Clinical trials: Inflammation, Brain
Inflammation, Coagulation and Hemorrhagic Disorders
Inflammation and Coagulation Factors for Predicting Cerebral Edema After SAH
Explore the role of Inflammation and coagulation factors in cerebrospinal fluid for predicting persistent cerebral edema after subarachnoid hemorrhage
- Conditions
- Inflammation, Coagulation and Hemorrhagic Disorders, Cerebral Edema
- Trial name
- NCT06009016
- Testing
- Inflammatory factors and coagulation factors level in cerebrospinal fluid after subarachnoid hemorrhage
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ischemic Stroke, Subarachnoid Hemorrhage, Aneurysmal
Effect of Targeted Temperature Management on Cerebral Autoregulation in Patients With Neurocritical Diseases
Change and effect of cerebral autoregulation during targeted temperature management in neurocritical patients
- Conditions
- Ischemic Stroke, Subarachnoid Hemorrhage, Aneurysmal, Sepsis, TBI (Traumatic Brain Injury)
- Trial name
- NCT04728438
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xiangya Hospital of Central South University
Enterocolitis, Necrotizing, Bacteremia
Antibiotic "Dysbiosis" in Preterm Infants
Prolonged antibiotic use in preterm neonates has significant consequences on the developing intestinal microbiome, metabolome and host response, predisposing the neonate to various major morbidities, including necrotizing…
- Conditions
- Enterocolitis, Necrotizing, Bacteremia, Bronchopulmonary Dysplasia, Intraventricular Hemorrhage
- Trial name
- NCT02784821
- Testing
- Antibiotic, Gastric fluid, Breast milk
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of Florida
Hepatic Encephalopathy, Acute-On-Chronic Liver Failure
Intravenous BCAA for HE in ACLF (BCAA-HE-ACLF)
This multi-centric study analyses the effect of intravenous branched-chain amino acids (BCAA) on overt HE in patients with ACLF.
- Trial name
- NCT05700695
- Testing
- Branch Chain Amino Acid, Lactulose
- Where
- India
- Volunteers
- 114 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Gaucher Disease Type 1
Role of Oxidative Stress and Inflammation in Type 1 Gaucher Disease (GD1)
The purpose of this study is to measure levels of blood and brain chemicals related to oxidative stress and inflammation in healthy volunteers and individuals with Type 1 Gaucher disease (GD1) to see if these levels are altered…
- Trial name
- NCT02583672
- Testing
- N-acetylcysteine
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Giant Cell Arteritis
Efficacy and Safety of Secukinumab in Patients With New Onset of Giant Cell Arteritis Who Are in Clinical Remission
The purpose of this study is to demonstrate the efficacy and safety of subcutaneously (s.c.) administered secukinumab 300 mg in combination with glucocorticoid taper regimen compared to placebo in combination with glucocorticoid…
- Trial name
- GigAINt (NCT05380453)
- Testing
- Secukinumab 300 mg, s.c.
- Where
- 25 sites in Germany
- Volunteers
- 151 people
- Sponsor
- Novartis Pharmaceuticals
Meningitis/Encephalitis
Clinical Evaluation of the FilmArray® Meningitis/Encephalitis (ME) Panel
The FilmArray Meningitis/Encephalitis (ME) Panel (hereinafter referred to as FilmArray ME Panel) is a qualitative multiplexed nucleic acid-based in vitro diagnostic test intended for use with FilmArray systems.
- Trial name
- NCT03895281
- Testing
- FilmArray Meningitis/Encephalitis (ME) Panel
- Volunteers
- 150 people
- Sponsor
- Shanghai Children's Medical Center
Systemic Lupus Erythematosus
Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus
The purpose of this study is to determine whether Libman-Sacks endocarditis (inflammation of the heart valves) is the cause of neuropsychiatric manifestations (stroke, transient ischemic attacks, cognitive dysfunction, seizures…
- Trial name
- NCT00858884
- Testing
- Clinical and laboratory evaluations, transesophageal echocardiography, carotid duplex, transcranial duplex, and magnetic resonance of the brain
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of New Mexico
Japanese Encephalitis, Hepatitis A
Immunogenicity and Safety of ChimeriVax™ Japanese Encephalitis Vaccine in Thai Toddlers and Children
Safety: To describe the safety profiles following vaccination. Immunogenicity: To describe the immune response after a single dose of vaccine.
- Trial name
- NCT00621764
- Testing
- Japanese encephalitis vaccine (Day 0) Hepatitis A vaccine (Day 28), Hepatitis A vaccine (Day 0) Japanese encephalitis vaccine (Day 28)
- Where
- 3 sites in Thailand
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Autoimmune Encephalitis, Anti-NMDAR Encephalitis
Clinical Evaluation of a Novel DAB Chromogenic Tissue-Based Assay for Detecting Anti-GABABR Antibodies
This multicenter, blinded, cross-sectional study aims to evaluate the clinical performance of a novel DAB chromogenic tissue-based assay (TBA) for detecting anti-GABAB receptor (anti-GABABR) antibodies.
- Conditions
- Autoimmune Encephalitis, Anti-NMDAR Encephalitis, Anti-GABABR Encephalitis
- Trial name
- GREAT (NCT07858175)
- Where
- 5 sites in China
- Volunteers
- 300 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Parkinson Disease, Movement Disorders
Characterizing Biomarkers of Early Parkinson's Disease Progression (TREG)
The purpose of this study is to look at a blood marker of inflammation in early untreated Parkinson's disease.
- Trial name
- TREG (NCT03716258)
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Oregon Health and Science University
THYROTOXICOSIS
The Association Between Autoimmune or Inflammation and Thyroid Disease
This study aims to evaluate the effects of thyroid functions on energy homeostasis and inflammation.
- Trial name
- NCT02886949
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- Taichung Veterans General Hospital
Anti NMDA Receptor Encephalitis
Clinical-immunological Features of Anti-NMDAR Encephalitis
Using a retrospective cohort of 501 patients with anti-NMDAR encephalitis to assess clinical and immunological prognostic biomarkers
- Trial name
- Bio-NMDAr (NCT05738668)
- Testing
- Description of clinical characteristic
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Hospices Civils de Lyon
Severe Sepsis With Septic Shock, Severe Sepsis Without Septic Shock
Long-term Cognitive and Cerebral Changes in Sepsis Survivors and Their Predictors
The main goals of this study are to provide a cognitive, neurological, brain morphological, and serological profile of sepsis survivors in order to make long-term prognosis of recovery and estimate the need for rehabilitation…
- Trial name
- BonSEP (NCT02339649)
- Testing
- Blood Sample, Neurocognitive Assessment, Resting State EEG
- Where
- 2 sites in Germany
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- German Center for Neurodegenerative Diseases (DZNE)
West Nile Virus, West Nile Fever Encephalitis
Early Interferon-beta Treatment for West-Nile Virus Infection
West Nile virus (WNV) is a mosquito-borne virus which in majority of cases causes only self-limited disease. Despite that, in minority of cases (~0.5%) it can infect the brain and cause severe and even life-threatening disease…
- Conditions
- West Nile Virus, West Nile Fever Encephalitis, West Nile Fever Myelitis, West Nile Fever With Other Complications
- Trial name
- NCT06510426
- Testing
- Rebif 44 MCG Per 0.5 ML Prefilled Syringe, Saline
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Post COVID-19, Cognitive Dysfunction
Multimodal Investigation of Post COVID-19 in Females
The purpose of this study is to investigate the effects of transcutaneous vagus nerve stimulation (t-VNS) on Long Covid symptoms in females and to identify factors influencing susceptibility and recovery-particularly in the…
- Trial name
- NCT05225220
- Testing
- Parasym Device (of Parasym Ltd, UK) using Transcutaneous Vagus Nerve Stimulation (t-VNS)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Ataxia Telangiectasia
Oxidative Stress, Low Grade Inflammation, Tissue Breakdown and Biomarkers in Cerebrospinal Fluid of A-T
Ataxia telangiectasia (A-T) is a rare devastating human recessive disorder characterized by progressive cerebellar ataxia, immunodeficiency, chromosomal instability, and cancer susceptibility.
- Trial name
- NCT02285348
- Testing
- Lumbar puncture
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
West Nile Fever
Phase I Study of West Nile Virus Vaccine
This study will test the safety of an experimental vaccine for preventing West Nile virus infection. The virus is spread mainly by mosquito bites.
- Trial name
- NCT00300417
- Testing
- VRC-WNVDNA020-00-VP
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Encephalitis
Immunogenicity of a Live Attenuated Chimeric JE Vaccine (IMOJEV) as a Booster Dose in Thai Children Primed With CD.JEVAX
This study was undertaken to assess the immunogenicity and safety of a booster dose of a live attenuated chimeric Japanese Encephalitis vaccine (JE-CV) after primary vaccination with SA14-14-2 in Thai children aged 1 to <5 years.
- Trial name
- NCT02526550
- Testing
- Live attenuated chimeric Japanese Encephalitis vaccine, Inactivated Hepatitis A vaccine
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Siriraj Hospital
Tick-borne Encephalitis
Tick-borne Encephalitis Virus Research in Limousin
Cases of encephalitis of varying severity have been described in recent years in eastern France involving tick-borne encephalitis virus (TBEV).
- Trial name
- VITAL (NCT05941546)
- Testing
- anti-TBEV serology
- Where
- France
- Volunteers
- 878 people
- Sponsor
- University Hospital, Limoges