Clinical trials: Inflammation Function
Shock, Septic, Pituitary Dysfunction
Pituitary Function After Recovery From Septic Shock Among ICU Survivors
Prolonged circulatory shock is associated with marked disturbances in vascular supply to the brain, and endothelial dysfunction which can lead to disseminated intravascular coagulation and microvascular thrombosis.
- Conditions
- Shock, Septic, Pituitary Dysfunction, Hypopituitarism
- Trial name
- NCT05990491
- Where
- 2 sites in India
- Volunteers
- 90 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Prediabetes, Obese
Inflammation Inhibition in Prediabetic Humans
Prediabetes, characterized by elevated fasting blood sugar or exaggerated blood sugar response to sugar ingestion, effects over 79 million adult Americans and is a precursor to the development of Type 2 diabetes.
- Trial name
- INCITE (NCT01977417)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce
Cardiovascular Function
Investigation of the Influence of Gender on Cardiovascular Function
Inflammation is a key initiating and damaging factor in many illnesses including infection, arthritis and cancer but also of particular relevance to this study in diseases of the heart and blood vessels (i.e.
- Trial name
- NCT01582321
- Testing
- Typhoid vaccine, Cantharidin
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Sex Differences, Postoperative Sleep Quality
Sex Differences in Postoperative Sleep Quality and Inflammation
Video-Assisted Thoracoscopic Surgery(VATS) is among the most common and disabling persistent pain and inflammation conditions, with increasing prevalence in the developed world, and affects women to a greater degree than men.
- Conditions
- Sex Differences, Postoperative Sleep Quality, Postoperative Pain, Inflammation Function
- Trial name
- NCT04608435
- Testing
- Video-Assisted Thoracoscopic Surgery
- Where
- China
- Volunteers
- 213 people
- Sponsor
- Shengjing Hospital
Polycystic Ovary Syndrome
Involvement of Reticulum Endoplasmic Stress in the Physiopathology of Polycystic Ovary Syndrome
The main objective of the present project is to evaluate the relevance of reticulum stress in the pathogenesis of polycystic ovary syndrome (PCOS), focusing particularly on the underlying mechanisms of insulin resistance, which…
- Trial name
- PI12/1984 (NCT02302326)
- Testing
- Metformin, Myo-inositol + folic acid
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Tetraplegia, Asthma
Exhaled Breath Condensate Biomarkers of Inflammation in Individuals With Chronic Cervical Spinal Cord Injury
The purpose of this study is to obtain markers of airway inflammation from the exhaled breath condensate (the moisture in exhaled air) for comparison to blood based markers.
- Trial name
- NCT02235714
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Prediabetes
Effects of Hourly Stair-Climbing Exercise Snacks on Metabolic and Vascular Health in Adults With Prediabetes
This study will examine whether very short bouts of stair climbing performed throughout the day can improve blood sugar control and cardiovascular health in adults with prediabetes.
- Trial name
- RISE UP (NCT07847684)
- Testing
- Hourly 3-Minute Light Walking Breaks, Hourly Stair-Climbing Exercise Snacks
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- St. Louis University
Locally Advanced Breast Cancer (LABC), Postoperative Inflammation
Preoperative Shoulder Exercises and Postoperative Inflammation, Pain, and Function After Modified Radical Mastectomy
This study evaluates whether preoperative shoulder range-of-motion exercises influence postoperative inflammatory response, pain, shoulder function, and quality of life in patients with locally advanced breast cancer undergoing…
- Conditions
- Locally Advanced Breast Cancer (LABC), Postoperative Inflammation, Prehabilitation
- Trial name
- NCT07420335
- Testing
- Preoperative shoulder exercise, Standard preoperative care
- Where
- Indonesia
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Surgery--Complications, Acute Illness
Perioperative Metabolic and Hormonal Aspects in Major Emergency Surgery
Emergency laparotomies, which most often is performed due to high risk disease (bowel obstruction, ischemia, perforation, etc.), make up 11 % of surgical procedures in emergency surgical departments, however, give rise to 80 % of…
- Conditions
- Surgery--Complications, Acute Illness, Gastrointestinal Disease, Stress
- Trial name
- PHASE (NCT03482830)
- Testing
- Major emergency gastrointestinal surgery
- Where
- Denmark
- Volunteers
- 98 people
- Sponsor
- Zealand University Hospital
Transgender, Gender Identity
Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Men
This study will examine markers of vascular endothelial function (vascular health) and metabolic profiles in older versus younger transgender men (people who were assigned female at birth but whose gender identity is male).
- Conditions
- Transgender, Gender Identity, Vascular Stiffness, Vascular Inflammation
- Trial name
- NCT04237467
- Testing
- No intervention
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Asthma
Effects of Montelukast in Children With Asthma
Leukotriene receptor antagonists (LTRAs) reduce fractional exhaled nitric oxide (FENO) concentrations in children with asthma, but the effect of LTRA withdrawal on FENO and lung function is unknown.
- Trial name
- NCT00675285
- Testing
- montelukast sodium
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Catholic University of the Sacred Heart
Bronchiolitis Obliterans
Lung Function, LCI, Bronchial Inflammation and Epigenetics of Patients With BO
Bronchiolitis obliterans is a chronic disease in which a persistent inflammatory process leads to obliteration of the small airways.
- Trial name
- FRABO-03 (NCT02627833)
- Testing
- observation
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Intestinal Inflammation, Metabolic Disease
The Role of Regular Physical Activity in Enhancing Metabolic Health, Reducing Inflammation, and Improving Gut Function
The goal of this clinical trial is to learn if regular physical activity can improve metabolic health, reduce inflammation, and decrease gut permeability in individuals aged 50 and older.
- Trial name
- NCT06606678
- Testing
- Exercise
- Where
- Poland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Sepsis, Intestinal Dysfunction
Effect of Different Feeding Method on Gastrointestinal Function of Septic Patients (DFM-GF Trial)
The intestine is the most vulnerable target organ in septic patients and is the first to be damaged organ in multiple organ dysfunction syndrome(MODS).
- Trial name
- DFM-GF (NCT03488940)
- Testing
- 24-hours group, 16-hours group, intermittent group
- Where
- China
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Endothelial Dysfunction
Different Oils For Frying and Endothelial Function
The purpose of this study is to compare the effects of the consumption of different oils (olive oil, sunflower oil, sunflower plus dimethyl-polysiloxane, sunflower plus phenols) previously submitted to heating in postprandial…
- Trial name
- NCT00837317
- Testing
- Olive Oil, SF, SF+DMP, SF+phenols
- Where
- Spain
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Reina Sofia de Cordoba
Sepsis, Septic Shock
Sepsis ICU Gut Microbiome Analysis
Sepsis is a life-threatening condition in which the body's response to an infection damages its own organs. This study aims to understand how the bacteria living in the gut change during sepsis and whether patterns of gut…
- Trial name
- SIGMA (NCT07864818)
- Testing
- Naturally Occurring Exposures
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Irritable Bowel Syndrome
Effects of Activia in IBS
The purpose of this study is to investigate the association between gut microbiota, immunology and typical pathophysiological factors in patients with IBS (all subtypes) AND to assess the effect of Activia consumption on GI…
- Trial name
- MOSAIC (NCT01252550)
- Testing
- Activia® (125g/pot), Acidified non-fermented dairy product
- Where
- 3 sites in Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Severe, Septic
Effects of Alkaline Phosphatase on Renal Function in Septic Patients
Septic shock is the most common cause of death in patients requiring intensive care. The kidney is one of the first organs to fail, stressing the importance to search for clinical interventions that may protect the kidneys during…
- Conditions
- Severe, Septic, Shock
- Trial name
- NCT00457613
- Testing
- bolus injection, followed by a continuous infusion ( 24 h) (Alkaline phosphatase)
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Sepsis, Sepsis Associated Encephalopathy
EEG Changes and Cognitive Profiles in Sepsis Patients With Different Inflammatory Phenotypes
To characterize the electroencephalogram (EEG) features of sepsis patients with distinct inflammatory response phenotypes, dynamically track their evolutionary trajectories, and analyze their associations with long-term changes…
- Conditions
- Sepsis, Sepsis Associated Encephalopathy, Sepsis and Septic Shock, Sepsis at Intensive Care Unit
- Trial name
- NCT07760415
- Testing
- EEG monitoring
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Xiangya Hospital of Central South University
Epworth Sleepiness Scale, Glycemic Control
LAP-BAND Observational Cohort
To prospectively observe the association of the LAP-BAND procedure on quality of life, anthropometric, metabolic and biochemical parameters in morbidly obese patients when performed by experienced US surgeons.
- Conditions
- Epworth Sleepiness Scale, Glycemic Control, Liver Function, Inflammation
- Trial name
- NCT00283972
- Testing
- LAP-BAND System
- Volunteers
- 240 people
- Sponsor
- Inamed