Clinical trials: Inflammation, Brain
Sleep, Sleep Restriction
Effects of Sleep Restriction on Female Soccer Players: Physical Performance, Muscle Damage, Inflammation, and BDNF Levels.
This research aims to investigate the interplay between menstrual cycles, sleep patterns, and athletic performance. Before experimental sessions, participants will maintain menstrual diaries for three months and complete…
- Trial name
- NCT06251362
- Testing
- Sleep restriction
- Where
- 2 sites in Poland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University School of Physical Education, Krakow, Poland
Central Nervous System Infections, Bacterial Meningitis
Central Nervous System Infections in Denmark
The Danish Study Group of Infections of the Brain is a collaboration between all departments of infectious diseases in Denmark. The investigators aim to monitor epidemiological trends in central nervous system (CNS) infections by…
- Conditions
- Central Nervous System Infections, Bacterial Meningitis, Viral Meningitis, Aseptic Meningitis
- Trial name
- DASGIB (NCT03418441)
- Testing
- Community-acquired CNS infections
- Where
- 8 sites in Denmark
- Volunteers
- 1,900 people
- Sponsor
- Aalborg University Hospital
Tick Borne Encephalitis, Virus Diseases
Study to Evaluate Long Term Immunogenicity up to 10 Years After the First Booster Immunization With Tick Borne Encephalitis Vaccine in Adults Who Received 1 of 3 Different Primary Vaccination Schedules
The aim of this study is to investigate the immunogenicity response in adults up to 10 years after one booster dose. Data collected from this study will allow for greater information to prescribers who administer TBE vaccine, so…
- Trial name
- NCT01562444
- Testing
- Blood draw
- Where
- Czechia
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Progressive Multiple Sclerosis (PMS), Neuromyelitis Optica
A Safety and Efficacy Study Evaluating CTX112 in Subjects With Refractory Neurologic Autoimmune Disease
This is a single-arm, open-label, multicenter, ascending dose Phase 1/2 trial evaluating the safety and preliminary efficacy of CTX112 in adult participants with neurological autoimmune diseases (AIDs), including Progressive…
- Conditions
- Progressive Multiple Sclerosis (PMS), Neuromyelitis Optica, Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease, Autoimmune Encephalitis
- Trial name
- CRSP-AID-502 (NCT07804004)
- Testing
- CTX112
- Volunteers
- 220 people
- Sponsor
- CRISPR Therapeutics
Mild Traumatic Brain Injury, Post Traumatic Stress Disorder
Biological Signatures, Probiotic Among Those With mTBI and PTSD
Exaggerated inflammation in the body and brain is thought to play a role in the vulnerability to and aggravation and perpetuation of adverse consequences among those with co-occurring mild TBI (mTBI) and post-traumatic stress…
- Trial name
- NCT02723344
- Testing
- of Lactobacillus reuteri (L. reuteri; DSM 17938), Sunflower and medium chain triglyceride oils
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- VA Office of Research and Development
Autoimmune Encephalitis, Epilepsy
Acute Sympotomatic Seizure Secondary to Autoimmune Encephalitis and Autoimmune-associated Epilepsy
Previously, scholars called the seizures secondary to autoimmune encephalitis（AE） "autoimmune related epilepsy", but the seizures secondary to AE are usually controlled after the improvement of encephalitis, which does not meet…
- Conditions
- Autoimmune Encephalitis, Epilepsy, Seizures
- Trial name
- NCT05422664
- Testing
- Lacosamide
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Liu Yonghong
Parkinson Disease
Mediterranean Diet Intervention to Improve Gastrointestinal Function in Parkinson's Disease a Randomized, Controlled, Clinical Trial
This is a 10-week randomized, controlled study to investigate the effect of a Mediterranean diet intervention on gastrointestinal function in Parkinson's disease.
- Trial name
- MEDI-PD (NCT04683900)
- Testing
- Standard of care + Mediterranean diet (intervention), Standard of care (control)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Florida
Concussion, Brain, Treatment
Modulating Exercise Dosage to Improve Concussion Recovery
Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects…
- Conditions
- Concussion, Brain, Treatment, Aerobic Exercise, Inflammation
- Trial name
- MEDIC (NCT05434130)
- Testing
- High Dose Exercise
- Where
- 3 sites in United States
- Volunteers
- 178 people
- Sponsor
- University of Colorado, Denver
Sepsis, Trauma Related Injuries
Stratifying Critically Ill Patients for Novel Ferroptosis or Pyroptosis Intervention Strategies
In order to better determine which therapy is best for patiënts which present with organ falure during the course of their stay in the intesive care unit (ICU) , one has to determine which underlying mechanism is causing this…
- Conditions
- Sepsis, Trauma Related Injuries, Subarachnoid Haemorrhage (SAH)
- Trial name
- ICU-FERRO (NCT06928649)
- Testing
- Blood sampling
- Where
- Belgium
- Volunteers
- 600 people
- Sponsor
- University Hospital, Antwerp
Efficacy of Olmesartan on Cerebral Glucose Metabolism in Essential Hypertension
Efficacy of Olmesartan on Cerebral Glucose Metabolism, Vascular Inflammation and Adipose Tissue
Hypertension is a leading risk factor for morbidity and mortality worldwide. The brain is a major target of the damaging effects of hypertension.
- Trial name
- NCT02996916
- Testing
- Olmesartan, Amlodipine
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Kurume University
Multiple Sclerosis, Optic Neuritis, Demyelinating Disease
Visual (Path)Ways in Multiple Sclerosis - Part II
Multiple sclerosis (MS) is an inflammatory demyelinating and degenerative disease of the central nervous system. The mechanisms of neuro-axonal loss remain incompletely elucidated.
- Trial name
- VWIMS - II (NCT06776224)
- Testing
- Measurement of retinal vascular density and visual cognition
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Lille
Intracranial Aneurysm, Aneurysm, Brain
Dimethyl Fumarate Treatment for Intracranial Unruptured Aneurysms.
This study was designed to identify whether there is a measurable reduction in inflammation in walls of intracranial aneurysms with oral dimethyl fumarate.
- Conditions
- Intracranial Aneurysm, Aneurysm, Brain, Inflammation Vascular
- Trial name
- NCT05959759
- Testing
- Dimethyl fumarate
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Obesity, Bariatric Surgery Candidate
Effects of Change in Insulin Resistance and Systemic Inflammation on Brain Structure and Function
Obesity is associated with alterations in brain structure and cognitive impairment and is a risk factor for Alzheimer's disease and vascular dementia.
- Trial name
- NCT03215888
- Testing
- bariatric surgery
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Minnesota
Anti-NMDA Receptor Encephalitis
Antibody-mediated NMDA Receptor Encephalitis: Symptoms, Biomarkers, and Mechanisms of the Prolonged Recovery Stage
The encephalitis mediated by antibodies against the NMDA receptor (NMDARe) predominantly affects young adults and children resulting in severe neurologic and psychiatric deficits.
- Trial name
- AMENDS (NCT06183788)
- Testing
- Remote cognitive rehabilitation program
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Hematopoietic Stem Cell Transplant (HSCT)
Developing Self-Management Interventions After HCT
This is a prospective, longitudinal, observational trial to evaluate quality of life in hematopoietic stem cell transplant survivors.
- Trial name
- NCT03710031
- Testing
- PNS Tracking
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Florida
Tuberculosis, Meningeal, Tuberculosis; Meningitis (Etiology)
Adjunctive Doxycycline for Central Nervous System Tuberculosis
Although tuberculosis is now considered a treatable disease, central nervous system tuberculosis (CNS-TB) when managed with the current standard-of-care (SOC), still has mortality rates ranging from 30-50% even in tertiary…
- Conditions
- Tuberculosis, Meningeal, Tuberculosis; Meningitis (Etiology), Tuberculosis, Central Nervous System, Tuberculosis; Meningoencephalitis (Etiology)
- Trial name
- DIRECT (NCT06446245)
- Testing
- Doxycycline, Anti Tuberculosis Drug, Adjunctive corticosteroid
- Where
- 6 sites in Indonesia, Malaysia and 1 more
- Volunteers
- 200 people
- Sponsor
- National University Hospital, Singapore
Subarachnoid Hemorrhage, Muscle Atrophy
Impact of NMES and HPRO on Recovery After SAH- Pilot Study
The study purpose is to investigate the hypothesis that in adults with SAH, early neuromuscular electrical stimulation (NMES) and high protein supplementation (HPRO) will improve muscle mass, metabolic and inflammatory biomarker…
- Conditions
- Subarachnoid Hemorrhage, Muscle Atrophy, Inflammation, Nutritional and Metabolic Disease
- Trial name
- NCT03201094
- Testing
- Neuromuscular Electrical Stimulation (NMES), High Protein Supplementation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Maryland, Baltimore
Intermediate AMD
A Clinical Trial Evaluating the Safety and Efficacy of a New Light Combination Therapy Addressing Intermediate AMD
The proposed clinical investigation wants primary to validate the safety of the innovative light therapy approach and in second priority provide insight and confirmations on therapeutic effect.
- Trial name
- retinaSEES-PoC (NCT06557369)
- Testing
- reSEES
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Oculox Technologies SA
Japanese Encephalitis
Long Term Persistence and Effect of a Booster Dose of the Japanese Encephalitis Vaccine IC51
The study investigates the long term persistence the Japanese encephalitis vaccine IC51 and the need of a booster dose
- Trial name
- NCT00595270
- Testing
- IC51
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- Valneva Austria GmbH
Multiple Sclerosis, Encephalitis
tDCS and Cognition in Adults With Multiple Sclerosis or Encephalitis
This research is being done to determine whether transcranial direct current stimulation (tDCS) can improve certain mental abilities in individuals with multiple sclerosis (MS) or encephalitis.
- Trial name
- NCT02538094
- Testing
- Anodal Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Johns Hopkins University