Clinical trials: Inflammatory
Sepsis
Prebiotic Fiber to Prevent Pathogen Colonization in the ICU
This is a pilot trial testing enteral feeds that are high versus low in prebiotic fiber in 20 critically ill adults. The long-term goal is to determine the efficacy of fiber for the prevention of pathogen colonization/infection…
- Trial name
- NCT03509753
- Testing
- High Fiber, Low Fiber
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Columbia University
Arthritis, Arthritis, Juvenile Idiopathic
Pain in Inflammatory Joint Diseases
Our primary objective is to better understand the etiology and consequences of chronic paint by using an explorative approach to identify phenotypes and endotypes of patients with inflammatory joint diseases, with a special focus…
- Conditions
- Arthritis, Arthritis, Juvenile Idiopathic, Arthritis,Rheumatoid, Arthritis, Reactive
- Trial name
- Nor-Pain (NCT06718569)
- Testing
- Biological or targeted synthetic DMARD
- Where
- Norway
- Volunteers
- 350 people
- Sponsor
- Diakonhjemmet Hospital
Obesity, Hyperlipidemia
Effects of Dietary Antioxidants on Cardiovascular Risk Factors
The aim of the Antioxidant Study was to compare the efficacy of foods naturally rich in antioxidants with that of antioxidants in a pill form on markers of inflammation and plasma cholesterol in healthy adults at risk of…
- Conditions
- Obesity, Hyperlipidemia, Hypertension
- Trial name
- NCT00756405
- Testing
- Antioxidant diet, Antioxidant supplement
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Christopher Gardner
Tobacco Use Cessation
Smoking Cessation Support for Patients With Rheumatologic Diseases Via WhatsApp
Smoking cessation support for patients with rheumatologist diseases is an underestimated issue. In the previous prospective cohort study the investigators determined that with the brief cessation interventions 63.5% of smokers…
- Trial name
- NCT06219551
- Testing
- Mobile messages via What's App
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Crohn Disease, Colitis, Ulcerative
Immune Modulation From Trichuris Trichiura
Mucosal immunology during helminth infection
- Conditions
- Crohn Disease, Colitis, Ulcerative, Intestinal Helminthiasis
- Trial name
- NCT02399683
- Testing
- Trichuris trichiura eggs
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Adequate Vitamin C Status, Inadequate Vitamin C Status
Anti-inflammatory Activities of Vitamin C Supplementation on the Gut Barrier Function in Adults With Obesity
This study is testing whether taking vitamin C every day can help improve gut health and reduce inflammation in adults with obesity.
- Trial name
- NCT07151105
- Testing
- Vitamin C Supplement + Low Vitamin C Diet
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Ohio State University
Colorectal Cancer, Gastric Cancer
Samples Procurement for Colorectal Cancer, Gastric Cancer, and Non-malignant Disease
The purposes of this study are to collect and store samples including blood, normal and tumor tissue from patients with colorectal cancer or gastric cancer, to collect and store samples including blood and/or normal…
- Conditions
- Colorectal Cancer, Gastric Cancer, Inflammatory Bowel Diseases, Gastric Ulcer
- Trial name
- NCT03972956
- Testing
- No intervention will be given to patients.
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Renmin Hospital of Wuhan University
Crohn's Disease
Understanding the Relationship Between Infliximab Levels to Clinical Response of Remicade in Crohn's Disease
The purpose of this study is to improve the investigators understanding of the relationship between Crohn's disease and blood levels of the drug infliximab (Remicade).
- Trial name
- NCT01438151
- Testing
- Remicade
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Shradha Agarwal
Osteoarthritis, Post-traumatic Arthritis
Foundation Knee Study - Retrospective
The purpose of this study is to evaluate the use and efficacy of the Encore Foundation Knee System in a group of 200 patients for whom data has already been collected.
- Conditions
- Osteoarthritis, Post-traumatic Arthritis, Inflammatory Tissue Disorders, Arthritis Secondary to Other Diseases
- Trial name
- NCT00764894
- Testing
- Foundation Knee
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Encore Medical, L.P.
Sepsis, Sepsis Bacterial
Clinical Outcomes and Inflammatory Responses in Viral vs. Bacterial Sepsis
This observational cohort study aims to compare clinical outcomes and inflammatory responses between patients with viral sepsis, specifically COVID-19-associated sepsis, and those with bacterial sepsis.
- Conditions
- Sepsis, Sepsis Bacterial, Viral Sepsis, Inflammatory Response
- Trial name
- NCT06491966
- Testing
- observation
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Sichuan Provincial People's Hospital
Colitis, Ulcerative
A Study of JNJ-78934804 in Participants With Moderately to Severely Active Ulcerative Colitis
The purpose of this study is to assess how well JNJ-78934804 works (efficacy) and how safe it is (safety) as compared to guselkumab at Week 48 in participants with moderately to severely active ulcerative colitis (UC, a chronic…
- Trial name
- DUET ENCORE-UC (NCT07577856)
- Testing
- JNJ-78934804, Guselkumab
- Where
- 318 sites in United States, Argentina and 31 more
- Volunteers
- 644 people
- Sponsor
- Janssen Research & Development, LLC
Spondylitis, Ankylosing
16-week Efficacy and 2-year Safety, Tolerability and Efficacy of Secukinumab in Participants With Active Ankylosing Spondylitis
The purpose of this study is to provide 16-week efficacy, safety and tolerability data versus placebo to support the use of secukinumab 150 mg by subcutaneous (s.c.) self-administration with or without a loading regimen and…
- Trial name
- MEASURE4 (NCT02159053)
- Testing
- Secukinumab
- Where
- 90 sites in United States, Australia and 17 more
- Volunteers
- 350 people
- Sponsor
- Novartis Pharmaceuticals
Sepsis, Septic Shock
Early and Late Neutrophil CD64 and Monocyte HLA-DR as Biomarkers for Septic Shock
Study Summary: Neutrophil CD64 \& Monocyte HLA-DR in Septic Shock What is studied? Doctors looked at two blood markers: Neutrophil CD64 (nCD64): rises quickly when the body fights infection.
- Trial name
- NCT07401329
- Where
- India
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Pandit Bhagwat Dayal Sharma, PGIMS, Rohtak
Septic Shock
Effect of IV Vitamin C, Thiamine, and Steroids on Mortality of Septic Shock
Preliminary studies show that giving a "cocktail" of intravenous vitamin C, vitamin B1, and steroids to critically ill patients with septic shock may dramatically improve mortality in those patients.
- Trial name
- NCT03828929
- Testing
- Vitamin C, Normal saline
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- New York Presbyterian Brooklyn Methodist Hospital
Psoriatic Arthritis, Osteoarthitis
CARTIZ Registry: Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts - A Four-Institute Mexican Observational Registry
CARTIZ is a prospective observational clinical registry of adults in Mexico receiving tirzepatide (a dual GLP-1/GIP receptor agonist) under an independent clinical indication - typically type 2 diabetes, insulin resistance…
- Conditions
- Psoriatic Arthritis, Osteoarthitis, Knee, Diabetes (DM)
- Trial name
- CARTIZ (NCT07567378)
- Testing
- Tirzepatide
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- JULIO GRANADOS MONTIEL
Crohn Disease
An Innovative Treatment for Fistula-in-ano in Crohn Disease : Local Micro Reinjection of Autologous Fat and SVF
Crohn's disease is a chronic inflammation of all or part of the digestive tract, " from the mouth to the anus ". . Cell therapy is a new and promising approach for the treatment of inflammatory disease including Crohn's disease…
- Trial name
- NCT02520843
- Testing
- stromal vascular fraction (SVF)
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Inflammation, Inflammation Biomarkers
Analysis of Inflammatory Biomarker Changes in Dry Blood Spot Versus Venous Blood Samples
The purpose of this study is to see whether dried blood spot (DBS) samples can measure inflammatory biomarkers as accurately as venous blood samples.
- Conditions
- Inflammation, Inflammation Biomarkers, Blood Sampling, Dried Blood Spot
- Trial name
- DBS-VB (NCT07435285)
- Testing
- Venous blood sampling, Dried blood spot sampling
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Inflammatory Bowel Diseases, Ulcerative Colitis
IBD-Sleep: A Pilot Study Looking at Changes in Sleep Timing and IBD Symptoms
This research study is testing whether changes in sleep timing and morning light treatment may have an impact on symptoms related to inflammatory bowel disease.
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT06094608
- Testing
- Morning light treatment, Treatment-as-usual
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Michigan
Pain
Pharmacokinetics & Safety of Diclofenac Potassium Oral Solution in Ped. Subjects (2-12 Yrs) With Mild-Mod. Acute Pain
As part of the Pediatric Research Equity Act (PREA) commitment, the objectives of the study are to characterize the pharmacokinetic (PK) profile and to determine the safety and tolerability of diclofenac potassium oral solution…
- Trial name
- NCT02287350
- Testing
- diclofenac potassium oral solution
- Where
- 5 sites in United States
- Volunteers
- 51 people
- Sponsor
- Depomed
Colitis, Ulcerative
Localized Therapeutics for the Treatment of Gastrointestinal Disorders II
The purpose of this study is to investigate a novel thermosensitive topical gel formulation for the treatment of inflammatory bowel disease (IBD), specifically ulcerative colitis.
- Trial name
- NCT02745678
- Testing
- Thermosensitive gel rectal formulation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Stanford University
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