Clinical trials: Inflammation Function
Impaired Glucose Tolerance
Effect of Saxagliptin Treatment on Myocardial Fat Content, and Monocyte Inflammation
The purpose of the study is to examine the effect of saxagliptin, an anti-diabetes medication, on hepatic and myocardial fat content and monocyte inflammation in patients with Impaired Glucose Tolerance (IGT).
- Trial name
- NCT01548651
- Testing
- Saxagliptin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Baylor College of Medicine
Pancreatic Adenocarcinoma, Pancreatic Cysts
Robotic Versus Open Pancreaticoduodenectomy for Pancreatic and Periampullary Tumors
This multicenter randomized trial aims to primarily assess and compare the functional recovery of patients who undergo open versus robotic pancreaticoduodenectomy for benign and malignant lesions of the head of the pancreas.
- Conditions
- Pancreatic Adenocarcinoma, Pancreatic Cysts, Pancreatic Endocrine Tumors, Chronic Pancreatitis
- Trial name
- PORTAL (NCT04400357)
- Testing
- Robotic pancreaticoduodenectomy, Open pancreaticoduodenectomy
- Where
- China
- Volunteers
- 268 people
- Sponsor
- Ruijin Hospital
HIV Infection, Cardiovascular Disease
The Role of Inflammation and Aging in HIV-Associated Cardiovascular Risk
It is the central hypothesis of the investigators study that HIV disease is a pro-inflammatory condition, and that years of inflammation result in premature "aging' of the immune system ("immunosenescence").
- Conditions
- HIV Infection, Cardiovascular Disease, Inflammation
- Trial name
- NCT01333644
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Inflammatory Bowel Diseases
Assessing Cardiovascular Dysfunction Pre- & Post-treatment in Inflammatory Bowel Diseases
The aim of this study is to compare medical and surgery treatment in IBD patients and healthy controls, by assessing the endothelial and cardiac function and the inflammation status.
- Trial name
- NCT03615287
- Where
- Greece
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Athens
Lung Diseases, Medication Compliance
Uncontrolled Lower Respiratory Symptoms in the WTC Survivor Program
The purpose of this study is to understand why patients in the World Trade Center program have continuing breathing problems. This study will improve investigators understanding of breathing problems among individuals with World…
- Trial name
- NCT02024204
- Testing
- Fluticasone propionate 230mcg for 3 Months, Current Treatment or no treatment, Salmeterol 21mcg for 3 Months
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Acute Coronary Syndrome
Comparison of Ticagrelor vs. Prasugrel on Inflammation, Arterial Stiffness, Endothelial Function, and Circulating Endothelial Progenitor Cells in Diabetic Patients With Non-ST Elevation Acute Coronary Syndrome (NSTE-ACS) Requiring Coronary Stenting
To investigate pleiotropic effects of ticagrelor in addition to its antiplatelet effects in type 2 diabetic patients with non-ST elevation acute coronary syndrome by measuring inflammatory markers, circulating number of…
- Trial name
- NCT02487732
- Testing
- Ticagrelor, Prasugrel
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Korea University Anam Hospital
Oxidative Stress, Inflammation
Effects of Magnesium and Spinning Training on Echocardiographic, Inflammatory, and Aerobic Outcomes
Regular aerobic exercise may improve cardiorespiratory fitness while modulating systemic inflammation and oxidative stress. Spinning, as a structured indoor cycling modality, provides a practical aerobic exercise model with…
- Conditions
- Oxidative Stress, Inflammation, Physical Fitness, Echocardiography
- Trial name
- NCT07662954
- Testing
- Spinning Training, Magnesium Supplementation
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Karamanoğlu Mehmetbey University
To Determine Whether Estrogen Influences the Effects of Training on Glycemic Control and Insulin Sensitivity
Does Estrogen Blunt the Effects of Exercise Training on Glycemic Control
Previous research has found that males and females respond differently to exercise training, particularly with respect to improvements in blood sugar control and immune system health.
- Trial name
- NCT07791394
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Sepsis, Septic Shock
The Effect of Fluid Resuscitation With 0.9% Sodium Chloride Versus Balanced Crystalloid Solution on Renal Function of Sepsis Patients
The high chloride content of 0.9%sodium chloride (0.9%NaCl) leads to adverse pathophysiological effects in both animals and healthy human volunteers.
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT03277677
- Testing
- Normal saline, Ringer's Acetate
- Where
- Thailand
- Volunteers
- 116 people
- Sponsor
- Chulalongkorn University
Healthy
The Effect of AGE on the Immune System
This is a nutritional intervention study using healthy overweight/obese humans to investigate if a supplement made from aged garlic extract has an impact on immunity.
- Trial name
- EAGESIS II (NCT01959646)
- Testing
- Aged Garlic Extract Supplementation Group, Standard for Groups
- Where
- 2 sites in United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Florida
Renal Transplant Failure and Rejection, Inflammation
The Effect of Biomarkers of Inflammation on Graft Function in Kidney Transplantation
The aim of the study was to investigate the relationship of inflammation markers with postoperative graft function and mortality in patients undergoing kidney transplantation.
- Trial name
- NCT05753488
- Testing
- graft function
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
SIRS, Sepsis
NT-proBNP in ICU Postoperative/Posttraumatic Patients With Shock
The purpose of this study is to determine the course of NT-proBNP plasma concentrations in the context of confounding parameters in postoperative/posttraumatic critically ill patients with severe SIRS/sepsis and shock.
- Conditions
- SIRS, Sepsis, Shock, Critically Ill
- Trial name
- NICUPS (NCT00736723)
- Where
- Germany
- Volunteers
- 51 people
- Sponsor
- University of Ulm
Cardiovascular Health, Obesity
Effects of the Atkins Diet Versus a Low Fat Diet on Inflammation
The purpose of this research is to assess the effects of a low-carbohydrate (modified Atkins) diet versus a low fat (Heart Healthy) diet on cardiovascular health.
- Trial name
- NCT00993278
- Testing
- Low-Carbohydrate (Modified Atkins) Diet, Low-Fat (Heart Healthy) Diet
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Osteoarthritis
Osteoarthritis: Weakness From Inflammation
The purpose of this study is to understand the factors that lead to muscle weakness with arthritis and aging.
- Trial name
- NCT00104312
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- National Institute on Aging (NIA)
Coronary Artery Disease
Intravenous Fish Oil in Critically Ill Cardiac Patients
A large body of evidence has accumulated showing that n-3 PUFAs exert extensive cardiac effects. The development of commercial solutions of FO opens perspectives for therapeutic applications in patients with acute cardiac…
- Trial name
- FO-cardiac (NCT00516178)
- Testing
- Fish oil emulsion, Saline
- Where
- 2 sites in Switzerland
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Functional Dyspepsia
Neuro-immune Interactions and PPI
Prospective interventional study on duodenal neuro-immune interactions in healthy volunteers and functional dyspepsia patients and the effects of PPI
- Trial name
- NCT04713969
- Testing
- Pantoprazole 40mg
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Immune System Processes, Inflammatory Activation and Modulation
The Sounds of Compassion: Testing How Specific Elements of Meditation Change Daily Life
Important health benefits of meditation may be conferred as much by what people actually do and say in their daily lives as by how they self-perceive the effect of training on their behavior and emotions.
- Conditions
- Immune System Processes, Inflammatory Activation and Modulation, ANS Function
- Trial name
- NCT01643369
- Testing
- Cognitive-Based Compassion Training, Adult Health Education Curriculum, Mindful Attention Training
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Hypertension
Effect of Polyphenols Combined to L-citrulline on Ambulatory Blood Pressure
The general objective of this project is to investigate the chronic effect of consuming supplements combining polyphenols from cranberry and grape seed extracts and L-citrulline (Nitric Oxide Ultra capsules, Pure Encapsulations…
- Trial name
- NCT03679195
- Testing
- NO Ultra
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Laval University
Cognitive Function, Cardiopulmonary Function
Commuter Air Pollution Intervention Study
Traffic related air pollution is a well-recognised and much studied contributor to smog and is linked to a number of adverse health outcomes.
- Conditions
- Cognitive Function, Cardiopulmonary Function, Saliva Stress Hormones, Air Pollution Exposure
- Trial name
- CAPI (NCT02277002)
- Testing
- Cabin Air Filtration
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Health Canada
Sepsis, SIRS(Systemic Inflammatory Response Syndrome)
Detection Of Monocytes/Macrophages Function And Tim-3 Expression In Septic Patients
The imbalance between anti- and pro-inflammation often occurs in patients with sepsis. And continuous such imbalance could lead to immunoparalysis, which is characterized by loss of delayed type hypersensitivity, failure of…
- Trial name
- NCT01801839
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital