Clinical trials: Inflammatory
Ischemic Reperfusion Injury
Lipid Emulsion in Cardiac Valve Replacement Surgery
Myocardial protection has become an essential adjunctive measure in cardiac surgery to bail the myocardium out of ischemia/reperfusion-induced damage during the operation.
- Trial name
- NCT04951791
- Testing
- SMOFlipid, Normal saline 0.9%
- Volunteers
- 68 people
- Sponsor
- Assiut University
Hemorrhagic Shock
Effect of Remote Ischemic Conditioning on Trauma Patients With Hemorrhagic Shock
The purpose of the study is to evaluate whether remote ischemic conditioning is a safe and effective intervention to prevent the development of inflammation and coagulopathy in trauma patients with hemorrhagic shock.
- Trial name
- NCT02071290
- Testing
- Pneumatic tourniquet
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
Crohn Disease
Evaluation of a New Oral Contrast Agent for MR Enterography in the Assessment of Crohn Disease in the Small Bowel
The purpose of this study is to assess the exam quality and accuracy of MR using a new oral contrast agent for the evaluation of Crohn Disease in the small bowel.
- Trial name
- NCT00587210
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Mayo Clinic
Neonate, Sepsis
Point of Care - Sepsis Study
This pilot study will evaluate whether a rapid point-of-care blood test can help identify early signs of infection and sepsis in preterm infants.
- Conditions
- Neonate, Sepsis, IL6, PCT
- Trial name
- POCT Sepsis (NCT07774013)
- Testing
- Point-of-Care Measurement of Inflammatory Biomarkers
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Medical University of Graz
Sepsis, Acute Respiratory Distress Syndrome
Corticosteroids in Hyperinflammatory Phenotype of Critical Illness
The goal of this clinical trial is to learn whether methylprednisolone improves outcomes in critically ill patients with a hyperinflammatory phenotype. It will also evaluate the safety of methylprednisolone at different doses.
- Trial name
- CHIP (NCT07511582)
- Testing
- Methylprednisolone (MP)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Bin Du
Crp
CRP/Albumin Ratio as a Predictive Inflammatory Marker for Postoperative SIRS and/or Sepsis
The goal of this observational study is to determine the value of CRP/Albumin Ratio as an inflammatory marker for predicting the development of postoperative Systemic Inflammatory Response Syndrome and/or Sepsis in…
- Trial name
- NCT06050759
- Testing
- CRP and Albumin level in blood sample
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Periodontitis, Periodontitis Chronic Generalized Severe
Effect of Non-surgical Treatment of Periodontitis Patients Focusing on Inflammatory Mediators in Gingival Crevicular Fluid
This study investigates inflammatory biomarkers in gingival crevicular fluid (GCF) from smokers and non-smokers with severe periodontitis, before and during non-surgical periodontal therapy (NSPT).
- Trial name
- NONSURG (NCT07503041)
- Testing
- Collecting fluid for biomarker analyses, Hygiene instruction, tooth cleaning, plaque removal
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Oral Health Centre of Expertise in Western Norway
Renal Stone Disease
Direct In-Scope Suction Versus Standard Flexible Ureterorenoscopy
This prospective study aims to compare the clinical, perioperative, and postoperative outcomes of flexible ureterorenoscopy using a direct in-scope suction system (DISS) with standard flexible ureterorenoscopy in patients…
- Trial name
- NCT07864194
- Testing
- Standard flexible ureterorenoscope, Flexible ureterorenoscope with direct in-scope suction
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Hitit University
Colitis Ulcerative, Crohn Disease
Mesalamine and Reproductive Health Study
The purpose of this study is to investigate the relationship of high exposure to dibutyl phthalate (DBP) from the use of Asacol with clinical and intermediate markers of male fertility, including semen quality, sperm DNA damage…
- Trial name
- MARS (NCT01331551)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Harvard School of Public Health (HSPH)
Sepsis
The Impact of Zinc Supplementation on Innate Immunity and Patient Safety in Sepsis
Sepsis is the body's response to a life-threatening infection. This study will determine if zinc supplementation is safe to use in patients with severe sepsis or septic shock.
- Trial name
- NCT02130388
- Testing
- Zinc
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Ohio State University
Crohn's Disease, Inflammatory Bowel Disease
Dietary Treatment of Crohn's Disease
Our objective is to determine whether a specific dietary intervention or a fructooligosaccharide (FOS) supplement has anti-oxidant or prebiotic effects and whether it is beneficial in the treatment of Crohn's Disease (CD.
- Trial name
- NCT00343642
- Testing
- Active fructo-oligosaccharide, Diet
- Where
- 2 sites in United States
- Volunteers
- 73 people
- Sponsor
- Rush University Medical Center
Ulcerative Colitis (UC), Crohn's Disease
A Study to Evaluate the Effect of Intravenous (IV) Infusions of Risankizumab on Pharmacokinetics of Cytochome P450 Substrates in Adult Participants With Moderately to Severely Active Ulcerative Colitis or Crohn's Disease
Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine).Crohn's disease (CD) is a long-lasting condition causing inflammation…
- Trial name
- NCT04254783
- Testing
- Risankizumab, Cytochrome P450 (CYP) Substrates
- Where
- 6 sites in United States, Germany and 1 more
- Volunteers
- 20 people
- Sponsor
- AbbVie
Healthy
Effect of Garlic on Inflammatory Mediators
This research will investigate the effect of garlic oil extract when added to daily diet on inflammatory mediators and blood clotting activation.
- Trial name
- NCT00275405
- Testing
- Garlic Oil Macerate
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Crohn's Disease
Safety of Celecoxib in Patients With Crohn's Disease
The investigators will select 60 people who are 18-70 years of age with Crohn's disease and randomly assign them to receive an 8-week trial of celecoxib and an 8-week trial of a placebo.
- Trial name
- NCT00177866
- Testing
- Celebrex
- Volunteers
- 28 people
- Sponsor
- University of Pittsburgh
Chronic Obstructive Pulmonary Disease
Anti-inflammatory Effects of Caffeine in Chronic Obstructive Pulmonary Disease (COPD) Subjects
Nowadays it has become evident that a chronic systemic inflammation is present in patients suffering from chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00826566
- Testing
- Caffeine
- Where
- Netherlands
- Sponsor
- Maastricht University Medical Center
Inflammatory Bowel Disease
Integrated Care for Inflammatory Bowel Disease Patients in the Netherlands With the Novel Telemedicine Tool myIBDcoach: a Randomized Controlled Trial
Inflammatory bowel diseases (IBD) is an invalidating disease mainly diagnosed in young people. The disease is characterized by a heterogenic phenotype and the disease course by flares and remissions.
- Trial name
- myIBDcoach (NCT02173002)
- Testing
- myIBDcoach, Standard care
- Where
- Netherlands
- Volunteers
- 909 people
- Sponsor
- Maastricht University Medical Center
Septic Shock
Plasmaexchange in Early Septic Shock
Sepsis is defined by the occurrence of a systemic inflammatory response syndrome (SIRS) in the context of infection. Unfortunately, its incidence appears to be rising, and the mortality of septic shock remains extraordinary high…
- Trial name
- EXCHANGE (NCT03065751)
- Testing
- Plasmaexchange
- Where
- Germany
- Volunteers
- 352 people
- Sponsor
- Hannover Medical School
Sepsis Syndrome, Systemic Inflammatory Response Syndrome
The Role of Myristic Acid in Serum for Early Diagnosis of Sepsis and Comparison With Selected Biomarkers of Sepsis
The aim of the study is to measure serum levels of myristic acid in septic patients and to compare them with myristic acid serum levels in patients with Systemic Inflammatory Response Syndrome of non infective etiology and in…
- Trial name
- NCT03314831
- Where
- Czechia
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Inflammatory Bowel Diseases, Calprotectin
Effect of Semi-vegetarian Diet in Inflammatory Bowel Disease Patients With Clinical Remission
In the 21st century, the incidence of inflammatory bowel disease (IBD) globally increases. Higher incidence of IBD development may implicate that environmental factors played essential roles in IBD pathogenesis.
- Conditions
- Inflammatory Bowel Diseases, Calprotectin, Fecal Microbiota, Vegetarian Diet
- Trial name
- NCT04835727
- Testing
- Semi-vegetarian diet and increase fiber consumption
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Myocarditis, Pericarditis
COVID-19 Vaccine-induced Inflammatory Heart Disease Prevalence Registry
Myocarditis and pericarditis are inflammatory diseases of the myocardium and pericardium, and can be related to different causes, including vaccines.
- Trial name
- COVID-VIHPR (NCT05046002)
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
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