Clinical trials: Inflammation Function
Pain Reduction, Physical Function Improvement
Methorexate and Knee Osteoarthritis
Osteoarthritis (OA) is considered a complex, multifactorial disease leading to considerable pain and functional disability amongst older adults in particular.Synovial inflammation and proliferation has emerged as a key component…
- Trial name
- NCT04326894
- Testing
- 25 mg/week oral methotrexate tablets
- Where
- Egypt
- Volunteers
- 128 people
- Sponsor
- University of Alexandria
Aging, Disease
Interval Training, Inflammation and Immune Function
PURPOSE: The purpose of this study is to investigate whether High Intensity Interval Training (HIIT)can improve the health and wellbeing of pre-diabetic elderly adults.
- Trial name
- NCT02441205
- Testing
- High Intensity Interval training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Duke University
Diabetes Mellitus, HIV/AIDS
Diabetes Mellitus and HIV Study in Mwanza
Emerging evidence from high-income countries suggests that diabetes mellitus is become a major health problem among HIV-infected patients.
- Trial name
- CICADA (NCT03106480)
- Where
- Tanzania
- Volunteers
- 1,947 people
- Sponsor
- National Institute for Medical Research, Tanzania
Psoriasis, Psoriatic Arthritis
SystemIc iNflammation and Microvascular diSease PreventIon in psoRiatic diseasE
This is a single-label open-arm mechanistic clinical study recruiting patients with psoriasis or psoriatic arthritis with elevated cardiovascular risk.
- Conditions
- Psoriasis, Psoriatic Arthritis, Cardiovascular Risk Factor
- Trial name
- INSPIRE (NCT04417114)
- Testing
- Rosuvastatin
- Sponsor
- Brigham and Women's Hospital
Heart Failure With Reduced Ejection Fraction
Neuromodulation of Inflammation and Vascular Function in Systolic Heart Failure
Heart failure (HF) is the leading cause of death in US. It is associated with abnormal vascular function termed endothelial dysfunction.
- Trial name
- TECO-HF (NCT03945058)
- Testing
- TVS
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Oklahoma
Diabetes, Atherosclerosis
Effects of Sitagliptin on Endothelial Function in Type 2 Diabetes on Background Metformin Therapy
The study is being performed to determine whether sitagliptin, a dipeptidyl peptidase-4 inhibitor, both acutely and chronically improves blood vessel function.
- Trial name
- NCT01859793
- Testing
- sitagliptin
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Medical College of Wisconsin
Atherosclerosis, Vascular Disease
The Effect of Folic Acid on Atherosclerosis, Cognitive Performance and Hearing
The purpose of this study is to determine if folic acid supplementation can slow down atherosclerotic progression, age-related cognitive decline and age-related hearing loss.
- Conditions
- Atherosclerosis, Vascular Disease, Cognitive Decline, Hearing Loss
- Trial name
- NCT00110604
- Testing
- folic acid (0.8 mg)
- Where
- Netherlands
- Volunteers
- 835 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Prediabetes
Effects of Hourly Stair-Climbing Exercise Snacks on Metabolic and Vascular Health in Adults With Prediabetes
This study will examine whether very short bouts of stair climbing performed throughout the day can improve blood sugar control and cardiovascular health in adults with prediabetes.
- Trial name
- RISE UP (NCT07847684)
- Testing
- Hourly 3-Minute Light Walking Breaks, Hourly Stair-Climbing Exercise Snacks
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- St. Louis University
Acute Coronary Syndrome
Comparison of Ticagrelor vs. Prasugrel on Inflammation, Arterial Stiffness, Endothelial Function, and Circulating Endothelial Progenitor Cells in Diabetic Patients With Non-ST Elevation Acute Coronary Syndrome (NSTE-ACS) Requiring Coronary Stenting
To investigate pleiotropic effects of ticagrelor in addition to its antiplatelet effects in type 2 diabetic patients with non-ST elevation acute coronary syndrome by measuring inflammatory markers, circulating number of…
- Trial name
- NCT02487732
- Testing
- Ticagrelor, Prasugrel
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Korea University Anam Hospital
Obesity
Mechanisms Underlying Postoperative Insulin Resistance and Inflammation
Having an operation places an enormous burden on the body, leading to the development of inflammation and so called 'insulin resistance'.
- Trial name
- NCT01470534
- Testing
- carbohydrate drink, Muscle biopsy, Blood sampling
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Nottingham
HIV Infections
Effect of Anti-HIV Therapy (HAART) on HIV Levels in the Lungs and on Lung Cell Inflammation in HIV-Infected Patients
The purpose of this study is to see: (1) how the amount of HIV in the lungs compares to that in the blood; (2) if HAART reduces the amount of HIV in the lungs; and (3) if HAART reduces lung inflammation in HIV-infected patients.
- Trial name
- NCT00001110
- Testing
- Bronchoalveolar lavage
- Where
- 5 sites in United States, Puerto Rico
- Volunteers
- 50 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cardiovascular Disease
The Effects of Trout Fed With a Vegetable Based Feed on Cardiovascular Risk Markers and Plasma Proteome
Fish from the aquaculture sector constitutes an increasing part of the fish consumption in Denmark. The most important farmed fish in Denmark is the rainbow trout.
- Trial name
- NCT00445614
- Testing
- Effects of trout on CVD risk markers and plasma proteome
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy, Hypercholesterolemia
Health Effects of Consuming Olive Pomace Oil
Healthy and at risk (hypercholesterolemic) subjects consumed during 4 weeks 45 g/d of either olive pomace oil (OPO) or high oleic acid sunflower oil (HOSO) as the only dietary fat in a randomized, crossover trial.
- Trial name
- ORUJOSALUD-1 (NCT04997122)
- Testing
- Olive pomace oil, High oleic acid sunflower oil
- Where
- Spain
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Instituto de Ciencia y Tecnología de Alimentos y Nutrición
Eosinophilic Esophagitis (EoE)
Effect of Dupilumab on the Muscle Function of the Esophagus (food Pipe) in Participants with Eosinophilic Esophagitis (EoE)
The goal of this study is to research Dupilumab, an FDA approved medication in treating patients diagnosed with Eosinophilic esophagitis (EoE). The drug works by controlling allergic inflammation of the esophagus.
- Trial name
- NCT06665971
- Testing
- Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT]
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Asthma
Study of TNFR:Fc (Enbrel) in the Treatment of Asthma
The proposed study is a phase II clinical trial of TNFR:Fc therapy in a segmental allergen bronchoprovocation model of atopic asthma.
- Trial name
- NCT00001893
- Testing
- TNFR:Fc
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Healthy
The Impact of OliPhenolia® Supplementation on Exercise Induced Inflammation and Functional Movement in Humans.
This research proposal follows on from previously undertaken work investigating a commercially available olive derived product (OliPhenolia®) on potential exercise / functional benefits for healthy adults.
- Trial name
- NCT07008586
- Testing
- OliPhenolia®
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Anglia Ruskin University
Inflammation
Effect of Omega-3 and Probiotic Dietary Supplements on Elevated High Sensitivity C-reactive Protein (Hs-CRP) as a Marker of Low-grade Inflammation
Study objectives: Immunity, Inflammation, and Brain Function To determine the effect of supplements with probiotics, Omega-3 and Vitamin D on the inflammatory marker highly sensitive CRP (primary outcome), markers of inflammation…
- Trial name
- NCT04126330
- Testing
- Probiotic, Omega-3, Vitamin D supplement
- Where
- Sweden
- Volunteers
- 176 people
- Sponsor
- Örebro University, Sweden
Asthma, Vitamin D Deficiency
A Study to Investigate the Effect of Vitamin D3 Supplementation on Asthma Symptoms in Adults With Asthma (VITDAS)
Asthma is a disease characterised by chronic inflammation of the airways leading to symptoms including periods of shortness of breath, wheezing and a tight chest due to airway narrowing in affected patients.
- Conditions
- Asthma, Vitamin D Deficiency, Nutritional Deficiency, Inflammation
- Trial name
- VITDAS (NCT04117581)
- Testing
- Vitamin D3
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Chester
Bladder Cancer
Stress-reducing Intervention in Urothelial Carcinoma
The aim of this interventional study is to test the heart-rate variability biofeedback intervention (HRV BI) in patients with muscle-infiltrating bladder carcinoma (MIBC) treated with chemotherapy based on cisplatin in…
- Trial name
- NCT06269536
- Testing
- HRV biofeedback
- Where
- Slovakia
- Volunteers
- 50 people
- Sponsor
- Comenius University
Hypertension (Without Type 2 Diabetes Mellitus), High Blood Pressure
Wild Blueberries for Gut, Brain, and Heart Health in Adults With High Blood Pressure
The purpose of the study is to determine the effectiveness of wild blueberries on cardiovascular health, cognitive function, and gut microbiota composition in non-Hispanic Black and White adults with elevated blood pressure.
- Conditions
- Hypertension (Without Type 2 Diabetes Mellitus), High Blood Pressure, Male, Female
- Trial name
- NCT06735599
- Testing
- Wild Blueberry
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Georgia State University