Clinical trials: Inflammation Chronic
HIV Infections, Dyslipidemias
Efprezimod Alfa (CD24Fc, MK-7110) Administration to Decrease Low-Density Lipoprotein (LDL) and Inflammation in Human Immunodeficiency Virus (HIV) Patients (CALIBER) (MK-7110-003)
This is a phase 2, randomized, double-blinded, placebo-controlled clinical trial. The intervention drug will be efprezimod alfa (intravenous [IV] infusion).
- Trial name
- CALIBER (NCT03960541)
- Testing
- Efprezimod alfa (human CD24 extracellular domain and human IgG1 Fc fusion protein), Saline Solution
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Oncoimmune, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
HIV-1-infection, Inflammation
The MISTRAL Study: Gut Microbiome Correlates of Serious AIDS and Non-AIDS Events
MISTRAL (Microbiome-based stratification of individuals at risk of HIV-1 acquisition, chronic clinical complications, antimicrobial drug resistance, and unresponsiveness to therapeutic HIV-1 vaccination) is a 5-year EU Horizon…
- Conditions
- HIV-1-infection, Inflammation, AIDS
- Trial name
- MISTRAL (NCT05421286)
- Where
- 22 sites in Belgium, Croatia and 9 more
- Volunteers
- 991 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Knee Pain
Effects of Photobiomodulation on Inflammation and Chronic Pain in Knee Osteoarthritis (EPIC-KO)
This study aims to determine analgesic and anti-inflammatory effects of dual-wavelength PBM in people with symptomatic knee OA.
- Trial name
- EPIC-KO (NCT07079969)
- Testing
- Photobiomodulation therapy (PBM) device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Complications of Injectable Permanent Synthetic Fillers
Natural History of Injectable Permanent Synthetic Filler Disease
Injectable permanent synthetic filler disease is characterized by heterogeneous local and systemic manifestations that may emerge years after filler injection.
- Trial name
- NCT07867353
- Where
- Colombia
- Volunteers
- 450 people
- Sponsor
- Research Inc
Pain
Acupuncture to Reduce Signs of Inflammation in Participants With Chronic Low Back Pain
Background: Acupuncture is a traditional Chinese medical treatment. Thin needles are used to stimulate specific points in the body. Previous studies have found that acupuncture can be useful in treating low back pain.
- Trial name
- NCT01376375
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Migraine
Efficacy of Anti-IL-6 Treatments on Migraine in Patients Treated With Anti-IL-6 for a Rheumatological Condition
Migraine affects approximately 15% of the global population. Its prevalence doubles or even triples in individuals with chronic inflammatory conditions, such as chronic inflammatory rheumatic diseases (34%), multiple sclerosis…
- Trial name
- RHUMIL-6 (NCT07598045)
- Testing
- Migraine assessement, Patient Global Impression of Change
- Where
- France
- Volunteers
- 320 people
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Cough
A Clinical Trial to Evaluate the Safety and Efficacy in Subjects With Chronic Cough
A Randomized, Double-Blind, Placebo-Controlled, Two-Period Crossover, Phase 2 Clinical Trial to Evaluate the Safety, Tolerability, and Efficacy of ADX-629 Administered Orally to Subjects with Chronic Cough
- Trial name
- NCT05392192
- Testing
- ADX-629
- Where
- 14 sites in United States
- Volunteers
- 51 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Graft-versus-Host Disease, Stomatitis
Effectiveness of Topical Thalidomide to Treat Chronic Graft-Versus-Host-Disease Related Stomatitis
This study was designed to be conducted in 2 parts. The first part is a pilot study to test the effects of topical thalidomide gel 20mg applied to up to 3 oral ulcers in patients who have developed oral chronic…
- Trial name
- NCT00075023
- Testing
- Thalidomide Gel
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Nursing Research (NINR)
Inflammation, Inflammatory Response
Effects of Multimodal Analgesia on Serum MCP-1, BDNF, and MiRNA-124 in Hysterectomy Surgery
The inflammatory process is the main mechanism in the occurrence of acute postoperative pain. It is also the main risk for the development of acute pain into persistent pain.
- Conditions
- Inflammation, Inflammatory Response, Acute Pain, Chronic Pain
- Trial name
- NCT05069311
- Testing
- Multimodal analgesia, Conventional intravenous analgesia
- Where
- Indonesia
- Volunteers
- 62 people
- Sponsor
- Udayana University
Obesity
Anti-obesity Pharmacotherapy and Inflammation
This study evaluates the relationship between weight loss, circulating inflammatory markers and lipids from 24 patients before and after 6 months of pharmacotherapy as a standard of care for anti-obesity treatment
- Trial name
- NCT05756764
- Testing
- Semaglutide, Phentermine-Topiramate combination, Phentermine
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Prematurity; Extreme
Risk of Chronic Diseases in Young Adults Born Preterm: Relationship With Inflammation and Oxidative Stress Biomarkers.
The purpose of the HAPI project is to study the overall health of preterm infants once they reach adulthood. The investigators would like to compare the health of adults born preterm with that of adults born full-term.
- Trial name
- NCT03261609
- Testing
- preterm birth
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Chronic Inflammation, Mobility
Effect of Maolactin™ FMR on Exercise Recovery, Inflammation and Muscle Comfort in an Otherwise Healthy Population
This is a double blind, randomised, placebo-controlled, parallel-group trial to evaluate the effect of Maolactin FMR supplementation on chronic inflammation, mobility and muscle and joint pain in an otherwise healthy population…
- Conditions
- Chronic Inflammation, Mobility, Muscle Pain, Joint Pain
- Trial name
- NCT06444763
- Testing
- Maolactin, Maltodextrin
- Where
- Australia
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- RDC Clinical Pty Ltd
Renal Insufficiency, Chronic
Interleukin-1 Trap to Treat Vascular Dysfunction in Chronic Kidney Disease (CKD)
Risk of cardiovascular diseases (CVD) is significantly elevated in patients with chronic kidney disease (CKD); however, this increased risk is only partially explained by traditional cardiovascular risk factors.
- Trial name
- NCT01663103
- Testing
- Rilonacept
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- University of Colorado, Denver
Arterial Hypertension, Atherosclerosis Occlusive Disease
Gut Microbiota in Chronic Noncommunicable Diseases
It is an observational study in patients with chronic noncommunicable diseases (i.e. cardiovascular diseases, diabetes mellitus, non-alcoholic fatty liver disease, chronic obstructive pulmonary disease and asthma ) and control…
- Conditions
- Arterial Hypertension, Atherosclerosis Occlusive Disease, Heart Failure With Preserved Ejection Fraction, Heart Failure With Reduced Ejection Fraction
- Trial name
- NCT04820556
- Where
- 2 sites in Russia
- Volunteers
- 1,084 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Hemodialysis, Chronic Kidney Disease
Effect of Parenteral Iron Therapy on Inflammatory Response and Oxidative Stress Chronic Hemodialysis
Parenteral iron therapy is now commonly administered to dialysis patients with the majority of patients receiving this therapy as part of the treatment for their anemia.
- Conditions
- Hemodialysis, Chronic Kidney Disease, Inflammation
- Trial name
- NCT00583973
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of California, Davis
End Stage Renal Disease, Chronic Kidney Disease Requiring Chronic Dialysis
Pumpkin Seed Oil as a Nutraceutical for Hemodialysis Patients
Patients with end-stage renal disease (ESRD) on maintenance hemodialysis experience chronic systemic inflammation, oxidative stress, and dyslipidemia, which together drive much of the excess cardiovascular morbidity and mortality…
- Conditions
- End Stage Renal Disease, Chronic Kidney Disease Requiring Chronic Dialysis, Inflammation, Oxidative Stress
- Trial name
- NCT07710183
- Testing
- Pumpkin Seed Oil 1000 mg, Standard hemodialysis care
- Where
- Iraq
- Volunteers
- 100 people
- Sponsor
- Al-Mustansiriyah University
COPD Acute Exacerbation
Rademikibart Add-on Treatment of an Acute COPD Exacerbation (Seabreeze STAT COPD)
This is a Phase 2, multicenter study in adult participants with an acute COPD exacerbation and type 2 inflammation
- Trial name
- NCT06940154
- Testing
- Rademikibart in prefilled syringe
- Where
- 52 sites in United States, Argentina and 4 more
- Volunteers
- 159 people
- Sponsor
- Connect Biopharm LLC
Heart Failure With Reduced Ejection Fraction
Comparison of Effects of Atorvastatin Versus Rosuvastatin on Cardiac Function in Heart Failure Patients
Statins have a protective effect in patients with established heart failure because of their lipid-lowering and pleiotropic effects.
- Trial name
- ASTRO-CHF (NCT05072054)
- Testing
- Atorvastatin Oral Tablet, Rosuvastatin Oral Tablet
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Chronic Infections and Inflammation in ME/CFS: An Observational Study
CHIIME is a study of people who have myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). People who do not have this condition will also be enrolled.
- Trial name
- CHIIME (NCT07227441)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Hidradenitis Suppurativa (HS)
Tibulizumab Skin Healing and Inflammation Evaluation for Lasting Defense
The study is a Phase 2, multi-center, randomized, double-blind, placebo-controlled study to evaluate the effects of tibulizumab over 16 weeks (Period 1) in adults with hidradenitis suppurativa, followed by a 16-week open-label…
- Trial name
- TibuSHIELD (NCT06993610)
- Testing
- Tibulizumab Dose A, Tibulizumab Dose B
- Where
- 61 sites in United States, Canada and 4 more
- Volunteers
- 247 people
- Sponsor
- Zura Bio Inc