Clinical trials: Inflammation Function
Gastric Cancer, Enteral Immunonutrition
Effect of Enteral Immunonutrition on Immune, Inflammatory Markers and Nutritional Status in Patients Undergoing Gastrectomy for Gastric Cancer
Enteral immunonutrition (EIN) has been gaining increasing attention, but data of its immune and anti-inflammatory function in patients undergoing gastrectomy for gastric cancer are poorly investigated.
- Trial name
- NCT03730545
- Testing
- enteral immunonutrition
- Volunteers
- 124 people
- Sponsor
- West China Hospital
Polycystic Ovary Syndrome
Involvement of Reticulum Endoplasmic Stress in the Physiopathology of Polycystic Ovary Syndrome
The main objective of the present project is to evaluate the relevance of reticulum stress in the pathogenesis of polycystic ovary syndrome (PCOS), focusing particularly on the underlying mechanisms of insulin resistance, which…
- Trial name
- PI12/1984 (NCT02302326)
- Testing
- Metformin, Myo-inositol + folic acid
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Chronic Periodontitis, Aggressive Periodontitis
B Cell Functions in Periodontitis
The inflammatory response involves many players from the immune response, including B lymphocytes. These cells are responsible for the synthesis of immunoglobulins in response to the presence of an antigen.
- Trial name
- LBPARO (NCT02833285)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Type2 Diabetes, Heart Failure
Impact of a Short-term Treatment With Canagliflozin (Canacardia-HF)
It is a mechanistic proof-of-concept study to demonstrate how SGLT-2 inhibitors (Canagliflozin) may have a beneficial role on cardiac energetic efficiency.
- Trial name
- Canacardia (NCT03298009)
- Testing
- Canagliflozin 100mg, PET imaging
- Sponsor
- Université de Sherbrooke
Ventilator-Induced Lung Injury, Sepsis Syndrome
CT for Personalized Mechanical Ventilation
The goal of this study is to compare two different ways of helping patients with a condition called sepsis who need help breathing using a machine called a ventilator.
- Conditions
- Ventilator-Induced Lung Injury, Sepsis Syndrome, Mechanical Ventilation Complication
- Trial name
- NCT05977153
- Testing
- PEEP (positive end-expiratory pressure) - maximum, PEEP (positive end-expiratory pressure) - standard
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Columbia University
Hypotension, Orthostatic, Total Hip Replacement
Study on Baroreceptor Function in Relation to Orthostatic Blood Pressure Regulation After Hip Surgery
The purpose of this observational study is to evaluate the baroreceptor function in relation to surgical inflammation and orthostatic intolerance after elective hip arthroplasty.
- Trial name
- NCT01866787
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Intestinal Functional Disorder, Inflammation
Lactiplantibacillus Plantarum PD01 Supplementation Reduces Microplastics and Microplastic-associated Chemicals in Humans
The study attempts to conduct randomized double-blind controlled trials to understand whether daily exposure to microplastics (MPs) can cause potential impacts on human health, explore whether the intake of Lactiplantibacillus…
- Trial name
- NCT07416214
- Testing
- Probiotics (Lactiplantibacillus plantarum PD01)
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Fudan University
Cystic Fibrosis
Early Assessment of Respiratory Function, Inflammation and Bronchial Reshuffle Among Newborns Screened for Cystic Fibrosis
The main objective of this study is to show that there is a concordance between lung disease at 13 months and the existing 9 weeks in newborn babies with cystic fibrosis asymptomatically.
- Trial name
- NCT02883816
- Testing
- assessment of lung function
- Where
- France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Montpellier
Heart Failure With Preserved Ejection Fraction
The COLchicine HEART Failure PRESERVED Trial (COLHEART-PRESERVED)
The purpose of this study is to investigate the effects of colchicine on heart failure related health status, quality of life, and vascular and cardiac function in patients with heart failure with preserved ejection fraction…
- Trial name
- NCT06081049
- Testing
- Colchicine
- Where
- Denmark
- Volunteers
- 152 people
- Sponsor
- Tor Biering-Sørensen
Mucus Colitis, Inflammation, Colon
The Impact of Red Meat and Whole-grains Intake on the Colonic Mucosal Barrier
This study evaluates the impact of red meat and whole-grain intake on the colonic mucosal barrier and the dietary impact of these groups on the induced low-grade inflammation
- Conditions
- Mucus Colitis, Inflammation, Colon, Dietary Exposure
- Trial name
- NCT04235348
- Where
- Denmark
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Bronchiolitis Obliterans
Bronchial Inflammation in Patients With Bronchiolithis Obliterans
The investigators plan to study the variability of lung function parameters and bronchial inflammatory markers in 20 patients with bronchiolitis obliterans at the age of 6 to 25 years compared with an age- and sex-matched control…
- Trial name
- FRABO-02 (NCT01633385)
- Where
- Germany
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Autoinflammatory Disease
Development and Characterization of Functional Assays for the Analysis of Inflammation Signaling Pathways
Auto-inflammatory diseases are part of a heterogeneous group of illnesses manifested by an inflammatory reaction in its initial phase (innate immunity) that is activated inappropriately: either because the reaction is too strong…
- Trial name
- DEFI (NCT06971289)
- Testing
- blood test
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Intestinal Barrier Function, Chronic Inflammation
Reduction of Obesity-Associated Intestinal Inflammation by Low-Fat Dairy Yogurt
The main objective of this work is to conduct a clinical trial in obese and non-obese individuals testing the ability of low-fat dairy yogurt to improve gastrointestinal health and reduce chronic inflammation.
- Trial name
- NCT01686204
- Testing
- Low fat dairy yogurt, Soy pudding
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Respiratory Inflammation, Systemic Inflammation
Woodsmoke Exposure and Cardiovascular Function
Air pollution is linked to respiratory and cardiovascular disease. Wood smoke is a common air in many parts of the world and previous studies indicate that wood smoke induce oxidative stress in the respiratory tract.
- Trial name
- NCT01488500
- Testing
- Bronchoscopy
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
T2DM (Type 2 Diabetes Mellitus)
GLP1-RAs Effects on Inflammatory and Endothelial Biomarkers in T2DM
Type II diabetes mellitus (T2DM) is a chronic disease associated with a very high risk of developing cardiovascular (CV) events, especially because of its long-term effects.
- Trial name
- STABLE-GLP1 (NCT07314684)
- Testing
- semaglutide, Standard Treatment (Guideline-Based)
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Federico II University
Inflammation
Impact of Acute Exercise Intensity and Pattern on Cytokine Function
The immune system helps prevent illness, fights off infections, and repairs damaged tissues following an injury. However, when immune cells remain active for prolonged periods of time - a state known as "chronic inflammation" …
- Trial name
- AEX (NCT05574413)
- Testing
- Moderate intensity continuous exercise, High intensity continuous exercise, High intensity interval exercise
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Asthma
Mechanism(s) of Airflow Limitation During Exacerbation of Asthma
The purpose of this study is to evaluate the site and mechanisms responsible for expiratory airflow limitation in chronic, treated, non-smoking, stable asthmatics with moderate to severe persistent expiratory airflow obstruction.
- Trial name
- NCT01225913
- Testing
- fluticasone/salmeterol in all asthmatics, budesonide/formoterol or fluticasone/salmeterol in all asthmatics
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Gelb, Arthur F., M.D.
HIV
Strength Training and Endurance Exercise for LIFE
Research is needed to determine safe and effective exercise rehabilitation programs to prevent and improve physical disability in older adults living with HIV. This problem is of great importance to the VA.
- Trial name
- STEEL (NCT02101060)
- Testing
- exercise
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
Hemodialysis
Functional Proteomics of Uremic Retention Solutes Associated With Immunosenescence, Inflammation and Impaired Adaptive Stress Response
This is a randomized controlled crossover trial (58) in order to characterize PBL damage and death rate in hemodialysis patients treated with membranes with different permeability, including protein-leaking dialysers.
- Trial name
- NCT07265635
- Testing
- HDF with PMMA, HDF
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Breast Cancer Female, Gynecologic Cancer
Cachexia in Gynecological Cancer and the Preventive Role of Weight Training
The study aim was to compare the effectiveness of combined training (CT; aerobic + resistance exercises) and high-intensity interval body weight training (HIITBW) on body composition, metabolic and inflammatory profile, physical…
- Conditions
- Breast Cancer Female, Gynecologic Cancer, Menopause, Physical Activity
- Trial name
- NCT03200639
- Testing
- Combined training, High intensity interval training with body weight
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Triangulo Mineiro