Sponsor
- St George's, University of London
Brain Disease
18F-DPA-714 PET/MR in Dysfunctional Brain Diseases
This is a diagnostic pilot study that recruited 25 normal volunteers and 40 patients with dysfunctional brain diseases and performed 18F-DPA-714 PET/MR imaging to evaluate the correlation between the multimodal imaging features…
- Trial name
- NCT06851143
- Testing
- 18F-DPA-714 PET/MR scan
- Volunteers
- 65 people
- Sponsor
- Xijing Hospital
Healthy
Brain and Mindfulness
The main aim of this project is to explore the neuro-anatomical and -physiological correlates of meditation on attention and emotion-regulation.
- Trial name
- MEDITATION (NCT03117478)
- Testing
- Magneto-encephalography (MEG), Electro-encephalography (EEG), Functional Magnetic Resonance Imaging (fMRI)
- Where
- France
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Brain Disease
Inflammatory and Infectious Diseases of the Nervous System
Background: Inflammation is how the body reacts to infection or injury. Infections or inflammation in the brain and nerves can be serious. There aren t always good tests to detect this.
- Trial name
- NCT02435810
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Tick-borne Encephalitis
Humoral Response to Tick-borne Encephalitis Vaccine in Elderly
Antibody titers after tick-borne encephalitis (TBE) vaccination are less in elderly and vaccination breakthroughs are more common in this age group.
- Trial name
- NCT01361776
- Testing
- FSME-immune
- Where
- 6 sites in Finland, Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sormland County Council, Sweden
Urea Cycle Disorders
Oxidative Stress, Inflammation and Acute Decompensation in Urea Cycle Disorders
The primary purpose of the proposed study is to characterize the oxidative stress and inflammatory cytokine status in UCD during baseline and decompensated states.
- Trial name
- NCT01541722
- Where
- 11 sites in United States, Canada
- Volunteers
- 10 people
- Sponsor
- Mark Batshaw
Leukoencephalopathy, Progressive Multifocal, HIV Infections
Early Intensification of Antiretroviral Therapy Including Enfuvirtide in HIV-1-Related Progressive Multifocal Leucoencephalopathy (ANRS125)
Progressive multifocal leucoencephalopathy (PML) is a rare infectious disease of the brain, provoked by the JC virus. It usually occurs in subjects with impaired immune system as during HIV infection.
- Trial name
- NCT00120367
- Testing
- Enfuvirtide, Tenofovir-Emtricitabine
- Where
- France
- Volunteers
- 30 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis