Clinical trials: Inflammatory
Crohn Disease
Post-operative CRP Trend After Ileocolic Resection in Crohn's Disease Patients.
Our aim is to analyze C-Reactive Protein trends during the post-operative course in Crohn's Disease patients having undergone ileocolic resection and primary anastomosis, for the purpose of anastomotic leak early diagnosis.
- Trial name
- NCT04739579
- Testing
- C-Reactive Protein
- Where
- France
- Volunteers
- 59 people
- Sponsor
- Central Hospital, Nancy, France
Shock,, Sepsis
Effects of Sedatives on Sublingual Microcirculation of Patients With Septic Shock
Previous studies have demonstrated that altered microvascular blood flow is an important marker of severe sepsis. Usually, these patients need invasive ventilatory support, frequent use of sedatives and it is unknown if these…
- Trial name
- NCT01618396
- Testing
- Sedation drug (Propofol and Midazolam)
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- Casa de Saúde São José
Locally Advanced Rectal Cancer (LARC)
AI-Based Prediction of Pathological Response in Rectal Cancer Patients Receiving Total Neoadjuvant Therapy
This study aims to better understand how body composition, inflammation, and nutrition affect how rectal cancer responds to treatment.
- Trial name
- CINR-AI (NCT07049627)
- Testing
- Total Neoadjuvant Therapy (TNT)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 93 people
- Sponsor
- Ankara Etlik City Hospital
Acute Sciatica, Lumbar Disc Herniation
Chiropractic Spinal Manipulative Therapy for Acute Sciatica Secondary to Lumbar Disc Herniation
Comparisons of surgical and non-operative treatment of patients with acute sciatica secondary to lumbar intervertebral disc herniation (AS/LDH) have shown no appreciable difference in outcome.
- Trial name
- NCT01552486
- Testing
- Chiropractic Spinal Manipulative Therapy, Usual Care
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Vancouver General Hospital
Heart; Dysfunction Postoperative, Cardiac Surgery, Cytokine Release Syndrome
Peri-operative Prediction of Prolonged Stay in the Cardiac Intensive Care Unit for Adult Cardiac Surgery
The purpose of this study is to create a model using intra-operative modified SOFA score and peri-operative clinical factors to predict prolonged stay in the cardiac intensive care unit (CICU) for adult cardiac surgery with…
- Trial name
- NCT01559870
- Where
- 3 sites in Thailand
- Volunteers
- 164 people
- Sponsor
- Thepakorn Sathitkarnmanee
Abnormality in Synovial Tissue
Examination of Biopsies From Healthy Knee Joints
The purpose of the project is to examine what kind of molecular mechanism which causes inflammatory joint diseases. This examination is carried out by a collection and analysis of synovial tissues for patients without…
- Trial name
- NCT02458170
- Where
- Denmark
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Northern Orthopaedic Division, Denmark
Sepsis
Time Course of Procalcitonin and C Reactive Protein in Septic Patients Under Treatment With Corticosteroids
A systemic treatment with corticosteroids has been advocated for various bacterial infectious diseases. Since the production of CRP is down-regulated by corticosteroids, a smaller increase or a more rapid decrease of this acute…
- Trial name
- NCT00141973
- Where
- Switzerland
- Sponsor
- Ospedale Regionale Bellinzona e Valli
Inflammatory Bowel Diseases, Crohn Disease
PIBD-SETQuality: the Inception Cohort and Safety Registry
The purpose of this study is to analyse effectiveness and safety signals of current treatment strategies in routine practice for patients with pediatric-onset inflammatory bowel disease (PIBD) and to correlate this to their…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- PIBD-SETQ (NCT03571373)
- Testing
- No intervention
- Where
- 2 sites in Netherlands, United Kingdom
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Ulcerative Colitis
Comparison of PillCamCOLON (C2) Capsule and Standard Endoscopy for the Evaluation of Patients With Ulcerative Colitis
Ulcerative colitis (UC) is an inflammatory bowel disease progressing through flare-ups. The therapeutic objective, which was originally based on clinical remission, is currently evolving with the development of biotherapies…
- Trial name
- VCC2-RCH (NCT02610569)
- Testing
- standard endoscopy, PillCamCOLON (C2)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Dr. Arnaud Bourreille
Crohn's Disease
Azithromycin Based Therapy for Induction of Remission in Active Pediatric Crohn's Disease
The purpose of this study is to evaluate effectiveness of 2 months antibiotic course of Azithromycin combined with Metronidazole compared with 2 months antibiotic course of Metronidazole alone.
- Trial name
- NCT01596894
- Testing
- Azithromycin + Metronidazole, Metronidazole
- Where
- Israel
- Volunteers
- 73 people
- Sponsor
- Prof. Arie Levine
The Prevelance and Complications of Pulmonary Manifestations in Patients With Inflammatory Bowel Disease
The Prevelance of Pulmonary Manifestation in Patients With Inflammatory Bowel Disease
Bronchopulmonary manifestations signs and symptoms are variable extraintestinal manifestations of IBD.
- Trial name
- NCT04613466
- Volunteers
- 60 people
- Sponsor
- Assiut University
Mild to Moderate Ulcerative Colitis
Once Versus Twice Daily Mesalamine to Induce Remission in Pediatric Ulcerative Colitis
The purpose of this study is to evaluate effectiveness of once daily dosing of Pentasa compared with twice daily in children with mild to moderate active ulcerative colitis.
- Trial name
- MUPPIT (NCT01201122)
- Testing
- Mesalamine
- Where
- Israel
- Volunteers
- 86 people
- Sponsor
- Wolfson Medical Center
Chronic Inflammatory Demyelinating Polyneuropathy
Hematopoietic Stem Cell Transplantation in Chronic Inflammatory Demyelinating Polyneuropathy
Chronic inflammatory demyelinating polyneuropathy is disease believed to be due to immune cells, cells which normally protect the body, but are now attacking the nerves in the body.
- Trial name
- NCT00278629
- Testing
- hematopoietic stem cell transplantation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwestern University
Inflammatory Bowel Diseases, Ulcerative Colitis
Vitamin D Regulation of Gut Specific B Cells and Antibodies Targeting Gut Bacteria in Inflammatory Bowel Disease
Specific Aim 1: Characterize the effects of vitamin D treatment on expression of α4β7 on B cells in patients with inflammatory bowel disease (IBD).
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT04828031
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Stanford University
Cancer, Cardiotoxicity
BIOMARKER and IMAGING CHARACTERISATION of INFLAMMATORY ATHEROMA in PATIENTS RECEIVING IMMUNOTHERAPY and ANGIOGENESIS INHIBITORS
The advent of immunotherapy (immune checkpoint inhibitors [ICI]) has been an extremely important advancement for cancer treatment in recent decades.
- Conditions
- Cancer, Cardiotoxicity, Atherosclerotic Disease
- Trial name
- BIOCAPRI (NCT06597045)
- Testing
- PET/CT with 18-FDG
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- NHS Greater Glasgow and Clyde
Sepsis, Respiratory Failure
Inert Gas Rebreathing in Ventilated Patients
Measuring hemodynamic parameters in ventilated patients is important yet still complicated to perform. Inert gas rebreathing (IGR) showed promising results when being compared to other invasive as well as non-invasive techniques…
- Conditions
- Sepsis, Respiratory Failure, Heart Failure, Renal Failure
- Trial name
- VIGR (NCT01891253)
- Testing
- non-invasive determination of cardiac output
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Universitätsmedizin Mannheim
Septic Shock
Pentaglobin in CRE and PA Neutropenic Infections
To demonstrate that the early addition of Pentaglobin to the best available antimicrobial therapy is able to reduce mortality and improve survival in neutropenic febrile acute leukemia or allo- Hematopoietic stem cell…
- Trial name
- PENTALLO (NCT03494959)
- Testing
- Pentaglobin
- Where
- 20 sites in Italy
- Volunteers
- 120 people
- Sponsor
- Gruppo Italiano Trapianto di Midollo Osseo
Covid19, Cytokine Storm
Intramuscular Effect of Polymerized Type I Collagen on the Cytokine Storm in COVID-19 Patients
SARS-CoV-2 infection induces a hyperinflammatory syndrome, causing the acute respiratory distress syndrome, massive lung cell destruction and, as a plausible sequelae, pulmonary fibrosis in COVID-19 patients.
- Conditions
- Covid19, Cytokine Storm, Regulation of Inflammatory Response, Pulmonary Fibrosis
- Trial name
- NCT04517162
- Testing
- Collagen-Polyvinylpyrrolidone
- Where
- Mexico
- Volunteers
- 90 people
- Sponsor
- Janette Furuzawa Carballeda
Asthma, Late-Onset Asthma
General Risk Factors and Inflammatory Determinants in Older Patients With Asthma
A cross-sectional study in asthma patients to determine if a late age of onset asthma (start symptoms >18 years old), is associated with more persistent airway/systemic inflammation, worse asthma control, more co-morbidity, a…
- Conditions
- Asthma, Late-Onset Asthma, Childhood Asthma
- Trial name
- GRANDMA (NCT03278561)
- Testing
- Sputum induction, Blood sample
- Where
- Netherlands
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Gerdien Tramper
Immune System Processes, Inflammatory Activation and Modulation
The Sounds of Compassion: Testing How Specific Elements of Meditation Change Daily Life
Important health benefits of meditation may be conferred as much by what people actually do and say in their daily lives as by how they self-perceive the effect of training on their behavior and emotions.
- Conditions
- Immune System Processes, Inflammatory Activation and Modulation, ANS Function
- Trial name
- NCT01643369
- Testing
- Cognitive-Based Compassion Training, Adult Health Education Curriculum, Mindful Attention Training
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Arizona
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