Clinical trials: Inflammatory
Crohn Disease (CD), Ulcerative Colitis (UC)
Education Intervention on Vaccination Adherence Among Inflammatory Bowel Disease (IBD) Patients
A retrospective chart review and a six-month prospective outcome analysis aimed to evaluate the efficacy of a vaccination education intervention and vaccination adherence among IBD patients at Weill-Cornell Medical Center.
- Conditions
- Crohn Disease (CD), Ulcerative Colitis (UC), Indeterminate Colitis
- Trial name
- NCT04672161
- Testing
- Vaccine Education
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Weill Medical College of Cornell University
COVID-19
Measurement of IL-6 and Secondary Inflammatory Markers Before and After Therapeutic Plasma Exchange (TPE) in Hospitalized Patients
Given the current lack of an effective drug or therapy, a clinical trial to better understand the safety and efficacy of therapeutic plasma exchange (TPE) in COVID-19 patients is urgently needed.
- Trial name
- NCT04592705
- Testing
- Therapeutic plasma exchange
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Larkin Community Hospital
Arthritis, Rheumatoid
Laser-based Photoacoustic Tomography of Human Inflammatory Arthritis
The purpose of this feasibility study is to determine if a new emerging technology called photoacoustic tomography (PAT) can be adapted for use in humans for the detection of chronic rheumatoid arthritis.
- Trial name
- NCT00748254
- Testing
- Laser Based Photoacoustic Tomography, MRI, Ultrasound
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University of Michigan
COVID-19 Pneumonia, Superinfection Lung
Superinfection and Hyperinflammatory Phenotype in COVID-19 (Coronavirus Disease 2019) Pneumonia Patients
Patients suffering from COVID-19 (Coronavirus Disease 2019) pneumonia are prone to bacterial and mycotic superinfection. According to existing evidence, the prevalence of superinfection is about 8% to 14% (95% CI 5-26%).
- Trial name
- SUPER-HI (NCT04867161)
- Testing
- Inflammatory markers sampling
- Where
- Czechia
- Volunteers
- 300 people
- Sponsor
- Brno University Hospital
Inflammatory Bowel Diseases
Comparison of Trough Level- and Clinical-based Spacing of Infliximab Infusions in Patients With IBD in Deep Remission
Comparison of trough level-based spacing and clinical-based spacing of infliximab infusions in patients with inflammatory bowel disease in deep remission A prospective, multicenter, open-label, randomized, controlled Study
- Trial name
- SPACIFIX (NCT03841942)
- Testing
- clinically-based spacing strategy, Trough level-based strategy
- Where
- 16 sites in France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Montpellier
Pelvic Inflammatory Disease
Technology Based Community Health Nursing(TECH-N) to Prevent Recurrent STIs After PID II
The investigators are enrolling 150 young women 13-25 years old diagnosed with pelvic inflammatory disease (PID) in Baltimore to receive community health nurse (CHN) clinical support visits and short messaging system…
- Trial name
- NCT03828994
- Testing
- Tech-PN
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Johns Hopkins University
Crohn Disease, Drug Monitoring
TDM Guided Early Optimization of ADAL in Crohn's Disease
To investigate the influence of early therapeutic drug monitoring and dose optimization on disease outcome in Crohn's patients treated with Adalimumab.
- Conditions
- Crohn Disease, Drug Monitoring, Inflammatory Bowel Diseases
- Trial name
- NCT03261102
- Testing
- Adalimumab
- Where
- 6 sites in Canada
- Volunteers
- 200 people
- Sponsor
- waqqas.afif
Severe Sepsis
Symphony IL-6 Study in Patients at Risk of Severe Sepsis
Symphony IL-6 is a device that quantitates human IL-6 by fluorescence enzyme immunoassay (FEIA) from whole-blood specimens. Use of Symphony IL- 6 removes the need for plasma separation before testing.
- Trial name
- NCT05665153
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Bluejay Diagnostics, Inc.
Granulomatosis With Polyangiitis, Wegener Granulomatosis
The Assessment of Prednisone In Remission Trial (TAPIR) - Patient Centric Approach
This is a randomized controlled trial in patients with a diagnosis of granulomatosis with polyangiitis (GPA; Wegener's)that are in remission to evaluate the effects of using low-dose glucocorticoids ( 5 mg/day of prednisone) as…
- Conditions
- Granulomatosis With Polyangiitis, Wegener Granulomatosis, Vasculitis
- Trial name
- TAPIR (NCT01933724)
- Testing
- 5 mg prednisone, 0 mg prednisone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of South Florida
Ulcerative Colitis, Inflammatory Bowel Diseases
Examining the Efficacy of Fecal Microbiota Transplantation (FMT) and Dietary Fiber in Patients With Ulcerative Colitis
A double-blind, randomized, placebo-controlled clinical trial examining the efficacy and safety of Fecal Microbiota Transplantation (FMT) and high fiber supplementation in patients with active mild to moderate Ulcerative Colitis…
- Trial name
- MINDFUL (NCT03998488)
- Testing
- Fecal Microbiota Transplantation, Psyllium Husk Powder
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Weill Medical College of Cornell University
Spondyloarthritis
SKIPPAIN - Speed of Onset of SecuKinumab-Induced Relief From Pain in Patients With AxIal SpoNdyloarthritis
The purpose of the study was to evaluate the efficacy and safety of secukinumab 150 mg compared to placebo in the early management (Baseline to Week 8) of spinal pain, disease activity, fatigue, and predictability of disease…
- Trial name
- SKIPPAIN (NCT03136861)
- Testing
- AIN457
- Where
- 66 sites in Belgium, Bulgaria and 15 more
- Volunteers
- 383 people
- Sponsor
- Novartis Pharmaceuticals
Acupuncture Analgesia, Acupuncture
ACU_Knee: Role of Acupuncture in Knee Prosthetic Surgery
Post-operative analgesia after total knee arthroplasty (TKA) has always been a challenge in the anesthesiological setting, having to combine good pain control and the need for early mobilization, both factors that can affect the…
- Conditions
- Acupuncture Analgesia, Acupuncture, Acupuncture Therapy, Total Knee Anthroplasty
- Trial name
- ACU_Knee (NCT07123805)
- Testing
- Acupuncture group
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Bacteremia
Central Venous Catheter Lock Solution
The purpose of this study is to determine whether the application of 47% citrate lock solution decreases the incidence of infection and thrombosis of central venous catheter in hemodialysis population.
- Trial name
- CVCLS (NCT00862966)
- Testing
- citrate, heparin
- Where
- Bosnia and Herzegovina
- Volunteers
- 40 people
- Sponsor
- University Medical Center, Tuzla
Sepsis
Sepsis in Critically Ill Patients
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host immune response to infection, and remains the leading cause of death in critical care medicine worldwide.
- Trial name
- NCT07707622
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 2,400 people
- Sponsor
- Beijing Chao Yang Hospital
Ulcerative Colitis
Fecal Microbiota Transplantation in Pediatric Ulcerative Colitis (UC)
This study included two topics: one was to test the efficacy and safety of fecal microbiota transplants plus partial enteral nutrition (PEN) in refractory pediatric UC where conventional therapy has failed, and the other was to…
- Trial name
- FMT (NCT05679622)
- Testing
- Fecal Microbiota Transplantation
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Biao Zou
Bruxism, Myofascial Pain
Botulinum Toxin Type A Versus Oral Ibuprofen for Bruxism
This randomized controlled trial evaluated the effectiveness of Botulinum Toxin Type A compared with oral ibuprofen in reducing pain and improving oral health-related quality of life in patients with sleep bruxism and jaw muscle…
- Trial name
- NCT07732751
- Testing
- Botulinum Toxin Type A 100U, Ibuprofen
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Cyprus Health and Social Sciences University
Septic Shock, Severe Sepsis
Lactated Ringer Versus Albumin in Early Sepsis Therapy
The use of albumin in critical ill patients is a matter of controversy. A large randomized controlled trial reported that albumin was as safe and effective as crystalloid solution for fluid replacement in intensive care unit…
- Trial name
- RASP (NCT01337934)
- Testing
- Lactated Ringer, Albumin
- Where
- Brazil
- Volunteers
- 360 people
- Sponsor
- University of Sao Paulo
Metabolism and Nutrition Disorder
Prospective Evaluation of the Incidence of PICS
Advances in modern medicine and critical care interventions have greatly impacted survival of critically ill patients, but these interventions are not without consequences.
- Trial name
- ProsPICS (NCT03584399)
- Testing
- PICS in critically ill pediatric population
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Indiana University
Extracorporeal Membrane Oxygenation, Sepsis
Pharmacokinetic Study of Antibiotics in Patients Assisted by Extracorporeal Membrane Oxygenation (PHARMECMO)
The PHARMECMO study is a pilot, prospective, pharmacokinetic study, conducted in a cardiac surgery intensive care unit of 18 beds.
- Conditions
- Extracorporeal Membrane Oxygenation, Sepsis, Intensive Care Unit, Antibiotics
- Trial name
- PHARMECMO (NCT03131063)
- Testing
- Antibiotic plasma dosage
- Volunteers
- 45 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Crohn's Disease
Contrast-Enhanced Ultrasound in Human Crohn's Disease
To determine if contrast enhanced ultrasound (CEUS) and shear wave elastography can accurately diagnose bowel wall inflammation and fibrosis in patients with known Crohn's disease.
- Trial name
- NCT02061163
- Testing
- Contrast Enhanced Ultrasound, Optison
- Where
- United States
- Sponsor
- University of Michigan
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