Clinical trials: Inflammation Chronic
Pseudoxanthoma Elasticum
What's Happen Under the Calcification Process in Pseudoxanthoma Elasticum
The investigators hypothesize is that in PXE patients, low grade chronic inflammation could preceed the molecular and the clinical calcification process.
- Trial name
- GOCAPXE (NCT03070860)
- Testing
- PET scan 18-FDG and 18-NAF
- Where
- France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Angers
Chronic Spinal Pain
RTMS and Steroid Joint Steroid Injection in Chronic Spinal Pain
Chronic spinal pain (CSP) is one of the most common chronic pain conditions globally. Steroid joint injections (SJI) are a routine treatment option for patients with CLBP that is recalcitrant to other treatments.
- Trial name
- NCT05840354
- Testing
- Magstim Rapid2
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Chronic Low Back Pain (CLBP)
Brain and Gene Expression Responses to Exercise in Chronic Back Pain
This study is registered retrospectively for transparency. This mechanistic randomized controlled trial examined whether a 14-week supervised physical exercise training program reduces chronic low back pain (CLBP) by modulating…
- Trial name
- CLBPE (NCT07480460)
- Testing
- Supervised physical exercise training
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- McGill University
Latent Tuberculosis, Diabetes Mellitus, Type 2
Impact of LTBI Treatment on Glucose Tolerance and Chronic Inflammation
This study will be investigating the effect of latent tuberculosis infection (LTBI) treatment on glucose tolerance and low-grade inflammation.
- Trial name
- NCT04830462
- Testing
- Rifampicin 300 Mg Oral Capsule, Isoniazid 300 Mg ORAL TABLET
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Herlev and Gentofte Hospital
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease (COPD)
Red Blood Cell and Platelet Indices for Predicting Outcomes in Acute Exacerbations of COPD
The purpose of this study is to evaluate if standard, easily accessible blood tests can help doctors predict the severity and outcomes of sudden flare-ups in patients with Chronic Obstructive Pulmonary Disease (COPD).
- Conditions
- Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease (COPD), AECOPD
- Trial name
- NCT07693127
- Volunteers
- 50 people
- Sponsor
- Assiut University
Obesity, Sarcopenia
Pilot Study of the Human Metagenome in Metabolic Diseases
This is a cohort study to understand the role of the human metagenome, and associated metabolites, in health and in various diseased states, in particular obesity as well as sarcopenia.
- Conditions
- Obesity, Sarcopenia, Sarcopenic Obesity, Chronic Inflammation
- Trial name
- NCT06363253
- Testing
- No specific intervention
- Where
- Singapore
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Sengkang General Hospital
Chronic Kidney Disease
Determinants of Muscle Strength in Chronic Kidney Disease
Aim of this study is to determine in chronic kidney disease patients: the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle…
- Trial name
- NCT02806089
- Testing
- Handheld dynamometer, Creatinine index, Electrical bioimpedance analysis
- Where
- 3 sites in France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Montpellier
Neuroinflammatory Response, Nerve Injury
Assessment of Nerve Damage Biomarkers in Acute and Chronic Organophosphate Toxicity
The aim of this observational study is to answer the following questions in individuals with acute and chronic exposure to organophosphates. The main questions to be addressed are 1.
- Conditions
- Neuroinflammatory Response, Nerve Injury, Nerve Damage, Neurotoxicity
- Trial name
- NCT06021262
- Testing
- exposure to organophosphates
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Abnormality, Inflammation
High-Field MRI Characterization of Wrist and Hand Cartilage Abnormalities in Inflammatory and Chronic Rheumatisms
The present project aims at evaluating the diagnostic potential of high-field MRI (3 Teslas) for joint disease. At this field, given that isotropic image resolution of 400 microns can be obtained, one could expect an early…
- Conditions
- Abnormality, Inflammation, Rheumatism
- Trial name
- NCT01058161
- Testing
- high-field MRI (3 Teslas)
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Chronic Low Back Pain
Periduroscopy: Correlation Between the Outcome of Procedure and Histological-biochemical, Neuroinflammation and Genetic Factors.
It is still unknown the pathogenesis of low back pain and a lot of hypothesis were discussed for a long time. Because non-invasive imaging modalities greatly underestimate the prevalence of epidural pathogenesis an endoscopic…
- Trial name
- NCT02076035
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- University of Parma
Cardiomyopathy, Heart Failure
International T1 Multicentre CMR Outcome Study
Myocardial fibrosis is the fundamental substrate for the development of heart failure. Cardiovascular magnetic resonance (CMR) allows non-invasive assessment of myocardial fibrosis based on late gadolinium enhancement (LGE) and…
- Conditions
- Cardiomyopathy, Heart Failure, Coronary Artery Disease, Chronic Kidney Diseases
- Trial name
- T1-CMR (NCT02407197)
- Where
- 4 sites in Australia, Germany and 1 more
- Volunteers
- 1,629 people
- Sponsor
- King's College London
Long COVID
Clinical Trial on a Natural Compound to Improve Chronic Inflammation After SARS-CoV-2 Infection
A controlled, randomized clinical trial is proposed to demonstrate the effectiveness of the experimental product in controlling hepato-pulmonary inflammation and neurovascular encephalic inflammation, which may constitute the…
- Trial name
- NUTRACOVID (NCT07397910)
- Testing
- Experimental Product, Physical exercise, No Physical Exercise
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad Católica San Antonio de Murcia
Rheumatoid Arthritis, Chronic Periodontitis
Impact of Photodynamic Therapy as an Adjunct to Non-surgical Periodontal Treatment on Clinical and Biochemical Parameters Among Patients Having Mild Rheumatoid Arthritis With Periodontitis
Purpose: To evaluate the efficacy of photodynamic therapy (PDT) as an adjunct to non-surgical periodontal therapy on the clinical periodontal and biochemical parameters among patients with rheumatoid arthritis (RA) having…
- Trial name
- NCT05122117
- Testing
- Methylene blue mediated Photodynamic therapy, Non-surgical periodontal therapy
- Where
- Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- Zohaib Akram
Cardiovascular Risk, Chronic Kidney Disease
ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation
This study is conducted to see if ziltivekimab reduces the risk of having cardiovascular events (for example heart attack and stroke) in people with cardiovascular disease, chronic kidney disease and inflammation.
- Conditions
- Cardiovascular Risk, Chronic Kidney Disease, Inflammation
- Trial name
- ZEUS (NCT05021835)
- Testing
- Ziltivekimab B, Ziltivekimab C
- Where
- 1,073 sites in United States, Argentina and 36 more
- Volunteers
- 6,385 people
- Sponsor
- Novo Nordisk A/S
Obesity
Ginger Capsules for the Chronic Treatment of Obesity
Regarding its complex pathogenesis and clinic-epidemiological meaning, different strategies are needed for the treatment of obesity.
- Trial name
- NCT02742194
- Testing
- Dry extract of ginger
- Where
- Brazil
- Volunteers
- 84 people
- Sponsor
- Federal University of Minas Gerais
Pulmonary Disease, Chronic Obstructive
Depemokimab as an Extended Treatment Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation
Depemokimab is being developed as a treatment for individuals with moderate to severe COPD. The aim of this study is to assess the efficacy and safety of depemokimab as an add-on medicine in participants with uncontrolled…
- Trial name
- ENDURA-1 (NCT06959095)
- Testing
- Depemokimab
- Where
- 281 sites in United States, Argentina and 21 more
- Volunteers
- 981 people
- Sponsor
- GlaxoSmithKline
CIDP, Chronic Inflammation
Ultrasound-driven Stratification in CIDP
Chronic inflammatory demyelinating polyradiculoneuritis (CIDP) is a rare autoimmune neuropathy characterized by significant clinical and therapeutic heterogeneity.
- Conditions
- CIDP, Chronic Inflammation, Demyelinating Polyneuropathy
- Trial name
- TAILOR-CIDP (NCT07719153)
- Testing
- Refractory CIDP, Standard-of-care treatment for CIDP
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Arthritis, Rheumatoid, Inflammation
A Study To Look At The Safety Of SB-681323 In Healthy Adult Subjects After Intravenous Administration Of A Single Dose
SB-681323 inhibits the action of an enzyme which is known to contribute to the inflammation seen in such conditions as Chronic Obstructive Pulmonary Disease and Rheumatoid Arthritis.
- Trial name
- NCT00439881
- Testing
- SB-681323
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Heart Failure, Heart Failure Preserved Ejection Fraction
Exercise, Mediterranean Diet and Inflammation in Heart Failure
This randomized clinical trial will test whether a multimodal anti-inflammatory program added to standard treatment improves the prognosis of patients with heart failure who have recently been hospitalized or visited the…
- Conditions
- Heart Failure, Heart Failure Preserved Ejection Fraction, Heart Failure, Diastolic (HFpEF), Chronic Inflammation
- Trial name
- FLARE-HF (NCT07885514)
- Testing
- Structured exercise training program, Mediterranean diet counseling, Standard heart failure management
- Volunteers
- 214 people
- Sponsor
- Hospital Severo Ochoa
Chronic Obstructive Pulmonary Disease (COPD)
Evaluation of the Effect of PUR118 on Ozone Induced Airway Inflammation in Healthy Normal Volunteers
This trial in healthy subjects will assess PUR118's effect on attenuating ozone induced airway inflammation. This trial will establish the tolerability of PUR118 in healthy normal volunteers.
- Trial name
- NCT01690949
- Testing
- PUR118
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pulmatrix Inc.