Clinical trials: Inflammation, Brain
Meningoencephalitis, Other Syndromes Requiring Lumbar Puncture in Emergency Department
Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients
Of all emergency room patients, persons presenting with encephalitis/meningitis syndrome of a potentially infectious nature are among those of greatest concern.
- Trial name
- NCT02207647
- Testing
- no intervention
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Olive View-UCLA Education & Research Institute
West Nile Fever
Safety and Immunogenicity Study of ChimeriVax West Nile Vaccine in Healthy Adults
The purpose of this study is to determine if ChimeriVax West Nile vaccine is safe and effective in preventing West Nile disease in adults over 50 years of age.
- Trial name
- WinVax004 (NCT00746798)
- Testing
- ChimeriVax-WN02 vaccine
- Where
- 15 sites in United States
- Volunteers
- 479 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Trauma Injury, Acute Coronary Syndrome
Smart Glasses in Emergency Medicine From the Hangzhou Asian Games
The findings of our study will reveal that using smart glasses in the emergency department(ED) could facilitate patient admission. AR Smart Glasses offer the potential to enhance the effectiveness and speed of treatment within ED.
- Conditions
- Trauma Injury, Acute Coronary Syndrome, Stroke, Acute, Septic Shock
- Trial name
- SGINHZAG (NCT06623825)
- Testing
- teleconsultation by Augmented Reality smart glasses, teleconsultation by two-way radio connection.
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Sir Run Run Shaw Hospital
Large Vessel Occlusion, Acute Ischemic Stroke
Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke
This is a randomized open-label, with blinded outcome pilot study to evaluate the effect on inflammatory and brain injury laboratory values and explore clinical outcomes in patients who present with ischemic strokes due to large…
- Trial name
- NUVISTA2 (NCT07404852)
- Testing
- transcutaneous auricular vagal nerve stimulation
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Washington University School of Medicine
Atherosclerosis of Artery, Coronary Artery Disease
Effects of aSPIrin Versus Aspirin Plus Low-dose RIvaroxaban on Carotid aTherosclerotic Plaque Inflammation
Primary Study Objective : To compare the effects of low-dose rivaroxaban plus aspirin versus aspirin on atherosclerotic plaque inflammation using serial FDG Positron Emission Tomography/Computed Tomography(PET-CT) imaging of…
- Conditions
- Atherosclerosis of Artery, Coronary Artery Disease, Peripheral Arterial Disease, Carotid Stenosis
- Trial name
- SPIRIT (NCT05797376)
- Testing
- Rivaroxaban 2.5mg
- Where
- South Korea
- Volunteers
- 92 people
- Sponsor
- Asan Medical Center
Hemodialysis, Malnutrition
The Influences of Malnutrition and Inflammation Complex Syndrome in Hemodialysis Patients
The purpose of this study is to explore the severity of malnutrition and inflammation in Taiwanese hemodialysis patients.
- Conditions
- Hemodialysis, Malnutrition, Inflammation, Myocardial Ischemia
- Trial name
- NCT00190125
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Far Eastern Memorial Hospital
Chronic Low Back Pain (CLBP)
Brain and Gene Expression Responses to Exercise in Chronic Back Pain
This study is registered retrospectively for transparency. This mechanistic randomized controlled trial examined whether a 14-week supervised physical exercise training program reduces chronic low back pain (CLBP) by modulating…
- Trial name
- CLBPE (NCT07480460)
- Testing
- Supervised physical exercise training
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- McGill University
Toxoplasmosis, Cerebral, HIV Infections
A Study of Pyrimethamine in the Treatment of Infection by a Certain Parasite in HIV-Positive Patients
To determine the manner in which pyrimethamine is metabolized and excreted in patients currently receiving zidovudine (AZT). An important goal of this measurement is to establish the optimal dose of pyrimethamine necessary to…
- Trial name
- NCT00000973
- Testing
- Pyrimethamine, Leucovorin calcium, Zidovudine
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy, West Nile Fever
Vaccine to Prevent West Nile Virus Disease
This study will test the safety of an experimental vaccine intended to prevent West Nile virus (WNV) infection and determine if it causes side effects.
- Conditions
- Healthy, West Nile Fever, Healthy Volunteer, HV
- Trial name
- NCT00106769
- Testing
- VRC-WNVDNA017-00-VP
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Autoimmune Encephalitis, LGI1 Encephalitis
Relapse and Functional Outcomes in Anti-LGI1 Encephalitis
This study focuses on a rare brain disease called anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis. In this condition, the body's immune system mistakenly attacks a protein in the brain, which can cause problems with…
- Conditions
- Autoimmune Encephalitis, LGI1 Encephalitis, Limbic Encephalitis
- Trial name
- NCT07722286
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Shen Chun-Hong
Rheumatic Diseases, Lupus Erythematosus, Systemic
Pain Phenotyping of Rheumatic Diseases - An Observational Study
Background: Rheumatic diseases can affect the joints, ligaments, tendons, bones, muscles, and skin. They can also cause inflammation, damage body tissues, and change nerve signals in the brain.
- Conditions
- Rheumatic Diseases, Lupus Erythematosus, Systemic, Lupus Vasculitis, Central Nervous System, Arthritis
- Trial name
- NCT07829497
- Testing
- Bedside quantitative sensory testing
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Hand, Foot and Mouth Disease (HFMD)
The Phase IVd of Inactivated Enterovirus 71 Vaccine
Enterovirus 71 (EV71), a major pathogen causing hand-foot-and-mouth disease (HFMD) worldwide, is a member of the Human Enterovirus species A, family Picornaviridae.
- Trial name
- NCT03296410
- Testing
- EV71 and two measles attenuated live vaccine, EV71 and attenuated Japanese encephalitis vaccine, two measles attenuated live vaccine
- Where
- China
- Volunteers
- 1,220 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Intracerebral Hemorrhage, Mesenchymal Stem Cell
Stem Cell Therapy for Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a common condition with high morbidity, mortality, and disability. The current treatments for ICH primarily include surgical and pharmacological interventions.
- Trial name
- NCT06862388
- Testing
- Device: Phase Ⅰ Dose Level 1, Device: Phase Ⅰ Dose Level 2, Device: Phase Ⅰ Dose Level 3
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Tang Zhouping
Herpes Simplex Meningo Encephalitis
Herpes Simplex Meningo Encephalitis Recurrence
study of risk factors and prognosis of herpes simplex encephalitis recurrence.
- Trial name
- NCT06627010
- Testing
- description
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Central Hospital, Nancy, France
Preterm Newborns
Inflammation and Cerebral Oxygenation in Preterm Newborns Following Fetal Red Blood Cell Transfusion Compared to Adult Red Blood Cell Transfusion
Among diseases associated with premature birth, retinopathy of prematurity (ROP) is one of the most important causes of childhood blindness. ROP develops in the immature retina as a consequence of prolonged exposure to hyperoxia.
- Trial name
- INCONTRA (NCT06851390)
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Multiple Sclerosis
This Study Involves a Positron Emission Tomography (PET) Scan Using a New Investigational Radioactive Tracer, [18F]-FZTA, to Detect Inflammation in the Brain. The Tracer Will be Tested in Healthy Younger Adults and Individuals With Multiple Sclerosis.
This study involves a Positron Emission Tomography (PET) scan using a new investigational radioactive tracer, [18F]-FZTA, to detect inflammation in the brain.
- Trial name
- FZTA Pilot (NCT07115017)
- Testing
- [18F] FZTA
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Depression, Adolescent
Biomarkers of Antidepressant Response and Suicidal Events in Depressed Youth
The aims of this study are to (1) identify inflammatory/neurotrophic and neurodevelopmental markers that predict antidepressant response and suicidal risk in depressed youth and (2) predict their treatment response and the…
- Trial name
- NCT03547219
- Testing
- Escitalopram
- Where
- South Korea
- Volunteers
- 152 people
- Sponsor
- Seoul National University
Encephalopathy, HIV Infections
A Phase I/II Pilot Treatment Study Of CSF Penetration And Response To Ganciclovir And Foscarnet In CMV Neurologic Disease.
To determine the safety and CSF penetration of combined ganciclovir and foscarnet treatment for presumed cytomegalovirus encephalitis or radiculomyelopathy.
- Conditions
- Encephalopathy, HIV Infections, Radiculitis
- Trial name
- NCT00000856
- Testing
- Foscarnet sodium, Ganciclovir
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Stroke, Immunoregulation
Vinpocetine Inhibits NF-κB-dependent Inflammation in Acute Ischemic Stroke Patients
Immunity and inflammation play critical roles in the pathogenesis of acute ischemic stroke. Therefore, immune intervention, as a new therapeutic strategy, is worthy of exploration.
- Conditions
- Stroke, Immunoregulation, Inflammation, Vinpocetine
- Trial name
- NCT02878772
- Testing
- vinpocetine, Aspirin
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Paraneoplastic Neurological Syndrome, Autoimmune Encephalitis
New Biomarkers in Auto-immune Encephalitis and Neurological Paraneoplastic Syndromes
Autoimmune encephalitis (AE) and paraneoplastic neurological syndromes (PNS) are rare neuroimmune syndromes with a wide range of clinical presentation but without pathognomonic clinical sign facilitating the diagnosis.
- Trial name
- DeNobio (NCT05728931)
- Testing
- Test of biological samples
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Hospices Civils de Lyon