Clinical trials: Inflammation Function
Metabolic Diseases, Endocrine System Diseases
Effect of Fish Oil (Omega-3 Fatty Acids) on Arteries
The overall objective of LUCHAR Specific Aims 4.1 and 4.2 is to assess the additional contribution of cardiovascular disease (CVD) risk markers to traditional biomedical risk factors in the prediction of pre-clinical CVD.
- Conditions
- Metabolic Diseases, Endocrine System Diseases, Heart Disease, Vascular Diseases
- Trial name
- NCT00935766
- Testing
- Omega-3
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Denver Health and Hospital Authority
Endothelial Function, Rheumatoid Arthritis
Cardiovascular Risk Markers in Patients With Rheumatoid Arthritis: Effect of Rituximab Therapy
The purpose of this investigation is to determine the effects of Rituxan therapy in individuals with rheumatoid arthritis on endothelial function and other markers of endothelial function
- Conditions
- Endothelial Function, Rheumatoid Arthritis, Inflammation
- Trial name
- NCT00844714
- Testing
- Rituxan
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Mucopolysaccharidosis Type I, Mucopolysaccharidosis Type II
Effects of Adalimumab in Mucopolysaccharidosis Types I, II and VI
The purpose of the study is to collect preliminary data on whether the drug adalimumab (also called Humira) can decrease pain and stiffness, improve quality of life, and is safe in people with mucopolysaccharidosis type I, II, or…
- Conditions
- Mucopolysaccharidosis Type I, Mucopolysaccharidosis Type II, Mucopolysaccharidosis Type VI
- Trial name
- NCT02437253
- Testing
- Adalimumab
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Inflammation
Fish Oil (Omega 3), Immune Function, and Mood
This study is designed to examine the effects of fish oil on immune function and mood.
- Trial name
- NCT00385723
- Testing
- Omega 3 (Fish Oil) Supplementation
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Coronary Artery Disease, Atherosclerosis
Rilonacept to Improve Artery Function in Patients With Atherosclerosis
This study will determine whether an experimental drug called Rilonacept can improve artery function in patients with atherosclerosis, a disease in which fatty deposits in arteries cause the vessels to stiffen, impeding blood…
- Conditions
- Coronary Artery Disease, Atherosclerosis, Inflammation, Endothelial Dysfunction
- Trial name
- NCT00417417
- Testing
- Rilonacept
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Endothelial Function, Lipids
Effects of Etravirine on Endothelial Function in HIV-uninfected Adults: A Pilot Study
The purpose of this study is to determine the safety and effects of etravirine, an HIV antiretroviral medication, on vascular function.
- Conditions
- Endothelial Function, Lipids, Insulin Resistance, Inflammation
- Trial name
- NCT00871234
- Testing
- Etravirine
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Indiana University
Pulmonary Sarcoidosis
Study of Efficacy, Safety and Tolerability of ACZ885 (Canakinumab) in Patients With Pulmonary Sarcoidosis
The purpose of this study is to assess if ACZ885 will improve lung function in association with reduction of tissue inflammation in patients with chronic sarcoidosis.
- Trial name
- NCT02888080
- Testing
- ACZ885
- Where
- 8 sites in United States, Germany and 1 more
- Volunteers
- 40 people
- Sponsor
- Novartis Pharmaceuticals
Type 2 Diabetes Mellitus
Effect of Exenatide on Liver and Heart Fat and Inflammation
The purpose of this study is to examine the effect of exenatide on liver and heart (myocardial) fat and inflammation.
- Trial name
- NCT01951651
- Testing
- Exenatide, Glipizide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Baylor College of Medicine
Obesity, Sarcopenia
Biological Effects of Weight Loss In Older, Obese Women
Obesity and sedentary lifestyle are associated with physical impairments and biological changes in older adults. Weight loss combined with exercise may reduce inflammation and may improve physical functioning in older adults who…
- Trial name
- WL+E (NCT01032733)
- Testing
- Lifestyle Counseling, Educational Control
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cardiovascular Disease
Efavirenz Versus Rilpivirine on Vascular Function, Inflammation, and Oxidative Stress
The purpose of this study is to compare the cardiovascular profiles of efavirenz and rilpivirine, which are two drugs used to treat HIV infection.
- Trial name
- NCT01585038
- Testing
- Efavirenz, Rilpivirine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indiana University
Eosinophilic Esophagitis
Use of Esophageal String Test to Understand Symptoms, Inflammation, and Function in Eosinophilic Esophagitis
Presently, the only method available to monitor disease activity in Eosinophilic Esophagitis (EoE) is endoscopy with pathological review of biopsies.
- Trial name
- NCT03305653
- Testing
- Esophageal String Test (EST)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Colorado, Denver
Asthma
The Effect of Dupilumab on Lung Inflammation and Related Changes in Airway Volumes Detectable by Functional Respiratory Imaging in Patients With Moderate-severe Asthma
Primary Objective: To assess the effect of dupilumab on lung inflammation and related changes in airway volumes detectable by functional respiratory imaging Secondary Objective: To evaluate the effect of dupilumab at Week 24 on…
- Trial name
- VESTIGE (NCT04400318)
- Testing
- Dupilumab
- Where
- 65 sites in United States, Bulgaria and 11 more
- Volunteers
- 109 people
- Sponsor
- Sanofi
HIV Infection
Comparing Blood Vessel Endothelial Function in HIV-Infected People and Matched HIV-Uninfected People
The blood vessels that carry blood from the heart to the rest of the body are normally capable of relaxing and constricting when needed to provide more or less blood to the body.
- Trial name
- NCT00919724
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Indiana University
Osteoarthritis, Knee, Osteoarthritis Knees Both
Astaxanthin for Management of Inflammation in Knee Osteoarthritis
Over 30 million Americans are currently affected by osteoarthritis (OA), with prevalence expected to increase 40% by 2025 as a result of the aging population and obesity epidemic.
- Conditions
- Osteoarthritis, Knee, Osteoarthritis Knees Both, Joint Inflammation
- Trial name
- NCT05138549
- Testing
- Astaxanthin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Prisma Health-Midlands
Chronic Obstructive Pulmonary Disease
Acute Effects of a Flutter Device in COPD
Chronic obstructive pulmonary disease (COPD) is characterised by airflow limitation that is not fully reversible, and is usually progressive and associated with an abnormal inflammatory response of the lungs to noxious particles…
- Trial name
- AEFLUC (NCT01832961)
- Testing
- Flutter valve exercises, Flutter and bronchodilator exercises
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Imperial College London
Dysbiosis, Endotoxemia
Gut-level Antiinflammatory Activities of Green Tea in Metabolic Syndrome
This study evaluates dietary green tea extract to improve gut health and inflammation in persons with metabolic syndrome and healthy adults.
- Conditions
- Dysbiosis, Endotoxemia, Metabolic Syndrome, Inflammation
- Trial name
- NCT03973996
- Testing
- Green Tea Extract
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Ohio State University
HIV-1 Infection
Endothelial Function, Lipoproteins, and Inflammation With Low HDL Cholesterol in HIV: ER Niacin Versus Fenofibrate
This study is being done with people with HIV infection who have low levels of HDL-C. HDL-C is a type of "good" cholesterol. People with low HDL-C have a higher risk of heart disease and may have problems with how their blood…
- Trial name
- NCT01426438
- Testing
- Niacin, Aspirin, Fenofibrate
- Where
- 14 sites in United States
- Volunteers
- 99 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Coronary Atherosclerosis, Coronary Artery Calcification
Firefighter Aged Garlic Extract Investigation With CoQ10 as a Treatment for Heart Disease (FAITH)
1. Statement of Problem According to the National Fire Protection Association (NFPA), 43.7% of all firefighters that died on the job experienced sudden cardiac death. The job also affords an incredible amount of stress.
- Conditions
- Coronary Atherosclerosis, Coronary Artery Calcification, Coronary Stenosis
- Trial name
- NCT00860847
- Testing
- Aged garlic extract and Coenzyme Q10
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Major Depressive Disorder, Depression
Anti-INFLammatory to Address Mood and Endothelial Dysfunction (INFLAMED)
The objective of this clinical trial is to evaluate whether an anti-inflammatory medication, pentoxifylline, reduces depressive symptoms and improves artery function.
- Conditions
- Major Depressive Disorder, Depression, Depressive Symptoms, Cardiovascular Disease (CVD)
- Trial name
- INFLAMED (NCT01625845)
- Testing
- Pentoxifylline, Standard Treatment
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Indiana University
Cardiovascular Diseases, Aging
Cardio-vascular Protective Effects of Wolfberry in Middle-aged and Older Adults
This purpose of this study is to assess the impact of consuming wolfberry on cardiovascular risk in Singapore's middle-aged and older adults.
- Trial name
- NCT03535844
- Testing
- Wolfberry, Healthy diet
- Where
- 2 sites in Singapore
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- National University of Singapore