Clinical trials: Inflammation, Brain
Anti-NMDA (N-Methyl D-Aspartate) Receptor Encephalitis
Predicting Functional Outcome and Response to Therapy of Anti-NMDAR Encephalitis at Diagnosis
The goal of this international cohort study is to develop a prediction model for long-term outcome and response to first-line immunotherapy of anti-NMDAR Encephalitis, already at the moment of diagnosis.
- Trial name
- NEOSII (NCT06023160)
- Where
- Netherlands
- Volunteers
- 714 people
- Sponsor
- Erasmus Medical Center
Infectious Metabolic Encephalopathy, Ischemic Stroke
Procedural Motor Memory in Long COVID-19
Background: Most people who get COVID-19 seem to recover with no long-term effects. However, some people who recover from acute COVID-19 infections report lingering symptoms. This is called long COVID.
- Conditions
- Infectious Metabolic Encephalopathy, Ischemic Stroke, Seizure, Viral Encephalitis, Small and Large Vessel
- Trial name
- NCT05746624
- Testing
- keypresses
- Where
- United States
- Volunteers
- 333 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Sepsis-Associated Encephalopathy
Adjunctive Sedation With Dexmedetomidine for the Prevention of Severe Inflammation and Septic Encephalopathy
Septic encephalopathy (SE) is defined as acute cerebral dysfunction in patients with sepsis or septic shock. SE occurs in up to 50% of critically ill patients with sepsis and is associated with a high mortality and morbidity.
- Trial name
- ADVISE (NCT04076826)
- Testing
- Dexmedetomidine, Propofol or Midazolam, Blood sampling
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Intracerebral Hemorrhage
A Study to Evaluate the Safety, Tolerability and the Effects of Ixodes Ricinus-Contact Phase Inhibitor (Ir-CPI) in Adult Patients With Spontaneous Intracerebral Haemorrhage
The purpose of the study is to provide a first assessment of safety, tolerability and efficacy of Ir-CPI, administered on top of standard-of-care, on secondary brain injury in patients with spontaneous intracerebral haemorrhage.
- Trial name
- BIRCH (NCT05970224)
- Testing
- Ir-CPI
- Where
- 8 sites in Belgium
- Volunteers
- 23 people
- Sponsor
- Bioxodes S.A.
Parkinson's Disease With LRRK2 Mutation, Healthy Controls
Measure of Microglial Activation in the Brain of Parkinson Disease Patients With PET
There is accumulating evidence suggesting that inflammatory processes, through microglial activation, would play a key role in the neurodegenerative process of Parkinson's disease (PD).
- Conditions
- Parkinson's Disease With LRRK2 Mutation, Healthy Controls, Parkinson's Disease Without LRRK2 Mutation
- Trial name
- INFLAPARK (NCT02319382)
- Testing
- PET with the tracer 18F-DPA-714, PET with the tracer 11C-PE2I, MRI
- Where
- France
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Encephalitis, Brain Diseases
Early Neurological Outcome in Pediatric Encephalitis
This prospective cohort study aims to identify baseline clinical, laboratory, and radiological factors at admission that are associated with early neurological outcomes in children with encephalitis admitted to Assiut University…
- Conditions
- Encephalitis, Brain Diseases, Neurologic Manifestations
- Trial name
- NCT07830927
- Volunteers
- 88 people
- Sponsor
- Assiut University
Gaucher Disease Type I, Oxidative Stress
Oxidative Stress and Inflammatory Biomarkers in Gaucher Disease
The objective of this study is to evaluate oxidative stress and/or inflammation in patients with Gaucher disease type I using a series of biomarkers and correlate with measurements of currently used diagnostic biomarkers.
- Conditions
- Gaucher Disease Type I, Oxidative Stress, Inflammation
- Trial name
- NCT02437396
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Minnesota
Encephalitis, Central Nervous System Infections and Inflammations
Brazil ICU Encephalitis Surveillance
Our proposal is to develop a sentinel syndromic surveillance strategy to identify encephalitis cases possibly related to emerging pathogens admitted to ICUs in Brazil.
- Conditions
- Encephalitis, Central Nervous System Infections and Inflammations, Intensive Care Neurological Disorder, Prognosis
- Trial name
- NCT05370573
- Testing
- No intervention
- Where
- Brazil
- Volunteers
- 451 people
- Sponsor
- D'Or Institute for Research and Education
Varicella Zoster, Varicella Meningitis
Clinical Features and Outcomes of VZV CNS Infections
The goal of this observational study is to learn about the clinical characteristics, risk factors, and long-term outcomes of varicella zoster virus (VZV)-related central nervous system (CNS) infections in adults.
- Conditions
- Varicella Zoster, Varicella Meningitis, Varicella Encephalitis, Varicella Neurological
- Trial name
- NCT07554261
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people
- Sponsor
- Kocaeli University
Hypertensive Intracerebral Hemorrhage, Intraventricular Hemorrhage
Neuroinflammatory Response in Patients With ICH and IVH Treated With rtPA
This study compares the neuroinflammatory response in patients with hypertensive ICH associated with IVH treated with intraventriculary applied rtPA, and the control group.
- Conditions
- Hypertensive Intracerebral Hemorrhage, Intraventricular Hemorrhage, Brain Injuries
- Trial name
- NCT03452722
- Testing
- intraventricual recombinant tissue plasminogen activator application
- Volunteers
- 88 people
- Sponsor
- University of Rijeka
HSV Encephalitis
Dexamethasone in Herpes Simplex Virus Encephalitis
Encephalitics is a serious condition in which the brain becomes inflamed (swollen). It usually happens as a direct result of virus, such as herpes simplex virus (HSV).
- Trial name
- DexEnceph (NCT03084783)
- Testing
- Dexamethasone
- Where
- 8 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Paraneoplastic Neurological Syndromes or Autoimmune Encephalitis
Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis Collection
Numerous neurological disorders affecting the central and peripheral nervous system can be attributed to the immune system through multiple effector mechanisms.
- Trial name
- SNP (NCT05198661)
- Testing
- Collection of biological sample with sera, CSF, buffy coat, PBMC, plasma.
- Where
- 62 sites in France
- Volunteers
- 3,500 people
- Sponsor
- Hospices Civils de Lyon
Stroke
Protecting the Brain From Post-Stroke Cognitive Impairment and Dementia With Multimodal Exercise Training
The rates of cognitive decline and dementia after stroke are disproportionately high. Strategies that can protect the brain early after the stroke event could reduce the future risk of cognitive decline and dementia in these…
- Trial name
- PROTECT (NCT07445841)
- Testing
- Multimodal Training, Balance, Toning and Stretching
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- McGill University
HIV Associated Cognitive Motor Complex
Effect of Galantamine on Inflammation and Cognition
This study tests whether galantamine (GAL) reduces HIV-related inflammation and cognitive deficits. In this double-blind placebo-controlled crossover study, HIV-infected individuals (N=120; 60 smokers and 60 non-smokers) will be…
- Trial name
- CHI (NCT03384784)
- Testing
- Galantamine
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Pennsylvania
Western Equine Encephalitis
Safety and Immunogenicity Study of the Western Equine Encephalitis (WEE) Vaccine
This study is being conducted to collect safety and immunogenicity data for the WEE vaccine, TSI-GSD 210. Enrollment in this protocol is offered for personnel who enter areas where this virus is used in research or is endemic (an…
- Trial name
- NCT02466750
- Testing
- Western Equine Encephalitis (WEE) Vaccine
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Healthy
Brain and Mindfulness
The main aim of this project is to explore the neuro-anatomical and -physiological correlates of meditation on attention and emotion-regulation.
- Trial name
- MEDITATION (NCT03117478)
- Testing
- Magneto-encephalography (MEG), Electro-encephalography (EEG), Functional Magnetic Resonance Imaging (fMRI)
- Where
- France
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Autoimmune Encephalitis, Paraneoplastic Syndromes
Characterisation of Clinical Phenotypes and Outcomes of Ma2 Patient
Paraneoplastic neurological syndromes (PNS) are rare complications of cancer occurring in 0.01% of cases. Their clinical, biological and radiological presentation is heterogeneous and may constitute a diagnostic challenge.
- Trial name
- CarMa2 (NCT05645185)
- Testing
- Diagnosis test
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Hospices Civils de Lyon
Sepsis, ARDS
Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit
As medicine advances, many lives can be saved in the intensive care unit. However, when multiple organ failure occurs, the mortality rate of patients increases dramatically.
- Conditions
- Sepsis, ARDS, Liver Failure, Renal Failure
- Trial name
- NCT00808691
- Testing
- Critical care
- Where
- Taiwan
- Volunteers
- 124 people
- Sponsor
- National Taiwan University Hospital
Headache Disorders
Assessment of Inflammation in Primary Headaches
Headache is the most common neurological complaint accounting for % 1 to % 4 in the emergency department (ED).Every year, nearly one million people with headache attacks have been consulted by healthcare professionals at the…
- Trial name
- NCT04891848
- Testing
- inflammation
- Where
- Turkey (Türkiye)
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
HIV Infections, Leukoencephalopathy, Progressive Multifocal
Comparison of Anti HIV Drugs Used Alone or in Combination With Cytosine Arabinoside to Treat Progressive Multifocal Leukoencephalopathy (PML) in HIV-Infected Patients
To compare the safety and efficacy of antiretroviral therapy (zidovudine plus either didanosine or dideoxycytidine) versus antiretroviral therapy plus intravenous cytarabine (Ara-C) versus antiretroviral therapy plus intrathecal…
- Trial name
- NCT00001048
- Testing
- Filgrastim, Cytarabine, Zidovudine
- Where
- 9 sites in United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)