Clinical trials: Inflammation Chronic
Chronic Pain, Alcohol Use, Unspecified
St. PETERsburg Pain and Alcohol Intervention With Naltrexone and Gabapentin
This study is a 3-arm pilot, randomized, double-blinded, placebo-controlled study of low-dose naltrexone and gabapentin versus placebo among HIV-positive persons with heavy alcohol use and chronic pain to provide estimates of…
- Conditions
- Chronic Pain, Alcohol Use, Unspecified, HIV Infections
- Trial name
- UH3 (NCT04052139)
- Testing
- Low-dose naltrexone, Gabapentin
- Where
- Russia
- Volunteers
- 45 people
- Sponsor
- Boston Medical Center
Noninvasive Ventilation
The Effects of Nocturnal Non-invasive Ventilation in Stable COPD
Rationale: Application of long-term non-invasive ventilation (NIV) in chronic obstructive pulmonary disease (COPD) patients with chronic hypercapnic respiratory failure (CHRF) has recently been shown to improve outcomes.
- Trial name
- RECAPTURE (NCT03053973)
- Testing
- nocturnal noninvasive ventilation, Standard Care
- Where
- Netherlands
- Volunteers
- 116 people
- Sponsor
- University Medical Center Groningen
Chronic Knee Pain
Effects of Photobiomodulation on Inflammation and Chronic Pain in Knee Osteoarthritis (EPIC-KO)
This study aims to determine analgesic and anti-inflammatory effects of dual-wavelength PBM in people with symptomatic knee OA.
- Trial name
- EPIC-KO (NCT07079969)
- Testing
- Photobiomodulation therapy (PBM) device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Idiopathic Granulomatous Mastitis, Granulomatous Mastitis
GRAnulomatous MAstitis REGistry Study
Idiopathic granulomatous mastitis (IGM) is a rare benign inflammatory breast condition with unknown cause, affecting approximately 2.4 per 100,000 women aged 20-40 years.
- Trial name
- GRAMAREG (NCT07422870)
- Where
- 2 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- European Breast Cancer Research Association of Surgical Trialists
Asthma
Neural Mechanisms in Asthma
Asthma is a chronic disease that affects nearly 13% of adults in the U.S., causing substantial impairment that is reflected in the tens of millions of missed days of work, and doctors' and emergency room visits it leads to…
- Trial name
- NCT01155843
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Chronic Kidney Failure
Palm Tocotrienols in Chronic Hemodialysis (Malaysia) (PATCH)
This study aims to determine if tocotrienol rich fraction (TRF) supplementation can improve markers of inflammation, oxidative stress and blood lipids in Malaysian hemodialysis (HD) patients.
- Trial name
- PATCH (NCT02913690)
- Testing
- TRF
- Where
- 4 sites in Malaysia
- Volunteers
- 336 people
- Sponsor
- Wayne State University
End Stage Renal Disease (ESRD)
Food Preparation Effects on Gut Bacteria in Patients on Peritoneal Dialysis
This is an intervention study of the effects of food preparation on the gut bacteria in patients with end stage renal disease on peritoneal dialysis.
- Trial name
- NCT02467530
- Testing
- AGE
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pancreatitis, Chronic
Tocilizumab for Painful Chronic Pancreatitis
This placebo-controlled study will investigate the effect of tocilizumab (an anti-interleukin-6 receptor antibody) on symptom burden, physical functioning, and quality of life in patients with chronic pancreatitis.
- Trial name
- TOPAC (NCT06426160)
- Testing
- Tocilizumab 20 MG/ML [Actemra], Sodium Chloride 0.9% Inj
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Soren Schou Olesen
Cardiovascular Disease, Chronic Kidney Failure
Effect of HCO1100 on Cardiovascular Function
The purpose of this study is to determine whether high porous membranes are effective in the treatment of cardiovascular events in chronic dialysis patients.
- Trial name
- HicoCARD (NCT01363921)
- Testing
- HCO 1100
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Vantive Health LLC
Hepatitis B Infection, Congenital Malformation
Tenofovir Disoproxil Fumarate in Combination of Hepatitis B Vaccine for Preventing Hepatitis B Vertical Transmission
Immunoprophylaxis with two hepatitis B vaccinations following the hepatitis B immune globulin (HBIg) and hepatitis B vaccine at birth is largely effective in protecting infants from hepatitis B virus (HBV) infection.
- Conditions
- Hepatitis B Infection, Congenital Malformation, Birth Defect, Viremia
- Trial name
- NCT03476083
- Testing
- Tenofovir Disoproxil Fumarate (TDF) 300 mg oral daily.
- Where
- 7 sites in China
- Volunteers
- 280 people
- Sponsor
- New Discovery LLC
Colorectal Cancer
Inflammatory Response in Laparoscopic and Open Colectomy
This study is designed to measure and compare the inflammatory response in laparoscopic and open colon cancer surgery
- Trial name
- NCT00942461
- Testing
- Laparoscopic colectomy, Open colectomy
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- G. Hatzikosta General Hospital
Periodontitis, Chronic, Chewing Problem
Assessment of Masticatory Performance in Periodontitis
The loss of periodontal attachment contributes to reduced masticatory performance and has a negative impact on general health.This clinical trial aims to assess the status of masticatory performance among patients with stage I…
- Conditions
- Periodontitis, Chronic, Chewing Problem, Inflammation
- Trial name
- NCT06426069
- Testing
- Masticatory efficiency assessment
- Where
- India
- Volunteers
- 555 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Exercise, Diet Interventions
Multimodal Intervention for Early Chronic Kidney Disease in Young People: Dysbiosis and Inflammation (CKD)
Chronic kidney disease (CKD) is a progressive condition associated with substantial morbidity, mortality, and healthcare costs. Early detection and timely intervention are critical to modify disease trajectory, particularly in…
- Conditions
- Exercise, Diet Interventions, Symbiotic, CKD Stage 1
- Trial name
- CKD (NCT07483697)
- Testing
- symbiotic
- Where
- Mexico
- Volunteers
- 200 people
- Sponsor
- Centenario Hospital Miguel Hidalgo
Chronic Hepatitis b, Non-alcoholic Fatty Liver Disease
Risk Factors for Hepatic Inflammation, Fibrosis and Prognosis in Patients With CHB and NAFLD
Chronic hepatitis B (CHB) affects an estimated 292 million people, and causes approximately 800,000 people deaths per year from liver-related complications including cirrhosis and hepatocellular carcinoma, remaining a major…
- Trial name
- NCT05766449
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
CIDP - Chronic Inflammatory Demyelinating Polyneuropathy, Guillain-Barré Syndrome (GBS)
Multispectral Optoacoustic Imaging for the Detection of Inflammation and Damage of Peripheral Nerves in Guillain-Barré Syndrome and Chronic Inflammatory Demyelinating Polyneuropathy
The aim of this study is to assess disease activity in patients with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and Guillain-Barré Syndrome (GBS) using multispectral optoacoustic tomography (MSOT).
- Trial name
- MIND (NCT07121985)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Inflammation, End-stage Renal Disease
Use of Telmisartan and Captopril in Inflammation of Hemodialysis Patients
The aim of this study was to compare the dual use of telmisartan and captopril vs the individual use of such drugs and placebo on the systemic inflammation of patients on hemodialysis (HD).
- Trial name
- NCT01271478
- Testing
- Telmisartan plus Captopril
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Chronic Obstructive Pulmonary Disease (COPD), Rheumatoid Arthritis
A Study to Examine the Effect of Particle Size on Bioequivalence and Bioavailability
This study is being conducted to measure the amount of study drug that is in your blood after you receive a different type of tablet in each of four study visits.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Rheumatoid Arthritis, Atherosclerosis
- Trial name
- NCT00517543
- Testing
- GW856553
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COPD, COPD Exacerbation
Evaluation of Eosinophil Phenotype in COPD Patients
This is a pilot non pharmacological observational study. Aim of the study is to analyze the immunophenotype of circulating eosinophils in chronic obstructive pulmonary disease (COPD) patients, and to correlate results with…
- Trial name
- V-FEO (NCT04494308)
- Testing
- biomarker identification
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS San Raffaele Roma
Chronic Hepatitis b, Liver Inflammation
Magnesium Isoglycyrrhizinate Followed by Diammonium Glycyrrhizinate and Combined With Entecavir in Chronic Hepatitis B
This study evaluates the addition of glycyrrhizin to entecavir in the treatment of patients with chronic hepatitis B in China. Half of participants will receive magnesium isoglycyrrhizinate followed by oral diammonium…
- Trial name
- MAGIC-101 (NCT03349008)
- Testing
- Entecavir, Magnesium Isoglycyrrhizinate, Diammonium Glycyrrhizinate
- Volunteers
- 480 people
- Sponsor
- Cttq
Renal Insufficiency, Chronic, Inflammation
Biological Effects of Citrate-buffered Solutions on Dialysis Efficiency and Systemic Inflammation
In this study 45 patients undergoing weekly dialysis for chronic end stage renal disease will be enrolled. The patients will be treated with a standard dialysis solution, containing acetate buffer, for 3 months; subsequently the…
- Trial name
- NCT03577249
- Testing
- Dialysis Solutions
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- A.O.U. Città della Salute e della Scienza