Clinical trials: Inflammatory
Inflammatory Bowel Disease
A Brief Intervention to Improve Adherence in Teens With Inflammatory Bowel Disease
This project will test if a phone intervention can improve the medicine-taking behavior of teens with IBD. The investigators will study teens who are taking medicine by mouth.
- Trial name
- PHONE (NCT01237847)
- Testing
- 2 Family-based problem solving phone sessions, 4 Family-based problem solving phone intervention sessions, Wait list comparison group
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Rosalind Franklin University of Medicine and Science
Multiple Sclerosis, Colitis, Ulcerative
A Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics (PD) of GSK3888130B in Healthy Participants
This is a first time in human study designed to assess the safety, tolerability, pharmacokinetics and PD of GSK3888130B over a range of dose levels in healthy participants.
- Trial name
- NCT05131971
- Testing
- GSK3888130B
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Autism Spectrum Disorder
Effect of Probiotic Compound K11T e K11TMax in ASD
The research is characterized as a randomized, double-blind clinical trial (phase III) in which administered the probiotic K11-T (with and without added amino acids, fatty acids and vitamins) to children between 3 and 11 years…
- Trial name
- ASD (NCT06382909)
- Testing
- Inflammatory level, Cognitive assessment, Pedagogical assessment
- Where
- 2 sites in Brazil
- Volunteers
- 505 people
- Sponsor
- Deivis de Oliveira guimaraes
Schizophrenia, Schizoaffective Disorder
Randomized Double Blind Placebo Control Study in Patients with Schizophrenia
Negative symptoms and cognitive deficits are two partially-related features of schizophrenia which have a major negative impact on social function and objective quality of life.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Psychosis Not Otherwise Specified, Schizophreniform Disorder
- Trial name
- ROSES (NCT01602029)
- Testing
- Ondansetron, Simvastatin, Odansetron plus simvastatin
- Where
- 3 sites in Pakistan
- Volunteers
- 303 people
- Sponsor
- Pakistan Institute of Living and Learning
Cancer Survivorship, Chemotherapy Side Effects
Remote Physical Activity Programming to Improve Outcomes in Cancer Survivors With and Without Type 2 Diabetes
The growing U.S. cancer survivor population is projected to hit 26M by 2040. Chemotherapy represents an effective cancer treatment but can diminish cancer survivors' quality of life-particularly cognitive function-through select…
- Trial name
- CICI-PA (NCT06725953)
- Testing
- Social Cognitive Theory-based, Technology-delivered Physical Activity Program
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Oklahoma
Sepsis
Derivation and Validation of a Prognostic Model for Septic Patients at Hospital Admission
The aim of the present study is to develop a prognostic tool to assess the risk of dead and major complications in patient admitted to hospital for infection.
- Trial name
- NCT03601767
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Azienda Ospedaliera San Paolo
Colitis, Ulcerative
An Efficacy and Safety Study of Mongersen (GED-0301) in Subjects With Active Ulcerative Colitis
This is a phase 2, open-label, multicenter study to explore the efficacy and safety of oral GED- 0301 in subjects with active UC, defined as a modified Mayo score (MMS) ≥ 4 and ≤ 9 and a Mayo endoscopic subscore≥ 2.
- Trial name
- NCT02601300
- Testing
- GED-0301
- Where
- 36 sites in United States, Bulgaria and 4 more
- Volunteers
- 41 people
- Sponsor
- Celgene
Ulcerative Colitis
Efficacy and Safety of SPD476 in Maintaining Remission in Patients With Ulcerative Colitis
Ulcerative colitis is a disease of the large bowel (colon) and rectum in which the lining of the bowel becomes red and swollen. Over time, patients with this disease may experience acute episodes of diarrhea, rectal bleeding and…
- Trial name
- NCT00151892
- Testing
- SPD476, Asacol
- Where
- 142 sites in United States, Argentina and 26 more
- Volunteers
- 829 people
- Sponsor
- Shire
Graft Versus Host Disease in Eye, Ocular Complications
Ocular Complications From Cancer Therapy - Patient Registry and Biobank
The purpose of this study is to collect data on patients seen at University of Maryland after undergoing cancer therapy. Previous medications, ocular history, medical history, clinical evaluations, surgical procedures and…
- Conditions
- Graft Versus Host Disease in Eye, Ocular Complications, Inflammatory Dry Eye Disease
- Trial name
- NCT06874283
- Testing
- Eye exam
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Endotoxemia, Intestinal Microbiota
Dietary Intervention to Reduce Metabolic Endotoxemia
The goal of this randomized clinical trial is to compare an antiinflammatory and environmentally friendly dietary strategy (AIA-D) designed based on the planetary health diet recommendations translated to the regional context and…
- Conditions
- Endotoxemia, Intestinal Microbiota, Dietary Habits, Clinical Trial
- Trial name
- NCT05776329
- Testing
- AIA-D, CONV-D
- Where
- 2 sites in Mexico
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Centro de Investigación en Alimentación y Desarrollo A.C.
Knee Osteoarthritis
Clinical Study of Artz in the Treatment of Knee Osteoarthritis
This is a multi-center, randomized, open-label, parallel-arm phase IV clinical study, for which a total of 300 patients with mild to moderate knee osteoarthritis will be enrolled.
- Trial name
- Artz (NCT02826031)
- Testing
- Sodium Hyaluronate Injection, DICL-SR
- Where
- 6 sites in China
- Volunteers
- 300 people
- Sponsor
- Kunming Baker Norton Pharmaceutical Sales Co., Ltd.
Graft Vs Host Disease, Inflammatory Bowel Diseases
Precision Diagnostics in Inflammatory Bowel Disease, Cellular Therapy and Transplantation (The PREDICT Trial)
The goal of the Precision Diagnosis in Inflammatory Bowel Disease, Cellular Therapies, and Transplantation (PREDICT) trial is to apply a systems-biology approach to enable precision diagnostics for the key immunologic outcomes…
- Conditions
- Graft Vs Host Disease, Inflammatory Bowel Diseases, Functional Gastrointestinal Disorders
- Trial name
- PREDICT (NCT03369353)
- Where
- 4 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Boston Children's Hospital
Psoriasis
Safety, Pharmacokinetics, and Efficacy of RA-18C3 in Subjects With Moderate to Severe Psoriasis
This is a 73-day phase II, open label trial of the true human monoclonal antibody RA-18C3 in subjects with moderate to severe plaque psoriasis. Ten (10) subjects will receive 200 mg of RA-18C3 via subcutaneous injection.
- Trial name
- NCT01384630
- Testing
- RA-18C3
- Where
- 3 sites in United States
- Volunteers
- 8 people
- Sponsor
- Janssen Research & Development, LLC
Lumbar Osteoarthritis, Spondylosis
Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion Outcomes
Patients undergoing spine surgery often have considerable pain post-operatively and frequently require opioid medication (Percocet, Norco, oxycodone, morphine, etc.) to control their pain postoperatively.
- Conditions
- Lumbar Osteoarthritis, Spondylosis, Lumbar Disc Disease, Spinal Stenosis
- Trial name
- NCT02700451
- Testing
- Ketorolac, Acetaminophen
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- Hospital for Special Surgery, New York
Ulcerative Colitis
Phosphatidylcholine (LT-02) vs. Placebo vs. Mesalamine for Maintenance of Remission in Ulcerative Colitis (PROTECT-2)
The purpose of this study is to prove the superiority of a 48-weeks treatment with 3.2 g/day delayed-release phosphatidylcholine (LT-02) versus placebo for the maintenance of remission in patients with ulcerative colitis (UC)
- Trial name
- PROTECT-2 (NCT02280629)
- Testing
- LT-02, Mesalamine
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Dr. Falk Pharma GmbH
Ebola Virus Disease, Marburg Virus Disease
Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults
Primary Objective: To evaluate the safety and tolerability of cAd3-EBO-S and cAd3 Marburg vaccines when administered Intramuscular (IM) at a dose of 1 x 10^11 particle units (PU) to healthy adults.
- Trial name
- NCT04723602
- Testing
- cAd3-Marburg, cAd3-EBO-S
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Pelvic Inflammatory Disease
First in Human Study to Investigate the Safety, Tolerability, Pharmacokinetics and to Explore Pharmacodynamics of BAY1834845
This study is a first in human study that will investigate the safety, tolerability and pharmacokinetics and explore the pharmacodynamics of ascending single doses of BAY1834845 using a placebo controlled, randomized, single…
- Trial name
- NCT03054402
- Testing
- BAY1834845
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Bayer
Acute Disseminated Encephalomyelitis, Devic's Syndrome
Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone
OBJECTIVES: I. Evaluate the effectiveness of plasma exchange in the treatment of acute severe attacks of inflammatory demyelinating disease in patients who have failed intravenous steroid therapy.
- Conditions
- Acute Disseminated Encephalomyelitis, Devic's Syndrome, Marburg's Variant of Multiple Sclerosis, Balo's Concentric Sclerosis
- Trial name
- NCT00004645
- Testing
- Plasma exchange
- Volunteers
- 22 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Ulcerative Colitis, Histology Remission
FIT Combining FC for Predicting MH and Histology Remission in UC
Investigaters will perform a clinical trial to asess the abilitiy of qFIT and FC on predicting UC MH and histology remission.
- Conditions
- Ulcerative Colitis, Histology Remission, Fecal Calprotetin, FIT
- Trial name
- NCT05447572
- Testing
- FIT + FC
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shandong University
Ulcerative Colitis, Crohn's Disease
Eicosapentaenoic Free Fatty Acid and Fecal Calprotectin in Inflammatory Bowel Diseases
The aim of this study is to test Eicosapentaenoic free fatty acid's effects on calprotectin levels in IBD patients in clinical remission.
- Trial name
- NCT02179372
- Testing
- Eicosapentaenoic acid
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
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