Clinical trials: Inflammation Chronic
Airway Inflammation, Chronic Obstructive Pulmonary Disease (COPD)
Immune Status and Disease Control of Inflammatory Airway Diseases
The goal of this study is to learn how the body's immune system affects disease control in people with different airway inflammatory diseases.We want to understand: 1.Whether specific immune cell patterns in the blood are linked…
- Conditions
- Airway Inflammation, Chronic Obstructive Pulmonary Disease (COPD), Asthma (Diagnosis), Bronchiectasis
- Trial name
- ISDC-IAD (NCT07493629)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Ningbo University
Diabetes, Atherosclerosis
Effects of Sitagliptin on Endothelial Function in Type 2 Diabetes on Background Metformin Therapy
The study is being performed to determine whether sitagliptin, a dipeptidyl peptidase-4 inhibitor, both acutely and chronically improves blood vessel function.
- Trial name
- NCT01859793
- Testing
- sitagliptin
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Medical College of Wisconsin
Restless Legs Syndrome
Gut Microbiota and Bacterial Translocation in Restless Legs Syndrome
Restless Legs Syndrome (RLS) is a common neurological sensorimotor disorder defined by an urge to move the legs when at rest that increase in the evening and at night.
- Trial name
- RLS-BIOT (NCT05985421)
- Testing
- Fecal collection, Blood sampling, Polysomnography
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Stroke, Insulin Resistance
Trial of Aerobic Exercise Training in Stroke Survivors
The purpose of this study is to examine the effects of treadmill training on inflammation in the skeletal muscle and adipose tissue, insulin action in the skeletal muscle, and whole body glucose metabolism in stroke survivors.
- Conditions
- Stroke, Insulin Resistance, Sedentary Lifestyle
- Trial name
- NCT00891514
- Testing
- Aerobic Exercise, Stretching
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Baltimore VA Medical Center
Lymphedema, Seroma
Breaststroke Swimming After Breast Cancer Treatment/Surgery as a Means of Treatment for Seroma, Lymphedema, and Chronic Arm and Chest Pain
Following surgery and treatment for breast cancer, many patients experience swelling of lymph nodes (lymphedema) or accumulation of fluid (seroma) that can cause pain, restrict movement, and reduce quality of life.
- Conditions
- Lymphedema, Seroma, Pain, Postoperative, Pain, Chest
- Trial name
- NCT04080934
- Testing
- Swimming
- Where
- Canada
- Volunteers
- 128 people
- Sponsor
- Ottawa Hospital Research Institute
Apical Periodontitis, Healhty
Inflammation-Related Endothelial Barrier Dysfunction in Patients With Apical Periodontitis
Inflammation is a common factor in chronic periodontitis and systemic diseases. However, to date, there is no scientific evidence supporting a causal effect of inflammation caused by apical periodontitis on endothelial barrier…
- Trial name
- NCT07292363
- Testing
- Apical lesions cure
- Where
- 2 sites in Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Chronic Kidney Disease stage3 and 4, Type 2 Diabetes Mellitus
Pentoxifylline Effect in Patients With Diabetic Nephropathy.(PENFOSIDINE STUDY)
One of the purposes of the management of the patient with chronic kidney disease (CKD)is to slow the decline of renal function. The mechanisms by which the renal function declines involve inflammatory and fibrotic responses due…
- Trial name
- PENFOSIDINE (NCT03664414)
- Testing
- pentoxifylline
- Where
- Mexico
- Volunteers
- 196 people
- Sponsor
- Maria Eugenia Galván Plata
Chronic Kidney Disease
Paricalcitol Over Inflammatory Parameters on Chronical Kidney Disease Patients
Use of Paricalcitol in stage Vd Chronic Kidney Disease patients, over the effect of inflammatory and oxidative stress parameters.
- Trial name
- SENPARIC (NCT01820767)
- Testing
- Paricalcitol, Paricalcitol, atorvastatin, Atorvastatin
- Where
- 2 sites in Spain
- Volunteers
- 31 people
- Sponsor
- Ricardo Mouzo Mirco
Chronic Obstructive Pulmonary Disease (COPD), Chronic Bronchitis
A Phase II, Randomized, Double-blind, Placebo-controlled Study to Assess MEDI3506 in Participants With COPD and Chronic Bronchitis
This is a research study to determine the efficacy and safety of investigational drug MEDI3506 for the treatment of adult participants with Chronic Obstructive Pulmonary Disease and Chronic Bronchitis.
- Trial name
- FRONTIER-4 (NCT04631016)
- Testing
- Tozorakimab
- Where
- 90 sites in United States, Australia and 13 more
- Volunteers
- 137 people
- Sponsor
- AstraZeneca
Emphysema, Pulmonary Disease, Chronic Obstructive
Biomarkers and Genetic Factors Related to Emphysema
Emphysema, a common type of chronic obstructive pulmonary disease (COPD), is a long-term lung disease that is usually caused by cigarette smoking.
- Trial name
- NCT00757120
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- Washington University School of Medicine
End Stage Renal Disease on Dialysis
Dietary Therapy in Dialysis Patients
Patients with end-stage kidney disease have hyperphosphatemia and accumulated uremic toxin level due to decreased urine excretion ability.
- Trial name
- NCT04505462
- Testing
- Therapeutic diet
- Where
- Taiwan
- Volunteers
- 32 people
- Sponsor
- Far Eastern Memorial Hospital
End-Stage Renal Disease
Anti-Cytokine Therapy for Hemodialysis InflammatION
Anti-Cytokine Therapy for Hemodialysis InflammatION (ACTION) is a phase II multi-center study to evaluate the safety and tolerability of anakinra, an IL-1 receptor antagonist, for patients treated with maintenance hemodialysis.
- Trial name
- ACTION (NCT03141983)
- Testing
- Anakinra
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Psoriasis
Effect of Chronic Inflammation on Myocardial Perfusion and Function
Background: Heart failure (HF) is a public health burden. Studies have shown a link between inflammation, myocardial dysfunction, and HF.
- Trial name
- NCT04870827
- Testing
- 13N Amonia
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Kidney Disease and Systemic Inflammation
A Research Study of How the Medicine Ziltivekimab Works in the Body of Chinese Men and Women With Kidney Disease and Inflammation
This study is conducted to see how the ziltivekimab works in the body of Chinese people with chronic kidney disease and systemic inflammation.
- Trial name
- NCT05379829
- Testing
- Ziltivekimab
- Where
- 7 sites in China
- Volunteers
- 24 people
- Sponsor
- Novo Nordisk A/S
Periodontal Inflammation
Saliva Levels of S100A12, CRP, Fetuin-A in Periodontal Disease Patients
Hs-CRP, Fetuin-A and S100A12 are acute phase proteins associated with many systemic diseases and conditions. The aim of this study was to determine the clinical parameters and salivary Hs-CRP, Fetuin-A and S100A12 levels before…
- Trial name
- NCT03345745
- Testing
- salivary samples
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ordu University
Pain
Acupuncture to Reduce Signs of Inflammation in Participants With Chronic Low Back Pain
Background: Acupuncture is a traditional Chinese medical treatment. Thin needles are used to stimulate specific points in the body. Previous studies have found that acupuncture can be useful in treating low back pain.
- Trial name
- NCT01376375
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Long COVID, Post Acute Sequelae of COVID-19
PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
Background: SARS-CoV-2 is the virus that causes COVID-19. Some people who recover from COVID-19 have long-term symptoms that affect the brain.
- Trial name
- NCT06920628
- Testing
- 11C-PS13
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
COPD Exacerbation, Periodontal Health
Efficacy of Periodontal Treatment on Systemic Inflammation and for Prevention of Exacerbations in Patients With COPD
Current data are showing a potential link between inflammatory biomarkers in chronic periodontitis and COPD. However the impact of periodontal treatment on systemic inflammation as measured by biomarkers and time to occurrence of…
- Trial name
- Expertention (NCT03279718)
- Testing
- Periodontal Treatment
- Where
- 3 sites in Germany
- Volunteers
- 4 people
- Sponsor
- Heidelberg University
Ulcerative Colitis, Crohn Disease
Spatially and Temporally Resolving Predictive Biomarkers of Postoperative Recurrence and Complications in Chronic Intestinal Inflammation
A portion of patients with Inflammatory bowel disease often require surgical intervention since they do not respond to the current therapies.
- Trial name
- NCT06516341
- Testing
- CD patients, UC patients
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- IRCCS Ospedale San Raffaele
Obesity, Morbid, NASH - Nonalcoholic Steatohepatitis
Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity
This study is being done to better understand the relationship between inflammation in adipose tissue (AT), abnormal deposition of fat around the liver and how this affects its appearance and function and ultimately insulin…
- Conditions
- Obesity, Morbid, NASH - Nonalcoholic Steatohepatitis, Chronic Inflammation
- Trial name
- NCT04232566
- Testing
- Bariatric surgery
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic