Clinical trials: Inflammatory
Breast Cancer
Combination Chemotherapy Before Surgery in Treating Women With Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells and shrink tumors so they can be removed during…
- Trial name
- NCT00008034
- Testing
- capecitabine, cyclophosphamide, epirubicin hydrochloride
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Rheumatoid Arthritis, Psoriatic Arthritis
Research Study on the Immunosuppressive Effects of a Cell Therapy Product on PBMC Isolated From Blood of Patients With Inflammatory Rheumatic Diseases
Rheumatic diseases regroup a variety of disorders affecting the locomotor system including joints, muscles, connective tissues and soft tissues around the joints and bones.
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Spondylarthritis
- Trial name
- NCT03454932
- Testing
- Blood sampling
- Volunteers
- 30 people
- Sponsor
- Bone Therapeutics S.A
Inflammatory Bowel Diseases, Crohn Disease
Sick Leave, Work Disability and Quality of Life in Korean Patients With Inflammatory Bowel Diseases
Inflammatory bowel diseases (IBD) is a chronic inflammatory condition of the gastrointestinal tract that significantly affects quality of life of patients.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT03565432
- Where
- South Korea
- Volunteers
- 402 people
- Sponsor
- Kyunghee University Medical Center
Diseases, Metabolic, Insulin Sensitivity
Comparing Soybean Oil-Based (Intralipid) With an Olive Oil-Based (ClinOleic) Lipid Emulsion on Healthy Volunteers
Many patients in the hospital who are malnourished or not eating received intravenous feeding or total parenteral nutrition (TPN). Despite improving nutrition, TPN may increase the risk of infections and hospital complications.
- Trial name
- TPN1 (NCT02185729)
- Testing
- Intralipid, ClinOleic, Dextrose
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Emory University
Systemic Lupus Erythematosus (SLE), Diffuse Systemic Sclerosis
YTS109 in Pediatric Relapsed/Refractory Autoimmune Diseases
This exploratory, single-arm, open-label study will evaluate the safety and preliminary efficacy of YTS109 cell therapy in pediatric patients with relapsed/refractory autoimmune diseases, including systemic lupus erythematosus…
- Conditions
- Systemic Lupus Erythematosus (SLE), Diffuse Systemic Sclerosis, Idiopathic Inflammatory Myopathies (IIMs), ANCA Associated Vasculitis (AAV)
- Trial name
- NCT07439029
- Testing
- YTS109 cell
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Children's Hospital of Fudan University
Crohn's Disease
Efficacy and Safety of Oral BT-11 in Moderate to Severe Crohn's Disease
This is a phase 2 randomized, placebo-controlled, double-blind, parallel-group multicenter induction study.
- Trial name
- NCT03870334
- Testing
- BT-11 880 mg
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- NImmune Biopharma
Acne
577-nm Diode Laser in the Treatment of Non -Inflammatory Acne
The aim of this study is to evaluate the clinical efficacy and safety of the 577 nm diode laser in the treatment of non -inflammatory acne.
- Trial name
- NCT06909344
- Testing
- 577 nm Diode laser
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Sepsis, Shock
Noninvasive Assessment of Tissue Perfusion Status in Critically Ill Pediatric Patients
Investigators are conducting research about oxygen levels in the body and whether it is possible to use a device to measure oxygen in the body's tissues noninvasively, without blood draws or a catheter (a plastic tube placed in a…
- Trial name
- NCT01760044
- Testing
- Tissue oxygenation monitoring
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Michigan
Chronic Inflammatory Disease
Chronic Inflammatory Rheumatism: Management of Comorbidities in Ambulatory Medicine
Identification of factors limiting compliance with the recommendations established during the evaluation of the SCORIC population by the rheumatology department of the CHU Grenoble Alpes
- Trial name
- SCORIC-A (NCT05613712)
- Testing
- Patients, Referring physician
- Where
- France
- Volunteers
- 229 people
- Sponsor
- University Hospital, Grenoble
Crohn's Disease of Both Small and Large Intestine
Crohn's Disease - Inflammation and Microbial Proteolytic Activity
This study postulates that altered microbiota associated with areas of mucosal inflammation in CD, can be characterized by an increased proteolytic profile.
- Trial name
- CIMPA (NCT06503081)
- Testing
- Colonoscopy
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Septic Shock
Dex on Microcirculation in SS-A Double-blinded Study
The investigators preliminary study showed that dexmedetomidine might improve microcirculation in septic shock patients. To test this effect, the investigators will conduct double-blinded study.
- Trial name
- NCT02612181
- Testing
- Dexmedetomidine for dexmedetomidine group
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Southeast University, China
Periodontitis, Type 2 Diabetes
Inflammatory Response and Gingival iNOS Levels in Diabetic vs. Non-Diabetic Periodontitis Patients
This study investigates the relationship between Type 2 diabetes mellitus (T2DM), glycemic control, and periodontal disease. Researchers analyzed the levels of inducible nitric oxide synthase (iNOS) and proinflammatory cytokines…
- Conditions
- Periodontitis, Type 2 Diabetes, Glycemic Control
- Trial name
- NCT06803836
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Systemic Sclerosis
Effect of Rosuvastatin on Systemic Sclerosis-related Pulmonary Hypertension
Although the aetiology of SSc-PAH remains elusive, vascular dysfunction seems to be the initial event and statins through their vasculoprotective effect might be of value in the treatment armamentarium of PAH related to SSc.
- Trial name
- NCT00984932
- Testing
- Rosuvastatin
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alexandria
Ulcerative Colitis
Safety and Efficacy Study of TLL018 in the Treatment of Ulcerative Colitis
A study to investigate the safety and efficacy of TLL018 compared with placebo in subjects with moderate to severe ulcerative colitis.
- Trial name
- NCT05121402
- Testing
- TLL018
- Where
- United States
- Sponsor
- TLL Pharmaceutical, LLC
Inflammatory Bowel Diseases
Correlation Between RISANKIZUMAB's Trough Levels, Clinical and Biological Remission in Moderate to Severe Crohn's Disease: a Retrospective Multicentric Study
The goal of this observational study is to determine if, as with other therapeutics such as anti-TNF, trough levels of Risankizumab are correlated with clinical and biological remission in patients with moderate to severe Crohn's…
- Trial name
- RISE-CD (NCT06589895)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Crohn Disease
A Study on the Impact of Online Positive Psychological Intervention on the Mental Health and Quality of Life of Crohn's Disease Patients
Crohn's disease (CD) is a chronic, nonspecific inflammatory disease that can affect the entire digestive tract. It is difficult to cure and often relapses, causing long-term suffering for patients.
- Trial name
- NCT06939712
- Testing
- Online Positive Psychology Intervention, Routine Care
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Sepsis
Multi-marker INDex for the Risk Assessment of Sepsis in the Emergency departmenT (MINDSET)
The purpose of the study is to procure blood samples from patients ≥18 years of age who present to the Emergency Department (ED) with at least two of the diagnostic criteria for sepsis.
- Trial name
- MINDSET (NCT00472628)
- Testing
- Blood samples collected
- Where
- 24 sites in United States
- Sponsor
- Abbott RDx Cardiometabolic
Beta Lactam Resistant Bacterial Infection, Enterobacteriaceae Infections
PipEracillin Tazobactam Versus mERoPENem for Treatment of Bloodstream Infections Caused by Cephalosporin-resistant Enterobacteriaceae (PETERPEN)
Data regarding optimal treatment for extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae blood-stream infection are lacking.
- Conditions
- Beta Lactam Resistant Bacterial Infection, Enterobacteriaceae Infections, Bacteremia
- Trial name
- PETERPEN (NCT03671967)
- Testing
- Piperacillin/tazobactam, Meropenem
- Where
- 14 sites in Canada, Israel
- Volunteers
- 1,084 people
- Sponsor
- Rambam Health Care Campus
Community-acquired Pneumonia, Sepsis
Anti-inflammatory Action of Oral Clarithromycin in Community-acquired Pneumonia
Traditional management of community-acquired pneumonia (CAP) relies on the prompt administration of antimicrobials that target the most common causative pathogens.
- Conditions
- Community-acquired Pneumonia, Sepsis, Inflammatory Response, Mortality
- Trial name
- ACCESS (NCT04724044)
- Testing
- Tablets, Clarithromycin 500mg
- Where
- 18 sites in Greece
- Volunteers
- 278 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Healthy Adults
Turmeric Anti-Inflammatory and Cell-Damage Trial
This trial will be conducted for the BBC. The aim of the project is to assess if consuming the spice turmeric every other day, in the amount consumed in a curry, can reduce cell damage and inflammation.
- Trial name
- TACT (NCT02815475)
- Testing
- Curcumin, Turmeric powder
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Newcastle University
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