Clinical trials: Inflammation Chronic
Pulmonary Disease, Chronic Obstructive
Effects of Liraglutide in Chronic Obstructive Pulmonary Disease
The study is a 44 weeks, prospective, randomized, placebo-controlled, double-blinded, parallel group two-center trial. Forty patients are recruited among the outpatients of the chronic obstructive pulmonary disease (COPD) clinic…
- Trial name
- NCT03466021
- Testing
- Liraglutide
- Where
- 2 sites in Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Claus Bogh Juhl
Colitis
Syndecan 1 as Biomarker for Inflammation
The aim of the study is to evaluate the soluble biomarker syndecan-1 (sSdc1) taken from venous blood of patients with infectious intestinal diseases such as Clostridium difficile-associated colitis, bacterial colitis, Norovirus…
- Trial name
- NCT02333526
- Where
- 2 sites in Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Helios Albert-Schweitzer-Klinik Northeim
Chronic Liver Disease and Cirrhosis
Immunological Measurement of Aspartate/Alanine Aminotransferase
Previous reports have suggested that ALT-immunoglobulin complex was increased according to the severity of the liver disease, and high concentration of mAST and this might indicate a severely damaged liver.
- Trial name
- NCT03562585
- Testing
- with sandwich ELISA immunoassay with fluorescence labeled monoclonal antibodies
- Volunteers
- 219 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Asthma, COPD
A Comparison of Two Nebulisers for Sputum Induction
Sputum induction is considered a relatively non-invasive, reliable procedure, which can be utilised to characterise the inflammatory profile of the airways. However, the procedure can be slightly uncomfortable for patients.
- Trial name
- FLAME (NCT04182009)
- Testing
- Omron NE-U17 Ultrasonic nebuliser, Akita Jet Inhalation System
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- University of Nottingham
Polycystic Ovary Syndrome
Effects of Metformin vs Oral Contraceptives on CV Risk Markers in PCOS
Cardiovascular risk factors cluster in hyperandrogenic women - including those presenting with the polycystic ovary syndrome - in association with insulin resistance, obesity, and other metabolic disorders.
- Trial name
- NCT00428311
- Testing
- Metformin, Ethynyl-estradiol plus cyproterone acetate
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Ramon y Cajal
The Efficacy and Safety for Super High-flux Dialyzer in Case of Sepsis in ESKD, End Stage Kidney Disease (ESRD)
Comparing Super High-flux and High-flux Dialyzer Performance Among Hemodialysis Patient With Sepsis : a Randomized Control Trial
Comparing the efficacy of superhigh-flux dialyzer with high-flux dialyzer in ESKD patient who have sepsis to improve mortality and sepsis outcome, an open label randomized control trial.
- Conditions
- The Efficacy and Safety for Super High-flux Dialyzer in Case of Sepsis in ESKD, End Stage Kidney Disease (ESRD), Sepsis
- Trial name
- NCT06989892
- Testing
- Super High-flux dialyzer (Elisio 19HDx), High-flux dialyzer (Elisio 19H)
- Where
- Thailand
- Volunteers
- 202 people
- Sponsor
- Navamindradhiraj University
Acute Liver Failure
ALSS - DPMAS and Therapeutic Plasma Exchange (TPE), Its Effect on Primary Coagulation, Inflammation and the Function of Vital Organs in ALF or ACLF
The artificial liver support system (ALSS) in patients with acute on chronic liver failure - the use of combined molecular adsorption system with double plasma (DPMAS) and therapeutic plasma exchange (TPE), its effect on primary…
- Trial name
- NCT07329036
- Testing
- The artificial liver support system (ALSS) - DPMAS/TPE
- Where
- Czechia
- Volunteers
- 25 people
- Sponsor
- Institute for Clinical and Experimental Medicine
HIV Infection, Diabetes Mellitus Type 2
Liraglutide for HIV-associated Neurocognitive Disorder
This study will test the effect of liraglutide on cognitive function in HIV-infected overweight or obese subjects with type 2 diabetes.
- Conditions
- HIV Infection, Diabetes Mellitus Type 2, Obesity, Overweight
- Trial name
- NCT02743598
- Testing
- Liraglutide
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Temple University
Sickle Cell Disease
Cannabinoids for the Reduction of Inflammation and Sickle Cell Related Pain
A randomized, double blind, study of dronabinol as a palliative agent in the treatment of pain, inflammation, and other complications of sickle cell disease (SCD).
- Trial name
- CRISP (NCT05519111)
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Kidney Disease, Hemodialysis
Red Blood Cell Lifespan
Background: A low amount of red blood cells in the blood of patients with limited kidney function is a well known problem. Besides the lack of substances in the blood like iron or erythropoietin the shortened survival of red…
- Trial name
- RBC (NCT01462071)
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Renal Research Institute
Autoimmune Lymphoproliferative Syndrome, Autoimmune Cytopenia
Conception of a Diagnosis, Prognosis and Therapeutic Decision Tool for Patients With Autoimmunity and Inflammation
The main objective of this study is to generate diagnosis and therapeutic-decision tools through the identification of molecular causes of PIDs with autoimmunity/inflammation and the variability in disease outcome at the…
- Conditions
- Autoimmune Lymphoproliferative Syndrome, Autoimmune Cytopenia, Autoimmune Diseases, Autoimmune Anemia
- Trial name
- ATRACTion (NCT04902807)
- Testing
- Collection of samples
- Where
- France
- Volunteers
- 325 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
End Stage Renal Disease (ESRD), End Stage Kidney Disease (ESRD)
Effect of a Plant-Focused Diet on Nutritional Status in Malnourished Peritoneal Dialysis Patients
The goal of this clinical trial is to determine whether a plant-focused diet improves nutritional and health outcomes of malnourished adults undergoing peritoneal dialysis (PD).
- Conditions
- End Stage Renal Disease (ESRD), End Stage Kidney Disease (ESRD), Peritoneal Dialysis (PD), Malnourished
- Trial name
- NCT07157397
- Testing
- Plant-Focused Diet Counselling, Standard Renal Diet Counselling
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- National University of Malaysia
Hemodialysis-Associated Pruritus, Malnutrition-Inflammation-Cachexia Syndrome
Investigation of the Effects of Medium Cut-off Dialyzers Versus High-Flux Dialyzers on Clinical and Laboratory Parameters of Prevalent Hemodialysis Patients
In this study, the investigators aimed to observe the effects of medium cut-off dialysis filters and high-flux dialysis filters on malnutrition inflammation score, uremic itching, restless leg syndrome, anemia, and ESA treatment…
- Conditions
- Hemodialysis-Associated Pruritus, Malnutrition-Inflammation-Cachexia Syndrome, Restless Legs Syndrome, Anemia of Chronic Kidney Disease
- Trial name
- NCT05698420
- Testing
- Dialysis using the Theranova-400 device., Dialysis using the FX80 device.
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Oxidative Stress, Inflammation
CoQ10 Biomarker Trial
The investigators believe that relieving the oxidative stress experienced by hemodialysis patients may help improve cardiovascular health.
- Conditions
- Oxidative Stress, Inflammation, Endothelial Dysfunction
- Trial name
- NCT01408680
- Testing
- Coenzyme Q10
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Washington
End Stage Renal Disease, Inflammation
A Study Evaluating the Association of Inflammation With Hemodialysis Access Type
To determine if the type of hemodialysis vascular access correlates with markers of inflammation, namely C-reactive protein and interleukin-6, and with both access and patient survival in the end stage renal disease population.
- Trial name
- NCT01011985
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Montefiore Medical Center
Cancer-related Fatigue
The Effects of a Food Product Containing Mushroom Extracts (AndoSanTM) in Subjects With Colorectal Cancer-related Fatigue
Effects of a food product containing mushroom extracts (AndoSanTM) in subjects with colorectal cancer-related fatigue. AndoSanTM is a specialized liquid food product that includes fermented extracts from the fungi Agaricus…
- Trial name
- NCT06599710
- Testing
- AndoSanTM
- Where
- 3 sites in Germany
- Sponsor
- Mycotech Pharma AS
Inflammation, End-stage Renal Disease
Use of Telmisartan and Captopril in Inflammation of Hemodialysis Patients
The aim of this study was to compare the dual use of telmisartan and captopril vs the individual use of such drugs and placebo on the systemic inflammation of patients on hemodialysis (HD).
- Trial name
- NCT01271478
- Testing
- Telmisartan plus Captopril
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Coronary Artery Disease, Atherosclerosis, Coronary
HIV Infection And Evolvement of Atherosclerotic Plaque
In a prospective multi-center observational study, 200 HIV-infected patients treated with antiretroviral treatment (ART) and who suffered from coronary artery disease (CAD) will be enrolled.
- Conditions
- Coronary Artery Disease, Atherosclerosis, Coronary, Hiv, HIV Infections
- Trial name
- HIVE (NCT04810364)
- Testing
- Quantitative coronary angiography, intravascular imaging with percutaneous intervention
- Where
- 2 sites in Russia
- Volunteers
- 1,000 people
- Sponsor
- Central Clinical Hospital of the Russian Academy of Sciences
IBS - Irritable Bowel Syndrome, Ulcerative Colitis
The IMAGINE-SPOR CIHR Chronic Disease Network
The IMAGINE Cohort Study will identify and recruit a cohort of 8000 patients with IBS, IBD and healthy controls (2000 of each) who will be assessed in terms of their psychological status, dietary intake, gut microbiome…
- Conditions
- IBS - Irritable Bowel Syndrome, Ulcerative Colitis, Crohn Disease, Healthy
- Trial name
- IMAGINE (NCT03131414)
- Testing
- Diet, Gastrointestinal microbiome
- Where
- Canada
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Autoimmune Diseases, Lupus Erythematosus, Systemic
Comparative Autoantibody and Immunologic Cell Marker Study
The purpose of this study is to compare immune phenotype, function, and specificity of B lymphocytes from different developmental stages in autoimmune patients to B cells from infectious disease patients and healthy controls.
- Conditions
- Autoimmune Diseases, Lupus Erythematosus, Systemic, Communicable Diseases
- Trial name
- NCT02422875
- Where
- 3 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Emory University