Clinical trials: Inflammatory Bowel Disease, open to volunteers
Inflammatory Bowel Disease
Impact of Morning Light Therapy in IBD
The pilot study will focus on the effects of morning light therapy (MLT) in adult patients with ulcerative colitis (UC) who have evidence of poor sleep quality and active inflammation.
- Trial name
- NCT07207200
- Testing
- Morning Light Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Enteric Hyperoxaluria
Efficacy and Safety of TRA16 Administered Orally in Patients With Enteric Hyperoxaluria (EH).
A Phase II, Multi-center, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Safety of TRA16 Administered Orally in Patients with Enteric Hyperoxaluria (EH).
- Trial name
- NCT07871669
- Testing
- TRA16
- Volunteers
- 30 people
- Sponsor
- Wuhan Kangfude Urolithiasis Research Institute Co., Ltd.
Crohn Disease, Colitis, Ulcerative
A Study of Guselkumab in Participants With Crohn's Disease and Ulcerative Colitis
The purpose of this study is to evaluate how long a participant keeps taking guselkumab or continues with their treatment plan without stopping (treatment persistence) in participants with moderate to severe Crohn's disease (CD)…
- Trial name
- G-FORCE (NCT07606339)
- Where
- Austria
- Volunteers
- 35 people
- Sponsor
- Janssen-Cilag Pharma GmbH
Inflammatory Bowel Disease, Colitis, Ulcerative
LMT503 First-in-human SAD, MAD, and FE Study
This is a double-blind, randomized, placebo-controlled study, consisting of a single ascending dose (SAD) part with integrated food effect (FE) arm, and a multiple ascending dose (MAD) part to assess the safety, tolerability, and…
- Conditions
- Inflammatory Bowel Disease, Colitis, Ulcerative, Crohn Disease
- Trial name
- NCT05659953
- Testing
- LMT503
- Where
- Netherlands
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Lmito Therapeutics Inc.
IBD, Rheumatoid Arthritis
Fluorescence Imaging of IBD and RA Using Adalimumab-800CW
Inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) are both auto-immune diseases that are characterized by chronic relapsing inflammation of respectively the ileocolonic tissue and the synovium.
- Trial name
- STRATIFY (NCT03938701)
- Testing
- Adalimumab-800CW, Fluorescence Imaging
- Where
- Netherlands
- Volunteers
- 36 people
- Sponsor
- University Medical Center Groningen
Overweight and/or Obesity, Perimenopausal Women
Effects of a 6-months Fiber- and Polyphenol-rich Diet on Brain Inflammatory Processes in Perimenopausal Women Living With Overweight or Obesity
People living with obesity have a higher risk of late-life cognitive decline and developing dementia. In women, the risk of cognitive decline may further raise during the menopausal transition, a period of substantial hormonal…
- Trial name
- INFLAME (NCT07501377)
- Testing
- Polybiotic dietary intervention
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Max Planck Institute for Human Cognitive and Brain Sciences
Healthy Lifestyle, Home Environment Related Disease
HomeStyles-Adults of Chinese Heritage
Individuals of Chinese heritage are the largest and fastest growing segment of the US Asian population. US Chinese have sociodemographic characteristics and culture that differ substantially from other US Asians, and therefore…
- Conditions
- Healthy Lifestyle, Home Environment Related Disease, Cardiometabolic Disease, Systemic Inflammatory Response
- Trial name
- NCT06136793
- Testing
- HomeStyles-China
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Crohn Disease
A Study on the Impact of Online Positive Psychological Intervention on the Mental Health and Quality of Life of Crohn's Disease Patients
Crohn's disease (CD) is a chronic, nonspecific inflammatory disease that can affect the entire digestive tract. It is difficult to cure and often relapses, causing long-term suffering for patients.
- Trial name
- NCT06939712
- Testing
- Online Positive Psychology Intervention, Routine Care
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
IBD (Inflammatory Bowel Disease), Crohns Disease
OPTImization of Inflammatory Bowel Disease Treatment Through Understanding of Gut VIRome Heterogeneity
Title: The Role of Good Viruses in Inflammatory Bowel Disease Background An imbalance in the bacteria in the gut - called gut dysbiosis - is linked to chronic bowel diseases such as Crohn's disease and ulcerative colitis (IBD).
- Conditions
- IBD (Inflammatory Bowel Disease), Crohns Disease, Colitis Ulcerative
- Trial name
- OPTIVIR (NCT07240181)
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Andreas Munk Petersen
Body Composition Changes, Malnutrition
Body Composition Assessment and Monitoring in Inflammatory Bowel Disease
This is a single-center, prospective observational study aiming to describe changes in body composition (specifically, percentage of lean mass and phase angle) in patients with active inflammatory bowel disease (IBD), including…
- Trial name
- BAMBIE (NCT07162701)
- Testing
- Bioimpedance analysis
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Crohn's Disease (CD)
Research on the Whole Process of AI Intelligent Management System for the Diagnosis and Treatment of Inflammatory Bowel Diseases
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a chronic immune-mediated disorder requiring long-term management.
- Conditions
- Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Crohn's Disease (CD), Ulcerative Colitis (UC), Artificial Intelligence (AI)
- Trial name
- NCT07590271
- Where
- Taiwan
- Volunteers
- 4,500 people
- Sponsor
- Taichung Veterans General Hospital
Primary Sclerosing Cholangitis
Unraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative Research Approach
Background: Primary sclerosing cholangitis is a rare chronic liver disease. It affects the bile ducts of the liver. It can result in bile duct infections, cirrhosis, cancer, and end stage liver disease.
- Trial name
- NCT04685200
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Inflammatory Bowel Diseases Weight Changes
Weight and BMI Patterns in Biological Based IBD Patients and Its Finacial Impact
Primary Objective To determine the pattern of weight and body mass index (BMI) changes in biologic-treated patients with inflammatory bowel disease (IBD).
- Trial name
- obesity/IFX (NCT07495800)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
IBD - Inflammatory Bowel Disease
Long-term Treatment With Ustekinumab in Patients With Crohn's Disease and Ulcerative Colitis: a Cohort Study
Monocentric observational retrospective/prospective pharmacological study. Clinical records of patients with Ulcerative Colitis and Crohn's Disease who started therapy with Ustekinumab between February 2019 and March 2021 at the…
- Trial name
- NCT06802887
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Crohn's Disease
Feasibility of a Minimally Invasive Diagnostic Algorithm in Suspected Crohn's Disease
The goal of this clinical trial is to learn whether a camera pill examination of the whole bowel can be used to diagnose Crohn's disease instead of colonoscopy and a small bowel examination (either MRI or camera pill) in patients…
- Trial name
- ANDI-3 (NCT06882993)
- Testing
- Panenteric capsule endoscopy, Ileocolonoscopy, MRI enterography
- Where
- 5 sites in Denmark, Sweden
- Volunteers
- 165 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Ulcerative Colitis (UC)
Safety, Tolerability and PK of ATTO 1091 in Healthy Adult Volunteers and Patients With Ulcerative Colitis
The goal of this clinical trial is to assess the safety, tolerability, and pharmacokinetics (PK) of ATTO-1091 in healthy adults and patients with ulcerative colitis.
- Trial name
- NCT07819799
- Testing
- ATTO-1091
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Attovia Therapeutics Inc
Inflamatory Bowel Disease, Crohn Disease (CD)
Safety and Efficiency of the Universal CNK-UT009 in Difficult-to-treat Inflammatory Bowel Disease Patients
Inflammatory bowel disease patients who failed from at least two types of biologics or suffered refractory after at least twice surgery are defiened as difficult-to-treat IBD.
- Conditions
- Inflamatory Bowel Disease, Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- NCT07416383
- Testing
- injection of CNK-UT009
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Crohn Disease (CD)
Familial Inflammatory Bowel Disease Early Risk
Brief Summary The aim of the FIBER study is to identify potential triggers associated with the later development of IBD (inflammatory bowel disease) based on baseline characteristics and biosamples (blood, urine, stool, saliva…
- Conditions
- Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- FIBER (NCT07791862)
- Where
- United States
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Ulcerative Colitis
TOFACITINIB vs TOFACITINIB WITH MESALAMINE IN ULCERATIVE COLITIS
All the trials using tofacitinib for maintenance of remission in UC have allowed the use of concomitant therapies except glucocorticoids.
- Trial name
- NCT06625450
- Testing
- Tofacitinib, Tofacitinib plus mesalamine
- Volunteers
- 75 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Inflammatory Bowel Diseases
Evaluation of an Anti-TREM-1 Treatment on an ex Vivo Human Intestinal Model
TIME is an observational study performed on UC and CD patients under endoscopic surveillance for monitoring the clinical activity of their disease.
- Trial name
- TIME (NCT06580418)
- Testing
- Additional biopsies and blood samples
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Inotrem