Clinical trials: Inflammation Function
Long Covid19, Dietary Supplements
IMMUNERECOV CONTRIBUTES TO IMPROVEMENT OF RESPIRATORY AND IMMUNOLOGICAL RESPONSE IN POST-COVID-19 PATIENTS.
Background: COVID-19 left consequences in different organs from months to years requiring different types of rehabilitation. In fact, a severe loss in the lung function, and in the respiratory and peripheral muscle strength is…
- Conditions
- Long Covid19, Dietary Supplements, Respiratory Tract Infections, Inflammation
- Trial name
- IRPC (NCT06166030)
- Testing
- Nutritional blend (ImmuneRecov).
- Where
- 2 sites in Brazil
- Volunteers
- 58 people
- Sponsor
- Federal University of São Paulo
HIV Associated Neurocognitive Disorder, HIV Dementia
SV2A & TSPO PET Imaging Measures to Reveal Mechanisms of HIV Neuropathogenesis During Antiretroviral Therapy
The purpose of this study is to longitudinally characterize and evaluate changes in synaptic density in the brain using novel positron-emission tomography (PET) scans; magnetic resonance imaging (MRI), and clinical laboratory…
- Conditions
- HIV Associated Neurocognitive Disorder, HIV Dementia, HIV Encephalitis, Healthy
- Trial name
- ART (NCT05586581)
- Testing
- SV2A PET, TSPO PET
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Yale University
Respiratory Tract Infections (RTI), Mucosal Immunity
Fermented Milk Drink With Lacticaseibacillus Paracasei Strain Shirota Helps Triathletes With Cold-Like Symptoms Before and After a Race
This study aims to evaluate whether a fermented milk drink containing the probiotic strain Lacticaseibacillus paracasei strain Shirota (LCS), commonly found in Yakult®, can help reduce upper respiratory symptoms in triathletes…
- Conditions
- Respiratory Tract Infections (RTI), Mucosal Immunity, Systemic Inflammation, Depressive Disorder
- Trial name
- NCT06970964
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Coronary Heart Disease
Glycocalyx and Oxidative Stress in Endothelial Function (Part 2)
The primary research objective of the project is to determine the role of eGC in microvascular reactivity in patients with coronary heart disease (CHD) before and after bypass grafting (cross-sectional study 2).The main objective…
- Trial name
- GlikoOxEND (NCT07451873)
- Where
- Croatia
- Volunteers
- 35 people
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Type 2 Diabetes Mellitus
Effect of Dapagliflozin on Inflammation and Endothelial Function
Sodium-glucose cotransporter 2 (SGLT-2) inhibitors reduce hyperglycemia and improve peripheral insulin sensitivity by ameliorating glucotoxicity.
- Trial name
- NCT02608905
- Testing
- Dapagliflozin
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Baylor College of Medicine
Healthy, Diet Modification
Uric Acid Metabolism, Endothelial Function and Oxidative Stress in Vegans and Omnivores.
50 vegans and 50 omnivores will be recruited at the Erasme Hospital, Brussels. Hypothesis Relative induced-hyperuricemia by the vegan diet is not associated with impaired endothelial function if vitamin B12 and folic acid levels…
- Trial name
- NCT03849677
- Testing
- Endothelial function and inflammation
- Where
- Belgium
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Inflammation
Effects of Resistin on Neutrophil Function
To assess the effect of resistin on neutrophil migration and intracellular bacterial killing
- Trial name
- NCT03626870
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Asthma, Sleep Apnea
Effect of CPAP (Continuous Positive Airway Pressure) on Lung Function in Asthmatics With Sleep Apnea
This is a research study of asthma and sleep apnea. Our hypothesis is that untreated sleep apnea causes inflammation in the lung, which can worsen asthma.
- Trial name
- NCT00238069
- Testing
- CPAP machine as a result of sleep study
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Jewish Health
Impaired Glucose Tolerance
Effect of Saxagliptin Treatment on Myocardial Fat Content, and Monocyte Inflammation
The purpose of the study is to examine the effect of saxagliptin, an anti-diabetes medication, on hepatic and myocardial fat content and monocyte inflammation in patients with Impaired Glucose Tolerance (IGT).
- Trial name
- NCT01548651
- Testing
- Saxagliptin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Baylor College of Medicine
Epworth Sleepiness Scale, Glycemic Control
LAP-BAND Observational Cohort
To prospectively observe the association of the LAP-BAND procedure on quality of life, anthropometric, metabolic and biochemical parameters in morbidly obese patients when performed by experienced US surgeons.
- Conditions
- Epworth Sleepiness Scale, Glycemic Control, Liver Function, Inflammation
- Trial name
- NCT00283972
- Testing
- LAP-BAND System
- Volunteers
- 240 people
- Sponsor
- Inamed
Type 2 Diabetes, Cardiovascular Diseases
Omega-3 Fatty Acids Supplementation and Atherothrombotic Biomarkers in Type 2 Diabetes and Cardiovascular Disease.
The major source of mortality and morbidity of diabetic patients is cardiovascular disease (CVD). Moreover, in CVD patients the presence of diabetes is associated with the increased risk of major adverse cardiac events as…
- Trial name
- NCT02178501
- Testing
- Omega-3 PUFA
- Where
- 2 sites in Poland
- Volunteers
- 126 people
- Sponsor
- Jagiellonian University
Endotoxemia, Diet, Healthy
Cereals and Intestinal Function
The aim of the present study is to determine the effect of dietary fiber on intestinal function in healthy subjects.
- Trial name
- NCT04019457
- Testing
- Dietary intervention
- Where
- Austria
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Joint Pain, Stiffness, Function
Instaflex and Joint Pain in Community Adults
The primary purpose of this study is to assess the effect of 8-weeks ingestion of the Instaflex Joint Support supplement (Direct Digital, Charlotte, NC) compared to placebo on joint pain, stiffness, and function (questionnaires…
- Trial name
- NCT01956500
- Testing
- Instaflex
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Hyperglycemia, Type 1 Diabetes Mellitus
The Influence of Acute Hyperglycaemia on Brain in T1D
The study is going to include 20 adolescents, 5-10 years after onset of T1D, aged 12-20 years, on insulin pump. The participants are going to have MRI of the head in euglycaemic and hyperglycaemic state.
- Trial name
- NCT03188757
- Testing
- hyperglycaemic clamp
- Where
- Slovenia
- Volunteers
- 20 people
- Sponsor
- University of Ljubljana, Faculty of Medicine
Irritable Bowel Syndrome
Effects of Vivatlac Synbiotic on Gut Micribiota of IBS Patients
Multi-center, randomized, double-blind, placebo-controlled, 12 weeks trial investigating the effects of a nine-strain synbiotic (Vivatlac Synbiotikum) on the gut microbiota of IBS patients
- Trial name
- ViIBS3 (NCT07235228)
- Testing
- Vivatlac Synbiotic
- Where
- 2 sites in Poland
- Volunteers
- 20 people
- Sponsor
- The President Stanisław Wojciechowski State University of Applied Sciences in Kalisz
Osteoarthritis
Osteoarthritis: Weakness From Inflammation
The purpose of this study is to understand the factors that lead to muscle weakness with arthritis and aging.
- Trial name
- NCT00104312
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- National Institute on Aging (NIA)
Aging Disorder, Obesity
Effects of Multicomponent Training on Inflammation Parameters and Muscle Quality in Elderly Obese Woman
Population aging worldwide has increased substantially in recent years. In order to prevent disabling diseases and improve the quality of life, it is necessary to understand the conditions related to the health of this specific…
- Conditions
- Aging Disorder, Obesity, Inflammation
- Trial name
- NCT05552677
- Testing
- Multicomponent Training
- Where
- Brazil
- Volunteers
- 38 people
- Sponsor
- University of Sao Paulo
Anxiety, PTSD
Rapid Entrainment and Signal-guided Neuromodulation for Behavioral Health
RESYNC-BH is a research study evaluating a personalized, non-drug brain-and-body treatment approach for adults with ongoing behavioral health symptoms such as depression, anxiety, trauma-related symptoms, sleep problems…
- Conditions
- Anxiety, PTSD, ADHD, Depression Disorders
- Trial name
- RESYNC-BH (NCT07812987)
- Testing
- AIP-Informed Integrative Psychotherapy, Transcutaneous Auricular Vagus Nerve Stimulation, Regulated Breathing and Autonomic Regulation
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Tactical Mind Research Coalition, Inc.
Oxidative Stress, Healthy
A Randomized, Double-Blind Study to Assess the Effect of a Postbiotic on Oxidative Stress and Exercise Performance
This is a prospective, randomized, placebo controlled, double-blind study to assess the effects of a postbiotic blend on exercise induced oxidative stress markers and exercise performance in healthy adult.
- Conditions
- Oxidative Stress, Healthy, Exercise-induced Muscle Damage, Exercise-induced Muscle Soreness
- Trial name
- PBE (NCT06795425)
- Testing
- Postbiotic Active Lifestyle Blend
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Colchicine, Diabetes Mellitus, Type 2
Dose-finding Study of Colchicine in Type 2 Diabetic Patients With Coronary Artery Disease
This study is designed to investigate dose-dependent effects of low dose colchicine on inflammatory responses, endothelial function in type 2 diabetic patients with coronary artery disease and leukocyte activation.
- Conditions
- Colchicine, Diabetes Mellitus, Type 2, Coronary Artery Disease, White Blood Cell
- Trial name
- DRC-04 (NCT03376698)
- Testing
- Colchicine 0.5 mg, Colchicine 0.25 mg
- Where
- 5 sites in Japan
- Volunteers
- 54 people
- Sponsor
- University of the Ryukyus