Clinical trials: Inflammation Function
Inflammatory Response, Metabolic Disturbance
Astaxanthin, Exercise Inflammation, Skin Health
Vigorous exercise can stress the body. Consuming special types of diet supplements may help the body recover better from exercise.
- Conditions
- Inflammatory Response, Metabolic Disturbance, Immune Suppression
- Trial name
- NCT05409092
- Testing
- Astaxanthin
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Rheumatoid Arthritis, Cardiovascular Diseases
NSAIDs vs. Coxibs in the Presence of Aspirin
The objectives of this single site, randomized, crossover study is to evaluate the pharmacodynamic interactions between aspirin, NSAIDs and Coxibs with respect to platelet function, biomarkers of inflammation and endothelial…
- Trial name
- NCT03699293
- Testing
- celecoxib 200mg capsule, naproxen sodium 550mg tablet, Aspirin 81mg tablet
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Platelet and Thrombosis Research, LLC
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Analysis of Microbiota Changes Induced by Microencapsulated Sodium Butyrate in Patients With Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is characterized by severe inflammation of the small bowel and/or the colon leading to recurrent diarrhea and abdominal pain.
- Trial name
- IBDMicro (NCT04879914)
- Testing
- Butyrate
- Where
- Italy
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Padova
Longevity, Healthy Aging
Collagen Peptides and Cellular Aging
The goal of this clinical trial is to learn if daily collagen peptide supplementation can stabilize or lengthen telomeres and improve related markers of cellular aging in adults aged 50-70 years with overweight and…
- Conditions
- Longevity, Healthy Aging, Biological Ageing
- Trial name
- NCT07456449
- Testing
- Collagen peptides
- Where
- Austria
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Septic Shock, Acute Kidney Injury
Personalized Mean Arterial Pressure Management on Renal Function During Septic Shock
Sepsis is the most severe complication of infections. Sepsis-associated Acute kidney injury (AKI) is commonly encountered in critically ill patients and independently predicts poor outcome.
- Trial name
- DORESEP (NCT01473498)
- Testing
- Haemodynamic management
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Modes of Exercise and Myocardial and Endothelial Function, Microcirculation
Investigation of Cardiac Function and Cardiovascular Risk Factors in Marathon Runners- The Munich Marathon Study
The purpose of this study is to determine the cardiovascular risk involved in the exertional exercise of marathon running. The researchers aim to investigate the beneficial effects of regular well-dosed exercise on health and…
- Conditions
- Modes of Exercise and Myocardial and Endothelial Function, Microcirculation, Subclinical Endorgan Damage, Obesity
- Trial name
- MMS (NCT00500773)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Schizophrenia
Anti-inflammatories and Adolescent Schizophrenia
A double-blind controlled trial assessing the efficacy of anti-inflammatories on symptoms and cognition of adolescents with schizophrenia
- Trial name
- NCT04020588
- Testing
- Celecoxib 200mg, Minocycline 100mg
- Where
- Mexico
- Volunteers
- 90 people
- Sponsor
- Hospital Psiquiatrico Infantil Dr. Juan N. Navarro, Mexico
Metabolic Syndrome
Effect of Brown Rice on the Risk Factors for Metabolic Syndrome
The purpose of the study is to determine the effect of consumption of brown rice on the risk factors of metabolic syndrome (MetS) as compared to consumption of white rice.
- Trial name
- NCT02321553
- Testing
- Brown rice, White rice
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Tufts University
HIV, Cardiovascular Diseases
Evaluating the Effectiveness of Pentoxifylline at Improving Blood Vessel Function in HIV-infected People Not Receiving Antiretroviral Medications
People infected with HIV have a greater risk of developing cardiovascular disease than people not infected with HIV. This may be due to increased inflammation brought on by either the HIV infection itself or the use of…
- Conditions
- HIV, Cardiovascular Diseases, Atherosclerosis
- Trial name
- NCT00796822
- Testing
- Pentoxifylline
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Indiana University
Diabetes Mellitus, Insulin-Dependent, Hypercholesterolemia
Statins in Children With Type 1 Diabetes and Hypercholesterolemia
Children with type1 diabetes (T1DM) have increased risk for cardiovascular disease (CVD) due to chronic increase in the blood sugars and inflammation.
- Trial name
- NCT01236365
- Testing
- Atorvastatin
- Where
- 5 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Septic Shock
Transcutaneous Electric Muscle Stimulation (TEMS) in Septic Patients
A growing number of critically ill patients survive intensive care to be discharged from hospital. However, critical illness and prolonged bedrest are associated with muscle wasting with subsequent implications for recovery of…
- Trial name
- NCT01071343
- Testing
- Transcutaneous electrical muscle stimulation
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Peripheral Neuropathic Pain
Gabapentin and Pregabalin Effects on Inflammation and Cardiac Function in Peripheral Neuropathic Pain
This prospective, controlled, observational cohort study will evaluate short-term changes in inflammatory biomarkers and subclinical cardiac function in adults with peripheral neuropathic pain who are prescribed gabapentin or…
- Trial name
- NCT07755514
- Testing
- Gabapentin, Pregabalin
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Giresun University
Psoriasis, Psoriatic Arthritis
SystemIc iNflammation and Microvascular diSease PreventIon in psoRiatic diseasE
This is a single-label open-arm mechanistic clinical study recruiting patients with psoriasis or psoriatic arthritis with elevated cardiovascular risk.
- Conditions
- Psoriasis, Psoriatic Arthritis, Cardiovascular Risk Factor
- Trial name
- INSPIRE (NCT04417114)
- Testing
- Rosuvastatin
- Sponsor
- Brigham and Women's Hospital
Allergic Asthma
A Study to Evaluate the Effect of Roflumilast on Airway Inflammation and Function Following Allergen Challenge in Subjects With Allergic Asthma
The study was a double-blind, placebo-controlled, crossover study to evaluate the efficacy of roflumilast on airway inflammation and function in patients with allergen-induced asthma.
- Trial name
- NCT01365533
- Testing
- Roflumilast
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- AstraZeneca
Vascular Health, Autonomic Function
Vascular and Neuro-inflammatory Effects of Endurance Exercise Training in African Americans
The purpose of this study is to test the effects of endurance exercise training on arterial structure and function, and to examine potential mechanisms producing changes in arterial structure and function in young (18-35 years of…
- Trial name
- VINE (NCT01024634)
- Testing
- Endurance Exercise
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Peripheral Vascular Disease
Observing the Role of Inflammation in Peripheral Artery Disease and Its Impact on Heart and Mobility Health: PANACEA-O.
This registry aims to collect detailed information about people in Canada who have Peripheral Artery Disease (PAD) and are receiving care in heart clinics while still able to walk and live in the community.
- Trial name
- PANACEA-O (NCT07500610)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Cardiology Research UBC
Primary Prevention
Genetical, Anthropometrical and Biochemical Factors Influencing High Risk Subclinical Atherosclerosis
Subclinical atherosclerosis is the atherosclerotic process identified before clinical symptoms and thus it can be a useful marker of future cardiovascular events. It can be evaluated by many methods.
- Trial name
- NCT02487615
- Where
- 2 sites in Brazil
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Cardiovascular Health
Pilot Study of Oligonol Supplementation to Promote Cardiovascular Health
The investigators hypothesize that acute consumption of Oligonol, a patented lychee fruit extract (Amino Up Chemical Co.) particularly rich in low molecular weight flavanols, will improve endothelial function, reduce platelet…
- Trial name
- NCT01162174
- Testing
- Oligonol
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
SIRS, Sepsis
NT-proBNP in ICU Postoperative/Posttraumatic Patients With Shock
The purpose of this study is to determine the course of NT-proBNP plasma concentrations in the context of confounding parameters in postoperative/posttraumatic critically ill patients with severe SIRS/sepsis and shock.
- Conditions
- SIRS, Sepsis, Shock, Critically Ill
- Trial name
- NICUPS (NCT00736723)
- Where
- Germany
- Volunteers
- 51 people
- Sponsor
- University of Ulm
Obesity, Bariatric Surgery Candidate
Effects of Change in Insulin Resistance and Systemic Inflammation on Brain Structure and Function
Obesity is associated with alterations in brain structure and cognitive impairment and is a risk factor for Alzheimer's disease and vascular dementia.
- Trial name
- NCT03215888
- Testing
- bariatric surgery
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Minnesota