Clinical trials: Inflammation, Brain
Neuroinflammatory Diseases, Multiple Sclerosis
FIT-ATOMIC Exercise Feasibility Trial
This multi-center, randomized controlled feasibility trial will assess a 20-week home-based exercise intervention in youth with Multiple Sclerosis (MS).
- Trial name
- FIT-ATOMIC (NCT06870968)
- Testing
- Exercise Training, Mobility and Flexibility Training
- Where
- 4 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- The Hospital for Sick Children
Rabies, Japanese Encephalitis
Safety and Immunogenicity of 2 Different Vaccination Schedules of Rabies and Japanese Encephalitis Vaccines in Healthy Adult Subjects
Establish non-inferiority of the immune response and evaluate the safety and tolerability of Rabies and Japanese Encephalitis (JE) vaccines given concomitantly or alone and according to either of 2 schedules for preexposure…
- Trial name
- NCT01662440
- Testing
- Rabies, Japanese Encephalitis
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 661 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Parkinson Disease, Inflammation
Modulation of Gut Microbiota by Rifaximin in PD Patients
The purposes of this clinical trial are to test 1. Whether 1-week rifaximin treatment is able to restore the gut microbiota in a long-term manner in people with Parkinson's disease? 2.
- Trial name
- NCT03958708
- Testing
- Rifaximin 550 MG
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Meningitis in Children, Encephalitis in Children
Causes of Secondary and Prolonged Fever During Treatment of Bacterial Meningitis and Viral Encephalitis
The aim of the present study is to investigate causes of secondary and prolonged fever during treatment of viral encephalitis and bacterial meningitis in children aged from one month to 18 years .
- Trial name
- NCT06971133
- Volunteers
- 50 people
- Sponsor
- Assiut University
Stroke, Dementia
Predictors for Poststroke Outcomes: Tel Aviv Brain Acute Stroke Cohort Acute Stroke Cohort (TABASCO)
Background: Recent studies have demonstrated that even mild stroke survivors experience residual damage, which persists and in fact increases in subsequent years.
- Conditions
- Stroke, Dementia, Cerebrovascular Disorders, Alzheimer's Disease
- Trial name
- TABASCO (NCT01926691)
- Where
- Israel
- Volunteers
- 575 people
- Sponsor
- Eli Sprecher, MD
Hepatic Encephalopathy, HE
Hepatic Encephalopathy: Lactulose or Polyethylene Glycol (H.E.L.P.)
The purpose of this study is to evaluate whether the use of polyethylene glycol is superior and more safe in treating hepatic encephalopathy compared to lactulose and also to determine if treatment with polyethylene glycol will…
- Conditions
- Hepatic Encephalopathy, HE, Cirrhosis, Altered Mental Status
- Trial name
- HELP (NCT01923376)
- Testing
- Lactulose, Polyethylene Glycol 3350
- Where
- United States
- Sponsor
- New York Presbyterian Brooklyn Methodist Hospital
Sepsis-Associated Encephalopathy
Ulinastatin Treatment Reduces the Incidence of Sepsis-associated Encephalopathy
This study was conducted to explore the association between ulinastatin treatment and the incidence of sepsis-associated encephalopathy (SAE) in patients with sepsis.
- Trial name
- NCT07090278
- Testing
- ulinastatin
- Where
- China
- Volunteers
- 2,734 people
- Sponsor
- Shusheng Li
Encephalitis, Tick-Borne
Evaluation of Long-Term Immunogenicity in Children and Adolescents Boosted With a New Pediatric TBE Vaccine After Five Years
blood draw five years after booster-immunization with TBE vaccine to investigate immunogenicity in children
- Trial name
- NCT00452621
- Testing
- blood draw
- Where
- 8 sites in Germany
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- Novartis
Hepatic Encephalopathy, Acute-On-Chronic Liver Failure
Intravenous BCAA for HE in ACLF (BCAA-HE-ACLF)
This multi-centric study analyses the effect of intravenous branched-chain amino acids (BCAA) on overt HE in patients with ACLF.
- Trial name
- NCT05700695
- Testing
- Branch Chain Amino Acid, Lactulose
- Where
- India
- Volunteers
- 114 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Traumatic Brain Injury, Aneurysmal Subarachnoid Hemorrhage
Dysregulated CNS Inflammation After Acute Brain Injury
By doing this study, the investigator hopes to learn how the levels of important proteins involved in inflammation change over time in patients with acute brain injury.
- Trial name
- NCT03287557
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Kentucky
Multiple Sclerosis
Brain Peripheral Benzodiazepine Receptors in Patients With Multiple Sclerosis
This study will use positron emission tomography (PET) to measure a brain protein called peripheral benzodiazepine receptor (PBR) in patients with multiple sclerosis.
- Trial name
- NCT00432900
- Testing
- [(11)C]PBR28
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Progressive Multifocal Leukoencephalopathy
Genetic Evaluation of Natalizumab-Treated Patients With Progressive Multifocal Leukoencephalopathy
The purpose of this study is to explore host genetic mutations which may render individual subjects more susceptible (or resistant) to developing Progressive Multifocal Leukoencephalopathy (PML).
- Trial name
- NCT01211639
- Where
- 11 sites in United States, Germany
- Volunteers
- 24 people
- Sponsor
- Biogen
Sclerosis, Multiple, Neurocognitive Impairment, Mild
The DANCEREX Proof-of-Concept Study for Chronic Neurological Disorders
The goal of this clinical trial is to test a new digital therapeutic solution which combines a holistic, multidimensional rehabilitation program based on dance and music with an innovative motivational system (DANCEREX-DTx) in…
- Conditions
- Sclerosis, Multiple, Neurocognitive Impairment, Mild, Neurocognitive Dysfunction
- Trial name
- DANCEREX-DTx (NCT06112639)
- Testing
- DANCEREX-DTx, Multidimensional dance-based program, Educational Program
- Where
- 3 sites in Italy
- Volunteers
- 192 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Schizophrenia
Anti-Inflammatory Challenge in Schizophrenia
This study aims to illuminate the biological underpinnings of negative symptoms in schizophrenia-particularly motivational impairments-by probing the link between systemic inflammation and neural activity in reward-related brain…
- Trial name
- NCT05823532
- Testing
- Infliximab
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Emory University
Insomnia, Nonorganic, Chronic Insomnia Disorder
Individualized TCM Pattern-Based Thread-Embedding Acupuncture Plus Auricular Acupressure for Chronic Insomnia
Chronic insomnia disorder is a common sleep disorder associated with impaired daytime functioning and may be accompanied by alterations in immune-inflammatory and gut-related biological processes.
- Trial name
- NCT07552714
- Testing
- Thread embedding acupuncture, Auricular acupressure
- Where
- Vietnam
- Volunteers
- 70 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Acquired Brain Injury, Stroke/ Cerebrovascular Accident (Ischemic or Hemorrhagic)
Regulating Emotions and Behaviors After Brain Injury
After acquired brain injury (ABI), persons can experience emotional and behavioral difficulties, that can be painful both for the person and his/her family.
- Conditions
- Acquired Brain Injury, Stroke/ Cerebrovascular Accident (Ischemic or Hemorrhagic), Brain Tumor (After Recovery), Encephalitis
- Trial name
- GREMO-LCA (NCT05393492)
- Testing
- Dialectical Behavior Therapy and Radically Open dialectical behavior therapy
- Where
- France
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Trauma Injury, Trauma
The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma
Traumatic injury followed by critical illness provokes pathophysiologic changes in the bone marrow and the gut that contribute to persistent anemia and changes in the microbiome which significantly impact long-term recovery.
- Conditions
- Trauma Injury, Trauma, Critical Illness, Microbiome
- Trial name
- NCT06606119
- Testing
- Data and tissue collection
- Where
- 3 sites in United States
- Volunteers
- 275 people
- Sponsor
- University of Florida
Insomnia, Cognitive Impairment
RESET-BRAIN: REhabilitation of SleEp and CogniTive Impairment in BReast Cancer Survivors Using an App-based Intervention
The goal of the study is to investigate whether treating insomnia using app-based cognitive behavioral therapy for insomnia (CBT-I) can improve cognitive impairment in breast cancer survivors compared to an active control group…
- Conditions
- Insomnia, Cognitive Impairment, Breast Cancer
- Trial name
- RESET-BRAIN (NCT06553235)
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I), Sleep hygiene education
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- Aarhus University Hospital
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Encephalopathy, Organ Dysfunction Syndrome
Prospective Analysis of Septic Associated Encephalopathy Using the Non-invasive Acoustocerebrography-ACG
The patients of the group "sepsis" are measured several times with the non-invasive multi-spectral sonography (Sonovum "ACG-Diagnosesystem") (days 1, 3, 7 and 14).
- Trial name
- SAEACG (NCT03173196)
- Testing
- Non-invasive Multispectral Sonography
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Rostock